Putative inhibitor proteins. Medical search. Frequent questions

Other inhibitors include, HIV protease inhibitors, glitazones and macrolide antibacterials. (guidetopharmacology.org)
BPTI/Kunitz family of serine protease inhibitors. (embl.de)
Serine protease inhibitors. (embl.de)
Plasma inter-alpha-trypsin inhibitor (I alpha TI) is a major representative of the superfamily of Kunitz-type protease inhibitors in mammals. (embl.de)
The newly discovered genes and gene products form the basis of a new family of I alpha TI-related protease inhibitors. (embl.de)
3 Given its homology and comparable transcription profile with known leukocyte protease inhibitors in the WFDC family of proteins, HE4 also presumably has a role in natural immunity. (nature.com)

Recent years have seen heat shock protein 90 kDa (Hsp90) attract significant interest as a viable drug target, particularly for cancer. (nature.com)
Characterization of a novel novobiocin analogue as a putative C-terminal inhibitor of heat shock protein 90 in prostate cancer cells. (ouhsc.edu)

and 3) To isolate, sequence and analyze at least one resulting positive peanut trypsin inhibitor clone. (usda.gov)
A trypsin inhibitor assay reveals that Ara h 3 allergen protein has trypsin inhibitory activity. (usda.gov)
the Kunitz/bovine pancreatic trypsin inhibitor family, they inhibit proteases of the S1 family [ ( PUBMED:14705960 ) ] and are restricted to the metazoa with a single exception: Amsacta moorei entomopoxvirus. (embl.de)
The pancreatic trypsin inhibitor (Kunitz) family [ ( PUBMED:6996568 ) ( PUBMED:1703675 ) ( PUBMED:1593645 ) ] is one of the numerous families of serine proteinase inhibitors. (embl.de)
Inter-alpha-trypsin inhibitor: emergence of a family within the Kunitz-type protease inhibitor superfamily. (embl.de)

PIAS protein's interaction with STAT signaling requires tyrosine phosphorylation of STAT proteins. (wikipedia.org)
Expression of partial sequences of BRO-A proved that theN-terminal 80 amino acid residues were required for DNA binding activity.We also demonstrated that BmNPV BRO proteins underwent phosphorylation andubiquitination followed by proteasome degradation, which may explain theirdistribution in the cytoplasm as well as the nucleus. (embl-heidelberg.de)
The alpha isoform is responsible for synaptic plasticity and participates in memory through its phosphorylation of synaptic proteins. (elifesciences.org)

Apart from PIAS1, each gene encodes two protein isoforms. (wikipedia.org)
In also encodes two more proteins that Lexacalcitol are critical for chemotaxis. (azadright.com)
gene that encodes the proteins neurofibromin. (abic2004.org)
The HE4 (WFDC2) gene encodes a WAP-type four disulphide core domain-containing protein with a presumptive role in natural immunity. (nature.com)
This gene encodes a transmembrane protein with two extracellular Kunitz domains that inhibits a variety of serine proteases. (oftalmic.ru)

The evolution of a genetic locus encoding small serine proteinase inhibitors. (nih.gov)
A new A4 amyloid mRNA contains a domain homologous to serine proteinase inhibitors. (embl.de)
The peptide predicted from this insert is very similar to the Kunitz family of serine proteinase inhibitors. (embl.de)

Although the effective concentration of K-252a did not cause significant inhibition of affinity-purified p34cdc2 protein kinase activity in vitro, in vivo the full activation of p34cdc2 kinase during the G2/M was blocked by K-252a. (rupress.org)
Here we report a SPIN1 chemical probe inhibitor with low nanomolar in vitro activity, exquisite selectivity on a panel of methyl reader and writer proteins, and with submicromolar cellular activity. (ox.ac.uk)

Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer's disease. (embl.de)
Pansensitive and panresistant genes to 21 NCCN-recommended drugs with concordant mRNA and protein expression were identified. (cdc.gov)

A locus on human chromosome 20 contains several genes expressing protease inhibitor domains with homology to whey acidic protein. (nih.gov)
For this purpose, NLRP3 homology model was built and the putative protein binding region of a non-covalent inhibitor MCC950 (used as a probe) was investigated using a combination of in silico techniques. (mdpi.com)

It is therefore essential to gain mechanistic insights on substrate specificity for OGT, develop reagents to more specifically enrich for O-GlcNAc modified proteins, identify O-GlcNAc 'readers' and develop OGT small molecule inhibitors. (qub.ac.uk)

We probe the open conformation of human Hsp90α for druggable sites that overlap with these allosteric control elements, and identify three putative natural compound allosteric modulators: Cephalostatin 17, 20(29)-Lupene-3β-isoferulate and 3′-Bromorubrolide F. We assess the allosteric potential of these ligands by examining their effect on the conformational dynamics of the protein. (nature.com)
Originally developed for β-turn mimetics, the method can now be applied generally to any known or putative bioactive conformation. (nquix.com)

In this article, we describe a simple computational approach, based on the effect allosteric ligands exert on protein flexibility upon binding, to predict the existence and position of allosteric sites on a given protein structure. (biomedcentral.com)
In drug discovery, it is of utmost importance to accurately calculate the free energies of binding ligands to various protein targets, such as enzymes and receptors. (lu.se)

In conclusion, putative peanut trypsin inhibitors have been isolated and reveal high similiarity at the nucleotide and amino acid level to peanut allergen Ara h 3 and Ara h 4. (usda.gov)

FAF2 (aka ETEA/UBXD8) helps mediate ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins in endoplasmic reticulum-associated degradation (ERAD) [12]. (abic2004.org)

Nurix's BTK degraders have the potential to address these limitations of BTK inhibitors and provide a new therapeutic option for patients. (pipelinereview.com)
Genetic mouse models and first PI3K isoform-specific inhibitors pinpointed putative therapeutic applications. (chimia.ch)
This relatively unexplored therapeutic potential and the putative advantages of allosteric drugs over classical active-site inhibitors fuel the attention allosteric-drug research is receiving at present. (biomedcentral.com)

The main aim was to detect putative protein hot spots involved in the stabilization of protein-ligand complex. (mdpi.com)
We performed normal-mode analysis and observed significant changes in protein flexibility upon allosteric-ligand binding in 70% of the cases. (biomedcentral.com)
These results agree with the current view that allosteric mechanisms are in many cases governed by changes in protein dynamics caused by ligand binding. (biomedcentral.com)
We introduce a simple computational approach to predict the presence and position of allosteric sites in a protein based on the analysis of changes in protein normal modes upon the binding of a coarse-grained ligand at predicted cavities. (biomedcentral.com)
We mostly used molecular mechanics (MM) in order to model the protein-ligand interactions, which is more approximate than quantum-mechanical (QM) methods, but necessary to reduce the computational cost when doing calculations on protein-ligand systems, which often contain tens of thousand of atoms. (lu.se)
In one study of a large set of protein-ligand complexes, we tried to improve the free energies of binding by using MD simulations with QM-derived charges, which sometimes led to improved results, but not always. (lu.se)
This entropy largely stems from the fluctuation of the protein and ligand. (lu.se)
Additionally, we compared how MD and grand-canonical Monte Carlo (GCMC) can be used to assess dynamics and thermodynamics of protein-ligand binding for both buried and solvent-exposed binding sites. (lu.se)

It contains common core signaling proteins, the CheA kinase, the CheW coupling protein, and the CheY response regulator, all of which are required for chemotaxis (1, 12, 13). (azadright.com)
CheV proteins combine the CheW coupling domain name with an additional phosphorylatable response regulator domain name (REC) (15). (azadright.com)
ChePep contains a putative response regulator domain name and is conserved in (22). (azadright.com)

These results highlight the interest of therapies targeting the PD-1/PD-L1 axis in activated lymphomas with PD-L1 expression, with possible synergies with tyrosine kinase inhibitors. (springer.com)

HMG-CoA reductase inhibitors (statins) are the medications of choice for the treatment of LDLc elevations in patients with heterozygous FH because they have the greatest efficacy and are easily tolerated and because multiple randomized, placebo-controlled trials have shown that lowering LDLc levels with statins reduces coronary morbidity and mortality and, in some cases, total mortality. (medscape.com)
PCSK9 inhibitors are now available in the United States to add to maximally tolerated statins for patients with HeFH. (medscape.com)

The CRCBT-02-001 monoclonal antibody specifically binds to human CD364 which is also known as Peptidase inhibitor 16 (PI-16) or Protease inhibitor 16. (bdbiosciences.com)
serine peptidase inhibitor, Kunitz type, 2. (oftalmic.ru)

We aim to study the coupling between LTCC and β adrenergic receptors in different cardiomyocyte microdomains, the distinct involvement of PKA and CAMKII (Ca2+/calmodulin-dependent protein kinase II) and explore how this functional complex is disrupted in heart failure.Methods:Global signaling between LTCCs and β adrenergic receptors was assessed with whole-cell current recordings and western blot analysis. (imperial.ac.uk)
NF1 is known to be regulated by proteolysis and Cul3, an E3 ubiquitin-protein ligase complex and a known FAF2 interacting partner [13,14,15]. (abic2004.org)

Cell proteins were analysed with 2-dimensional electrophoresis and differentially expressed proteins were identified by matrix-assisted laser desorption/ ionization time-of-flight mass spectrometry. (who.int)

One option involves modulation of the protein through allosteric activation/inhibition. (nature.com)
S. cerevisiae Lsm protein overexpression strains showed increased acetate and HMF resistance as compared to the wild-type, while the overexpression strains showed greater inhibition under vanillin stress conditions. (biomedcentral.com)
One approach to overcome the issue of inhibition caused by pretreatment processes is to remove the inhibitor after pretreatment from the biomass physically or chemically, which requires extra equipment and time leading to increased costs. (biomedcentral.com)
In comparison, the inhibition of autophagy reduced the phrase amounts of ATG protein in the tissue targeted by NDV. (immune-source.com)
Here, we present through pharmacological inhibition that is certainly indie of Ras signaling, as the inhibitors, rapamycin and selumetinib, usually do not alter keratin appearance. (abic2004.org)

The seven proteins that belong to the mammalian PIAS family are encoded by four genes: PIAS1, PIAS2 (PIASx), PIAS3, and PIAS4 (PIASy). (wikipedia.org)
The table below lists the seven known proteins that belong to the mammalian PIAS protein family. (wikipedia.org)
The bacterial type II fatty acid synthesis (FASII) pathway is an attractive target for the development of inhibitors and is particularly favourable due to the differences from mammalian type I fatty acid synthesis. (rcsb.org)
In mammalian cells, FAF2 protein directly interacts with and negatively regulates neurofibromin by promoting its ubiquitin-dependent proteolysis. (abic2004.org)

Due to the multispecificity of these proteins, this guide lists classes of substrates and inhibitors for each family member. (guidetopharmacology.org)
More comprehensive lists of substrates, inhibitors, and their relative affinities may be found in the review articles listed below. (guidetopharmacology.org)

PIAS proteins act as transcriptional co-regulators with at least 60 different proteins in order to either activate or repress transcription. (wikipedia.org)
These functions include acting as E3 SUMO-protein ligases during SUMOylation, which is an important process in transcriptional regulation. (wikipedia.org)
Homologues of PIAS proteins have been found in other eukaryotes, and several are listed below: Zimp/dPIAS in Drosophila melanogaster zfPIAS4a in zebrafish SIZ1 and SIZ2 in yeast PIAS proteins contribute to the control of gene expression, and may be considered transcriptional co-regulators. (wikipedia.org)
One function of PIAS proteins is to relocate transcriptional regulators to different compartments within the nucleus of the cell. (wikipedia.org)
Additionally, PIAS proteins are important transcriptional co-regulators of the JAK/STAT signaling pathway. (wikipedia.org)
The spindlin1 (SPIN1) protein contains three Tudor methyllysine/arginine reader domains and was identified as a putative oncogene and transcriptional coactivator. (ox.ac.uk)

Although rat and mouse OATP1A4 are considered the orthologs of human OATP1A2 we do not cross-link to gene or protein databases for these since in reality there are five genes in rodents that arose through gene duplication in this family and it is not clear which one of these is the "true" ortholog. (guidetopharmacology.org)
Subcutaneous injection of sodium selenite led to severe oxidative damage in the lenticular tissues, shown by increased formation of formazan crystals, elevated generation of superoxide, hydroxyl, and nitric oxide radicals, and elevated inducible nitric oxide synthase gene and protein expression that possibly contributed to the opacification of the lens and thus cataract formation. (molvis.org)
Here, we examined the expression of the HE4 gene and protein in a large series of normal and malignant adult tissues by oligonucleotide microarray and tissue microarray, respectively. (nature.com)
Here, we used oligonucleotide and tissue microarrays to survey HE4 gene and protein expression in a large group of malignant and normal tissues from adults. (nature.com)
This gene is a putative tumor suppressor, and mutations in this gene result in congenital sodium diarrhea. (oftalmic.ru)
Analysis of Wnt target gene expression and axis formation assays revealed that only a subset of these GR-fusion proteins is indeed inducible. (uni-goettingen.de)
Programmable DNA binding proteins have emerged as an exciting platform for engineering synthetic transcription factors for modulating endogenous gene expression 5 - 11 . (cdc.gov)

Immunoblot analysis was also performed to confirm the differential expression of the inducible nitric oxide synthase protein. (molvis.org)

The WFDC domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor. (nih.gov)
The encoded protein contains four WFDC domains. (nih.gov)

Chemotaxis proteins in are organized into two unique polar complexes. (azadright.com)
Proteins that contain "reader" domains can bind to these modifications and form specific effector complexes, which ultimately mediate chromatin function. (ox.ac.uk)

Here, we review the relevance of OGT in cancer progression and the potential targeting of this metabolic enzyme as a putative oncogene. (qub.ac.uk)

While PIAS proteins interact with at least 60 different proteins involved in transcription, they are known to act as E3 SUMO-protein ligases. (wikipedia.org)
mechanics (QM), in particular the Schr ¨odinger equation, allow us different proteins, e.g. alcohol dehydrogenase, blue copper proteins, to calculate any measurable property of a defined set of atoms. (lu.se)

The transcription factors STAT, NF-κB, p73, and p53 are among the many proteins that PIAS interacts with. (wikipedia.org)
TlpD possesses the canonical chemoreceptor domain name, called MA or methyl-accepting chemotaxis receptor protein (MCP) transmission, which typically interacts with the transmission transduction proteins CheW and CheA. (azadright.com)
As proteinCprotein connections (PPIs) imply useful cable connections that may impact neurofibromin activity, determining protein with which neurofibromin interacts increase our knowledge of NF1. (abic2004.org)

Mathematical modeling of signal transduction networks has previously been used to map out thermodynamical using rate equations is increasingly attracting attention as a properties of protein-folding models (6,7). (lu.se)

They have 12 TM domains and intracellular termini, with multiple putative glycosylation sites. (guidetopharmacology.org)

Purification and characterization of two protein kinases acting on the aquaporin SoPIP2;1. (lu.se)

This manuscript reports the fundamental finding that an oligomeric protein kinase, CaMKII, can be phosphorylated by another molecule of the holoenzyme in a manner that does not involve subunit exchange. (elifesciences.org)

Yet, emerging evidence suggest that, much like proteasome inhibitors, specific compounds targeting OGT elicit selective anti-proliferative effects in cancer cells, and can prime malignant cells to other treatments. (qub.ac.uk)

When rat pups were treated with intraperitoneal administration of the extract of C. maritima , the generation of free radicals as well as the messenger ribonucleic acid and protein expression of inducible nitric oxide synthase were maintained at near normal levels. (molvis.org)
Image analysis of the matched maps identified 7 proteins that were either over- or down-expressed: activated protein kinase c receptor (LACK), alpha tubulin (×2), prostaglandin f2-alpha synthase, protein disulfide isomerase, vesicular transport protein and a hypothetical protein. (who.int)

Five cryogenic X-ray structures were solved of the monomeric protease with allosteric inhibitors bound to the dimer interface site. (rcsb.org)
This study tested this hypothesis by determining the effect of the PCAIs on the levels of RAS and related monomeric G-proteins. (oncotarget.com)
These findings implicate the potential role of PCAIs as anticancer agents through their direct interaction with monomeric G-proteins. (oncotarget.com)
Small G-proteins, monomeric GTPases, or the RAS (Rat sarcoma) superfamily are a large family of small guanine nucleotide-binding proteins with molecular weights ranging from 20 to 30 kDa [ 1 , 2 ]. (oncotarget.com)

Homologues of PIAS proteins have been found in other eukaryotes, including Zimp/dPIAS in Drosophila melanogaster and zfPIAS4a in zebrafish. (wikipedia.org)
Genes predicting interactions with host cellular mechanismsinclude homologues of the inhibitor of apoptosis protein, stress responseprotein phosphatase 2C, extracellular matrixin metalloproteases,ubiquitin, calcium binding EF-hand protein, glycosyltransferase, and atriacylglyceride lipase. (embl-heidelberg.de)

The three-dimensional protein structures of PIAS2, PIAS3, and PIAS-like protein SIZ1 were recently solved using X-ray crystallography. (wikipedia.org)
The most common strong alternative and complement to experimental methods to methods to obtain protein structures are X-ray crystallography obtain insight in biochemical processes. (lu.se)

Discrete enzymes in this pathway include two reductase enzymes: 3-oxoacyl-acyl carrier protein (ACP) reductase (FabG) and enoyl-ACP reductase (FabI). (rcsb.org)

It is hypothesized that PCAIs work as anticancer agents by disrupting polyisoprenylation-dependent functional interactions of the G-Proteins. (oncotarget.com)

Protein kinase A (PKA or cAMP-dependent protein kinase) is a serine/threonine kinase that plays essential roles in the regulation of proliferation, differentiation, and apoptosis. (nih.gov)

Due to alternative splicing, some PIAS protein-encoding genes encode multiple protein products called isoforms. (wikipedia.org)
We also synthesize a library consisting of 70,290 guides targeting all human RefSeq coding isoforms to screen for genes which, upon activation, confer resistance to a BRAF inhibitor. (cdc.gov)

The discovery of wortmannin as the first potent PI3K inhibitor (PI3Ki) in the 1990s provided rapid identification of PI3K-dependent processes, which drove the assembly of the PI3K/protein kinase B (PKB/Akt)/target of rapamycin (mTOR) pathway. (chimia.ch)

The 90 KDa heat shock protein (Hsp90) is a highly conserved molecular chaperone crucially involved in maintaining cellular homoeostasis in organisms from most kingdoms of life with the exception of archea 1 . (nature.com)
Based on our identified miRNA-regulated molecular machinery, an inhibitor of PDK1/Akt BX-912, an anthracycline antibiotic daunorubicin, and a multi-targeted protein kinase inhibitor midostaurin were discovered as potential repositioning drugs for treating lung cancer. (cdc.gov)
Protein structures are invaluable for biochemical studies and for mechanical or molecular mechanics calculations have become the understanding of how proteins work. (lu.se)
The main aim of our research is to understand the molecular details and physiological roles of the multitude of water channel-like proteins present in plants and animals. (lu.se)

Recent evidence also suggests certain resistance mutations are catalytically inactive yet maintain the ability to drive cell growth through a putative scaffolding function of the protein. (pipelinereview.com)

These proteins are located on the plasma membrane of cells throughout the body. (guidetopharmacology.org)
Chemoreceptors can be divided into two classes based on whether they reside in the inner membrane or are soluble cytoplasmic proteins. (azadright.com)
Affinity tags can reduce merohedral twinning of membrane protein crystals. (lu.se)

ABSTRACT In order to define the protein expressional changes related to the process of meglumine antimoniate resistance in anthroponotic cutaneous leishmaniasis (CL), we performed a comparative proteomics analysis on sensitive and resistant strains of Leishmania tropica isolated from Iranian CL patients. (who.int)

To date, designed inhibitors that target the ATPase domain demonstrate potent anti-proliferative effects, but have failed clinical trials due to high levels of associated toxicity. (nature.com)

Micrococcal nucleasetreatment released these BRO proteins from the chromatin fraction,suggesting their involvement in nucleosome structures. (embl-heidelberg.de)
A Chemical Probe for Tudor Domain Protein Spindlin1 to Investigate Chromatin Function. (ox.ac.uk)

At the protein level, it is demonstrated that peanut allergen Ara h 3 also has trypsin inhibitory activity. (usda.gov)
Allostery is one of the most powerful and common ways of regulation of protein activity. (biomedcentral.com)
Tight regulation of these processes is fundamental in all kingdoms of life and allostery represents one of the most commmon and powerful means of modulating protein activity[ 1 ]. (biomedcentral.com)
HTR6 is a serotonin receptor whose activity is mediated by G proteins that stimulate adenylate cyclase. (abic2004.org)
These constructs were overexpressed in the endoderm of Xenopus embryos and protein activity was induced before or after specification of endodermal precursor cells. (uni-goettingen.de)

Receptor-like protein kinase. (or.jp)

The Popeye domain containing (POPDC) genes encode sarcolemma-localized cAMP effector proteins. (imperial.ac.uk)

PIAS proteins contain each conserved domain and motif of the PIAS protein family, with a few exceptions. (wikipedia.org)
The known functions of these domains and motifs are similar among all PIAS protein family members. (wikipedia.org)
The whey acidic protein family: a new signature motif and three-dimensional structure by comparative modeling. (nih.gov)
It is a member of the cysteine-rich secretory protein (CRISP) family and is likewise known as CRISP9. (bdbiosciences.com)
This family includes the N-terminus of baculovirus BRO and ALI motif proteins. (embl-heidelberg.de)
The baculovirus Bro proteins are encoded by a multigene family. (embl-heidelberg.de)
Hfq is a conserved bacterial member of the Sm-like family of RNA-binding proteins, coordinating a broad array of responses including multiple stress responses. (biomedcentral.com)
One member of the family is encoded by an alternatively-spliced form of Alzheimer's amyloid beta-protein. (embl.de)
Annotation of Selaginella moellendorffii major intrinsic proteins and the evolution of the protein family in terrestrial plants. (lu.se)

We generated a set of putative hormone-inducible activators or repressors of the canonical Wnt signaling pathway. (uni-goettingen.de)

Protein inhibitor of activated STAT (PIAS), also known as E3 SUMO-protein ligase PIAS, is a protein that regulates transcription in mammals. (wikipedia.org)

LC-MS/MS analyses identified 2755 and 3191 phosphopeptides from experiments with activator or inhibitor of PKA. (nih.gov)
The protein inhibits HGF activator which prevents the formation of active hepatocyte growth factor. (oftalmic.ru)
Among the established custom DNA binding domains, Cas9 is most easily scaled to facilitate genome-scale perturbations 3 , 4 due to its simplicity of programming relative to zinc finger proteins and transcription activator-like effectors (TALEs). (cdc.gov)

Attachment of a SUMO protein to the target allows for protein-protein interaction between PIAS and the transcription factor. (wikipedia.org)
The interaction of POPDC proteins was investigated by co-precipitation, proximity ligation, bioluminescence resonance energy transfer and bimolecular fluorescence complementation. (imperial.ac.uk)
Site-directed mutagenesis was utilised to map the domains involved in protein-protein interaction. (imperial.ac.uk)
Hsp90's diverse array of clientele implicate the chaperone in several associated biological functions and place it at the intersection of various fundamental cellular pathways, where it acts as a central hub in maintaining numerous protein interaction networks 1 . (nature.com)
The methods have been applied in the design of focused screening libraries for regular secondary structure conformations, notably the α-helix, and targeting specific bioactive conformations for individual protein-protein interaction targets. (nquix.com)

The three-dimensional protein structures of PIAS2, PIAS3, and SIZ1 have only recently been solved. (wikipedia.org)
They are short (~50 residue) alpha/beta proteins with few secondary structures. (embl.de)

Our preliminary study using 2D isolates were recovered from liq- new cases throughout the world cu- gel electrophoresis in drug sensitive/ uid nitrogen, and sub-cultured in taneous leishmaniasis (CL) remains resistant strains of L. tropica showed RPMI1640 medium (Gibco/BRL) a serious public health problem in that some proteins were differentially supplemented with 10% fetal bovine numerous countries [1,2]. (who.int)

Distinct coordinated movements captured by the allosteric inhibitors were also revealed as alternative states in room-temperature X-ray data and comparative analyses of other dimeric herpesvirus proteases. (rcsb.org)

Using the dimeric protease (Pr) from Kaposi's sarcoma-associated herpesvirus (KSHV) as a model system, we sought to dissect a putative allosteric network linking a cryptic site at the dimerization interface to enzyme function. (rcsb.org)
For metal- powerful methods to obtain and compare reaction and activation loproteins, a third method to obtain local information about the energies for suggested enzyme mechanisms and they can also provide atomic details about the protein dynamics. (lu.se)

This Pfam domain does not include the characteristic invariant alanine, leucine, isoleucine motif of the ALI proteins ( PUBMED:9847359 ). (embl-heidelberg.de)
Although their functions are unknown, their amino acidsequences contain a motif found in all known viral and prokaryoticsingle-stranded DNA binding proteins. (embl-heidelberg.de)

Anatomy14

Organisms8

Diseases1

Chemicals and Drugs79

Analytical, Diagnostic and Therapeutic Techniques and Equipment20

Phenomena and Processes38

Disciplines and Occupations1

Information Science3

Health Care1

Protease inhibitors6

Heat shock prot2

Trypsin inhibitor5

Phosphorylation3

Encodes5

Serine proteinase3

Vitro2

MRNA2

Homology2

Small molecule1

Conformation2

Ligands2

Amino acid1

Degradation1

Therapeutic3

Ligand8

Regulator3

Tyrosine1

Statins2

Peptidase2

Complex2

Differentially expressed1

Inhibition5

Mammalian4

Substrates2

Transcriptional6

Gene7

Differential1

WFDC2

Complexes2

Oncogene1

Different proteins2

Interacts3

Transduction1

Intracellular1

Characterization1

Subunit1

Selective1

Synthase2

Monomeric4

Homologues2

Crystallography2

Reductase1

Anticancer1

Apoptosis1

Isoforms2

Rapamycin1

Molecular4

Mutations1

Membrane3

Abstract1

Potent1

Chromatin2

Activity5

Receptor1

Genes encode1

Family9

Inducible1

Mammals1

Activator3

Interaction5

Structures2

Bovine1

Proteases1

Enzyme2

Motif2