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Serine EndopeptidasesSerineMolecular Sequence DataAmino Acid SequenceProtein-Serine-Threonine KinasesSequence Homology, Amino AcidBase SequenceCloning, MolecularSerine ProteasesSerine Proteinase InhibitorsPhosphorylationSerine C-PalmitoyltransferasePhosphoserineSerine O-AcetyltransferaseGlycine HydroxymethyltransferaseThreonineSubstrate SpecificityMutagenesis, Site-DirectedBinding SitesCell LineMutationRecombinant ProteinsKineticsMannose-Binding Protein-Associated Serine ProteasesSerpinsEnzyme ActivationProtein BindingProtein KinasesSignal TransductionAmino AcidsL-Serine DehydrataseProtein Structure, TertiaryIsoflurophatePhosphoprotein PhosphatasesProtease InhibitorsPeptide MappingPhenylmethylsulfonyl FluorideTrypsinCathepsin GAmino Acid SubstitutionGlycineEndopeptidasesSequence AlignmentProtein Processing, Post-TranslationalElectrophoresis, Polyacrylamide GelCysteineRacemases and EpimerasesTransfectionPhosphothreonineChymotrypsinPhosphoglycerate DehydrogenaseModels, MolecularPhosphopeptidesAlaninePhosphoproteinsEscherichia coliCells, CulturedStructure-Activity RelationshipPhosphoamino AcidsEnzyme InhibitorsOkadaic AcidProtein Phosphatase 2Catalytic DomainDNA, ComplementaryPeptide FragmentsProtein ConformationRecombinant Fusion ProteinsCasein Kinase IICOS CellsSubtilisinsCatalysisMolecular WeightProtein Kinase CTrypsin InhibitorsBlotting, WesternTyrosineHydrolysisPeptide HydrolasesPancreatic ElastaseSubtilisinLeukocyte ElastaseDNA PrimersKallikreinsPeptidesEnzyme PrecursorsHeLa CellsRNA, Transfer, SerPrecipitin TestsCyclic AMP-Dependent Protein KinasesProteinase Inhibitory Proteins, SecretoryRNA, Messenger14-3-3 ProteinsBacterial ProteinsCarrier ProteinsDNA-Binding ProteinsMembrane ProteinsProto-Oncogene ProteinsEsterasesHydrogen-Ion ConcentrationProto-Oncogene Proteins c-akt
KinasePhosphorylationGeneProteaseProteasesHydroxymethyltransferaseCell ProliferationResiduesProteinsSubfamilyAlanineCommonly foundFamilyGenesActivitySiteFactorResponsibleProtein phosphataseThreonine-richArabidopsisCharacterizationGlycineSynthesis pathwayExtracellularSequencesMotifsAlanineCysteineHydrolaseMutationsIsoformFunctionalPathogensProgressionHuman
Kinase11
  • Protein kinase A (PKA or cAMP-dependent protein kinase) is a serine/threonine kinase that plays essential roles in the regulation of proliferation, differentiation, and apoptosis. (nih.gov)
  • This gene encodes one of the three members of the human AKT serine-threonine protein kinase family which are often referred to as protein kinase B alpha, beta, and gamma. (senescence.info)
  • These highly similar AKT proteins all have an N-terminal pleckstrin homology domain, a serine/threonine-specific kinase domain and a C-terminal regulatory domain. (senescence.info)
  • T01711 probable serine/threonine-specific protein kinase (EC 2.7.1. (cornell.edu)
  • Serine/threonine-protein kinase that phosphorylates histone H3 at 'Ser-3' (H3T3ph) during mitosis. (antibodies-online.com)
  • This PSK domain harbors a putative phosphorylation site for the mitotic kinase cyclin/p34cdc2. (nih.gov)
  • The PAR proteins include the PDZ domain-containing PAR-3 and PAR-6, the atypical protein kinase PKC-3, the serine/threonine kinase PAR-1 and, in nematodes, the putative ubiquitin E3 ligase PAR-2. (biologists.com)
  • The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. (cancerindex.org)
  • AURK significantly promotes activation of IκBα at serine 32, but not serine 36 residues, unlike IκB kinase (IKK) family proteins activate both IκBα serine residues. (researchsquare.com)
  • Akt1, Akt2, and Akt3 make up a family of serine/threonine kinases, often activated downstream of growth factor receptors and PI 3-Kinase. (rndsystems.com)
  • We have previously described a member of a series of guanidinium based compounds which inhibits BRAF, a serine/threonine kinase component of the RAS/ERK signalling pathway, through a putative type-III allosteric mechanism [Diez-Cecilia et al, (2015) Bioorg. (confex.com)
Phosphorylation3
Gene3
  • This gene is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains. (origene.com)
  • However, the SbCIccr was integrated into the serine acetyltransferase gene rimL, not into the canonical integration site for SCCs, methyltransferase gene rlmH (orfX). (muni.cz)
  • Plasmodium falciparum contains PF3D7_1235600, a previously characterized cSHMT gene (Pfcshmt), and PF3D7_1456100, a putative gene of mSHMT (Pfmshmt). (pberghei.eu)
Protease4
  • PI-16 is a putative serine protease inhibitor and can serve as a binding protein for PSP94 (prostate secretory protein of 94 amino acids) termed PSPBP. (bdbiosciences.com)
  • ORF2 is a polyprotein which is presumably cleaved into a serine-protease, a VPg and a RdRp protein. (expasy.org)
  • The viral serine protease is responsible for all the cleavages. (expasy.org)
  • Serine protease (EC 3.4.21. (expasy.org)
Proteases1
Hydroxymethyltransferase1
  • Serine hydroxymethyltransferase (SHMT), a pyridoxal phosphate-dependent enzyme, plays a vital role in the de novo pyrimidine biosynthesis pathway in malaria parasites. (pberghei.eu)
Cell Proliferation1
  • They have putative roles in cell proliferation and survival, and Akt perturbations are thought to play an important role in tumorigenesis. (rndsystems.com)
Residues1
  • SF2 contains two N-terminal RNA recognition motifs (RRMs), also termed RBDs (RNA binding domains) or RNPs (ribonucleoprotein domains), followed by a C-terminal domain rich in proline, serine and lysine residues (PSK domain), a composition reminiscent of histones. (nih.gov)
Proteins5
  • PEST domains are polypeptide sequences enriched in proline (P), glutamic acid (E), serine (S) and threonine (T) that target proteins for rapid destruction. (embl.de)
  • Of the four putative novel defence proteins (DFPs) annotated by PSI-BLAST three showed similarity to extracellular matrix proteins from vertebrates implicated in innate immunity, while the fourth was similar to, yet distinct from, the anti-microbial protein cecropin. (biomedcentral.com)
  • The present study has identified many potential immune-related genes in A. mylitta some of which are vertebrate homologues and others are hitherto unreported putative defence proteins. (biomedcentral.com)
  • Proteins in the serine esterase family are widely distributed in bacterial phyla and display activity against a range of biologically produced and chemically synthesized esters. (ed.ac.uk)
  • All of these proteins contained the Ser-Asp-His motif common to serine esterases and a highly conserved pentapeptide nucleophilic elbow motif. (ed.ac.uk)
Subfamily1
  • It differs from other members of this subfamily in that its putative catalytic triad contains an asparagine instead of the serine residue. (thermofisher.com)
Alanine1
  • Using LC-MS/MS analysis, Serine 346 was identified as the sole autophosphorylation site of Drosophila PINK1 and it was found that substitution of Serine 346 to Alanine completely abolishes the PINK1 autophosphorylation. (sdbonline.org)
Commonly found2
  • The genomic island harbours genes for the restriction-modification system commonly found on SCC elements, a putative transposon with IS6 family element similar to IS431mec, a putative transcriptional regulator and accessory genes, which have been found frequently on plasmids. (muni.cz)
  • Several isolates encode putative virulence factors commonly found in Enteropathogenic and Enteroaggregative E. coli, and 53% of the isolates encode resistance to three or more classes of antimicrobials. (peerj.com)
Family1
  • here we report on the identification and characterization of further putative esterases with OsmC-like domains constituting a new esterase family that is found in a variety of bacterial species from different environmental niches. (ed.ac.uk)
Genes1
  • A third of the transcriptome showed similarity with previously characterized immune-related genes that included both the known and putative immune genes. (biomedcentral.com)
Activity1
  • Neuronal activity triggers an increase in astrocytic calcium levels, prompting the release of gliotransmitters, such as glutamate, ATP, and D-serine.These gliotransmitters diffuse into the extracellular space, interacting with nearby neurons and influencing synaptic transmission. (wikipedia.org)
Site1
  • When such a putative site would be occupied, the capacity of additional oxon molecules to phosphorylate the active site is reduced. (cdc.gov)
Factor1
  • This subgroup corresponds to the RRM1 of SF2, also termed SR1 protein, a plant serine/arginine (SR)-rich phosphoprotein similar to the mammalian splicing factor SF2/ASF. (nih.gov)
Responsible1
  • Using a custom-spotted glycoprotein and neoglycoprotein dot blot array, we identify candidate glycan motifs recognized by PsrP and by the putative S. pneumoniae adhesin that could perhaps be responsible for pneumococcal binding to salivary MUC7 and glycoproteins on RBCs. (lu.se)
Protein phosphatase1
  • We previously identified a putative binding motif for the serine/threonine protein phosphatase PP2A-B56 in BRCA2, which is of unknown significance 20 . (nature.com)
Threonine-rich1
  • The alpha isoform of ICAP-1 is a 200 amino acid serine/threonine-rich phosphoprotein which binds the cytoplasmic tail of beta1 integrins. (nih.gov)
Arabidopsis1
  • Arabidopsis thaliana contains 23 putative EXO70 genes, which can be classified into eight clusters on the phylogenetic tree. (or.jp)
Characterization2
  • Functional characterization of a putative serine carboxypeptidase in vascular smooth muscle cells. (nih.gov)
  • Molecular cloning and characterization of a putative nuclear DEAD box RNA helicase in the spruce budworm, Choristoneura fumiferana. (gc.ca)
Glycine1
  • Three pathways were significantly perturbed in exposed workers and had an impact score >0.5: beta-alanine metabolism, histidine metabolism, and glycine, serine, and threonine metabolism. (cdc.gov)
Synthesis pathway2
  • Although PSAT1 is postulated to promote tumor growth through its enzymatic function within the serine synthesis pathway (SSP), its role in cancer progression has not been fully characterized. (nih.gov)
  • Phosphoserine phosphatase (PSPH) is one of the key enzymes of the L-serine synthesis pathway. (molcells.org)
Extracellular1
  • Neuronal activity triggers an increase in astrocytic calcium levels, prompting the release of gliotransmitters, such as glutamate, ATP, and D-serine.These gliotransmitters diffuse into the extracellular space, interacting with nearby neurons and influencing synaptic transmission. (wikipedia.org)
Sequences4
  • A ) Schematic diagram of putative structural motifs and characteristic sequences of human TFIIEβ. (nih.gov)
  • We found 1,595 putative non-redundant PI sequences across 26 ixodid tick species. (biomedcentral.com)
  • Upon measuring the phosphatase activity of PSPH on a serine-phosphorylated peptide, we found that PSPH dephosphorylated phospho-serine in peptide sequences. (molcells.org)
  • Bioinformatic analysis of the date palm genome revealed nine oleosin-like, five caleosin-like, and five steroleosin-like sequences, with predicted structures having putative lipid-binding domains that match their LD stabilizing roles and use as bio-based encapsulation systems. (frontiersin.org)
Motifs1
  • CfrHlc113 contained the eight functional motifs, which are highly conserved in the DEAD box RNA helicase family, and an arginine-serine-aspartate (RSD) domain at its N-terminal end. (gc.ca)
Alanine1
  • Primer sets 1517/1183, 1518/1183 and 1180/1183 were used to insert serine/alanine, serine/threonine and serine/serine mutations. (pberghei.eu)
Cysteine1
Hydrolase1
Mutations1
  • Mutations at upstream and downstream of serine 106 was created by using primers 1856/1857. (pberghei.eu)
Isoform1
  • CG30463 is one putative PGANT isoform based on sequence conservation. (nih.gov)
Functional1
  • studying the functional details of the L-serine-independent pathway of PSPH will be useful to understand cancer progression. (molcells.org)
Pathogens1
  • Therefore, we predicted that they may target the glutamyl endopeptidases, a family of serine proteases found in several human opportunistic pathogens including Staphylococcus aureus and Enterococcus faecalis. (harvard.edu)
Progression3
  • Here, we explore a putative non-canonical function of PSAT1 that contributes to lung tumor progression. (nih.gov)
  • PSPH is reported to affect the progression and survival of several cancers in an L-serine synthesis-independent manner, but the mechanism remains elusive. (molcells.org)
  • We demonstrate that PSPH promotes lung cancer progression through a noncanonical L-serine-independent pathway. (molcells.org)
Human1
  • Orthologous to human SCPEP1 (serine carboxypeptidase 1). (nih.gov)