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  • pathways
  • However, the genes involved in the hypocrellin A anabolic pathways were still unknown due to the lack of genomic information for this species. (mdpi.com)
  • Some of the major alkaloids, including mescaline, were identified by GC-MS and relevant metabolic pathways were reconstructed using the Kyoto encyclopedia of genes and genomes database (KEGG). (biomedcentral.com)
  • Because PRKDC has been associated with many pathways with genes likely to be involved in human ageing, such as WRN [ 558 ], it is possible that PRKDC itself is involved in human ageing, though further research is necessary to investigate this hypothesis. (senescence.info)
  • Saccharomyces
  • We present a machine learning approach where the identification of putative NCR genes in the yeast Saccharomyces cerevisiae is formulated as a supervised two-class classification problem. (springer.com)
  • The LEU3 gene of the yeast Saccharomyces cerevisiae , which is involved in the regulation of at least two LEU structural genes ( LEU1 and LEU2 ), has been cloned by complementation of leu3 mutations and shown to reside within a 5.6-kb fragment. (genetics.org)
  • upstream
  • Classifiers predict whether genes are NCR-sensitive or not from a large number of variables related to the GATA motif in the upstream non-coding sequences of the genes. (springer.com)
  • Instead of simply considering the number of occurrences of motifs that are over-represented in the upstream non-coding sequences of NCR genes, we consider a wide range of properties related to the GATA motif. (springer.com)
  • promoters
  • Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. (senescence.info)
  • metabolic
  • Safflower ( Carthamus tinctorius L.), an important traditional Chinese medicine, is cultured widely for its pharmacological effects, but little is known regarding the genes related to the metabolic regulation of the safflower's yellow pigment. (mdpi.com)
  • yeast
  • Instead of randomly selecting genes in the yeast genome, we use a set composed of manually-selected genes known to be insensitive to NCR. (springer.com)
  • Strains containing a disrupted leu3 allele were constructed by deleting 0.7-kb of LEU3 DNA and inserting the yeast HIS3 gene in its place. (genetics.org)
  • homology
  • The protein encoded by this gene is highly similar to the N-acetyltransferase 8 (NAT8) gene product, which is a kidney and liver protein with homology to bacterial acetyltransferases involved in drug resistance. (mybiosource.com)
  • mutations
  • Second, we combine individual probabilities into a multiple-sample value using Fisher-Lancaster theory, thereby improving differentiation between a few highly mutated genes and many genes having only a few mutations apiece. (nih.gov)
  • Floating-point operations as a function of the number of observed mutations for a test set of m = 60 genes for exact (dashed curves) and approximate (solid curves) solutions. (nih.gov)
  • This gene contains two polymorphic nonsense mutations that disrupt the active site of the protein. (mybiosource.com)
  • Mutations in this gene are associated with susceptibility to cerebral infarction. (senescence.info)
  • candidates
  • Hence, biologists need only to test a small number of "promising" candidates, instead of testing all genes, saving time and resources. (springer.com)
  • experiments
  • Northern transfer experiments showed that the LEU3 gene produces mRNA approximately 2.9 kilonucleotides in length. (genetics.org)
  • In RNAi knock-down experiments of desaturase gene function in D. melanogaster, several desaturases were shown to affect CHC profiles of males and females, including some that were previously unlinked to CHC production. (bl.uk)
  • pseudogene
  • MBS9318897 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the N-acetyltransferase 8B (GCN5-related, putative, gene/pseudogene) (NAT8B) ELISA Kit target analytes in biological samples. (mybiosource.com)
  • suppressor
  • Southern transfer and genetic analyses of strains carrying a disrupted leu3 allele demonstrated that the cloned gene was LEU3 , as opposed to a suppressor. (genetics.org)
  • production
  • This study sets the theoretical foundation for bioassay design directed at confirming the participation of these genes in mescaline production. (biomedcentral.com)
  • An 18-gene cluster is responsible for scytonemin production in Nostoc punctiforme ATCC 29133. (frontiersin.org)
  • duplication
  • Indeed, scyD presents an interesting evolutionary paradox: it likely originated in a duplication event from scyE , and unlike other genes in the operon, it has not been subjected to purifying selection. (frontiersin.org)
  • known
  • The positive and negative training sets are composed of annotated NCR genes and manually-selected genes known to be insensitive to NCR, respectively. (springer.com)
  • several
  • We show that all classifiers make significant and biologically valid predictions by comparing these predictions to annotated and putative NCR genes, and by performing several negative controls. (springer.com)