• On the other hand, the recent finding that activated pyrimidine ribonucleotides can be synthesized under plausible prebiotic conditions means that it is premature to dismiss the RNA-first scenarios. (wikipedia.org)
  • citation needed] A cyclobutane pyrimidine dimer (CPD) contains a four membered ring arising from the coupling of the C=C double bonds of pyrimidines. (wikipedia.org)
  • The heterodimer DDB binds with intermediate strength to DNA containing another UV light-induced photoproduct (the cyclobutane pyrimidine dimer), and binds weakly to DNA that has no DNA damage. (wikipedia.org)
  • Nucleotide synthesis is an anabolic mechanism generally involving the chemical reaction of phosphate, pentose sugar, and a nitrogenous base. (wikipedia.org)
  • The nucleotides must be in the diphosphate form for the reaction to occur. (wikipedia.org)
  • Jones worked as postdoctoral fellow with Fritz Lipmann at Massachusetts General Hospital from 1951 to 1957 Her work with Lipmann and Leonard Spector included the novel demonstration of ATP being involved in a reaction to activate Coenzyme A and produce pyrophosphate, and the discovery of carbamoyl phosphate, a key component of nucleotides which are essential to energy transfer within cells. (wikipedia.org)
  • The driving force for the loss of the carboxyl linked to the C6 of the pyrimidine ring comes from the close proximity of an aspartate residue carboxyl group in the enzyme's active site, which destabilizes the ground state relative to the transition state of the uncatalyzed reaction. (wikipedia.org)
  • Instead of assembling the nucleotide components in stepwise linear reactions, the synthesis proceeds through the reaction of cyanoacetylene with an aminooxazole intermediate that is formed from glycolaldehyde and cyanamide, molecules that were likely present on early Earth. (wikipedia.org)
  • The Traube purine synthesis (1900) is a classic reaction (named after Wilhelm Traube) between an amine-substituted pyrimidine and formic acid. (wikipedia.org)
  • Reaction of the former with amidines to give 2-substituted pyrimidines, with urea to give 2-pyrimidinones, and guanidines to give 2-aminopyrimidines are typical. (wikipedia.org)
  • Pyrimidines can be prepared via the Biginelli reaction. (wikipedia.org)
  • A novel method is by reaction of N-vinyl and N-aryl amides with carbonitriles under electrophilic activation of the amide with 2-chloro-pyridine and trifluoromethanesulfonic anhydride: Because of the decreased basicity compared to pyridine, electrophilic substitution of pyrimidine is less facile. (wikipedia.org)
  • The predicted deamination reaction is driven by a direct nucleophilic attack on position 4 of the cytidine pyrimidine ring by the zinc-coordinated enzyme. (wikipedia.org)