AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesInformation ScienceHealth Care
Helicobacter pyloriHelicobacter InfectionsGastritisGastric MucosaUreasePylorusPeptic UlcerStomachClarithromycinAmoxicillinMetronidazoleDyspepsiaDuodenal UlcerAnti-Ulcer AgentsOmeprazoleBacterial ProteinsStomach NeoplasmsPyloric AntrumStomach DiseasesGastritis, AtrophicBreath TestsStomach UlcerBismuthAnti-Bacterial AgentsAntibodies, BacterialGastroscopyLansoprazoleDrug Therapy, CombinationPepsinogen AMetaplasiaProton Pump InhibitorsTinidazoleBiopsyLewis Blood-Group SystemDuodenitisEndoscopy, GastrointestinalGerbillinaeUreaFurazolidoneRanitidineHelicobacterCampylobacterGastrinsPepsinogensGastric AcidDNA, BacterialPepsinogen CAntacidsPolymerase Chain ReactionTetracyclineCytotoxinsGastric JuiceImmunoglobulin GAntitrichomonal AgentsLymphoma, B-Cell, Marginal ZoneBacterial AdhesionOrganometallic CompoundsMolecular Sequence DataPenicillinsSeroepidemiologic StudiesVirulenceEnzyme-Linked Immunosorbent AssayPrevalenceVirulence FactorsGenes, BacterialEndoscopy, Digestive SystemAzure StainsGastric MucinsNitroreductasesAchlorhydriaGastrointestinal DiseasesGastroesophageal RefluxDuodenumAntigens, CD15Adhesins, BacterialParietal Cells, GastricEpithelial CellsEndoscopySensitivity and SpecificitySulfoxidesInterleukin-8Peptic Ulcer HemorrhageEsophagitisSerologic TestsMicrobial Sensitivity TestsColony Count, MicrobialEsophagitis, PepticGenomic IslandsChronic DiseaseGene Expression Regulation, BacterialProspective StudiesHelicobacter felisGenotypeHelicobacter heilmanniiCase-Control StudiesGastric Acidity DeterminationBase SequenceGenome, BacterialFecesBacterial Vaccines
GastritisCarcinogenesisDeveloping gastric cancerMucosaDevelopment of gastricIncidenceEpithelialStrainsHelicobacter pylori InfectionAbstractHuman gastricUlcersChronicInfection and gastric cancerAtrophyUlcerBacteriumPatientsGastroenterologyCagAMucosalBacteriaMetaplasiaWorld's populationBiopsyStomach cancerPrevalenceCancersBiopsiesDiagnosisMALTMechanismsAntibiotic resistanceUreaResectionPathogenesisBacterialInfections2017ClinicalRegressionInteractionPreventionSymptomsLesionsPositivityColonizationHistologicalAntibioticsTissueSerumTissuesRegimensRisk
Gastritis15
  • Sixty nine cases with gastric cancer and 96 cancer-free control subjects with either gastric ulcer or chronic gastritis were studied. (scialert.net)
  • At the 20-year follow-up, a total of 367 instances of a gastric diagnosis were made, including 109 of multifocal atrophic gastritis without intestinal metaplasia, 228 with intestinal metaplasia, 30 with dysplasia, and 1 with gastric cancer. (cancertherapyadvisor.com)
  • This perception changed in 1982, when two Australian scientists Barry Marshall and Robin Warren reported the presence of H. pylori in a patient with chronic gastritis and gastric and duodenal ulcers [3]. (emerypharma.com)
  • Moreover, since the prevalence of H. pylori and pattern of superficial gastritis can change quickly within a specific population, the incidence of gastric cancer can also shift rapidly (10). (docksci.com)
  • Helicobacter pylori is commonly detected based on hematoxylin-eosin (H-E) choices, nevertheless, immunohistochemistry (IHC) and real-time PCR (RT-PCR) are additional actual in chronic-gastritis. (pharmas-eu.org)
  • Clinically, patients presenting with symptoms of gastritis, routinely undergo gastric biopsies. (biomedcentral.com)
  • and Ashktorab, Hassan, "Association between Helicobacter pylori infection in gastric cancer, ulcers and gastritis in Iranian patients [2]" (2004). (howard.edu)
  • Lymphocytic gastritis is an inflammatory stomach disorder that is characterized by superficial inflammation of the stomach lining (mucosa) that mainly involves the gastric antrum in children. (glutenfreeworks.com)
  • When H. pylori infects a child, it often leads to a type of gastritis that can cause both stomach ulcers and cancer. (readabstracts.com)
  • When an adult contracts H. pylori, this gastritis does not occur, but the adult may develop duodenal ulcer. (readabstracts.com)
  • Helicobacter pylori eradication down-regulates matrix metalloproteinase-9 expression in chronic gastritis and gastric ulcer. (unicatt.it)
  • Helicobacter pylori has been shown to be the causative agent in chronic-active gastritis, and evidence has almost completely satisfied Koch's postulates for this organisms' pathogenicity in primary duodenal ulcers. (cdc.gov)
  • It is concluded that both spiral and coccoid forms of H. pylori can cause acute gastritis in BALB/c A mice. (lu.se)
  • Helicobacter pylori-which is passed from cross contamination of fecal matter, was present in patients with chronic gastritis and gastric ulcers. (cdc.gov)
  • H pylori infection is associated with chronic atrophic gastritis, and patients with a history of prolonged gastritis have a sixfold increased risk of developing gastric cancer. (medscape.com)
Carcinogenesis11
  • The disruption of Wnt/PCP signaling by the oncoprotein CagA seems to promote gastric carcinogenesis. (medicalxpress.com)
  • A specialized protein delivered by H. pylori to the host, oncoprotein "CagA," has been shown to interact with multiple host proteins and promote gastric carcinogenesis (transformation of normal cells to cancer cells ). (medicalxpress.com)
  • CagA interacts with multiple host proteins within the gastric epithelial cells, thereby inducing pathways associated with oncogenesis and promoting gastric carcinogenesis. (medicalxpress.com)
  • In summary, the researchers conclude that through this study, they were able to elucidate the molecular mechanisms involved in gastric carcinogenesis induced by H. pylori, gain insights into the role of the Wnt/PCP pathway in carcinogenesis, and propose it as a potential target for clinical interventions against H. pylori cagA + infections. (medicalxpress.com)
  • The biological effects of exposure to this plant within the gastric carcinogenesis process are not fully understood. (pasteur.fr)
  • The gene transcription alterations and the induced glycophenotypic changes observed in the gastric mucosa contribute for the understanding of the molecular mechanisms underlying the role of Pteridium aquilinum in the gastric carcinogenesis process. (pasteur.fr)
  • Bacterial-secreted CagA, inducing high levels of chronic inflammation, is the main factor increasing mutagenesis rate, oxidative-stress, and increased mismatch repair pathways, resulting in gastric carcinogenesis (14, 15). (docksci.com)
  • This study aimed to evaluate the changes in epigenetic and genetic expression of multiple Rho GTPases in Helicobacter pylori -related gastric carcinogenesis by comparing H. pylori -positive GCs and negative controls. (gutnliver.org)
  • Because H. pylori virulence factor CagA has been associated with aberrant expression of the transcription factor CDX1, which regulates intestinal differentiation, we explored its relationship with H. pylori infection and function during gastric carcinogenesis in normal gastric epithelial cells and gastric cancer cell lines. (figshare.com)
  • These findings provide insight into the mechanisms by which H pylori might promote gastric carcinogenesis (persisting despite constant inflammation) and ineffectiveness of T-cell-based vaccines against H pylori. (mdc-berlin.de)
  • Furthermore, at-risk cohorts should be particularly examined to address unresolved controversies regarding route of transmission, environmental risk factors (i.e., food or water), inheritability or familial tendencies for infection susceptibility, factors leading to carcinogenesis, the demographics of susceptibility in very young children, and possible growth disturbances caused by H. pylori infection. (cdc.gov)
Developing gastric cancer1
  • Clinical evidence suggests that infection with H. pylori cagA + strains dramatically increases the risk of developing gastric cancer. (medicalxpress.com)
Mucosa15
  • Helicobacter pylori eradication is generally accepted as the first choice of treatment for stage IE low-grade gastric MALT lymphoma (mucosa-associated lymphoid tissue-type lymphoma). (nih.gov)
  • In the present work, effects in the gastric mucosa of mice treated with Pteridium aquilinum were evaluated, as well as molecular mechanisms underlying the synergistic role with Helicobacter pylori infection. (pasteur.fr)
  • Our results showed that exposure to Pteridium aquilinum induces histomorphological modifications including increased expression of acidic glycoconjugates in the gastric mucosa. (pasteur.fr)
  • The transcriptome analysis of gastric mucosa showed that upon exposure to Pteridium aquilinum several glycosyltransferase genes were differently expressed, including Galntl4, C1galt1 and St3gal2, that are mainly involved in the biosynthesis of simple mucin-type carbohydrate antigens. (pasteur.fr)
  • These results disclose the molecular basis for the altered pattern of glycan structures observed in the mice gastric mucosa. (pasteur.fr)
  • Now it is widely accepted that H. pylori infection can contribute to the development of gastric cancer and of gastric mucosa-associated lymphoid tissue (MALT) lymphoma [5]. (emerypharma.com)
  • The aim of the present study is to evaluate the expression of tryptophan hydroxylase (TpH-1) in gastric mucosa of patients with symptomatic and asymptomatic H. pylori infection in relation to the intensity of bacterial colonization and severity of dyspeptic symptoms. (archivesofmedicalscience.com)
  • The level of mRNA expression of tryptophan hydroxylase (TpH-1) was estimated in gastric mucosa with RT-PCR. (archivesofmedicalscience.com)
  • Moreover, it leads to destructive changes in the gastric and duodenal mucosa and can be the cause of asymptomatic peptic ulcers [ 17 - 19 ]. (archivesofmedicalscience.com)
  • Moreover, no morphological differences have been found in gastric mucosa or in the level of pro-inflammatory cytokines [ 31 - 33 ]. (archivesofmedicalscience.com)
  • This insoluble mucus forms a protective gel-like coating over the entire surface of the gastric mucosa. (wikipedia.org)
  • The mucus protects the gastric mucosa from autodigestion by e.g. pepsin and from erosion by acids and other caustic materials that are ingested. (wikipedia.org)
  • BACKGROUND & AIMS: Despite inducing an inflammatory response, Helicobacter pylori can persist in the gastric mucosa for decades. (mdc-berlin.de)
  • Simultaneously, we observed changes in the prevalence of Helicobacter pylori infection and in serological atrophy of the gastric mucosa, and compared the results with those involving changes hi the incidence of gastric cancer. (elsevierpure.com)
  • The frequency of serological atrophy of the gastric mucosa significantly declined in all age groups between 1989 and 1996, with young age groups experiencing a more marked decrease. (elsevierpure.com)
Development of gastric5
  • This, in conjunction with other oncogenic CagA actions, may contribute to the development of gastric cancer . (medicalxpress.com)
  • The molecular mechanism of the interaction between gastric epithelial cells and H. pylori may also suggest a novel strategy for effective prevention of the development of gastric cancer (19, 20). (docksci.com)
  • Further studies are necessary to elucidate actual role of H. pylori as causative agent to the development of gastric cancer. (docksci.com)
  • It has also been associated with the development of gastric cancer. (grantome.com)
  • Helicobacter pylori infection and the development of gastric cancer. (readabstracts.com)
Incidence12
  • Although over the last years, incidence of gastric carcinoma is decreasing worldwide, it remains the fourth most common cancer and the second most common cause of malignancy-related death worldwide (6, 7). (docksci.com)
  • Efficacy of eradication may vary in extent among countries with different incidence ratesof gastric cancer. (waocp.org)
  • 1) Background: Saudi Arabia (SA) is a country with a low incidence of gastric cancer (GC). (mdpi.com)
  • MAIN OUTCOME MEASURES: Primary outcomes were cumulative incidence of gastric cancer identified through scheduled gastroscopies and active clinical follow-up through 2017, and deaths due to gastric cancer ascertained from death certificates and hospital records. (dragonsmedicalbulletin.com)
  • A protective effect of H pylori treatment on gastric cancer incidence persisted 22 years post-intervention (odds ratio 0.48, 95% confidence interval 0.32 to 0.71). (dragonsmedicalbulletin.com)
  • Effects of H pylori treatment on both gastric cancer incidence and mortality and of vitamin supplementation on gastric cancer mortality appeared early, but the effects of vitamin supplementation on gastric cancer incidence and of garlic supplementation only appeared later. (dragonsmedicalbulletin.com)
  • H pylori treatment and vitamin supplementation were also associated with a statistically significantly reduced incidence of gastric cancer. (dragonsmedicalbulletin.com)
  • Effects of Helicobacter pylori treatment and vitamin and garlic supplementation on gastric cancer incidence and mortality: follow-up of a randomized intervention trial. (dragonsmedicalbulletin.com)
  • Although age-adjusted mortality from gastric cancer has been decreasing in Japan, the crude incidence of gastric cancer shows a slight increase. (elsevierpure.com)
  • We have observed trends in the incidence of gastric cancer by sex and 20-year age groups over the past two decades (1976-1996). (elsevierpure.com)
  • The marked decline in gastric cancer incidence observed in the young population will also begin to occur in the elderly population in the future. (elsevierpure.com)
  • A diet rich in pickled vegetables, salted fish, salt, and smoked meats correlates with an increased incidence of gastric cancer. (medscape.com)
Epithelial8
  • In order to carry out their study, the researchers expressed oncoprotein CagA in three different models-embryos of Xenopus laevis (lab frog), adult mouse stomach, and cultured human gastric epithelial cells-and tried to understand its effect on the host cells and pathways. (medicalxpress.com)
  • Finally, the team expressed the CagA oncoprotein in cultured human gastric epithelial cells. (medicalxpress.com)
  • Similar associations have been noted for gastric cancer and for other epithelial malignancies such as lung, pharynx, larynx, esophageal and breast cancer. (wishstudio.ro)
  • Infection of HFE 145 cells with CagA+ H. pylori increased expression of CDX1, as well as the epithelial-to-mesenchymal transition (EMT) markers Snail and Slug, increased invasion and migration, but those effects were not found in HFE 145 cells infected with CagA-deficient H. pylori. (figshare.com)
  • We investigated how cgt affects gastric epithelial cells and the host immune response. (mdc-berlin.de)
  • METHODS: MKN45 gastric epithelial cells, AGS cells, and human primary gastric epithelial cells (obtained from patients undergoing gastrectomy or sleeve resection or gastric antral organoids) were incubated with interferon gamma (IFNG) or interferon beta (IFNB) and exposed to H pylori, including cagPAI and cgt mutant strains. (mdc-berlin.de)
  • CONCLUSIONS: H pylori expression of cgt reduces cholesterol levels in infected gastric epithelial cells and thereby blocks IFNG signaling, allowing the bacteria to escape the host inflammatory response. (mdc-berlin.de)
  • Upon infection of the gastric epithelial cells, the Helicobacter pylori cytotoxin-associated gene A (CagA) virulence protein is injected into the epithelial cells via the type IV secretion system (TFSS), which is dependent on cholesterol. (tmu.edu.tw)
Strains5
  • To our knowledge, certain H. pylori strains seem to differently increase the risk of cancer, depending on the existence of certain bacterial genotypes (for example: cagA) (12, 13). (docksci.com)
  • Taking together, in this paper, we aim to point out all important topics concerning management of H. pylori strains associated with gastric cancer. (docksci.com)
  • It was believed to depend on the virulence of H. pylori strains, but in many studies conducted in patients with symptomatic and asymptomatic infection, there were no significant differences in the prevalence of virulent CagA and VacA strains [ 23 - 28 ], although there is still a search for them [ 29 , 30 ]. (archivesofmedicalscience.com)
  • Both spiral and coccoid forms of all H. pylori strains gave significantly higher inflammation scores than a control group of animals 1 week after inoculation. (lu.se)
  • Genome-wide association study of gastric cancer- and duodenal ulcer-derived Helicobacter pylori strains reveals discriminatory genetic variations and novel oncoprotein candidates. (cdc.gov)
Helicobacter pylori Infection10
Abstract2
  • H. pylori infection disproportionately affects racial/ethnic minorities and those of lower socioeconomic status," Leiman, coauthor Julius Wilder, MD, PhD, of Duke University in Durham, and colleagues wrote in their abstract presented at the annual meeting of the American College of Gastroenterology. (medscape.com)
  • article{12d8652c-fb65-4fea-9b79-c16ee78a1a0e, abstract = {{Helicobacter pylori exists in two different morphological forms, spiral and coccoid. (lu.se)
Human gastric2
  • The messenger RNA expression and methylation of Rho GTPases (RhoA, Rac1, DOCK180, ELMO1, and CDC42) were evaluated in H. pylori -negative (control) human gastric tissues and H. pylori -positive GCs by using real-time reverse transcription-polymerase chain reaction and the quantitative MethyLight assay, respectively. (gutnliver.org)
  • We compared gene expression patterns among primary human gastric cells, uninfected or infected with H pylori P12 wt or P12Δcgt, using microarray analysis. (mdc-berlin.de)
Ulcers5
  • Moreover, now it is estimated that H. pylori accounts for majority of the stomach and upper small intestine ulcers in humans [1 - 2]. (emerypharma.com)
  • Helicobacter pylori (H. pylori), which increases the risk of gastric diseases, including digestive ulcers and gastriccancer, is highly prevalent in Asian countries. (waocp.org)
  • H. pylori has been linked to both stomach ulcers and duodenal ulcers. (readabstracts.com)
  • With the discovery of the association between H. pylori infection and PUD, appropriate antibiotic regimens can now successfully eradicate gastrointestinal infection with this organism and permanently cure ulcers in a high proportion of patients. (cdc.gov)
  • In 1994, a National Institutes of Health consensus development conference panel concluded that patients with ulcers caused by H. pylori infection require treatment with antimicrobial agents (7). (cdc.gov)
Chronic4
  • Gastric MALT lymphoma is frequently associated (72-98%) with chronic inflammation as a result of the presence of Helicobacter pylori, potentially involving chronic inflammation, or the action of H. pylori virulence factors such as CagA. (wikipedia.org)
  • Gastric MALT lymphoma is etiopathologically related to chronic H. pylori infection. (revistagastroenterologiamexico.org)
  • More recent evidence has suggested that chronic H. pylori infection as well as early age of H. pylori -acquisition is a critical precursor to gastric carcinoma. (cdc.gov)
  • Chronic bacterial infection with H pylori is the strongest risk factor for stomach cancer. (medscape.com)
Infection and gastric cancer1
  • This disparity may exacerbate the already increased burden of H. pylori infection and gastric cancer among Black individuals, according to principal author David A. Leiman, MD, MSHP , of Duke University Medical Center in Durham, N.C. (medscape.com)
Atrophy1
  • A recent randomized study inChina also showed a significant reduction of gastric cancer risk among those without any gastric atrophy, intestinalmetaplasia, and dysplasia. (waocp.org)
Ulcer3
  • Most individuals infected with H. pylori do not present any symptoms or have serious illness, but in some individuals H. pylori causes peptic ulcer disease. (emerypharma.com)
  • There is no doubt that eradication of the bacterium is effective as atreatment of digestive ulcer, but eradication aiming to reduce the gastric cancer risk is still controversial. (waocp.org)
  • The diagnosis of H. Pylori is a high medical priority because: this bacterium infects approximately 50% of the world's population;causes peptic ulcer disease, gastric cancer, a form of lymphoma (MALToma) and likely several other diseases;and is treatable with antibiotics, but if this organism is not eradicated, patients remain at risk for serious complications. (grantome.com)
Bacterium5
  • H. pylori secrete urease, an enzyme that breaks down urea into ammonia which neutralizes the acidic pH in stomach, allowing the bacteria to survive in this harsh environment [1] H. pylori is a common bacterium found in humans and according to the Center for Disease Control (CDC) about two-thirds of the world's population harbors H. pylori . (emerypharma.com)
  • The genome of the bacterium Helicobacter pylori has evolved over the millennia since its migration out of Africa along with its human host approximately 60,000 years ago. (gutnliver.org)
  • Helicobacter pylori , a 2 × 1 μm spiral-shaped bacterium, is the most common risk factor for gastric cancer worldwide. (biomedcentral.com)
  • Discovered in 1982, Helicobacter pylori (H. pylori) is a disease-causing bacterium that survives in our stomachs despite the harsh acidic conditions. (phys.org)
  • The age at which a person becomes infected with Helicobacter (H.) pylori could explain why the bacterium causes different manifestations. (readabstracts.com)
Patients20
  • This study assessed the value of morphological grading and the expression of the co-stimulatory markers CD40, CD80 and CD86 and their ligands to predict clinical outcome in 23 consecutive low-grade MALT lymphoma patients treated with H. pylori eradication. (nih.gov)
  • Twenty-year follow-up of a cohort of patients with gastric precancerous lesions. (cancertherapyadvisor.com)
  • however, some patients with incidental complaints are diagnosed with early gastric cancer. (medscape.com)
  • Group I - healthy volunteers without H. pylori infection, group II - subjects with asymptomatic H. pylori infection, group III - H. pylori-infected patients with dyspeptic symptoms, mainly fasting and nocturnal epigastric pain. (archivesofmedicalscience.com)
  • In asymptomatic infections eradication of H. pylori is a preventive management of gastric cancer, especially in patients with a family history of this disease [ 20 - 22 ]. (archivesofmedicalscience.com)
  • Patients with more advanced intestinal metaplasia staging exhibited higher CDX1 expression than those with earlier intestinal metaplasia staging (P = 0.039), and those with H. pylori tended to have more CDX1 expression than noninfected patients (P = 0.061). (figshare.com)
  • Our specific aims are to 1) Perform UBTs in patients using our sensor to determine NH3, and 2) Develop a portable breath analyzer for the detection of H. pylori based on the determination of NH3 in human breath. (grantome.com)
  • Our aim was to assess the relationship between gastric motor and sensory function and symptom patterns in community subjects and patients with functional dyspepsia (FD) or irritable bowel syndrome (IBS). (bmj.com)
  • Overall, 25 of 48 blood donors with symptoms and 18 of 40 patients had slow gastric emptying. (bmj.com)
  • It has been demonstrated that approximately 40% of patients with FD have impaired gastric emptying, and this has been linked to fullness. (bmj.com)
  • Lymph node metastasis (LNM) is a significant barrier to the prognosis of patients with gastric cancer (GC). (bvsalud.org)
  • Helicobacter pylori (H. pylori)-positive GC patients experience a higher rate of LNM than H. pylori-negative GC patients . (bvsalud.org)
  • Based on the findings of this study, H. pylori-positive GC patients have greater lymphangiogenesis and lymph node immunosuppression than H. pylori-negative GC patients . (bvsalud.org)
  • In addition, miR-1246 is overexpressed in the plasma small extracellular vesicles (sEVs) of H. pylori-positive GC patients , indicating a poor prognosis . (bvsalud.org)
  • The investigators analyzed electronic medical records from 1,711 patients diagnosed with H. pylori infection through the Duke University Health System between June 2016 and June 2018, most often (71%) via serum antibody test. (medscape.com)
  • These findings are consistent with other work that has shown low rates of testing to confirm cure in patients treated for H. pylori ," Leiman said. (medscape.com)
  • Complete remission after H. pylori eradication has been described in low-grade MALT lymphomas as well as in high-grade MALT lymphomas in both immune-competent and AIDS patients, without the use of anti-cancer chemotherapeutic agents. (revistagastroenterologiamexico.org)
  • The validity of these measures was compared with Campylobacter-like organism analysis (gold standard) performed on patients requiring gastric biopsy. (who.int)
  • Salivary anti-H. pylori antibody positivity showed low sensitivity (36.6%) and high specificity (75.8%) in CLD patients. (who.int)
  • RÉSUMÉ Dans cette étude, des patients soumis à une endoscopie et souffrant ou non d'une pathologie hépatique chronique (PHC) ont fait l'objet d'un examen et d'une recherche d'infection à Helicobacter pylori par détection de la présence d'anticorps anti-H. pylori dans le sérum et la salive. (who.int)
Gastroenterology1
  • Researchers observed that anti- Helicobacter pylori therapy had a long-term beneficial effect among a population at increased risk for gastric cancer, according to findings from a study published in Gastroenterology . (cancertherapyadvisor.com)
CagA3
  • Corresponding author Masanori Hatakeyama, Laboratory Head, Institute of Microbial Chemistry, Microbial Chemistry Research Foundation, says, "Perturbation of Wnt/PCP signaling by the H. pylori CagA-VANGL interaction induces hyperplastic changes, along with impaired cell differentiation in gastric pyloric glands. (medicalxpress.com)
  • Atsushi Takahashi-Kanemitsu, The Helicobacter Pylori CagA Oncoprotein Disrupts Wnt/PCP Signaling and Promotes Hyperproliferation of Pyloric Gland Base Cells, Science Signaling (2023). (medicalxpress.com)
  • The relationship between H. pylori genome and gastric cancer rates is linked to the presence of the cagA gene, but the knowledge on this subject is incomplete because other genes may be involved in certain populations. (gutnliver.org)
Mucosal1
Bacteria6
  • Moreover, we summarize the relationship between H. pylori and gastric microecology, including non- H. pylori bacteria, fungi, and viruses and the possibility of facilitating H. pylori eradication by gastric microecology modulation, including probiotics, prebiotics, postbiotics, synbiotics, and microbiota transplantation. (nih.gov)
  • Correa scores diverged between infection status groups at 6 years, and individuals negative for H pylori had consistently lower scores compared with those who remained infected with the bacteria. (cancertherapyadvisor.com)
  • This is true in the case of Helicobacter pylori , a Gram negative spiral shaped bacteria which colonizes the mucus layer that covers the inner human stomach tissues. (emerypharma.com)
  • H. pylori is very difficult bacteria to grow and is microaerophilic, meaning it grows in environments with lower levels of oxygen than are present in the atmosphere. (emerypharma.com)
  • A gastric tissue culture may be considered normal if it does not show certain bacteria. (medlineplus.gov)
  • Therefore, we aimed to (1) design a deep learning based decision support algorithm that highlights H. pylori bacteria in image regions of gastric biopsies samples that are routinely tested for H. pylori presence and (2) validate this algorithm both on Giemsa stains and regular H&E stains comparing with microscopic diagnosis, immunohistochemistry and PCR. (biomedcentral.com)
Metaplasia1
World's population1
  • H pylori may infect 50% of the world's population, but many fewer than 5% of infected individuals develop cancer. (medscape.com)
Biopsy2
Stomach cancer2
Prevalence11
  • Approximately one-quarter of these cancers occur in countries with low socio-economic levels where food deficiencies are implicated in etiology by the imbalance between physical activity and energy intake, while high sugar and fat content are the main factors incriminated gastric cancer prevalence developed countries where a third of the most common cancers occur. (wishstudio.ro)
  • As nitrates change gastric cancer prevalence nitrosamines, the carcinogenic potential of these types of food increases. (wishstudio.ro)
  • The protective effect against cancer found for both fruits and gastric cancer prevalence is most likely due to a high content of vegetable fibers, specific vitamins and certain bioactive compounds such as carotene found in red vegetablesfolates found in green vegetablesglucosinolates brassica and alkyl sulfates garlic. (wishstudio.ro)
  • Aproximativ un sfert din aceste tipuri de cancer gastric cancer prevalence în ţările cu un nivel socioeconomic scăzut, unde deficienţele alimentare sunt implicate în etiologie prin dezechilibrul dintre activitatea fizică gastric cancer prevalence consumul de energie, în timp ce conţinutul ridicat de zahăr şi grăsimi este principalul factor incriminat în ţările dezvoltate unde apar o treime din cele mai frecvente tipuri de cancer. (wishstudio.ro)
  • Gastric cancer prevalence dintre dietă şi riscul de cancer este complexă. (wishstudio.ro)
  • Consumul crescut de peşte şi carne afumată a fost asociat cu cancerul gastric în unele ţări, cum ar gastric cancer prevalence Japonia. (wishstudio.ro)
  • Unele legume, precum ţelina, andivele, varza, spanacul sau strugurii, au un conţinut ridicat de nitraţi, mai ales gastric cancer prevalence sunt depozitate mai mult de două zile, dacă sunt supuse procesării termice sau dacă sunt combinate cu proteine animale. (wishstudio.ro)
  • Consumul unor cantităţi mari de alimente care gastric cancer prevalence fitoestrogeni modulatori selectivi ai estrogenului poate contribui la profilaxia primară şi secundară a cancerelor endocrin-dependente. (wishstudio.ro)
  • Efectul protector împotriva cancerului, constatat atât pentru fructe, cât şi pentru legume, este cel mai probabil datorat unui conţinut ridicat de gastric cancer prevalence vegetale, vitamine şi anumiţi compuşi bioactivi, cum ar fi carotenul aflat în legume roşiifolaţii din legumele verziglucozinolatul Brassica şi sulfatul de alchil usturoi. (wishstudio.ro)
  • However, the prevalence of H. pylori infection differs greatly between 20 and 80% within populations [ 16 ]. (biomedcentral.com)
  • The prevalence of H. pylori infection declined in both sexes between 1989 and 1998. (elsevierpure.com)
Cancers3
  • In total, 12 gastric cancers were diagnosed during the entire study duration in 8 men and 4 women with an average time to gastric cancer of 9.5 (interquartile range [IQR], 3-12) years. (cancertherapyadvisor.com)
  • We evaluated the relevance of these checks in Peruvian gastric most cancers samples. (pharmas-eu.org)
  • H-E evaluation is right in gastric most cancers, and IHC and RT-PCR can complement its outcomes. (pharmas-eu.org)
Biopsies4
  • We designed a deep-learning-based decision support algorithm that can be applied on regular whole slide images of gastric biopsies. (biomedcentral.com)
  • Together, we provide the first evidence of a decision support algorithm proving as a sensitive screening option for H. pylori that can potentially aid pathologists to accurately diagnose H. pylori presence on gastric biopsies. (biomedcentral.com)
  • Endoscopy is key to diagnosing MALT lymphoma, with multiple biopsies of the visible lesions required, as well as samples of macroscopically normal tissue, termed gastric mapping. (wikipedia.org)
  • Infection was followed over a 30-week period by histological scoring of the grade of inflammation in gastric biopsies. (lu.se)
Diagnosis3
  • We propose to develop a novel method for the diagnosis of Helicobacter Pylori. (grantome.com)
  • Thus it will make widely available a simple device for the diagnosis of H pylori and the monitoring of treatment efficacy. (grantome.com)
  • This assay is intended for use as an aid in the diagnosis of H. pylori infection in persons with gastrointestinal symptoms. (cdc.gov)
MALT4
  • These results suggest that morphological grading and immunological criteria can be defined to recognize the transition into the antigen-independent phase of gastric MALT-NHL. (nih.gov)
  • Owing to the causal relationship between H. pylori infection and MALT lymphoma, identification of the infection is imperative. (wikipedia.org)
  • Following the recognition of the association of gastric MALT lymphoma with H. pylori infection, it was established that early-stage gastric disease could be cured by H. pylori eradication, which is now the mainstay of therapy. (wikipedia.org)
  • On the other hand, gastric MALT lymphomas are often associated with Helicobacter pylori ( H. pylori ) infection. (revistagastroenterologiamexico.org)
Mechanisms1
  • Impaired meal induced relaxation of the proximal stomach, 3, 4 visceral hypersensitivity to distension, 3, 5, 6 gastric motor abnormalities, 7 as well as disturbed central nervous function 8, 9 have all been implicated as important pathophysiological mechanisms causing dyspeptic symptoms, but overlap is frequent. (bmj.com)
Antibiotic resistance1
  • The persistent increase in antibiotic resistance worldwide has made H. pylori eradication challenging for clinicians. (nih.gov)
Urea3
Resection1
  • Observationalstudies in Japan demonstrated that the eradication decreased the gastric cancer risk among 132 stomach cancerpatients undergoing endoscopical resection (65 treated with omeprazol and antibiotics and 67 untreated). (waocp.org)
Pathogenesis1
  • Using metagenomic experiments can help scientists to determine properties of each microbiota member, which contributes in pathogenesis of gastric cancer. (docksci.com)
Bacterial1
  • The study authors concluded that anti- H pylori therapy and clearance of the bacterial infection had a long-term benefit among a population at high risk for gastric cancer. (cancertherapyadvisor.com)
Infections1
  • Helicobacter pylori (H. pylori) infections are commonly associated with abdominal pain, bloating, and acidity. (medicalxpress.com)
20171
  • RESULTS: 151 incident cases of gastric cancer and 94 deaths from gastric cancer were identified during 1995-2017. (dragonsmedicalbulletin.com)
Clinical3
  • The only method approved by the U.S. Food and Drug Administration (FDA) to test the antimicrobial susceptibility of H. pylori is by performing an Agar MIC following the Clinical Laboratory Standard Institute (CLSI) guidelines. (emerypharma.com)
  • We maintain more than 100 well-characterized clinical isolates of H. pylori in our strain collections. (emerypharma.com)
  • Another issue is to explain why H. pylori infection induces clinical symptoms in only 15-20% of subjects. (archivesofmedicalscience.com)
Regression1
  • In Columbia,976 participants were randomized into eight groups in a three-treatment factorial design including H. pylorieradication, resulting in significant regression in the H. pylori eradication group. (waocp.org)
Interaction2
  • A significant interaction between H pylori status and time ( P =.036) was observed. (cancertherapyadvisor.com)
  • 우선 BBJ에 있는 10,426명의 위암 환자 샘플과 38,153명의 대조군 샘플을 대상으로 27개의 암 유발 유전자에 존재하는 생식계열 병원성 변이와 위암의 위험(relative excess risk due to interaction) 사이의 연관성을 평 가한 다음, HERPACC의 위암 환자 1,433명과 대조군 5,997명을 대상으로 병원성 변이와 H. pylori 감염 여부가 결합되어 위암의 발생 위험에 미치는 영향을 평가하고 누적 위험도를 계산하였다. (helicojournal.org)
Prevention3
  • To now, prevention is an optimal approach to deal with gastric cancer. (docksci.com)
  • 2004). 'Helicobacter Pylori Eradication as a Preventive Tool Against Gastric Cancer', Asian Pacific Journal of Cancer Prevention , 5(3), pp. 246-252. (waocp.org)
  • OBJECTIVE: To assess the effects of Helicobacter pylori treatment, vitamin supplementation, and garlic supplementation in the prevention of gastric cancer. (dragonsmedicalbulletin.com)
Symptoms2
  • Most symptoms of gastric cancer reflect advanced disease. (medscape.com)
  • In group III a positive correlation was found between intensity of H. pylori colonization and TpH-1 expression as well as between TpH-1 expression and severity of dyspeptic symptoms. (archivesofmedicalscience.com)
Lesions3
  • Helicobacter pylori eradication and endoscopic surveillance of gastric precancerous lesions are strategies to reduce gastric cancer risk. (cancertherapyadvisor.com)
  • Individuals who had precancerous lesions (n=800) were randomly assigned in a double-blind trial to receive 2 weeks of anti- H pylori therapy with beta-carotene and/or ascorbic acid supplementation for 6 years. (cancertherapyadvisor.com)
  • In this study, we sought to assess the epidemiology of GC, its clinicopathological profiles, and its association with risk factors as well as to identify premalignant gastric lesions (PGL) and examine neoplastic progression. (mdpi.com)
Positivity2
  • Salivary H. pylori positivity was significantly associated with older age. (who.int)
  • Questions must be addressed in a carefully considered manner that combines systematic, demographic epidemiology with the knowledge of H. pylori positivity or negativity. (cdc.gov)
Colonization1
  • H pylori expression of cholesterol-α-glucosyltransferase (encoded by cgt) is required for gastric colonization and T-cell activation. (mdc-berlin.de)
Histological1
  • There is a strong rational to accelerate the detection process of H. pylori on histological specimens, using novel technologies, such as deep learning. (biomedcentral.com)
Antibiotics2
  • There is a huge interest in studying H. pylori among scientists and the pharmaceutical industry because of the rapid emergence of drug resistance to currently available proton pump inhibitor with antibiotics, e.g. (emerypharma.com)
  • The following histo-morphological evaluation dictates therapeutic decisions, where antibiotics are used for H. pylori eradication. (biomedcentral.com)
Tissue2
  • The evaluated tissue had to include at least 50% of gastric tissue to be included. (biomedcentral.com)
  • H. pylori typically exists inside and around glandular structures that can be described as white regions image regions inside the gastric tissue (Fig. 1 b). (biomedcentral.com)
Serum1
  • The Wampole Laboratories (Wampole) H. pylori IgG Enzyme-Linked Immunosorbent Assays (ELISA) is intended for the detection and qualitative determination of IgG antibodies to Helicobacter pylori in human serum. (cdc.gov)
Tissues1
Regimens1
  • Five H. pylori treatment regimens have been approved by the Food and Drug Administration. (cdc.gov)
Risk9
  • Adult volunteers (N=1219) were recruited from 2 towns in Colombia at high risk for gastric cancer. (cancertherapyadvisor.com)
  • Considering genetical background bound to high risk of gastric cancer, it is a major recommendation to eradicate H. pylori in persons with a family history of gastric cancer (21, 22). (docksci.com)
  • Since the lifetime cumulative risk (0 to 84 years old) of gastric cancer in Japan is reported to be12.7% for males and 4.8% for females (Inoue and Tominaga, 2003), the corresponding values for H. pylori infectedJapanese can be estimated at 21.2% in males and 8.0% in females under the assumptions that the relative risk forinfected relative to uninfected is 5 and the proportion of those infected is 0.5. (waocp.org)
  • Treatment of CDX1-expressing cells with metformin, an antidiabetic drug known to decrease the risk of gastric cancer, decreased expression of EMT and stemness markers, and reduced spheroid formation. (figshare.com)
  • Studies have shown that African Americans with a higher proportion of African ancestry have higher rates of H. pylori , suggesting a genetic component to this increased risk," he said. (medscape.com)
  • PARTICIPANTS: 3365 residents of a high risk region for gastric cancer. (dragonsmedicalbulletin.com)
  • H pylori treatment for two weeks and vitamin or garlic supplementation for seven years were associated with a statistically significant reduced risk of death due to gastric cancer for more than 22 years. (dragonsmedicalbulletin.com)
  • Wu et al found that carriage of IL-17F 7488GA and GG genotypes were associated with an increased risk of gastric cancer. (medscape.com)
  • SVF startas då en välgrundad misstanke (VGM) uppstår, vilket innebär att det föreligger en betydande risk för cancer. (cancercentrum.se)