• adults
  • Pyrazinamide has been used in children and, in effective doses, has not been reported to cause different side effects or problems in children than it does in adults. (mayoclinic.org)
  • Although there is no specific information comparing pyrazinamide in the elderly with use in other age groups, this medicine is not expected to cause different side effects or problems in older people than it does in younger adults. (mayoclinic.org)
  • nine
  • Nine pyrazinamide derivatives also inhibited PET in spinach chloroplasts and the IC 50 values of these compounds varied in the range from 14.3 to 1590.0 μmol/L. The inhibitory activity was connected not only with the lipophilicity, but also with the presence of secondary amine fragment bounded to the pyrazine ring. (mdpi.com)
  • active
  • In this work, we present the cocrystallization of three model active pharmaceutical ingredients: pyrazinamide, lidocaine and pentoxifylline. (rsc.org)
  • results
  • The results of our work show that the dominant supramolecular bond in pyrazinamide cocrystals is the X⋯N type halogen bond (where X = Br or I) established with the pyrazinyl nitrogen atom, in lidocaine cocrystals it is the X⋯O type halogen bond, while in pentoxifylline cocrystals it is dependent on the donor strength. (rsc.org)