Putative gene expression regulation. Medical search. Frequent questions

Gene expression dependent on RNF20 includes histones H2A and H2B and the p53 tumor suppressor. (tau.ac.il)
RNF20 may thus be a putative tumor suppressor, acting through selective regulation of a distinct subset of genes. (tau.ac.il)
William Kaelin, Jr. was in 1995 engaged in the study of the von Hippel-Lindau tumor suppressor gene, and after isolation of the first full-length clone of the gene showed that it could suppress tumor growth in VHL mutant tumorigenic cell lines. (nobelprize.org)
It is commonly known that inactivation of certain tumor-suppressor genes occurs as a consequence of hypermethylation within the promoter regions and a numerous studies have demonstrated a broad range of genes silenced by DNA methylation in different cancer types. (nih.gov)
Apart from DNA methylation alterations in promoter regions and repetitive DNA sequences, this phenomenon is associated also with regulation of expression of noncoding RNAs such as microRNAs that may play role in tumor suppression. (nih.gov)
Additionally, EZH2 occupies promoter regions of putative tumor suppressor as well as oncogenic miRNAs and influences Argonaute Protein 2 expression. (tum.de)
EZH2 bindet zudem an Promotorregionen putativer Tumor-supprimierender als auch onkogener microRNAs und beeinflusst die Expression des Argonaute Proteins 2. (tum.de)
Moreover, PanDrugs2 now considers cancer genetic dependencies to extend tumor vulnerabilities providing therapeutic options for untargetable genes. (bsc.es)

FSS also caused a time-dependent increase in the expression of miR-124a, a microRNA known to reduce GR mRNA expression, which was inversely correlated with a reduction in GR mRNA levels 30 min after FSS. (karger.com)
Acute stress results in decreased GR mRNA expression specifically in the dentate gyrus. (karger.com)
Against this background, we develop a Monte Carlo time-series stochastic model of transcription where the parameters governing promoter status, mRNA production and mRNA decay in multipotent cells are fitted to experimental static gene expression distributions. (lu.se)
The model suggests distinct dependencies of different commitment-associated genes on mRNA dynamics and promoter activity, which globally influence the probability of lineage commitment. (lu.se)
Total RNA was isolated on P16, and the relative abundance of mRNA of the crystallin structural genes, redox components, and apoptotic cascade were ascertained with real-time PCR with reference to the internal control β-actin . (molvis.org)
C-PC treatment possibly prevented cataractogenesis triggered by sodium selenite, by regulating the lens crystallin, redox genes, and apoptotic cascade mRNA expression and thus maintains lens transparency. (molvis.org)
The prophylactic efficacies of the drugs were compared by carrying out biochemical estimations (ROS, MDA, GSH and transvascular leakage), western blotting analysis, mRNA expression studies, ELISA and by determining peNOS levels in the lungs of rats under hypoxia. (heraldopenaccess.us)
These genes, encoding for RNA binding proteins, contain a highly conserved RNA recognition motif and at least one DAZ repeat encoding for a 24 amino acids sequence able to bind other mRNA binding proteins. (ijbs.com)
The potential anti-neuroinflammatory effects of propranolol were interrogated by analysis of cytokine mRNA expression. (cdc.gov)
Propranolol treatment abrogated the elaboration of inflammatory cytokine mRNA expression in the brain instigated in our model, having no treatment effects in non-DFP exposed groups. (cdc.gov)

Transcriptional regulation of the human ferritin gene by coordinated regulation of Nrf2 and protein arginine methyltransferases PRMT1 and PRMT4. (embl.de)
PRMT6 is a protein arginine methyltransferase that has been implicated in transcriptional regulation, DNA repair, and human immunodeficiency virus pathogenesis. (embl.de)
Chromatin target of Prmt1 (Chtop) is a vertebrate-specific chromatin-bound protein that plays an important role in transcriptional regulation. (embl.de)
The transcriptome of the Pf asexual intraerythrocytic developmental cycle (IDC) has been analysed and transcriptional regulation has been shown to orchestrate a continuous cascade of gene expression, with genes being induced once per cycle, in a "just-in-time" manner, only when the gene product is required by the cell [ 3 ]. (biomedcentral.com)
Regulation of the NANOG gene by TFs, epigenetic factors, and autoregulatory factors is well characterized in ESCs, and transcriptional regulation of NANOG is well established in these cells. (biomedcentral.com)
Although NANOG plays a key role in germ cells, the molecular mechanism underlying its transcriptional regulation in PGCs has not been studied. (biomedcentral.com)
Therefore, identification of regulatory elements within the promoter region is considered crucial to understand the mechanism underlying transcriptional regulation in specific cell types. (biomedcentral.com)
She collaborated with the Leishmania Genome Project initiative and subsequently focused on studying post-transcriptional regulation of gene expression in Leishmania. (usp.br)
The repression and activation of transcriptional regulation require a complex interplay of protein-DNA and protein-protein interactions. (yu.edu)
Transcriptional regulation of aquaporins in accessions of Arabidopsis in response to drought stress. (lu.se)

identify putative SSRs in the genome of E. coli . (biomedcentral.com)
The study seeks to identify putative regulatory motifs in the upstream regions of 13 functional groups of genes expressed in the intraerythrocytic developmental cycle of Pf . (biomedcentral.com)
Micro- array data from the ovalbumin and TMA model of asthma were also compared to previous data using Aspergillus as allergen to identify putative asthma `signature genes', i.e. genes up-regulated with all 3 allergens. (cdc.gov)

In this review, we assess the potential role of putative gut microbiota products in the etiopathogeny of Parkinson's disease, with a special emphasis on functional bacterial amyloid proteins, bacterial biosurfactants, endotoxins and short-chain fatty acids. (techscience.com)
We have made the surprising observation that an Arabidopsis line (pdko3) mutated in genes encoding plasmodesmal proteins is defective in some, but not all, of the typical plant responses to herbivory. (jic.ac.uk)
The mutations in genes for plasmodesmal proteins have provided valuable genetic tools for the dissection of the complex spectrum of responses to herbivory and shown us that the responses to herbivory can be separated into a calcium-activated oxidative response and a K(+) -dependent Vm-activated jasmonate response associated with the release of VOCs. (jic.ac.uk)
Many molecules have been reported to associate with desmin, such as other IF proteins (including members of the membrane dystroglycan complex), nebulin, the actin and tubulin binding protein plectin, the molecular motor dynein, the gene regulatory protein MyoD, DNA, the chaperone alphaB-crystallin, and proteases such as calpain and caspase. (biologicalworld.com)
The encoded protein is involved in regulation of vascular smooth muscle cells (VSMC) contractile proteins. (nih.gov)
We have shown that ATR-X results from diverse mutations of XH2, a member of a subgroup of the helicase superfamily that includes proteins involved in a wide range of cellular functions, including DNA recombination and repair (RAD16, RAD54, and ERCC6) and regulation of transcription (SW12/SNF2, MOT1, and brahma). (ox.ac.uk)
ii) Protein Arginine Methyl Transferases and their targets, RNA binding proteins, to understand their effect on gene expression and pathogenesis. (usp.br)
The aim of this thesis is to quantitatively and structurally describe the interactions that occur between DNA-bound proteins that regulate transcription, the DNA distortions brought about by them, and the putative role of DNA conformation on the regulation of transcriptional initiation. (yu.edu)
The Escherichia coli gal operon was chosen for this study since regulation of this operon is conferred by a small, but well characterized number of proteins, namely, GalR and the cAMP receptor protein (CAP). (yu.edu)
Dazl can regulate the expression, transport and localization of target mRNAs of proteins which control the differentiation, growth and maturation of germ cells. (ijbs.com)
The SALL1 gene is part of a group of related genes that provide instructions for making proteins involved in the formation of tissues and organs before birth. (medlineplus.gov)
These proteins are transcription factors, which means they attach (bind) to specific regions of DNA and help control the activity of particular genes. (medlineplus.gov)
The SALL1 protein helps turn off (repress) gene activity by interacting with other proteins that alter how tightly regions of DNA are packaged. (medlineplus.gov)
This interference prevents the normal proteins from entering the nucleus to regulate gene activity. (medlineplus.gov)
Programmable DNA binding proteins have emerged as an exciting platform for engineering synthetic transcription factors for modulating endogenous gene expression 5 - 11 . (cdc.gov)
RafK carries a C-terminal regulatory domain present in a subset of ATP-binding proteins that has been involved in both direct regulation of transporter activity (inducer exclusion) and transcription of transporter genes. (lu.se)

While H2B ubiquitylation is broadly associated with transcribed genes, only a subset of genes was transcriptionally affected by RNF20 depletion and abrogation of H2B ubiquitylation. (tau.ac.il)
Antioxidant genes such as ferritin are transcriptionally activated in oxidative stress via the antioxidant responsive element (ARE), to which nuclear factor-E2-related factor 2 (Nrf2) binds and activates transcription. (embl.de)
In particular, the importance of a cAMP-dependent pathway, which down-regulates binding of a putative transcriptionally repressive protein factor from a negative regulatory element in the promoter region of the CD25 gene, is highlighted. (gla.ac.uk)
Treatment with 200 mg/kg bodyweight C-PC (Group III) transcriptionally regulated the instability of the expression of these genes, thus ensuring C-PC is a prospective anticataractogenic agent that probably delays the onset and progression of cataractogenesis induced by sodium selenite. (molvis.org)

CAMTAs participate in gene expression regulation by binding to the cis -elements in the promoter regions of numerous target genes. (frontiersin.org)
The analysis of both authentic Dorsal target genes and defined synthetic promoters suggests that the ectopic gradient is sufficient to generate the full repertory of DV patterning responses along the AP axis of the embryo. (sdbonline.org)

Unlike the cip-cel operon, these genes are transcribed as monocistronic units of transcription, except cel5D. (nottingham.ac.uk)
Similarly to the cip-cel operon, cel5A and cel5I expressions are regulated by a carbon catabolite repression mechanism, whereas cel44O and cel5D expressions do not seem to be submitted to this regulation. (nottingham.ac.uk)
Pneumococci lacking RafK showed a 50- to 80-fold reduction in expression of the raf operon genes aga (alpha-galactosidase) and rafEFG (raffinose substrate binding and permease genes), and both glucose and sucrose inhibited raffinose uptake through inducer exclusion. (lu.se)
Like RafK, the presence of DLDH also activated the expression of raf operon genes, as DLDH-negative pneumococci showed a significantly decreased expression of aga and rafEFG, but DLDH did not regulate rafK or the putative regulatory genes rafR and rafS. (lu.se)

However, literature has also elaborated on the putative roles of hypoxia-induced oxidative stress in causing vasoconstriction which finally ends-up to the fluid build-up in the lungs [4]. (heraldopenaccess.us)

With 176 samples profiled for genotype, gene expression, and open chromatin, we used regression modeling to infer genetic-epigenetic interactions on a genome-wide scale. (elifesciences.org)
Local regulatory mechanisms within the genome and their interaction with chromatin structure give rise to subtle variations in gene expression. (elifesciences.org)
Yet the interacting effects that genetic and epigenetic factors produce on gene transcription are rarely studied at a genome-wide scale, leaving us without global information on a key step between the genetic code and the phenotype. (elifesciences.org)
Understanding the scope and landscape of these interactions on a genome-wide scale is a vital step towards deciphering the genetic regulation of gene expression and, in turn, the mechanisms of non-coding variation on phenotypic outcomes. (elifesciences.org)
Physical distance along a linear genome is a common metric for determining whether a putative regulatory element will affect a given gene's transcription. (elifesciences.org)
A and T appear more often in these repeats than G and C. The putative SSRs were not randomly distributed in the genome. (biomedcentral.com)
In this study, we first identified all the CAMTA homologous genes in the whole genome of maize. (frontiersin.org)
In eukaryotes, many lncRNAs have been identified and shown to be pivotal regulators of genome structure and gene expression. (biorxiv.org)
ChIRP-seq of candidate lncRNAs revealed that lncRNA occupancy sites within the parasite genome are focal and sequence-specific with a particular enrichment for several parasite-specific gene families, including those involved in pathogenesis, erythrocyte remodeling, and regulation of sexual differentiation. (biorxiv.org)
Achieving systematic, genome-scale perturbations within intact biological systems is important for elucidating gene function and epigenetic regulation. (cdc.gov)

The recombinant protein GlyR2 was produced and was shown to bind in vitro to the cel5D and glyR2 promoter regions, suggesting that besides regulating its own expression, GlyR2 may regulate cel5D expression. (nottingham.ac.uk)
Furthermore, 15/15 candidate TFs might regulate at least three key genes and contribute to carotenoids/flavonoids accumulation in CNO fruit. (researchsquare.com)
Additionally, chelation of intracellular calcium and down-regulation of PKC, by chronic phorbol ester treatment, attenuates the ability of IL-4 to up-regulate CD25. (gla.ac.uk)

Differentially expressed genes (DEGs) were seared by combing the TCGA database and the Gene Expression Omnibus (GEO) database, and the key molecule AKR1B10 was identified by weighted gene coexpression network analysis (WGCNA). (portlandpress.com)
To increase our understanding of these differentially expressed unigenes, we performed Gene ontology and KEGG pathway enrichment analyses. (biomedcentral.com)

They postulate that the SSRs they find close to genes are good candidates for such regulators. (biomedcentral.com)
Direct regulators of nuclear-encoded mitochondrial genes are members of the estrogen-related receptor (ERR) family, encoded by Esrra , Esrrb and Esrrg . (nature.com)
While over half the genes are estimated to be regulated at the transcriptional level, few regulatory motifs and transcription regulators have been found. (biomedcentral.com)
We define putative regulators of commitment and probabilistic rules of transition through machine learning methods, and employ clustering and correlation analyses to interrogate gene regulatory interactions in multipotent cells. (lu.se)

We explored the roles of histone H2B ubiquitylation in human cells by reducing the expression of hBREl/RNF20, the major H2B-specific E3 ubiquitin ligase. (tau.ac.il)
2019). Regulation of photoprotection gene expression in Chlamydomonas by a putative E3 ubiquitin ligase complex and a homolog of CONSTANS. (agrisera.com)

We demonstrate that deletion of ERRγ from DAergic neurons in adult mice was sufficient to cause a levodopa-responsive PD-like phenotype with reductions in mitochondrial gene expression and number, that partial deficiency of ERRγ hastens synuclein-mediated toxicity, and that ERRγ overexpression reduces inclusion load and delays synuclein-mediated cell loss. (nature.com)
EZH2 inhibits neuronal and endothelial differentiation and promotes expression of stem cell markers, thus maintaining the undifferentiated and highly malignant ET phenotype via epigenetic gene regulation. (tum.de)
Low AKR1B10 expression induced M2 macrophage polarization and promoted the malignant phenotype of GC. (portlandpress.com)
The complex ATR-X phenotype suggests that XH2, when mutated, down-regulates expression of several genes, including the alpha-globin genes, indicating that it could be a global transcriptional regulator. (ox.ac.uk)

The transcripts of five carotenogenesis genes were highly correlated with lycopene contents, and 16, 40, 48, 24 and 18 transcription factors (TFs) were predicted to potentially bind their promoters, respectively. (researchsquare.com)
14 ). It is important to identify the transcription factors involved in regulation of these genes to reveal potential avenues for modulating transcriptional programs that could be dysfunctional in PD. (nature.com)
TFBMs act as binding sites for transcription factors and coordinate the expression of the genes in whose promoter regions they appear. (biomedcentral.com)
Gene transcription is mainly regulated by transcription factors (TFs) that bind to specific DNA sequences (called motifs) located in the promoter regions of genes [ 1 ]. (biomedcentral.com)
Gene network analysis indicated an overall increase in lipid metabolism by WY and all LCFA with a central role of PPAR-α but also additional putative transcription factors. (oregonstate.edu)

DNA methylation seems to be promising in putative translational use in patients and hypermethylated promoters may serve as biomarkers. (nih.gov)
Many studies have investigated germ cell-specific gene promoters to understand their regulatory mechanisms. (biomedcentral.com)
High concentrations of fermentable carbon sources repress gene expression from galactose promoters (GAL) via a carbon catabolite repression mechanism [ 7 ], and galactose utilisation genes are not activated during growth on sucrose [ 8 ]. (biomedcentral.com)
This means that cheap, fermentable sugars such as glucose or sucrose cannot be used during a production phase when the GAL promoters are used to achieve dynamic regulation. (biomedcentral.com)

Previous analyses of dopaminergic (DAergic) neurons from patients with Lewy-body pathology revealed a deficiency in nuclear-encoded genes for mitochondrial respiration, many of which are targets for the transcription factor estrogen-related receptor gamma ( Esrrg /ERRγ). (nature.com)
While ERRγ deletion did not fully recapitulate the transcriptional alterations observed in postmortem tissue, it caused reductions in genes involved in synaptic and mitochondrial function and autophagy. (nature.com)
Further evidence suggests that during PD progression, transcriptional programs for the expression of genes involved in mitochondrial structure and function are disrupted 11 . (nature.com)
Laser-captured microdissected (LCM) DAergic neurons from postmortem tissue of patients with Lewy-pathology revealed a deficiency in expression for nuclear-encoded genes involved in mitochondrial respiration and function 12 . (nature.com)
in fact, these genes are targets of the transcriptional coactivator and master regulator of transcription of mitochondrial genes peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α) 12 . (nature.com)

There are five distinct thresholds of gene activity in response to the Dorsal nuclear gradient in early embryos. (sdbonline.org)
Here we discuss DAZ family genes in a phylogenic perspective, focusing on the common and distinct features of these genes, and their pivotal roles during gametogenesis evolved during evolution. (ijbs.com)

Although the current generation of dCas9-based transcription activators is able to achieve up-regulation of some endogenous loci, the magnitude of transcriptional up-regulation achieved by individual single-guide RNAs (sgRNAs) 12 typically ranges from low to ineffective 8 - 11 . (cdc.gov)

This important work substantially advances our understanding of the interplay between genetic variation, chromatin, and genes within topologically associated domains and how this interplay regulates gene expression. (elifesciences.org)
Therefore, we investigated the mechanism that regulates transcription of the chicken NANOG ( cNANOG) gene in PGCs and ESCs. (biomedcentral.com)
This finding might help to elucidate the mechanism that regulates cNANOG expression in PGCs and ESCs. (biomedcentral.com)
Direct binding of ZFP143 to the proximal region of the NANOG promoter regulates NANOG expression by modulating OCT4 binding [ 24 ]. (biomedcentral.com)
We conclude that RpoH itself regulates clpQ + Y + gene expression. (openmicrobiologyjournal.com)

We proposed that hypoxic preconditioning could increase survival of bone marrow mesenchymal stem cells (MSCs) via upregulation of Pim-1 and aimed to determine the microRNAs that modulate the expression of Pim-1. (biomedcentral.com)
Methods A next-generation sequencing (NGS) panel was created for the human TRPV1 gene and in addition, for the leukotriene receptors BLT1 and BLT2 recently described to modulate TRPV1 mediated sensitisation processes rendering the coding genes LTB4R and LTB4R2 important co-players in pharmacogenetic approaches involving TRPV1. (researchgate.net)
These dCas9-activator fusions targeted to the promoter region of endogenous genes can then modulate gene expression 7 - 11 . (cdc.gov)

Here, we introduce PanDrugs2, a major upgrade of PanDrugs that, in addition to somatic variant analysis, supports a new integrated multi-omics analysis which simultaneously combines somatic and germline variants, copy number variation and gene expression data. (bsc.es)
A Large-Scale Analysis of Genetic Variants within Putative miRNA Binding Sites in Prostate Cancer. (ox.ac.uk)
We hypothesized that a comprehensive analysis of genetic variations found within the 3' untranslated region of genes predicted to affect miRNA binding (miRSNP) can identify additional prostate cancer risk variants. (ox.ac.uk)

The regulation of gene expression is pivotal for cellular survival. (yu.edu)

E3 ubiquitin-protein ligase BRE1A is an enzyme that in humans is encoded by the RNF20 gene. (wikipedia.org)
Furthermore, nucleotide sequences related to the cluster vanHAX are present in this DNA, suggesting that the prolonged use of avoparcin in agriculture led to the uptake of glycopeptide resistance genes by animal commensal bacteria, which were subsequently transferred to humans. (cdc.gov)
A cluster and humans coming into contact with the animals (farm that includes three genes, vanH , vanA , and vanX , is required for high-level resistance to glycopeptides. (cdc.gov)
Deletion of DAZ gene is the most common causes of infertility in humans. (ijbs.com)
DAZ (Deleted in Azoospermia) family genes are important fertility factors in many animals including humans. (ijbs.com)

Furthermore, the expression pattern of ZmCAMTA genes under RBSDV infection was analyzed to investigate their potential roles in responses of different maize cultivated varieties to RBSDV. (frontiersin.org)
The roles of immunomodulatory elements such as microRNAs, which alter gene expression, and regulatory T cells (Tregs), which suppress T cell-mediated responses, in TDI sensitization are unknown. (cdc.gov)

Studies are generally limited to examination of individual regions or overlapping single-nucleotide polymorphisms (SNPs) and open chromatin peaks with limited investigation into how these regulatory elements combine to affect gene transcription 1 , 2 . (elifesciences.org)
The identification of positionally conserved over-represented upstream motifs throws light on putative regulatory elements for transcription in Pf . (biomedcentral.com)
cNANOG expression required transcriptional regulatory elements, which were positively regulated by POU5F3 ( OCT4) and SOX2 and negatively regulated by TP53 in PGCs. (biomedcentral.com)
We then surveyed the distribution of stress-related cis -regulatory elements in the −1.5 kb promoter regions of ZmCAMTA genes. (frontiersin.org)

Three motif-discovery programs were used for the purpose, and motifs were searched for only on the gene coding strand. (biomedcentral.com)

The ET-specific fusion protein EWS/FLI1 induces the expression of the histone methyltransferase EZH2 (enhancer of zeste, Drosophila, homolog 2). (tum.de)
Das ET-spezifische EWS/FLI1 Fusionsprotein induziert die Expression der Histon-Methyltransferase EZH2 (enhancer of zeste, Drosophila, homolog 2). (tum.de)

Database of human genes associated with cellular senescence. (senescence.info)
The NGS workflow was based on a custom AmpliSeq™ panel and designed for sequencing of human genes on an Ion PGM™ Sequencer. (researchgate.net)

Resistance arises by mutation (influencing the target or efflux of the antimicrobial agent) or by the acquisition of resistance genes (encoding antimicrobial or target alteration, or alternate pathways) ( 2 , 3 ). (cdc.gov)
The actual origins of acquired resistance genes are unknown, but environmental microbes, including the strains producing antimicrobial agents, are believed to be important sources ( 4 , 5 ). (cdc.gov)
Substantial genetic and biochemical similarities exist between resistance determinants in antimicrobial agent-producing actinomycetes and resistance genes found in gram-positive and gram-negative pathogens ( 6 - 9 ). (cdc.gov)
Expected and potentially novel resistance genes are enriched in the top hits and are validated using individual sgRNA as well as cDNA overexpression. (cdc.gov)

similarly, it is thought to be likely that genes with similar functions are regulated by the same mechanism. (biomedcentral.com)
It has been suggested that SETDB1 protects ERVs from TET-dependent DNA demethylation, but the relevance of this mechanism for ERV expression remains unclear. (biomedcentral.com)

Although the genes that encode carotenogenesis and flavonoids enzymes are well characterized, the transcriptional regulatory mechanisms that are related to the pathway genes remain to be investigated. (researchsquare.com)
Finally, a hierarchical model for the regulatory network among the pathway genes and TFs was proposed. (researchsquare.com)
In higher plants, the isomeric C5 isopentenyl pyrophosphate (IPP) is synthesized in 2-C-methyl-D-erythritol-4-phosphate (MEP) pathway, and is used as the precursor of geranylgeranyl diphosphate (GGPP) by GGPP synthase gene, GGPPS. (researchsquare.com)
In contrast, unlike WT plants, the mutant line showed an almost complete loss of voltage gated K(+) channel activity and Vm depolarization, a loss of shoot-induced root-Vm depolarization, a loss of activation and regulation of gene expression of the JA defense pathway, and a much diminished release and altered profile of VOCs. (jic.ac.uk)
The ICE1-CBF-COR transcriptional cascade (inducer of CBF expression 1 and C-repeat binding factor transcriptional cascade) is the best characterized pathway for gene regulation under cold conditions in many species [ 8 ]. (biomedcentral.com)

Over the past few years, substantial progress has been made in the elucidation of the complex expression patterns and clinically relevant phenotypes of intermediate filaments. (biologicalworld.com)

Quantitative real-time PCR was used to test the expression of ZmCAMTA genes under several abiotic stresses (drought, salt, and cold), various stress-related hormones [abscisic acid, auxin, salicylic acid (SA), and jasmonic acid] and biotic stress [rice black-streaked dwarf virus (RBSDV) infection]. (frontiersin.org)
The expression of Pim-1 in MSCs was enhanced in a time-dependent manner, detected by quantitative PCR and western blot. (biomedcentral.com)

Immunoflourescence images of expression of Nrf2 and HO-1 showing thealteration of key protein markers of antioxidant gene expression, read more in 'Melatonin targets ferroptosis through bimodal alteration of redox environment and cellular pathways in NAFLD model' from Saha et al, in this edition of Bioscience Reports. (portlandpress.com)
Alterations in expression of putative miR-210 transcription factor targets were observed in the dLN during TDI sensitization. (cdc.gov)
Among fifteen known PPAR-α targets in non-ruminants, ten had greater expression with WY, suggesting that they are bovine PPAR-α targets. (oregonstate.edu)
The expression of SPP1 and LPIN3 was increased by WY, with no evidence of a similar effect in the published literature, suggesting that both represent bovine-specific PPAR-α targets. (oregonstate.edu)
We observed the strongest effect on the expression of PPAR-α targets with 16 : 0, 18 : 0 and 20 : 5n-3.When considering the overall effect on expression of the thirty selected genes 20 : 5n-3, 16 : 0 and 18 : 0 had the greatest effect followed by 20 : 0 and c9t11-18 : 2. (oregonstate.edu)
They also affected the expression of non-PPAR-α targets, eliciting an overall increase in the expression of genes related to lipid metabolism, signalling and inflammatory response. (oregonstate.edu)
Previously published work on DNA methylation status in GWI was reanalyzed focusing specifically on the predicted shared targets indicating significant changes in DNA methylation of the associated genes. (cdc.gov)

The PE enhancer from the twist promoter region exhibits a similar pattern of expression. (sdbonline.org)

It seemed possible therefore, that the ability of IL-4 to promote increases in intracellular calcium, protein kinase C activation and cAMP generation might have a role in IL-4-induced CD25 expression. (gla.ac.uk)
The versatile regulation of intracellular redox components is the primary factor in lens homeostasis. (molvis.org)

Arsenic exposure of human HaCaT keratinocytes induced nuclear accumulation of PRMT1 and PRMT4, histone H4R3 and H3R17 methylation proximal to the ARE, but not to the non-ARE regions of ferritin genes. (embl.de)
Recent biochemical work suggests that SSRs might have a role in the regulation of gene expression, histone binding or DNA replication. (biomedcentral.com)
The authors hypothesize that, as has been found in other organisms, SSRs in E. coli might have a role in the rapid mutation of the regulation of gene expression or histone binding. (biomedcentral.com)

The aim of this study was to test for the molecular and functional expression of the non-gastric H + /K + ATPase ATP12A/ATP1AL1 in unstimulated and butyrate-stimulated (1 and 10 mM) human myelomonocytic HL-60 cells, to unravel its potential role as putative apoptosis-counteracting ion transporter as well as to test for the effect of the H + /K + ATPase inhibitor SCH28080 in apoptosis. (karger.com)
Although glucocorticoid receptors (GRs) in the hippocampus play a vital role in the regulation of physiological and behavioural responses to stress, the regulation of receptor expression remains unclear. (karger.com)
The role of the putative transcriptional regulator GlyR2 in the regulation of cel5D expression was investigated. (nottingham.ac.uk)
however, its role in antioxidant gene transcription remains elusive. (embl.de)
In addition, using invitro methylation assay we identified 4 new substrates for PRMT6, extending the involvement of this enzyme to other cellular processes beyond its well-established role in gene expression regulation. (embl.de)
Therefore, regulation of NANOG expression plays a critical role in determining the fate of pluripotent cells. (biomedcentral.com)
Increasing evidence now suggests a major role for epigenetic mechanisms in gene expression in the parasite. (biorxiv.org)
Further, using miRNA mimics and reporter gene assays, we showed that miR-3162-5p has specific affinity for the KLK3 rs1058205 miRSNP T-allele, whereas miR-370 has greater affinity for the VAMP8 rs1010 miRSNP A-allele, validating their functional role. (ox.ac.uk)
We use naïve ESCs to investigate the role of SETDB1 in ERV regulation and its relationship with TET-mediated DNA demethylation. (biomedcentral.com)
By controlling gene activity, the SALL1 protein plays an important role in development of the hands (particularly the thumbs), ears, anus, kidneys, and other parts of the body before birth. (medlineplus.gov)

These are accompanied by major changes in gene regulation and the molecular evolution of caste determination. (nature.com)
Desmin: molecular interactions and putative functions of the muscle intermediate filament protein. (biologicalworld.com)
There are a limited number of molecular tools available for implementing dynamic regulation in yeast, with most being inadequate for industrial application. (biomedcentral.com)
Examples of high molecular environmental factors are known to influence the development weight occupational allergens include proteases used in the and expression of asthma, and a vast array of triggers of asthma detergent industry, laboratory animal allergens, and ovalbumin have been identified. (cdc.gov)

Finally, we added data produced using the 10X genomics system for 7,000 postmitotic progenitors with significantly increased sequencing depth (1,500-11,000 UMI/cell, 1,000-4,000 genes/cell), and observed identical branching patterns as in our original Drop-seq dataset. (authorea.com)

Using sucrose as an activator of gene expression circumvents the need for expensive inducer compounds and enables gene expression to be triggered during growth on a fermentable, high energy-yield carbon source. (biomedcentral.com)
For example, the commonly used galactose induction system [ 4 ] has a noise level (expression in the absence of inducer) which is unacceptable for some applications such as controlling RNA interference [ 5 ]. (biomedcentral.com)
Previous efforts to implement dynamic regulation under industrially relevant conditions required the knockout of galactose utilization genes so that a small amount of galactose can be added to fermentations as a gratuitous inducer for gene expression [ 6 ]. (biomedcentral.com)

This was related to an increased DNMT3a protein association with a discreet region of the Nr3c1 (GR gene) promoter, shown here to undergo increased DNA methylation after FSS. (karger.com)
However, this resulted in only very subtle DNA methylation changes, and it remains unknown whether these alterations affect the expression of IAP elements and other ERVs. (biomedcentral.com)

This gene encodes one of the three members of the human AKT serine-threonine protein kinase family which are often referred to as protein kinase B alpha, beta, and gamma. (senescence.info)
The vanH gene encodes a D‑lactate dehydrogenase that provides the requisite D‑lactate. (cdc.gov)
The third gene, vanA , encodes an ATP-dependent D-Ala-D-Lac ligase. (cdc.gov)

In stem cells, open chromatin participating in the most significant regression models demonstrated an enrichment for developmental genes and the TAD-forming CTCF binding complex, providing an opportunity for statistical inference of shifting TAD boundaries operating during early development. (elifesciences.org)

Subsequent phosphorylation of both threonine residue 308 and serine residue 473 is required for full activation of the AKT1 protein encoded by this gene. (senescence.info)
The protein encoded by this gene shares similarity with BRE1 of S. cerevisiae. (wikipedia.org)
The protein encoded by this gene is a transcriptional repressor and a member of the PRDM family. (nih.gov)

As a result of her postdoctoral training with Stephen M. Beverley at Harvard Medical School (1989-92) investigating the genetics of the protozoan Leishmania, gene knockout was established and made possible in Leishmania. (usp.br)
Both genetics and environmental factors influence the expression of asthma, and not all asthma is the result of a specific immune response to allergen. (cdc.gov)

In contrast, RNF20 suppresses the expression of several proto-oncogenes, which reside preferentially in closed chromatin and are modestly transcribed despite bearing marks usually associated with high transcription rates. (tau.ac.il)

Through the combined work of these three laureates it was thus demonstrated that the response by gene expression to changes in oxygen is directly coupled to oxygen levels in the animal cell, allowing immediate cellular responses to occur to oxygenation through the action of the HIF transcription factor. (nobelprize.org)
Our results suggest that cold temperature significantly affects genes related to protein translation and cellular metabolism in this chilling sensitive species. (biomedcentral.com)
In physiological systems, active ROS levels, which can be produced in healthy smooth muscles, endothelial and adventitious cells in the systemic and pulmonary vasculatures are responsible for routine regulation of cellular and physiologic responses [7]. (heraldopenaccess.us)

[ 7 ] Similarly, in 2001, Priolo and Laganà reclassified the ectodermal dysplasias into 2 main functional groups: (1) defects in developmental regulation/epithelial-mesenchymal interaction and (2) defects in cytoskeleton maintenance and cell stability. (medscape.com)

Gene expression is known to be affected by interactions between local genetic variation and DNA accessibility, with the latter organized into three-dimensional chromatin structures. (elifesciences.org)
We found that these interactions occur within the local area of the affected gene, and that this locality corresponds to topologically associated domains (TADs). (elifesciences.org)
This review focuses on the biochemical interactions of desmin, with a discussion of its putative functions. (biologicalworld.com)
Fine metabolic regulation in ruminants via nutrient-gene interactions: saturated long-chain fatty acids increase expression of genes involved in lipid metabolism and immune response partly through PPAR-α activation. (oregonstate.edu)

Mutations in a putative global transcriptional regulator cause X-linked mental retardation with alpha-thalassemia (ATR-X syndrome). (ox.ac.uk)

Different statistical methods with varying selection criteria resulted in identification of similar candidate genes. (cdc.gov)

[ 8 ] Other classification systems categorize the ectodermal dysplasias based on defects in cell-cell communication and signaling, adhesion, transcription regulation, or development. (medscape.com)

This thesis describes the regulation of CD25 gene expression by interleukin-4-activated signal transduction pathways in quiescent human B lymphocytes. (gla.ac.uk)
The initial aim of this work was to identify signalling pathways which were responsible for up-regulation of CD25 expression, by artificially activating specific second messenger systems. (gla.ac.uk)
Two of these genes, arginase 1 and eotaxin 1 are the focus of continuing investigations in mouse models of asthma regarding differences in mechanistic pathways depending on the allergen. (cdc.gov)
Array studies provide candidate genes to identify common mechanistic pathways in the effector phase, as well as mechanistic pathways unique to individual allergens. (cdc.gov)

Regulation of gene expression in Plasmodium falciparum (Pf) remains poorly understood. (biomedcentral.com)
The complex life cycle of Plasmodium falciparum requires coordinated gene expression regulation to allow host cell invasion, transmission, and immune evasion. (biorxiv.org)

argue that the SSRs they find near gene sequences are biologically important, but this needs to be confirmed by mutational analysis in vitro . (biomedcentral.com)
A cohort of 80 healthy subjects of Western European descent was screened to evaluate and validate the detection of exomic sequences of the coding genes with 25 base pair exon padding. (researchgate.net)
However, it is difficult to capture the complexity of transcript isoform variance using these libraries, and large cDNA sequences are often difficult to clone into size-limited viral expression vectors. (cdc.gov)

Engineering dynamic, environmentally- and temporally-responsive control of gene expression is one of the principle objectives in the field of synthetic biology. (biomedcentral.com)

Furthermore, differences in expression between nymphs and adults of the cockroach were compared to differences in expression between workers and reproductives of the three termites, to gain insights into how expression patterns changed along with the evolution of castes. (nature.com)
The results showed that nine ZmCAMTA genes showed highly diversified gene structures and tissue-specific expression patterns. (frontiersin.org)

Anatomy21

Organisms20

Diseases3

Chemicals and Drugs63

Analytical, Diagnostic and Therapeutic Techniques and Equipment37

Phenomena and Processes113

Disciplines and Occupations4

Technology, Industry, Agriculture1

Information Science8

Health Care3

Tumor8

MRNA10

Transcriptional regulation10

Identify putative3

Proteins16

Transcriptionally4

Target genes2

Operon4

Oxidative stress1

Genome10

Regulate3

Differentially2

Regulators4

Ubiquitin ligase2

Phenotype4

Transcription factors5

Promoters4

Mitochondrial5

Distinct2

RNAs1

Regulates5

Modulate3

Variants3

Pivotal1

Humans5

Roles2

Regulatory elements4

Motifs1

Methyltransferase2

Human genes2

Resistance genes4

Mechanism2

Pathway5

Phenotypes1

Quantitative2

Targets7

Promoter region1

Intracellular2

Histone3

Role10

Molecular4

Genomics1

Inducer3

Methylation2

Encodes3

Enrichment1

Protein encoded3

Genetics2

RNF201

Cellular3

Developmental1

Interactions4

Regulator1

Identification1

Signaling1

Pathways4

Plasmodium2

Sequences3

Control of gene expression1

Patterns2