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  • analogues
  • Herein we describe the structure-aided design and synthesis of a series of pyridone-conjugated monobactam analogues with in vitro antibacterial activity against clinically relevant Gram-negative species including Pseudomonas aeruginosa, Klebsiella pneumoniae, and Escherichia coli. (owu.edu)
  • conjugate addition
  • A combination of [RhCl(C 2 H 4 ) 2 ] 2 and BINAP was determined to be the most effective catalyst to promote the 1,4-conjugate addition reactions of arylzinc chlorides to N -Boc-4-pyridone. (mdpi.com)
  • A broad scope of arylzinc reagents with both electron-withdrawing and electron-donating substituents on the aromatic ring successfully underwent 1,4-conjugate addition to N -Boc-4-pyridone to afford versatile 1,4-adducts 2-substituted-2,3-dihydropyridones in good to excellent yields (up to 91%) and excellent ee (up to 96%) when ( S )-BINAP was used as chiral ligand. (mdpi.com)
  • Guo F, McGilvary MA, Jeffries MC, Graves BN, Graham SA, Wu Y. Rhodium(I)-Complexes Catalyzed 1,4-Conjugate Addition of Arylzinc Chlorides to N -Boc-4-pyridone. (mdpi.com)
  • NEUTROPHIL ELASTASE
  • This invention relates to substituted 4-pyridones of formula 1 ##STR00001## and their use as inhibitors of neutrophil elastase activity, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of pulmonary, gastrointestinal and genitourinary diseases, inflammatory diseases of the skin and the eye and other auto-immune and allergic disorders, allograft rejection, and oncological diseases. (patentsencyclopedia.com)
  • tautomer
  • We studied the photoionization of 2-pyridone and its tautomer, 2-hydroxypyridine by means of VUV synchrotron radiation coupled to a velocity map imaging electron/ion coincidence spectrometer . (rsc.org)
  • potent
  • A pyridone analogue (5) of the potent bicyclic cannabinoid CP 47,497 (6) has been synthesized as a model for one conformational isomer of anandamide and to test the hypothesis that an amide carbonyl may serve as a hydrogen bond acceptor in interactions with the CB1 cannabinoid receptor. (rti.org)
  • undergo
  • A comprehensive study of methylated pyridone-derived endoperoxides has led to the development of water-soluble molecules that undergo retro Diels-Alder reactions in aqueous environment releasing oxygen in high yield and with half-lives of up to 13 hours. (uzh.ch)
  • 2-Pyridones are known to undergo a facile [4+ photocycloaddition with themselves and other conjugated molecules . (temple.edu)
  • Additionally , enyne-pyridone photoadducts can undergo transannular ring closure when treated with bromine and also be transformed into valuable bicyclo [5.1. octane structures that incorporate a rare example of a stable cyclopropanone by a fast and selective epoxidation-rearrangement process . (temple.edu)
  • novel
  • Third , the fundamental basis for the novel photochemical transformation (enyne-pyridone cycloaddition) was set and major trends for this reaction were established resulting in obtaining stable allenic photoadducts . (temple.edu)
  • unusual
  • Two unusual pyridones, trichodin A ( 1 ) and trichodin B ( 2 ), together with the known compound, pyridoxatin ( 3 ), were extracted from mycelia and culture broth of the marine fungus, Trichoderma sp. (mdpi.com)
  • central
  • The study is devoted to investigation of a number of ketocyanine dyes (polyenic ω , ω ′ -bisaminoketones) with a central pyranone or pyridone fragment and respective polymethine salts by UV-VIS absorption and NMR spectroscopies. (hindawi.com)
  • effect
  • In a manuscript appearing online today in Tetrahedron , John, Van, and Miranda report a new method to effect intermolecular N -alkylation of 2-pyridones using an alkene as the alkylating reagent. (englelab.com)