• Calcium binds to and regulates the small regulatory protein calmodulin that in turn binds to and regulates several hundred calmodulin binding proteins. (biomedcentral.com)
  • Many of these proteins are linked to multiple neurodegenerative diseases indicating that calmodulin binding proteins lie at the heart of neuroinflammatory events associated with multiple neurodegenerative diseases. (biomedcentral.com)
  • The small calcium-binding protein calmodulin (CaM) is a primary effector of calcium function and works in turn by binding to and regulating CaM-binding proteins (CaMBPs) [ 53 ]. (biomedcentral.com)
  • The Calcium Hypothesis was thus extended as the Calmodulin Hypothesis since CaM not only binds to and regulates CaMBPs critical to learning and memory but also proteins involved in the formation of amyloid plaques and tangles, hallmarks of AD [ 41 ]. (biomedcentral.com)
  • The intimate role of CaMBPs in AD was recently reviewed reinforcing the role of CaM in binding to and regulating multiple key proteins adding further support for the Calmodulin Hypothesis of O'Day and Myre [ 41 , 47 ]. (biomedcentral.com)
  • Putative zinc-binding domain present in dystrophin-like proteins, and CREB-binding protein/p300 homologues. (embl.de)
  • 140 mouse brain proteins identified by Ca2+-calmodulin affinity chromatography and tandem mass spectrometry. (lu.se)
  • We describe the proteomic characterization of mouse brain Ca2+-calmodulin-binding proteins that were purified using calmodulin affinity chromatography. (lu.se)
  • After comparing the results from the different experiments, we were able to exclude a significant number of proteins suspected to bind in a nonspecific manner. (lu.se)
  • A total of 140 putative Ca2+-calmodulin-binding proteins were identified of which 87 proteins contained calmodulin-binding motifs. (lu.se)
  • Among the 87 proteins that contained calmodulin-binding motifs, 48 proteins have not previously been shown to interact with calmodulin and 39 proteins were known calmodulin-binding proteins. (lu.se)
  • The deduced proteins for NOS, CBS, and HO are thought to contain domains to generate NO, H 2 S, and CO, respectively, and to contain putative Ca 2+ /calmodulin-binding domains. (elsevierpure.com)
  • We have previously shown that docosahexaenoic acid (DHA) stabilizes αSOs against dissociation without compromising their ability to colocalize with glutamatergic synapses of primary hippocampal neurons, suggesting that they bind to synaptic proteins. (au.dk)
  • In addition, likely binding sites on these ligands were identified by computational analysis, highlighting a diversity of possible interactions between αSOs and target proteins. (au.dk)
  • PI(4,5)P 2 is able to bind to a variety of actin binding proteins, and serves to keep and change the shape of a cell by allowing rearrangement of actin in the cell. (justia.com)
  • Calmodulin binding proteins are shown in green text. (utoronto.ca)
  • CaMBOT: Profiling and Characterizing Calmodulin Binding Proteins. (utoronto.ca)
  • Actin binding domains present in duplicate at the N-termini of spectrin-like proteins (including dystrophin, alpha-actinin). (embl.de)
  • A number of actin-binding proteins, including spectrin, alpha-actinin and fimbrin, contain a 250 amino acid stretch called the actin binding domain (ABD). (embl.de)
  • In addition, the CH domain occurs also in a number of proteins not known to bind actin, a notable example being the vav protooncogene. (embl.de)
  • A Ca2+-ATPase was purified from plasma membranes (PM) isolated from Arabidopsis cultured cells by calmodulin (CaM)-affinity chromatography. (unimi.it)
  • At-ACA8 encodes a plasma membrane-localized calcium-ATPAse of arabidopsis with a calmodulin-binding domain at the N terminus / M.C. Bonza, P. Morandini, L. Luoni, M. Geisler, M.G. Palmgren, M.I. De Michelis. (unimi.it)
  • lyrata (Lyre-leaved rock-cress) putative lipase , arath-At2g15230 Arabidopsis thaliana (Mouse-ear cress) Arabidopsis lyrata subsp. (inrae.fr)
  • Characterizing the roles of Arabidopsis calmodulin-like protein, CML39, in hormonal regulation of early seedling development and fruit formation. (weebly.com)
  • This analysis revealed the presence of at least one binding domain within which visual scanning demonstrated the presence of valid binding motifs. (biomedcentral.com)
  • A CaM-Binding Domain or CaMBD (171EDVSRFIKGKLLQKQQKIYKDLERF195) containing both calcium-dependent-binding motifs and an IQ-like motif for calcium-independent binding has been experimentally validated. (utoronto.ca)
  • AJ249352) encodes a 1,074 amino acid protein with 10 putative transmembrane domains, which contains all of the characteristic motifs of Ca2+-transporting P-type Ca2+-ATPases. (unimi.it)
  • Identified as a protein that binds to abscisic acid response elements. (or.jp)
  • Calmodulin is an essential Ca2+-binding protein that binds to a variety of targets that carry out critical signaling functions. (lu.se)
  • The protocol involved co-immunoprecipitation in combination with a photoactivatable heterobifunctional sulfo-LC-SDA crosslinker which did not compromise neuronal binding and preserved the interaction between the αSOs-binding partners. (au.dk)
  • May act by competing with the putative neuronal protein kinase DCLK1 in binding to a target protein. (string-db.org)
  • Actin, spectrin, putative myosin and calmodulin are concentrated in these motile structures, and are co-transported with the contents of the varicosities and inclusions. (grantome.com)
  • In Mauthner axons, a spectrin-actin cytoskeletal system is localized near the axon's surface, as are also putative myosin and calmodulin, presumably within the subaxolemmal domain where hypolemmal cisternae are also located. (grantome.com)
  • putative KIF4 [Oryza sativa (japonic. (nig.ac.jp)
  • CAMTAs participate in gene expression regulation by binding to the cis -elements in the promoter regions of numerous target genes. (frontiersin.org)
  • BLAST search revealed that 19 putative candidate genes linked to 24 significant markers. (usda.gov)
  • Here, we develop a proteomic screen for putative αSO binding partners in rat primary neurons using DHA-stabilized human αSOs as a bait protein. (au.dk)
  • MCDO calmodulin - slime mold (Dictyostelium discoi. (nig.ac.jp)
  • Nucleomorphin: A novel, acidic, nuclear calmodulin-binding protein from Dictyostelium that regulates nuclear number. (utoronto.ca)
  • Dictyostelium calcium-binding protein 4a interacts with Nucleomorphin, a BRCT-domain protein that regulates nuclear number. (utoronto.ca)
  • Zinc-binding domain, present in Dystrophin, CREB-binding protein. (embl.de)
  • The ZZ in dystrophin appears to bind calmodulin. (embl.de)
  • As such, a patent application relating to a monoclonal antibody against IP 3 R (See prior art document 1), a patent application relating to a method of competition for IP 3 (See prior art document 2) and a patent application relating to polypeptides that bind to IP 3 R with high affinity (see prior art document 3) have been filed. (justia.com)
  • The N-terminal CH domain has the intrinsic ability to bind actin, albeit with lower affinity than the complete ABD, whereas the C-terminal CH bind actin extremely weakly or not at all. (embl.de)
  • Phosphatidylinositol (PI) is a substance that inositol is bound as a phosphate ester to a remaining hydroxyl group of diacylglycerol. (justia.com)
  • The released inositol-1,4,5-triphosphate (IP3) binds to an IP 3 receptor (IP 3 R) residing on the surface of an endoplasmic reticulum of a cell and release Ca 2+ stored in endoplasmic reticula into the cytoplasm, thereby activating a variety of Ca 2+ dependent enzymes. (justia.com)
  • Upon binding of substances such as hormones, cytokines and neurotransmitters on receptors of a cell, production of inositol-1,4,5-triphosphate (IP 3 ) is induced in the cell, and the IP 3 binds to inositol-1,4,5-triphosphate (IP 3 ) receptor (IP 3 R) residing on the surface of endoplasmic reticula of the cell. (justia.com)
  • Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and memory consolidation. (string-db.org)
  • Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, activates CREB-dependent gene transcription, regulates calcium- mediated granulocyte function and respiratory burst and promotes basal dendritic growth of hippocampal neurons. (string-db.org)
  • Three out of four selected hits were subsequently validated with dot-blot binding assays. (au.dk)
  • The gene encoding NumA1 was isolated using the Calmodulin-Binding Overlay Technique (CaMBOT) and the protein was subsequently validated as a calcium-dependent calmodulin (CaM) binding protein (CaMBP). (utoronto.ca)
  • However, their calcium-binding domain is restricted by calmodulin from metazoans. (mdpi.com)
  • In this study, we developed red GECI, called FRCaMP, using calmodulin (CaM) from Schizosaccharomyces pombe fungus as a calcium binding domain. (mdpi.com)
  • The chromo-domain binds histone H3 tails methylated on lysine 9. (cipsm.de)
  • In the PINK1 gene we identified two novel putative pathogenic substitutions, P416R and S419P, located in a conserved motif of the serine/threonine kinase domain. (biomedcentral.com)
  • At-ACA8 is the first plant PM localized Ca2+-ATPase to be cloned and is clearly distinct from animal PM Ca2+-ATPases due to the localization of its CaM-binding domain. (unimi.it)
  • CaM overlay assays localized the CaM-binding domain of At-ACA8p to a region of the N terminus of the enzyme around tryptophan-47. (unimi.it)
  • Since CERK lacks a calcium binding site, the regulatory mechanism of CERK was poorly understood. (wikipedia.org)
  • Transcriptional activator that binds to the DRE/CRT regulatory element and induces COR (cold-regulated) gene expression increasing plant freezing tolerance. (or.jp)
  • In this brief review, a detailed account of the putative mechanisms by which the normal physiology of T cells are disturbed and why regulatory T cells fail to alleviate proinflammatory response in SLE will be discussed. (hindawi.com)
  • Breakdown of immune tolerance is believed to be one of the major mechanisms which triggers the production of autoantibodies by B cells and antibody forming cells, leading to inflammation upon binding to autoantigens and consequent tissue damage [ 2 ]. (hindawi.com)
  • PREDICTED: EIN3-binding F-box protein 1 [Beta vulgaris subsp. (nibb.ac.jp)
  • Using a Yeast 2 Hybrid Screen, we showed that NumA1 binds to the calcium-binding protein Cbp4a in the nucleolus in a calcium-dependent manner. (utoronto.ca)
  • The calmodulin-binding transcription activators (CAMTA) play critical roles in plant growth and responses to environmental stimuli. (frontiersin.org)
  • Recently, Np95 (also known as UHRF1 or ICBP90) has been found to interact with Dnmt1 and to bind hemimethylated DNA, indicating together with genetic studies a central role in the maintenance of DNA methylation. (cipsm.de)
  • Each single ABD, comprising two CH domains, is able to bind one actin monomer in the filament. (embl.de)
  • Lectin binding studies suggest that membranes of hypolemmal cisternae contain glycoconjugates, similar to plasma membrane. (grantome.com)
  • Stimulation of TCRs upon antigen binding triggers downstream signalling pathways which enables various physiological functions of the T cells. (hindawi.com)
  • B ) Cartoon representation of activation of CaMKII by calcium:calmodulin (top) and proposed mechanism for spread of kinase activity (bottom). (elifesciences.org)
  • Binds to actin filaments (F-actin) and shows cross- linking activity. (string-db.org)
  • A nuclear/nucleolar localization sequence was also revealed (48KKSYQDPEIIAHSRPRK64) that includes both a putative bipartite and classical NLS. (utoronto.ca)
  • It is suspected that in the presence of all-trans retinoic acid (ATRA), chicken ovalbumin upstream promoter transcription factor I (COUP-TFI), retinoic acid receptor (RARα), retinoid X receptor (RXRα) bind the RARE-like of CERK in 5H-SY5Y cells. (wikipedia.org)
  • In contrast to SH-SY5Y neuroblastoma cells, HL60 leukemia cells demonstrated no binding of CERK even in the presence of ATRA. (wikipedia.org)
  • Considering the relationship to the cell cycle, nucleolar/nucleolar targeting and calmodulin binding, this protein presents an interesting subject for continued analyses. (utoronto.ca)