• These intrinsic and synaptic properties of mossy cells may explain this cell type's exceptional vulnerability to excitotoxic damage by intense afferent stimulation. (nih.gov)
  • 6. In summary, mossy cells were significantly different from CA3c pyramidal cells in many of their morphological, intrinsic physiological, and synaptic properties. (nih.gov)
  • Using paired recordings of retrogradely labeled cells, we investigated the synaptic connectivity between two projection cell types: those projecting to the pons [corticopontine (CPn) cell], often with collaterals to the striatum, and those projecting to both sides of the striatum but not to the pons [crossed corticostriatal (CCS) cell]. (jneurosci.org)
  • CCS cells had reciprocal synaptic connections with each other and also provided synaptic input to CPn cells. (jneurosci.org)
  • Therefore, our data demonstrate that these two types of corticostriatal cells distinct in their dendritic morphologies show directional and domain-dependent preferences in their synaptic connectivity. (jneurosci.org)
  • Alexander and Crutcher, 1990 ), knowledge of the patterns of synaptic connectivity between corticostriatal cells may suggest a physiological substrate for cortical influence on the basal ganglia circuitry. (jneurosci.org)
  • To this end, we investigated the synaptic connections between retrograde-labeled CCS and CPn pyramidal cells. (jneurosci.org)
  • Our results demonstrate distinct morphologies and selective patterns of synaptic connectivity between CCS and CPn cells. (jneurosci.org)
  • Voltage-activated sodium currents were observed in dendritic outside-out patches, while action potentials could be evoked by depolarizing current pulses or by synaptic stimulation during dendritic whole-cell recordings. (nih.gov)
  • Previous studies revealed the basic features governing the integration of LOT synaptic input and spike output of layer 2/3 (L2/3) principal cells in APC slices. (jneurosci.org)
  • Thus, the firing of principal cells in APC reflects the integration of subthreshold excitatory synaptic responses generated by multiple afferent fibers. (jneurosci.org)
  • The magnitude of the simulated E-S potentiation depended on the passive electrical properties of the cell, the excitability of the soma, and the relative locations on the dendrites of the synaptic inputs and hot spots. (jneurosci.org)
  • In addition, we summarize the way synaptic interaction can occur between these bursting cells to bring about population synchrony. (springer.com)
  • Following postsynaptic activation of a pyramidal cell, the degree of GABAergic synaptic inhibition that the cell receives is reduced dramatically for many seconds. (nih.gov)
  • Despite the central position of CA3 pyramidal cells in the hippocampal circuit, the experimental investigation of their synaptic properties has been limited. (springer.com)
  • Recent slice experiments from adult rats characterized AMPA and NMDA receptor unitary synaptic responses in CA3b pyramidal cells. (springer.com)
  • Models of synaptic responses in active cells suggest altered axial resistivity and the presence of synaptically activated potassium channels in spines. (springer.com)
  • Loss of dystroglycan in pyramidal cells had little influence on clustering of other GABAergic postsynaptic proteins and of glutamatergic synaptic proteins. (jneurosci.org)
  • The neural cell adhesion molecule (NCAM), has been shown to be an obligate regulator of synaptic stability and pruning during critical periods of cortical maturation. (frontiersin.org)
  • Protopapas A.D., Bower J.M. (1997) Pyramidal Cell Response to Patterns of Synaptic Input Believed to Underlie Gamma Oscillations. (springer.com)
  • If the voltage changes by a large enough amount, an all-or-none electrochemical pulse called an action potential is generated and this change in cross-membrane potential travels rapidly along the cell's axon, and activates synaptic connections with other cells when it arrives. (wikipedia.org)
  • Generally, excitatory postsynaptic potentials (EPSPs) from synaptic activation are not large enough to activate the dendritic voltage-gated calcium channels (usually on the order of a couple milliamperes each) so backpropagation is typically believed to happen only when the cell is activated to fire an action potential. (wikipedia.org)
  • The short time course required to observe these effects (3 d for the estradiol effect and 5 hr for the progesterone effect) implies that CA1 pyramidal cell dendritic spine density may fluctuate during the normal (4-5 d) rat estrous cycle. (jneurosci.org)
  • In the present study we have compared the morphological and physiological characteristics of mossy cells and nearby CA3c pyramidal cells with the use of a rat hippocampal slice preparation. (nih.gov)
  • b ) Subsequent morphological analysis allowed for evaluation of cell identity (green) and distance to probe track. (nih.gov)
  • Reconstructed CA3b pyramidal cells from the public repository NeuroMorpho.Org were used to allow for cell-specific morphological variation. (springer.com)
  • RS and IM cells had comparatively simpler morphological profiles. (jneurosci.org)
  • These electrophysiological and morphological properties of the four principal pyramidal PFC cell types have provided valuable details for understanding further how PFC processes input and transmit outputs to regions such as the NAc. (jneurosci.org)
  • The Schaffer collateral clearly affects whether the target cells fire action potentials or not. (wikipedia.org)
  • Predictions were made for passive-cell current clamp recordings, combined AMPA and NMDA receptor responses, and local dendritic depolarization in response to unitary stimulations. (springer.com)
  • Na + /Ca 2+ exchanger (NCX) and plasma membrane Ca 2+ -ATPase (PMCA) molecules play an essential role in Ca 2+ clearance across the plasma membrane in excitable cells ( 10 ). (pnas.org)
  • In this chapter we describe the membrane conductance system of the pyramidal cells that allows burst generation. (springer.com)
  • All PFC cells exhibited either subthreshold oscillation in membrane voltage or pacemaker-like rhythmic firing. (jneurosci.org)
  • We applied a combination of ultrastructural and functional imaging methods to assess the subcellular distribution and role of NCX1 in rat CA1 pyramidal cells. (pnas.org)
  • Thus, the firing dynamics of hippocampal PCs are exquisitely controlled at subcellular and microcircuit levels in a cell type-selective manner. (nih.gov)
  • Author: Etay Hay 2014 Reference: Dendritic excitability and gain control in recurrent cortical microcircuits (Hay and Segev, 2014, Cerebral Cortex) microcircuit.hoc: Parallel simulation of microcircuit of L5 thick tufted pyramidal cells (TTCs). (yale.edu)
  • Four principal pyramidal cell types were identified and classified as regular spiking (RS) (19%), intrinsic bursting (IB) (64%), repetitive oscillatory bursting (ROB) (13%), and intermediate (IM) (4%) types. (jneurosci.org)
  • Here, we generated a conditional transgenic mouse strain in which double-strand RNA-dependent protein kinase (PKR)-mediated phosphorylation of eIF2α, a key translation initiation protein, was specifically increased in hippocampal CA1 pyramidal cells by the chemical inducer AP20187. (jneurosci.org)
  • Formation of Hirano bodies in Dictyostelium and mammalian cells induces by expression of a modified form of an actin-crosslinking protein," J.Cell Sci. (wikipedia.org)
  • To identify expressing cells, they replaced the cytoplasmic tail of the algal protein with the fluorescent protein YFP, generating the first generally applicable optogenetic tool. (wikipedia.org)
  • Between postnatal days 3 and 21, pyramidal cells have been shown to double in the size of the soma, increase in length of the apical dendrite by fivefold, and increase in basal dendrite length by thirteenfold. (wikipedia.org)
  • Theta phase precession emerges from a hybrid computational model of a CA3 place cell. (springer.com)
  • As a rat approached the place field, the corresponding place cell would fire slightly in advance of the theta wave peak. (wikipedia.org)
  • At the center of the place field, when the cell would fire at its maximal rate, the firing had been advanced sufficiently to be anti-phase to the theta potential (at the bottom, rather than at the peak, of the theta waveform). (wikipedia.org)
  • Subsequent studies showed that each time a rat entered a completely different area and the phase fields would be remapped, place cells would again become phase-locked to the theta rhythm, and that theta wave phase precession is also a property of grid cells in the entorhinal cortex. (wikipedia.org)