Putative receptors antigen t cell. Medical search. Frequent questions

Allogene Therapeutics acquired Pfizer's portfolio of assets related to allogeneic chimeric antigen receptor T cell. (ropesgray.com)
Glypican-3 (GPC3) is an oncofetal tumor antigen that is an attractive target for chimeric antigen receptor T cell therapy due to its highly restricted expression on normal tissue and high prevalence in several solid tumors. (oncotarget.com)

Oncocytic carcinomas and mitochondrion-rich carcinomas are more often grade III tumors and show human epidermal growth factor receptor 2 overexpression. (unimore.it)

C-X-C chemokine receptor type 4 ( CXCR-4 ) also known as fusin or CD184 (cluster of differentiation 184) is a protein that in humans is encoded by the CXCR4 gene . (wikidoc.org)
Our analysis further suggests that human viruses have evolved their miRNA repertoire to target specific human pathways, such as cell growth, axon guidance, and cell differentiation. (biomedcentral.com)
In this context, a new molecule, B-cell activating factor (BAFF), has emerged as a positive regulator of B cell survival and differentiation functioning through various signaling pathways and potentiating the activity of various receptor complexes through pleiotropic means. (medsci.org)
It is expressed by monocytes and neutrophils but absent from leukemic cell lines representing early stages of myelomonocytic differentiation. (fishersci.com)
Synaptic network activity induces neuronal differentiation of adult hippocampal precursor cells through BDNF signaling. (mdc-berlin.de)
This makes their identification and differentiation from resident mesenchymal cells extremely difficult in the absence of further specific markers. (ersjournals.com)

Despite valuable efforts to discover novel immune checkpoints and their ligands, the precise roles of their therapeutic functions, as well as the broad identification of their counterpart receptors, remain to be addressed. (journaltocs.ac.uk)
CD44 is a receptor for hyaluronic acid and also interacts with other ligands, such as osteopontin, collagens, and matrix metalloproteinases. (whispermovie.com)
Small‑molecule γ‑secretase inhibitors (AL101, MRK‑560, nirogacestat and others) and antibody‑based biologics targeting Notch ligands or receptors [ABT‑165, AMG 119, rovalpituzumab tesirine (Rova‑T) and others] have been developed as investigational drugs. (spandidos-publications.com)

In this review, we examine the prospects for the application of newly emerging checkpoints, such as T-cell immunoglobulin and mucin domain 3, lymphocyte activation gene-3, T-cell immunoreceptor with Ig and ITIM domains (TIGIT), V-domain Ig suppressor of T-cell activation (VISTA), new B7 family proteins, and B- and T-cell lymphocyte attenuator, in association with immunotherapy of malignancies. (journaltocs.ac.uk)
It has been proposed that increased levels of intramitochondrial proteins in cancer cells are associated with high OXPHOS activity and increased sensitivity to OXPHOS inhibitors. (bvsalud.org)
NF90ctelevision can be a C-terminal variant [30] from the NF90 double-stranded RNA (dsRNA)-binding proteins that was originally reported like a putative transcription element knowing the antigen receptor response component (ARE) in the IL-2 gene regulatory area [31]. (thetechnoant.info)
The repeat is found in a variety of proteins that include, vitellogenin receptor from Drosophila melanogaster, low-density lipoprotein (LDL) receptor [ ( PUBMED:6091915 ) ], preproepidermal growth factor, and nidogen (entactin). (embl.de)
In addition, CD11c + ATMs were enriched for mitochondria and for RNA transcripts encoding mitochondrial, proteasomal, and lysosomal proteins, fatty acid metabolism enzymes, and T-cell chemoattractants, whereas CD11c − ATMs were enriched for transcripts involved in tissue maintenance and repair. (diabetesjournals.org)
A family of proteins that play a role as cofactors in the process of CLATHRIN recycling in cells. (lookformedical.com)
A network of membrane compartments, located at the cytoplasmic side of the GOLGI APPARATUS, where proteins and lipids are sorted for transport to various locations in the cell or cell membrane. (lookformedical.com)
The guanine nucleotide exchange factor (GEF) Dbl targets Rho family proteins thereby stimulating their GDP/GTP exchange, and thus is believed to be involved in receptor-mediated regulation of the proteins. (embl-heidelberg.de)

Impairment of genomic DNA binding to a putative dysfunctional receptor on erythrocytes independent of complement and antibodies in systemic lupus erythematosus. (degruyter.com)
We therefore aimed to characterize these antibodies and identify target antigens. (ox.ac.uk)
Small-molecule inhibitors, antagonistic monoclonal antibodies (mAbs), antibody-drug conjugates (ADCs), bispecific antibodies or biologics (bsAbs) and chimeric antigen receptor-modified T cells (CAR-Ts) targeting Notch signaling components have been developed as investigational anti-cancer drugs ( 10 - 12 ). (spandidos-publications.com)
Here, we report the discovery of human monoclonal antibodies (mAbs) from the circulating memory B cells of the only known human case and survivor of SOSV infection. (cdc.gov)
INTRODUCTION: In this study, we evaluated whether SARS-CoV-2 mRNA vaccines induce anti-human leukocyte antigen (HLA) antibodies and anti- ABO blood type antibodies (ABOAb) in kidney transplant recipients (KTRs). (bvsalud.org)
Changes in anti-ABO blood type immunoglobulin IgM and IgG antibody titers, flow panel reactive antibody (PRA), de novo donor-specific anti-human leukocyte antigen antibodies (DSA), and kidney allograft function before and after vaccination were evaluated. (bvsalud.org)
The 2 most widely proposed theories include (1) glomerular trapping of circulating immune complexes and (2) in situ immune antigen-antibody complex formation resulting from antibodies reacting with either streptococcal components deposited in the glomerulus or with components of the glomerulus itself, which has been termed "molecular mimicry. (medscape.com)

Believed to target protein phosphatase 1/PP1 to dendritic spines, which are rich in F-actin, and regulates its specificity toward ion channels and other substrates, such as AMPA-type and NMDA-type glutamate receptors. (string-db.org)

To determine whether humans with SLE also have a defect in this apotosis pathway, we analyzed the expression of APO-1 on freshly isolated blood mononuclear cells and on lymphocytes activated in vitro using flow cytometry and the monoclonal antibody anti-APO-1. (jci.org)
Description: This 1RNM44N monoclonal antibody recognizes mouse CD170, also known as Siglec F. Siglec F is a cell surface lectin belonging to the Ig superfamily that binds glycoconjugates containing sialic acids that are commonly found on various cell types. (fishersci.com)
However, spontaneous antitumor CD8+ T cell immunity in peripheral blood and tumors was restricted to a few clonal neoantigens featuring an oligo-/monoclonal T cell-receptor (TCR) repertoire. (nih.gov)

Purified lymphocyte function-associated antigen 3 binds to CD2 and mediates T lymphocyte adhesion. (ox.ac.uk)
ST13 is an adaptor protein (co-chaperone) that mediates the association of HSP70 & HSP90 and appears in early receptor complexes. (prospecbio.com)
SIGLEC5 is a putative adhesion molecule that mediates sialic-acid dependent binding to cells. (fishersci.com)
Cannabinoid receptor CB1 mediates baseline and activity-induced survival of new neurons in adult hippocampal neurogenesis. (mdc-berlin.de)

Failed T cell-based immunotherapies in the presence of genomic alterations in antigen presentations pathways may be overcome by NK cell-based immunotherapy. (elifesciences.org)
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
Therefore, SLE is currently believed to be a T cell-driven condition and, indeed, targeting molecules expressed on T cells and their signalling pathways can be one of the potential therapeutic strategies in SLE. (hindawi.com)
Stimulation of TCRs upon antigen binding triggers downstream signalling pathways which enables various physiological functions of the T cells. (hindawi.com)

These pits are the entry route for macromolecules bound by cell surface receptors. (lookformedical.com)

CD44 is a cell-surface glycoprotein that plays a role in cell-cell interactions, cell adhesion and migration. (whispermovie.com)
CD2 is a T lymphocyte glycoprotein that functions in adhesion of T lymphocytes and also as a putative receptor for activation signals. (ox.ac.uk)
CXCR4 is upregulated during the implantation window in natural and hormone replacement therapy cycles in the endometrium, producing, in presence of a human blastocyst , a surface polarization of the CXCR4 receptors suggesting that this receptor is implicated in the adhesion phase of human implantation . (wikidoc.org)
CD44 has functional roles in cell migration, lymphocyte homing and adhesion during hematopoiesis and lymphocyte activation. (bdbiosciences.com)

Here, we show that a group of neurons in the Drosophila larval brain expresses the adiponectin receptor (AdipoR) and controls systemic growth and metabolism through insulin signaling. (cnrs.fr)
The levels of the receptor decrease as neurons mature. (wikidoc.org)
Melatonin modulates cell survival of new neurons in the hippocampus of adult mice. (mdc-berlin.de)

CXCR-4 is an alpha- chemokine receptor specific for stromal-derived-factor-1 ( SDF-1 also called CXCL12), a molecule endowed with potent chemotactic activity for lymphocytes . (wikidoc.org)
Inhibition of chemokine receptor 4, the receptor for the stem cell mobiliser stromal-derived factor-1, significantly prevented and reversed hypoxia-induced pulmonary hypertension in neonatal mice [ 13 ]. (ersjournals.com)

This molecule is expressed by monocytic/myeloid lineage cells. (fishersci.com)
We have recently identified a family with a mutation close to the protease docking site of tumor necrosis factor alpha converting enzyme in the tumor necrosis factor receptor p55 molecule, leading to a periodic fever syndrome with autoimmune phenomena. (biomedcentral.com)

PD-L1 CAR haNKs reduced levels of macrophages and other myeloid cells endogenously expressing high PD-L1 in peripheral blood from patients with head and neck cancer. (elifesciences.org)
Methods: Identification of tumour-associated endothelial markers (TEM) by comparing antigen expression on normal vs t-CEC and assess the presence of t-CEC in peripheral blood of cancer patients by incorporating TEM in our novel flow cytometry-based CEC detection assay. (researchgate.net)
Significantly higher level of APO-1 expression were detected on freshly isolated peripheral B cells and both CD4+ and CD8+ T lymphocyte populations obtained from lupus patients when compared with normal controls (P (jci.org)
Resident memory (T RM ) cells are a distinct tissue-localized T cell lineage that is crucial for protective immunity in peripheral tissues. (frontiersin.org)
Recent studies in mouse tumor models have shown that T RM cells are induced by cancer vaccines delivered in peripheral tissue sites, or by the depletion of regulatory T cells. (frontiersin.org)
Such tumor-specific T RM cells are recognized as both necessary and sufficient for long-lived protection against tumors in peripheral tissue locations. (frontiersin.org)
Following effective priming in lymph nodes, T cells traffic to tumors and other peripheral tissues. (frontiersin.org)
whereas T EM cells were shown to recirculate predominantly through blood, and peripheral tissues ( 10 ). (frontiersin.org)
In the early 2000's, large and persistent populations of antigen (Ag)-specific CD8 T cells in peripheral tissues were initially classified as T EM cells in recirculation from the blood ( 8 , 11 ). (frontiersin.org)
Drugs that block the CXCR4 receptor appear to be capable of "mobilizing" hematopoietic stem cells into the bloodstream as peripheral blood stem cells . (wikidoc.org)
Peripheral blood stem cell mobilization is very important in hematopoietic stem cell transplantation (as a recent alternative to transplantation of surgically harvested bone marrow ) and is currently performed using drugs such as G-CSF . (wikidoc.org)
Adaptive peripheral immune response increases proliferation of neural precursor cells in the adult hippocampus. (mdc-berlin.de)
The fibrocyte is one of many populations of bone marrow-derived cells that can be detected in the peripheral blood and is considered to represent a mesenchymal progenitor cell [ 1 ]. (ersjournals.com)

CRTH-2 binds Prostaglandin D2 and induces chemotaxis of these cells in allergic and inflammatory immune responses. (rndsystems.com)
The LDL receptor binds LDL and transports it into cells by acidic endocytosis. (embl.de)

NK cells express germ-line receptors that are either stimulatory or inhibitory, and the summation of these signals determines activation status ( Caligiuri, 2008 ). (elifesciences.org)
In the tumor microenvironment, T cells, as crucial immune response against malignant diseases as well as other immune central effector cells, such as natural killer cells, are regulated via co-stimulatory or co-inhibitory signals from immune or tumor cells. (journaltocs.ac.uk)
Studies have shown that exposure of T cells to tumor antigens upregulates the expression of inhibitory checkpoint receptors, leading to T-cell dysfunction or exhaustion. (journaltocs.ac.uk)
As control we used a human leukocyte antigen DR (HLA DR) antibody with equal inhibitory capacities on cell proliferation. (biomedcentral.com)

CD44 is the receptor for hyaluronic acid. (bdbiosciences.com)

Treatment of syngeneic tumors resulted in CD8 and PD-L1-dependent tumor rejection or growth inhibition and a reduction in myeloid cells endogenously expressing high levels of PD-L1. (elifesciences.org)
Thus, addressing the presence of immunosuppressive myeloid cell populations in the periphery and tumor microenvironment of patients with cancer is likely to be required for effective NK cell-based immunotherapy. (elifesciences.org)

Interleukin (IL)-9-producing subset called Th9 cell, Th22 cells which primarily secrete IL-22, IL-13 and tumor necrosis factor- and Th25 cells via producing IL-25 are believed to be important for initiating allergic reactions and developing airway inflammation. (cdc.gov)

CD205 also called Lymphocyte antigen 75 is a protein that in humans is encoded by the LY75 gene. (wikipedia.org)
To characterise the signals with which infection might be communicated between blood cells and fat body, we ablated circulating haemocytes and defined the parameters of AMP gene activation in larvae. (cnrs.fr)
We found that targeted ablation of blood cells influenced the levels of AMP gene expression in the fat body following both septic injury and oral infection. (cnrs.fr)
Complete cloning and sequencing of rat gp330/"megalin," a distinctive member of the low density lipoprotein receptor gene family. (embl.de)
We have identified a novel gene, gtcA , involved in the decoration of cell wall teichoic acid of Listeria monocytogenes serotype 4b with galactose and glucose. (asm.org)
immune destruction of insulin-pro- vestigate the relationship of VDR gene ducing beta cells by T-cell infiltration polymorphism to the risk of type 1 DM DNA isolation and PCR experiments of the pancreatic islets [1]. (who.int)

Therefore, assays that allow the discrimination between these two putative types of CEC are thought to improve the specificity of the enumeration of CEC in cancer. (researchgate.net)
Isolation of T cell clones by limiting dilution from tumor-infiltrating lymphocytes (TILs) permitted functional validation regarding neoantigen specificity. (nih.gov)

Many of these factors stem from the location of the epitope that can affect accessibility of the antibody to the epitope at a cellular or molecular level, direct inhibition of target antigen activity, conservation of function despite escape mutations, and even non-competitive inhibition sites. (preprints.org)

The supporting examinations showed abnormal blood cell counts, positive antinuclear antibody profile, serositis, and neuropathy. (journaltocs.ac.uk)
A mechanistic study of the dissociation of individual antibody-antigen pairs by atomic force microscopy. (degruyter.com)
Through the incorporation of novel computational methods for predicting antigen changes to model-informed drug discovery and development, superior vaccines and antibody-based therapeutics or diagnostics can now be more easily designed to mitigate failures. (preprints.org)
Breakdown of immune tolerance is believed to be one of the major mechanisms which triggers the production of autoantibodies by B cells and antibody forming cells, leading to inflammation upon binding to autoantigens and consequent tissue damage [ 2 ]. (hindawi.com)
Applications Tested: This 1RNM44N antibody has been tested by flow cytometric analysis of mouse thioglycolate-elicited peritoneal exudate cells. (fishersci.com)
A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. (fishersci.com)
Anti-NAPlr-Ab: Anti-NAPlr-antibody.Courtesy of open access article, "The Role of Nephritis-Associated Plasmin Receptor (NAPlr) in Glomerulonephritis Associated with Streptococcal Infection. (medscape.com)

May act by competing with the putative neuronal protein kinase DCLK1 in binding to a target protein. (string-db.org)

NOTCH1, NOTCH2, NOTCH3 and NOTCH4 are transmembrane receptors that transduce juxtacrine signals of the delta‑like canonical Notch ligand (DLL)1, DLL3, DLL4, jagged canonical Notch ligand (JAG)1 and JAG2. (spandidos-publications.com)
CD44 is an 80-95 kDa type I transmembrane glycoprotein, also known as Phagocytic glycoprotein-1 (Pgp-1), or Extracellular matrix receptor type III (ECMR-III). (bdbiosciences.com)

Autologous as well as allogeneic CD8 + T cells transduced with tumor antigen specific T cell receptors (TCR) may cause significant tumor lysis upon adoptive transfer. (oncotarget.com)

Dendritic cells (DC) are postulated to play a role in autoimmune diseases such as Systemic Lupus Erythematosus (SLE). (journaltocs.ac.uk)
Mature dendritic cell (mDC) vaccination with tumor-encoded amino acid-substituted (AAS) peptides revealed diverse neoantigen-specific CD8+ T responses, each composed of multiple TCR clonotypes. (nih.gov)

Its activity is directed by intracellular signals mediated by various types of receptors such as G protein-coupled receptors. (embl-heidelberg.de)

PDF) Kraan J, van den Broek P, Verhoef C, Grunhagen DJ, Taal W, Gratama JW, Sleijfer SEndothelial CD276 (B7-H3) expression is increased in human malignancies and distinguishes between normal and tumour-derived circulating endothelial cells. (researchgate.net)
Results: No difference in antigen expression between normal and malignant endothelial cells (ECs) was found for CD54, CD109, CD137, CD141, CD144 and CXCR7. (researchgate.net)
In addition, their clinical and biological significance is discussed, including their expression in various human cancers, along with their roles in T-cell-mediated immune responses. (journaltocs.ac.uk)
24h after TCR transduction, CD107a expression correlated with low expansion rates due to apoptosis of ADRB3 specific T cells in contrast to CHM1 specific transgenic T cells. (oncotarget.com)
These results reveal that, while APO-1/Fas may play an important role in the regulation of lymphocyte survival in SLE, no consistent defect in the expression or function of the receptor could be detected in these studies. (jci.org)
It has been also shown that CXCR4 signalling regulates the expression of CD20 on B cells. (wikidoc.org)
Expression of this receptor in cancer cells has been linked to metastasis to tissues containing a high concentration of CXCL12, such as lungs, liver and bone marrow. (wikidoc.org)
[12] [13] However, in breast cancer where SDF1/CXCL12 is also expressed by the cancer cells themselves along with CXCR4, CXCL12 expression is positively correlated with disease free (metastasis free) survival. (wikidoc.org)
2 ] in 1994 and is defined by the expression of a variety of cell surface antigens, including the stem cell marker CD34, the pan-leukocyte marker CD45, and monocyte markers CD14 and CD11. (ersjournals.com)
The fibroblast-like nature of these cells is evidenced by their expression of collagen I, collagen II and vimentin. (ersjournals.com)
Here, we show the association of Dbl with G protein betagamma subunits (Gbetagamma) in transient co-expression and cell-free systems. (embl-heidelberg.de)

Three independent mutations involving the apoptosis-1 (APO-1)/Fas receptor or its putative ligand have led to lupuslike diseases associated with lymphadenopathy in different strains of mice. (jci.org)
Loss‑of‑function NOTCH1 mutations are early events during esophageal tumorigenesis, whereas gain‑of‑function NOTCH1 mutations are late events during T‑cell leukemogenesis and B‑cell lymphomagenesis. (spandidos-publications.com)
[9] WHIM like mutations in CXCR4 were recently identified in patients with Waldenstrom's macroglobulinemia , a B-cell malignancy. (wikidoc.org)
PMID:18786442 mutations and the risk of esophageal squamous cell carcinoma. (who.int)

ABSTRACT Reported associations between vitamin D receptor (VDR) polymorphism and type 1 diabetes mellitus vary across ethnic groups. (who.int)

Effects of Lipofectamine 2000/siRNA complexes on autophagy in hepatoma cells Mol Biotechnol. (usc.edu)
1983) and the multipotent progenitor cells from fetal disease (Bjorklund and Lindvall, 2000). (lu.se)
2000). In *Correspondence to: Perrine Barraud, Department of Veterinary Medi- contrast, several cell surface markers have been used to cine, Neurosciences, Madingley Road, Cambridge CB3 OES, United enrich for NSCs in the rodent CNS. (lu.se)

CD44 and CD49d are putative activity markers and CD44 a potential novel therapeutic target in multiple sclerosis. (whispermovie.com)

T cell-based immunotherapy, such as immune checkpoint blockade or adoptive T cell transfer, is limited by the ability of T cells to detect major histocompatibility complex (MHC)-presented antigen by tumor cells. (elifesciences.org)
Tumor development has been said to occur in three distinct steps: inefficient elimination of early transformed cells, development of a state of equilibrium between tumor cells and immune cells, and tumor escape from immune pressure ( 2 ). (frontiersin.org)
[14] Another explanation of this observation is provided by a study that shows the ability of CXCL12 (and CCL2 ) producing tumors to entrain neutrophils that inhibit seeding of tumor cells in the lung. (wikidoc.org)

In: Chemically induced cell proliferation: Implications for risk assessment. (cdc.gov)

T RM responses against tumor/self-antigens can concurrently result in the development of pathogenic T RM responses to self, with a growing number of autoimmune diseases and inflammatory pathologies being attributed to T RM responses. (frontiersin.org)
Informed by studies in infectious disease models, and instructed by a clear role for T RM cells in autoimmunity, we will discuss strategies for therapeutically promoting T RM responses in settings where they don't naturally occur. (frontiersin.org)
The persistence of such responses is fundamentally thought to be based on the ability of T cells to act as potent effectors and, subsequently, generate long-lived memory ( 6 ). (frontiersin.org)
article{shia_toll-dependent_2009, title = {Toll-dependent antimicrobial responses in Drosophila larval fat body require Spätzle secreted by haemocytes}, author = {Alice K H Shia and Marcus Glittenberg and Gavin Thompson and Alexander N R Weber and Jean-Marc Reichhart and Petros Ligoxygakis}, doi = {10.1242/jcs.049155}, issn = {1477-9137}, year = {2009}, date = {2009-12-01}, journal = {J. Cell. (cnrs.fr)
At the receptor level, it is a chemical entity that opposes the receptor- associated responses normally induced by another bioactive agent. (genomicglossaries.com)
However, recent successful preclinical and clinical trials have advocated for the significance of B cell-dependent immunopathogenic responses and has led to the development of novel biologicals that target specific B cell phenotypes. (medsci.org)
In neutrophil cells, required for cytokine-induced proliferative responses and activation of the respiratory burst. (string-db.org)

Figure 2A), and 3) those based on fragments containing binding to the receptor, angiotensin-converting enzyme 2 neutralizing epitopes (Figure 2B). (cdc.gov)
Putative corresponding receptors were identified using antagonistic drugs, and synthesized peptide sequences corresponding to segments of these receptors were used to identify the target epitopes. (ox.ac.uk)
Here, we performed deep targeted DNA sequencing of multiple metastases from melanoma patients and observed ubiquitous sharing of clonal and subclonal single nucleotide variants (SNVs) encoding putative HLA class I-restricted neoantigen epitopes. (nih.gov)

Synovial sarcomas encompass both biphasic (epithelial and spindle cell components) and monophasic (purely spindle cell) variants. (medscape.com)

Enhancement of hepatitis B virus replication by androgen and its receptor in mice J Virol. (usc.edu)

NMDA and benzodiazepine receptors have synergistic and antagonistic effects on precursor cells in adult hippocampal neurogenesis. (mdc-berlin.de)

The fifth domain is the cytoplasmic tail that directs the receptor to clathrin-coated pits. (embl.de)
Mitochondrion-rich carcinomas are histologically similar to oncocytic carcinomas and constitute 19.7% of all invasive carcinomas, indicating that cytoplasmic eosinophilia in breast cancer cells is often due to accumulation of mitochondria. (unimore.it)

We completed the cDNA cloning and sequencing of gp330, the major kidney glomerular antigen for rat Heymann nephritis. (embl.de)
Additional evidence has also been presented to support the anti-immunoglobulin activity or glomerular plasmin-binding activity of streptococcal antigens. (medscape.com)

Background: Mature circulating endothelial cells (CEC) are surrogate markers of endothelial damage. (researchgate.net)
Mature circulating endothelial cells (CEC) are surrogate markers of endothelial damage. (researchgate.net)
CD133+), but are rarely codetected with the neural stem dents, very few human-specific NSC markers have been cell (NSC) marker CD15. (lu.se)

Indeed a wealth of studies from humans and mouse models establishes a particularly potent role for CD8 T cells in controlling the outgrowth of malignancies ( 3 ). (frontiersin.org)
2002). In humans, SSEA4 is expressed by building the nervous system but also for their prospec- nonneural cells such as the erythrocytes (Kannagi et al. (lu.se)

After TCR identification, we generated HLA-A*02:01/peptide restricted TCR transgenic T cells by retroviral transduction and tested T cell expansion rates as well as A*02:01/peptide recognition and ES killing in ELISpot and xCELLigence assays. (oncotarget.com)
TCR transgenic T cells demonstrated HLA-A*02:01/ADRB3 295 mediated ES recognition and killing in ELISpot and xCELLigence assays. (oncotarget.com)
However, there was no DSA in single antigen flow-bead assays. (bvsalud.org)

Experimental techniques PlasmidsRecombinant plasmids for appearance in mammalian cells had been constructed the following: pJK2 (HIV-1LTR/-galactosidase reporter), pSV2-Tat72, (SV40 promoter powered vector encoding the 72 amino acidity initial exon of Tat), pCMV-NF90ctelevision (CMV promoter powered construct of primary NF90ctelevision appearance vector was given by Dr. Peter Kao, Stanford School CA) [31]. (thetechnoant.info)
The low-density lipoprotein receptor (LDLR) is the major cholesterol-carrying lipoprotein of plasma, acting to regulate cholesterol homeostasis in mammalian cells. (embl.de)

The surface topography of red blood cells (RBCs) was investigated under near-physiological conditions using atomic force microscopy (AFM). (degruyter.com)
An endogenous substance or a drug that can interact with a receptor and initiate a physiological or a pharmacological response characteristic of that receptor (contraction, relaxation, secretion, enzyme activation, etc. (genomicglossaries.com)

Our findings implicate immunological ignorance of clonal neoantigens as the basis for ineffective T cell immunity to melanoma and support the concept that therapeutic vaccination, as an adjunct to checkpoint inhibitor treatment, is required to increase the breadth and diversity of neoantigen-specific CD8+ T cells. (nih.gov)

CD44 is expressed on leucocytes, erythrocytes, epithelial cells and weakly on platelets. (bdbiosciences.com)
It presents a functional unit of a physical barrier consisting of a mucus layer and a monolayer of epithelial cells and of a mucosal lymphoid system that together efficiently discriminate between pathogenic and commensal microorganisms 16 . (nature.com)

Natural killer (NK) cell-based immunotherapy may overcome genetic mechanisms of resistance to T cell-based immunotherapy through antigen- and MHC-independent recognition of malignant cells. (elifesciences.org)
Here, potential mechanisms involving alterations in T-cell receptor expressions, postreceptor downstream signalling, epigenetics, and oxidative stress which favour activation of lupus T cells will be discussed. (hindawi.com)
In this brief review, a detailed account of the putative mechanisms by which the normal physiology of T cells are disturbed and why regulatory T cells fail to alleviate proinflammatory response in SLE will be discussed. (hindawi.com)
However, the mechanisms underlying receptor-dependent regulation of Rho family members remain incompletely understood. (embl-heidelberg.de)

The firm also secured another key victory for Sarepta Therapeutics, Inc . when the U.S. Court of Appeals for the First Circuit affirmed the complete dismissal of a putative securities class action lawsuit brought against the company in a unanimous decision. (ropesgray.com)

Background Examination of sponsor cell-based inhibitors of HIV-1 transcription could be very important to attenuating viral replication. (thetechnoant.info)
Lastly, while currently available outcomes of clinical trials evaluating therapeutic agents which manipulate the T cells such as calcineurin inhibitors indicate that they are at least as efficacious and safe as conventional immunosuppressants in treating lupus glomerulonephritis, larger clinical trials are undoubtedly required to validate these as-yet favourable findings. (hindawi.com)
One possible cognate receptor for BAFF includes the Nogo receptor (NgR) and its homologs, previously established as potent inhibitors of axonal regeneration during central nervous system (CNS) injury and disease. (medsci.org)

We identified these autoantibodies as immunoglobulin G directed against peptide sequences from the second extracellular loop of these receptors. (ox.ac.uk)

Autoimmunity against the β2 adrenergic receptor and muscarinic-2 receptor in complex regional pain syndrome. (ox.ac.uk)

Cancer can be considered a disease of immune dysfunction, with a failure of immune recognition leading to the outgrowth of malignant cells as tumors ( 1 ). (frontiersin.org)

Almost 90% of the cells that stained positive for APO-1 also expressed the CD29 antigen, suggesting that APO-1 was upregulated after lymphocyte activation in vivo. (jci.org)

CXCL12 (over-)expressing cancers might not sense the CXCL12 gradient released from the metastasis target tissues since the receptor, CXCR4, is saturated with the ligand produced in an autocrine manner. (wikidoc.org)

Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. (embl.de)

Recent studies by F rid and co-workers [ 9 - 11 ] in the chronically hypoxic neonatal calf and in rats have shown that a proportion of the adventitial cells of pulmonary hypertensive animals are of a blood-derived fibrocyte phenotype. (ersjournals.com)
However, those authors did confirm the presence of inflammatory cells accumulating in the adventitia of monocrotaline-treated/pneumonectomised rats. (ersjournals.com)
The stage-specific embryonic antigen 4 (SSEA4) is com- isolate the NSCs from neonatal mice and rats (Campos monly used as a cell surface marker to identify the pluri- et al. (lu.se)

Functional data suggest that LFA-3, a widely distributed cell surface glycoprotein, may be the biological ligand of CD2. (ox.ac.uk)
Compelling evidence has however shown that without the assistance of the helper T lymphocytes, it is indeed difficult for the "helpless" B cells to become functional enough to trigger SLE-related inflammation. (hindawi.com)
Recently, a number of phenotypic and functional alterations which increase the propensity to trigger lupus-related inflammation have been identified in lupus T cells. (hindawi.com)
Phenotypic and functional alterations in lupus T cells including expansion of the Th17 population, perturbations of the physiology of T-cell receptors (TCRs) and postreceptor downstream signalling, oxidative stress, and epigenetic changes result in exaggeration of TCR response to stimuli and the propensity of lupus T cells to get activated [ 6 ]. (hindawi.com)
Mouse Siglec F is a functional ortholog of human Siglec 8, however, unlike human Siglec 8, mouse Siglec F is not expressed on mast cells. (fishersci.com)

In a growing number of cases, CD8 T cells have been shown to mediate the regression of large bulky tumors, resulting in durable long-term disease remissions ( 5 ). (frontiersin.org)
Phase III clinical trials of Rova‑T for patients with small‑cell lung cancer and a phase III clinical trial of nirogacestat for patients with desmoid tumors are ongoing. (spandidos-publications.com)
Oncocytic breast carcinomas are tumors composed of no fewer than 70% of oncocytic cells (World Health Organization). (unimore.it)

Anatomy29

Organisms15

Diseases7

Chemicals and Drugs128

Analytical, Diagnostic and Therapeutic Techniques and Equipment29

Phenomena and Processes50

Disciplines and Occupations1

Information Science3

Health Care2

Chimeric antigen receptor T cell2

Epidermal growth f1

Differentiation6

Ligands3

Proteins8

Antibodies7

Glutamate receptors1

Monoclonal3

Mediates4

Pathways4

Surface receptors1

Adhesion4

Neurons3

Chemokine receptor2

Molecule2

Peripheral13

Binds2

Inhibitory4

Hyaluronic acid1

Myeloid2

Interleukin1

Gene6

Specificity2

Inhibition1

Antibody7

Neuronal1

Transmembrane2

Allogeneic1

Dendritic2

Signals1

Expression11

Mutations4

Polymorphism1

20003

Multiple sclerosis1

Tumor cells3

Proliferation1

Responses7

Epitopes3

Variants1

Androgen1

Antagonistic1

Cytoplasmic2

Glomerular2

Markers3

Humans2

Assays3

Mammalian cells2

Physiological2

Vaccination1

Epithelial cells2

Mechanisms4

Therapeutics1

Inhibitors3

Extracellular1

Autoimmunity1

Malignant cells1

Lymphocyte activation1

Metastasis1

Lipoprotein1

Rats3

Functional5

Tumors3