Putative tumor. Medical search. Frequent questions

TRG is located in an intron of the putative tumor suppressor gene Testin in the common fragile site 7G region at 7q31.2. (elsevierpure.com)
Multiple endocrine neoplasia type 1 (MEN1) is an endocrine tumor syndrome caused by inactivating mutations of the MEN1 tumor suppressor gene at the 11q13 locus. (medscape.com)
A scaffold protein DAB2 and its interaction partner DAB2IP have putative tumor suppressor gene (TSG) functions. (nih.gov)
Tumor suppressor gene. (nih.gov)
Genomic loss of the putative tumor suppressor gene E2A in human lymphoma. (mpg.de)

Molecular features of these tumors have expanded our vision of tumorigenesis and progression and provided abundant specifically targeted pathways [ 5 ]. (hindawi.com)
As an important member of the miRNA family, miR-381-3p also mediates tumor progression. (hindawi.com)
There is increasing interest in the role played by the innate and adaptive immune systems in the regulation of tumour development and progression 2 , 3 and it is anticipated that a better understanding of the molecular and cellular immunology of NSCLC will lead to the identification of novel targets for immunotherapy. (ersjournals.com)
The role of macrophage phenotypes in tumour progression has been extensively reviewed 6 - 10 . (ersjournals.com)
Angiogenesis, the growth of new blood vessels, occurs at different stages during embryonic development, physiological processes such as wound healing and reproduction, and numerous diseases, including inflammation, tumor progression, and metastasis [ 1 ]. (hindawi.com)
Importantly, during tumor progression, myeloid cells are implicated in promoting tumor angiogenesis, causing resistance against antiangiogenic therapies in cancer, and suppressing the immune response during cancer [ 3 - 5 ]. (hindawi.com)
The study identified 2 genes known to contribute to tumor progression and 8 known to be present in tumor cells but which have unknown functions. (frontiersin.org)
Molecular mechanisms of tumour initiation, progression and chemoresistance are insufficiently understood. (helsinki.fi)
In addition, a population of cancer cells having stem cell-like properties are suggested to play a role in tumour initiation, progression and chemoresistance. (helsinki.fi)
The remaining urine will be stored to evaluate biomarkers for the detection of tumor presence or progression using protein-based analyses. (centerwatch.com)
The levels of serum or urine beta-hCG are good tumor marker for the progression or remission of disease. (atlasgeneticsoncology.org)
β-catenin, when translocating to and accumulating in the nucleus, induces transcription of other oncogenes involved in tumor progression, malignancy and metastasis ( 15 ). (spandidos-publications.com)
PSA testing not only helps identify men in whom a prostate biopsy would be appropriate but also assists in assessing the response to therapy, determining tumor progression, and, in its most controversial role, screening for prostate cancer. (medscape.com)
Efforts to link CD44 to CSCs and tumor progression should consider the expression of various CD44 isoforms. (lu.se)

RNF20 may thus be a putative tumor suppressor, acting through selective regulation of a distinct subset of genes. (tau.ac.il)
However, as they reported in Nature Genetics today , the Stanford team found few genomic differences between the paired primary and metastatic tumors they studied, suggesting that metastatic driver genes are acquired early in tumor development. (genomeweb.com)
Within this cohort, the researchers noted high concordance among putative driver genes. (genomeweb.com)
The genes identified in this study," Cree explains, "fall into several categories linked with much studied mechanisms such as metabolism within the cell, membrane drug pumps, and DNA repair but also with apoptosis, suggesting that the general susceptibility of the cell to undergo this process may be an important determinant of tumor chemosensitivity, outweighing more specific mechanisms. (genengnews.com)
Chemosensitivity was compared with quantitative expression of putative resistance genes measured by RT-PCR. (genengnews.com)
In addition, the identified signature genes characterizing putative Pemetrexed responsiveness predicted therapeutic benefit in a subset of squamous cell carcinoma. (eur.nl)

However, HACE1 mutations are rare and therefore can only make a small contribution to Wilms tumour incidence. (ox.ac.uk)
Mutations in KRAS, TP53, SMAD4, and others were similar in primary and metastatic tumor pairs. (genomeweb.com)
In the last few years, it has become clear that activation events associated with FGFR-3 can be found associated with 40%-60% of low-grade, low-stage bladder tumors whilst p53 mutations are linked to a more aggressive phenotype progressing via the CIS pathway. (centerwatch.com)

Gastrinomas, seen in the image below, are the most common functional pancreatic neuroendocrine tumors and occur in 40-55% of patients. (medscape.com)
Functional malignant cell heterogeneity in pancreatic neuroendocrine tumors revealed by targeting of PDGF-DD. (lu.se)

This runs counter to the prevailing assumption that metastasis occurs late in advanced primary tumors. (genomeweb.com)
The cells that formed the metastasis were more closely related to the ancestors of the primary tumor than its present-day relatives," Curtis said. (genomeweb.com)
Myeloid cells are a heterogeneous population of bone marrow-derived cells that play a critical role during growth and metastasis of malignant tumors. (hindawi.com)
Myeloid cells promote tumor growth by stimulating tumor angiogenesis, suppressing tumor immunity, and promoting metastasis to distinct sites. (hindawi.com)
This suggested that EPCs are able to differentiate into endothelial cells and that such cells are incorporated into sites of active angiogenesis including ischemia, tumor angiogenesis, and metastasis in adult organisms [ 16 , 17 ]. (hindawi.com)
165 U/L were 3.29 times more likely to have lymph node involvement than patients with ALP levels 165 U/L. There was no statistically significant correlation between ALP level and sex, age, tumour histological type, site and size of tumour, depth of penetration, distant metastasis, degree of differentiation, presence of lymphatic invasion and presence of simultaneous multiple cancers. (who.int)
In this study, we found a negative correlation of IRS-1 expression with tumor metastasis both in human tissue samples and in cell lines. (spandidos-publications.com)
Furthermore studies in tumor metastasis are quite limited and controversial. (spandidos-publications.com)
While in lung cancer, IRS-1 has been confirmed to suppress tumor metastasis ( 11 ). (spandidos-publications.com)
The epithelial-mesenchymal transition (EMT) plays important roles in tumor metastasis. (spandidos-publications.com)

Both U and V exhibited complementary pulmonary inflammatory potential, with U driving a classical inflammatory cytokine profile (elevated interleukin [IL]-1b, tumor necrosis factor-alpha, and keratinocyte chemoattractant/human growth-regulated oncogene) while V preferentially induced a different cytokine pattern (elevated IL-5, IL-6, and IL-10). (cdc.gov)

Four putative biomarkers were studied: ALDH1A1, BMI1, MYC and SOX2. (helsinki.fi)
New breast cancer biomarkers have been sought for better tumor characterization and treatment. (bvsalud.org)

Gliomas are the most common primary brain tumors. (scirp.org)
Definition of Genetic Events Directing the Development of Distinct Types of Brain Tumors from Postnatal Neural Stem/Progenitor Cells. (lu.se)

Our immunohistochemistry (IHC) studies showed that IRX2 and TBL1XR1 were frequently over-expressed in breast tumors. (cancer.gov)
The CD44 cell adhesion molecule is aberrantly expressed in many breast tumors and has been implicated in the metastatic process as well as in the putative cancer stem cell (CSC) compartment. (lu.se)
We used q-RT-PCR and exon-exon spanning assays to analyze the expression of four alternatively spliced CD44 isoforms as well as the total expression of CD44 in 187 breast tumors and 13 cell lines. (lu.se)

Nongestational choriocarcinoma arises in women under 40 years old because of germ cell tumor, and the frequency is reported less than 0.6% of all ovarian tumors. (atlasgeneticsoncology.org)

Approximately 90% of malignant tumors arising in the bladder are of epithelial origin, the majority being transitional cell carcinomas. (centerwatch.com)

It is involved in determining cell survival fate in association with tumor suppressor protein p53. (wikipedia.org)
MDC1 has anti-apoptotic properties by directly inhibiting the apoptotic activity of the tumor suppressing protein p53. (wikipedia.org)

An integrative approach for analyzing the interplay of genetic and epigenetic changes in tumors. (mpg.de)
As part of the multicenter, population-based Ohio Colorectal Cancer Prevention Initiative, tumor DNA was sequenced for 419 consecutive CRC cases undergoing standard universal tumor screening and germline genetic testing, and 46 patients with CRC known to have LS due to a germline mutation in a mismatch repair gene. (cdc.gov)

The rate of occurrence of these tumors is highest in the developed countries, ranking as the sixth most frequent neoplasm. (centerwatch.com)

In this review, we assess the potential role of putative gut microbiota products in the etiopathogeny of Parkinson's disease, with a special emphasis on functional bacterial amyloid proteins, bacterial biosurfactants, endotoxins and short-chain fatty acids. (techscience.com)
The cancer assays to be tested use DNA analysis and antibodies to specific proteins as well as functional assays for proteins to attempt to identify bladder tumor presence. (centerwatch.com)
A recent study compared the performance of tumor next-generation sequencing to the current multistep approach (using microsatellite instability (MSI) testing and/or immunohistochemistry (IHC) for MMR proteins). (cdc.gov)

Constitutional translocation breakpoint mapping by genome-wide paired-end sequencing identifies HACE1 as a putative Wilms tumour susceptibility gene. (ox.ac.uk)
This method was used to fine map a de novo t(5;6)(q21;q21) translocation in a child with bilateral, young-onset Wilms tumour. (ox.ac.uk)
To evaluate the contribution of HACE1 to Wilms tumour predisposition, the gene was mutationally screened in 450 individuals with Wilms tumour. (ox.ac.uk)
One child with unilateral Wilms tumour and a truncating HACE1 mutation was identified. (ox.ac.uk)
CONCLUSIONS: These data indicate that constitutional disruption of HACE1 likely predisposes to Wilms tumour. (ox.ac.uk)

Strain susceptibility and resistance to 1,2-dimethylhydrazine-induced enteric tumors in germfree rats (40146). (cdc.gov)

The aim of this study was to test for the molecular and functional expression of the non-gastric H + /K + ATPase ATP12A/ATP1AL1 in unstimulated and butyrate-stimulated (1 and 10 mM) human myelomonocytic HL-60 cells, to unravel its potential role as putative apoptosis-counteracting ion transporter as well as to test for the effect of the H + /K + ATPase inhibitor SCH28080 in apoptosis. (karger.com)
We suggest that a combination of classical pathological markers can be used to identify molecular tumor subclasses associated with predicted Pemetrexed response. (eur.nl)
Early stage bladder tumors have been classified into two groups with distinct behaviors and different molecular profiles: Low-grade tumors (always papillary and usually superficial), and high-grade tumors (either papillary or non-papillary and often invasive). (centerwatch.com)
El càncer de pulmó de cèl·lula no petita (CPCNP) es pot definir a nivell molecular per les alteracions genètiques que es produeixen en múltiples oncogens, inclosos els reordenaments dels gens ALK i ROS1. (tesisenred.net)
Unsupervised hierarchical cluster analysis of CD44 isoform expression data divided tumors into four main clusters, which showed significant correlations to molecular subtypes and differences in 10-year overall survival. (lu.se)
The researchers explored genome-wide DNA methylation profiles in samples of endemic Burkitt lymphoma tissue and identified a molecular signature shared by both Epstein-Barr virus infection and aflatoxin B1 exposure that affects the expression of a putative tumour suppressor, TGFBI. (who.int)

Finally, we review the developing body of literature on the participation of lncRNAs in epigenetic regulation of AML, and discuss their putative therapeutic relevance. (frontiersin.org)

Recent evidence, however, supports a dual role for macrophages in the regulation of tumour proliferation and immune control 10 , 16 , and indicates that the local tissue microenvironment plays a critical role in determining cell phenotypes. (ersjournals.com)
Tumors exhibit significant myeloid cell infiltrates, which are actively recruited to the tumor microenvironment. (hindawi.com)
Finally, we will comment on the mechanisms regulating myeloid cell recruitment to the tumor microenvironment and on the potential of myeloid cells as new targets for cancer therapy. (hindawi.com)
Further research clarifying the functional consequences of TGFBI suppression on B cell fate and the impact on reshaping the tumour microenvironment is warranted, because it may provide a relevant target for novel therapies. (who.int)

Glioma is the most frequent primary central nerve tumor, which originates from glial progenitor cells [ 1 ]. (hindawi.com)

The genomic investigation has led to the identification of two putative oncogenes, IRX2 and TBL1XR1. (cancer.gov)

Our epigenomic investigation has led to the identification of DNA methylation signatures that are selectively associated with clinical phenotypes such as lymph node involvement, histological grade, tumor size, and ER/PR/HER2 status. (cancer.gov)

Adoptive cell therapy using tumor-infiltrating lymphocytes (TILs) has shown activity in melanoma, but has not been previously evaluated in metastatic non-small cell lung cancer. (nature.com)
In the majority of metastatic colorectal cancer patients analyzed in this study, the cancer cells had already spread and begun to grow long before the primary tumor was clinically detectable," senior author Christina Curtis, an assistant professor of medicine and genetics at Stanford, said in a statement. (genomeweb.com)
In addition, primary and metastatic tumor pairs were also likely to share somatic SNVs and small indels. (genomeweb.com)
Through a phylogenetic analysis, the researchers traced the origins of these metastatic tumors. (genomeweb.com)
They found that in their dataset 83 percent of the primary metastatic tumor pairs from 17 of the 21 patients likely underwent metastatic dissemination when the primary tumor was below the limits of clinical detection - smaller than 0.01 cm 3 in size. (genomeweb.com)
These tumors are important to diagnose, since by the age of 80 the penetrance of pNETs is over 80% and metastatic disease is the most important cause of MEN1-related mortality. (medscape.com)
Clinically, superficial bladder tumors (stages Ta, Tis and T1) account for 75-80% of bladder neoplasms, while the remaining 15-20% are invasive (T2, T3, T4) or metastatic lesions at the time of presentation. (centerwatch.com)

moreover, normal cell regulation can be disrupted by tumor-suppressive or oncogenic miRNAs. (scirp.org)
Taken together we have shown that LTD4 might have an impact on tumour development through the regulation of CysLT1R and its downstream signalling pathways. (lu.se)

Two of the subclasses correlated to putative Pemetrexed resistance. (eur.nl)

There is a marked survival advantage for patients with nonsmall cell lung cancer (NSCLC) expressing high numbers of macrophages in their tumour islets. (ersjournals.com)
Macrophages infiltrating the tumour islets in nonsmall cell lung cancer were predominantly of the M1 phenotype in patients with extended survival. (ersjournals.com)
Thus, increasing numbers of macrophages within the tumour islets conferred a marked survival advantage, while increased numbers of macrophages in the tumour stroma were associated with worse prognosis. (ersjournals.com)
The PI3K/AKT signalling pathway is crucial for tumor cell survival. (senescence.info)
VEGF, produced in large amounts by cancer cells during tumor growth, interacts with its receptors VEGFR1 and VEGFR2 thereby causing endothelial cell survival, proliferation, and sprouting [7] . (plos.org)
Associations of a Breast Cancer Polygenic Risk Score With Tumor Characteristics and Survival. (cancercentrum.se)

We discuss the value of lncRNAs as putative diagnostic, prognostic and therapeutic targets in myeloid leukemias and indicate novel directions in this exciting research field. (frontiersin.org)

There was considerable heterogeneity between tumors, and while this showed no direct correlation with individual gene expression, there was strong correlation of multigene signatures for many of the single chemotherapy agents and combinations tested," says Ian Cree, who led the study. (genengnews.com)

This disease is classified two types in origin, gestational choriocarcinoma and nongestational germ cell tumor. (atlasgeneticsoncology.org)
The nongestational type is as a component of a mixed germ cell tumor and a pure ovarian choriocarcinoma is a very rare malignant tumor. (atlasgeneticsoncology.org)
In nongestational choriocarcinoma, no factors have been associated with the etiology of germ cell tumor, apart from an increased incidence associated with dysgenetic gonads. (atlasgeneticsoncology.org)

NEW YORK (GenomeWeb) - Many colorectal cancer metastases may have arisen and spread even before the primary tumor was large enough to be detected, according to a new study. (genomeweb.com)
Further, they noted most of these metastases actually diverged early in the emergence of the primary tumor. (genomeweb.com)
The primary objective of this study is to evaluate the utility of emerging technologies in the detection of bladder tumor cells using non-invasive approaches utilizing voided urine samples. (centerwatch.com)
As an example, we observed a specific DNA methylation signature that distinguishes primary breast cancer samples diagnosed as high-grade from those diagnosed as low-mid-grade tumors. (cancer.gov)

One TRG peptide had the ability to induce HLA-B52-restricted CTL cytotoxic to TRG + tumor cells in peripheral blood mononuclear cells (PBMC) of epithelial cancer patients. (elsevierpure.com)
TRV-β sequencing of tumor and peripheral T cells as the project 'TIL trial for NSCLC' are available in the immuneACCESS free public database at https://clients.adaptivebiotech.com/immuneaccess . (nature.com)

These observations stimulated an intensive search for the mechanisms regulating tumor angiogenesis. (hindawi.com)

Further, Fgfr3 + endosteal stromal cells give rise to aggressive osteosarcoma-like lesions upon loss of p53 tumor suppressor through unregulated self-renewal and aberrant osteogenic fates. (nature.com)
The M1 phenotype (classically activated) macrophages are thought to be induced by interferon-γ, with or without lipopolysaccharide and tumour necrosis factor (TNF)-α, and exert a cytotoxic effect against cancer cells. (ersjournals.com)
In this review, we discuss the role of myeloid cells in promoting tumor angiogenesis. (hindawi.com)
In 1971, Dr. Judah Folkman observed that neovascularization occurs around tumors and proposed that new blood vessel growth is necessary to supply nutrients and oxygen to tumor cells during exponential tumor growth [ 6 ]. (hindawi.com)
Specific growth factors, such as vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF), stimulate the proliferation and migration of naturally quiescent endothelial cells, resulting in the formation of new vessel structures during embryonic development and tumor growth [ 7 ]. (hindawi.com)
Although tumor cells were first thought to drive the cellular events underpinning tumor angiogenesis and growth, considerable evidence has now emerged for the central role of tumor infiltrating myeloid cells such as monocytes, macrophages, and neutrophils in this phenomenon [ 8 - 12 ]. (hindawi.com)
The researchers tested docetaxel, cisplatin, gemcitabine, and combinations of the agents on tumor cells taken from 49 fresh NSCLC samples. (genengnews.com)
We propose to assess the use of a multiple mutation-based assay, using DNA from exfoliated cells in the urine of patients, to establish the sensitivity and specificity in tumor detection compared to cystoscopy and cytology. (centerwatch.com)
We used the shRNA approach to knock down the expression of TBL1XR1 in breast cancer cells and found that depletion of the TBL1XR1 protein in the cells reduced cell migration/invasion and suppressed tumor growth in mouse xenografts. (cancer.gov)
Choriocarcinoma of the ovary is a highly malignant ovarian tumor which is characterized pathologically by the presence of trophoblastic malignant cells, and biochemically by the production of the pregnancy hormone human chorionic gonadotrophin (hCG) in the absence of an ongoing pregnancy. (atlasgeneticsoncology.org)
Microscopically, hemorrheage and necrosis are found, and tumor cells resemble placental trophoblastic cells: cytotrophoblast (CT), intermediate trophoblast (IT), and syncytiotrophoblast (ST). The CT and IT tend to grow in clusters and sheets separated by ST. The typical pattern of choriocarcinoma has been called two cell pattern, biphasic-terms that reflect the relatively regular, alternating arrangement of CT and ST in the tumor interspread with intermediate trophoblast. (atlasgeneticsoncology.org)
However, recently Houghton et al ( 7 ) showed increased cell proliferation after silencing of IRS1 gene expression in A549 cells suggesting tumor suppression potential. (spandidos-publications.com)
Loss of E-cadherin, not only results in loss of adherens junctions between neighbor cells resulting in dissemination of cells from the original tumor, but also results in releasing its cytoplasmic binding with β-catenin. (spandidos-publications.com)

Tumors characterized as positive for the CD44+/CD24- phenotype by immunohistochemistry were associated to all isoforms except the CD44 standard (CD44S) isoform, which lacks all variant exons. (lu.se)

Vascular endothelial growth factor (VEGF), a key component in the process of angiogenesis, is known to be produced by tumour-associated macrophages 17 , 18 , which have been traditionally reported as M2 macrophages. (ersjournals.com)

Monocytes activated by tumour-derived microvesicles from pancreatic, colon and lung cancer cell lines have been found to show increased expression of human leukocyte antigen (HLA)-DR and a resulting increase in production of reactive oxygen intermediates and TNF-α 11 . (ersjournals.com)

M2 (alternatively activated) macrophages are thought to be modulated by IL-4 and -13 and associated with tumour formation. (ersjournals.com)
Additionally, M2 macrophages have been traditionally thought of as being the predominant macrophage phenotype in solid tumours (tumour-associated macrophages). (ersjournals.com)

Cancers with similar histology may show dramatically different responses to therapy, indicating that a refined approach needs to be developed to classify tumors by intrinsic characteristics that may predict response to chemotherapy. (eur.nl)

90% of adults carry the virus) which normally gives rise to an inconspicuous or benign infection, paradoxically, however, under rare circumstances it induces tumors. (ki.se)

Together these tumor alterations might play a role in tumorigenesis of GC and CRC with MSI-H by down-regulating the tumor-inhibiting activities of DAB2IP. (nih.gov)
Swedish Research Counsil (R.J.A.N.), National Cancer Institute (NCI) CA069246 and CA86355 (X.O.B.), and the American Brain Tumor Association (T.W.). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. (plos.org)
Based on the role of miRNA in tumor development, it can be classified as tumor-suppressive miRNA (TS-miRNA) or oncogenic miRNA [6]. (scirp.org)
Psoriasin is strongly induced by interleukin (IL)-22 and by the combination of IL-17 and tumour necrosis factor (TNF)-α, which emphasizes the role of psoriasin in the pathogenesis of psoriasis (7). (medicaljournals.se)
however, it also suppresses cancer cell proliferation and recent findings have implicated its role as a tumor suppressor. (oregonstate.edu)

The foundations for multistep tumorigenesis in this biology can be partly explored in vivo in patient cohorts where the tumor development increases significantly, due to immunosuppression like in post-transplant patients and HIV-carriers. (ki.se)

Gene expression dependent on RNF20 includes histones H2A and H2B and the p53 tumor suppressor. (tau.ac.il)
Our objective was to determine if CDK2AP1 mRNA expression levels were consistent with tumour-suppressive functions in breast cancer. (cancerindex.org)
There were no significant associations between CDK2AP1 expression and estrogen receptor status, tumour grade and tumour type. (cancerindex.org)
When these results were compared to gene expression in the tumors, there was a strong correlation of multigene signatures for many of the single agents and combinations tested. (genengnews.com)
Using diagnostic tumour tissue specimens from 95 patients allowed capturing the expression in situ. (helsinki.fi)
Global expression profile-based classification has the potential to identify such tumor-intrinsic subclasses. (eur.nl)
Conversely, tumors with strong expression of the CSC marker ALDH1 had elevated expression of CD44S. (lu.se)
High expression of CD44S was associated with strong HER2 staining and also a subgroup of basal-like tumors. (lu.se)

This peptide also induced HLA-B62-restricted and tumor-reactive CTL in PBMC of cancer patients. (elsevierpure.com)
This suggested to the researchers that early dissemination can occur in many colorectal cancer patients, underscoring the need for early detection, possibly through detecting cell-free tumor DNA as these small tumors fall at the limits of detection for imaging approaches. (genomeweb.com)
The first solid tumor exomes to be investigated were from 11 breast and 11 colorectal cancer tissue samples. (frontiersin.org)
Treatment of rectal cancer often consists of surgical resection of the tumor. (stanford.edu)
Medical information on your tumor, treatment received, and side effects will be compiled and maintained in a database to learn more about outcomes of treatment for rectal cancer. (stanford.edu)
Universal Screening for Lynch Syndrome: Can Tumor Sequencing Have a Larger Public Health Impact on Treatment and Prevention of Colorectal Cancer? (cdc.gov)
In the meantime, new genomic research could be changing clinical and public health approaches to reducing the burden of colorectal cancer from LS and in general, by shifting the laboratory testing approach toward tumor next generation sequencing. (cdc.gov)
We conducted a chemical library screen to identify nontoxic AhR ligands with anti-cancer effects and discovered flutamide (Eulexin) as a putative AhR ligand. (oregonstate.edu)
CD44 isoforms are heterogeneously expressed in breast cancer and correlate with tumor subtypes and cancer stem cell markers. (lu.se)

The relevance of this novel phenotyping was linked to other tumor characteristics. (eur.nl)

There were considerable differences between tumors in their sensitivity to individual agents and combinations, though the combination of cisplatin with gemcitabine was usually the most active. (genengnews.com)

Fig. 4: Summary of tumor-specific antigens tested for all patients. (nature.com)
Pancreatic islet cell tumors represent the second most common manifestation of MEN1, occurring in 30-80% of patients. (medscape.com)
Over 70% of patients affected with superficial tumors will have one or more recurrences after initial treatment, and about one-third of those patients will progress and eventually succumb to their disease. (centerwatch.com)
All patients harboring tumors and scheduled to have a cystectomy, cystoscopy,or nephroureterectomy will be eligible for this study. (centerwatch.com)
A universal tumor sequencing test can identify LS patients as well as guide treatment of CRC patients who do not have LS. (cdc.gov)
The test can identify CRC patients with MSI-high tumors who may respond well to PD1 blockade immunotherapy , recently approved by the Food and Drug Administration. (cdc.gov)

Chronic exposure of rats resulted in increased thyroid follicular cell tumors from sustained perturbation of thyroid hormone homeostasis. (cdc.gov)

Autologous TILs were expanded ex vivo from minced tumors cultured with interleukin-2. (nature.com)

MEN1 predisposes to the development of tumors in target neuroendocrine tissues. (medscape.com)

World Health Organization (WHO) grade IV glioma, which includes glioblastoma multiform (GBM), is a highly invasive and fatal malignant tumor [1]. (scirp.org)

Most MEN1 tumors are not aggressive, and many of them (particularly nonfunctioning tumors) follow a long-term indolent course, remaining asymptomatic for years. (medscape.com)

Carcinogenicity of tumor cell populations: origin of a putative h-2 isoantigenic loss variant tumor. (jax.org)

Anatomy22

Organisms8

Diseases84

Chemicals and Drugs49

Analytical, Diagnostic and Therapeutic Techniques and Equipment44

Phenomena and Processes68

Disciplines and Occupations1

Information Science4

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Suppressor Gene5

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Metastasis10

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Protein p532

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