We will also discuss an innovative and more sustainable approach to pyrrolobenzodiazepine (PBD) dimer linker-toxins. (acs.org)
We describe the characterization of antigen binding fragments (Fab)-drug conjugates prepared using a dual maleimide pyrrolobenzodiazepine dimer cytotoxic payload (SG3710). (academic-accelerator.com)
ZYNLONTA, Overland ADCT BioPharma's lead product candidate, is an ADC composed of a humanized monoclonal antibody directed against human CD19 and conjugated to a pyrrolobenzodiazepine (PBD) dimer cytotoxin. (adctherapeutics.com)
Our patients were treated with an alternative ADC directed against CD33, SGN-CD33A, a monoclonal anti-CD33 antibody conjugated to a pyrrolobenzodiazepine (PBD) dimer. (biomedcentral.com)
Conjugates2
From Anthramycin to Pyrrolobenzodiazepine (PBD)‐Containing Antibody-Drug Conjugates (ADCs) Angew Chem Int Ed Engl. (wikipedia.org)
ADCT develops antibody drug conjugates (ADCs) that target major cancers by incorporating highly potent pyrrolobenzodiazepine (PBD)-based warheads. (journalforclinicalstudies.com)
Payload1
Once bound to a CD19-expressing cell, ZYNLONTA is internalized by the cell, where enzymes release a pyrrolobenzodiazepine (PBD) payload. (adctherapeutics.com)
Antibody1
The antibody-drug conjugate (ADC) is composed of a humanized monoclonal antibody that binds to human CD19, conjugated through a linker to a pyrrolobenzodiazepine (PBD)-based cytotoxic warhead. (bioprocessintl.com)
Antibody-Drug Conjugates4
From Anthramycin to Pyrrolobenzodiazepine (PBD)‐Containing Antibody-Drug Conjugates (ADCs) Angew Chem Int Ed Engl. (wikipedia.org)
10. Discovery of novel polyamide-pyrrolobenzodiazepine hybrids for antibody-drug conjugates. (nih.gov)
12. Antibody-drug conjugates (ADCs) delivering pyrrolobenzodiazepine (PBD) dimers for cancer therapy. (nih.gov)
16. Antibody-Drug Conjugates Bearing Pyrrolobenzodiazepine or Tubulysin Payloads Are Immunomodulatory and Synergize with Multiple Immunotherapies. (nih.gov)
ADCs2
Pyrrolobenzodiazepine (PBD)-conjugated CD276 ADCs killed both cancer cells and tumor vasculature, eradicating large established tumors and metastases, and improving long-term overall survival in mouse models. (nih.gov)
Here, we apply computational systems pharmacology approaches to study ADCs with pyrrolobenzodiazepine (PBD) as the cytotoxic drug entity, combining experimental data and mechanistic modeling to conduct simulations of ADCs in different experimental scenarios relevant to drug development. (nih.gov)
Conjugate3
2. Preclinical Evaluation of MEDI0641, a Pyrrolobenzodiazepine-Conjugated Antibody-Drug Conjugate Targeting 5T4. (nih.gov)
A Phase I Study of ADCT-402 (Loncastuximab Tesirine), a Novel Pyrrolobenzodiazepine-Based Antibody-Drug Conjugate, in Relapsed/Refractory B-Cell Non-Hodgkin Lymphoma. (nih.gov)
New CD33-Directed Antibody-Drug Conjugate, Utilizing Pyrrolobenzodiazepine Dimers, Demonstrates Anti-tumor Activity in. (oncozine.com)
Pyrrolobenzodiazepines1
Pyrrolobenzodiazepines eller PBD, är en klass av naturliga produkter med antitumöregenskaper som produceras av olika bakterier och är betydligt mer potenta än systemiska kemoterapeutiska läkemedel. (biostock.se)
Potent1
ADCT-301 combines HuMax ® -TAC™, a monoclonal antibody targeting CD25 (the alpha chain of the IL-2 receptor) created by Genmab A/S , a biotechnology company, based in Copenhagen, Denmark, with a highly potent pyrrolobenzodiazepine (PBD)-based warhead . (european-biotechnology.com)
Toxin1
LCB71 has a proprietary tumor-activated pyrrolobenzodiazepine ("PBD") prodrug toxin that addresses the typical toxicity problem associated with traditional PBD payloads. (biospace.com)