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  • inhibitor
  • Pre-treatment of de-endothelialized rat caudal arterial smooth muscle strips with the pyrazolo[3,4-d]pyrimidinone inhibitor HS38 decreased the velocity of contraction (time to reach half-maximal force) induced by the phosphatase inhibitor calyculin A in the presence of Ca2+ without affecting maximal force development. (aspetjournals.org)
  • compounds
  • We conclude that pyrimidinone-like compounds are a promising new scaffold for reversible inhibition of DPP IV. (springer.com)
  • The latter compounds were treated with ammonium acetate to afford 2-methylpyrimidinones 10a - c , followed by methylation with methyl iodide to yield 2,3-dimethyl-pyrimidinones 11a - c . (mdpi.com)
  • Of these compounds, 2-bromophenyl-2-[(4-cyanophenyl)amino]-4-pyrimidinone hydrazone (9k) displayed the most potent anti-HIV-1 activity (EC(50) =1.7±0.6 nM), with excellent selectivity for infected over uninfected cells (SI=5762). (neb.com)
  • poly
  • Subsequently, poly(methyl-2-ureido-4[1 H ]-pyrimidinone- co -butyl acrylate) (P(MAUPy- co-n BA)) was modified on the surface of the microcapsules by click chemistry. (rsc.org)
  • PARP Inhibitor XIDR 2313, PARP Inhibitor XI, is a water soluble pyrimidinone compound that functions as a PARP (Poly(ADP-ribose) polymerase) inhibitor. (adooq.com)