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  • cardiac
  • Sodium (Na + ) currents are responsible for excitation and conduction in most cardiac cells, but their study has been hampered by the lack of a satisfactory method for voltage clamp. (springer.com)
  • Carmeliet, E., Slow inactivation of the sodium current in rabbit cardiac Purkinje fibres. (springer.com)
  • Together, these results demonstrate that PCP4 regulates cardiac excitability through both Purkinje cell-autonomous and central mechanisms and identify this modulator of CaMKII signaling as a potential arrhythmia-susceptibility candidate. (jci.org)
  • Single cardiac Purkinje cells should permit improved control of membrane potential during voltage clamp studies. (ahajournals.org)
  • spatial
  • The spatial expression of L7, a protein specific for Purkinje cells, and L7 beta Gal, a gene expressed in transgenic mice that was constructed from the L7 promoter and the marker beta-galactosidase, delineated bands of Purkinje cells that increased in number during early postnatal development. (sciencemag.org)
  • V. Spatial organization of Purkinje cell perikarya. (springer.com)
  • cortex
  • In addition, the patterns of synchronous complex spike activity were also similar to those observed in the anesthetized preparation (i.e., simultaneous activity was found predominantly among Purkinje cells located within the same parasagittally oriented strip of cortex). (jneurosci.org)
  • pathological
  • Importantly, increasing evidence points to the existence of common pathological pathways in different forms of ataxia, including transcriptional regulation, protein aggregation, and calcium homeostasis, which trigger the degeneration of Purkinje cells in these disorders ( 1 , 5 ). (pnas.org)
  • The neuroprotective effect of RU486 could also be observed in pathological Purkinje cell death. (pnas.org)
  • Climbing
  • It is well established that the climbing fiber (CF) input to a cerebellar Purkinje cell (PC) can exert a controlling influence on the background simple spike (SS) activity of the cell, in that repetitive stimulation of CFs causes a decrease in SS activity, and removal or inactivation of CFs is followed by a rise in activity. (jneurosci.org)
  • Large Ca 2+ signals essential for cerebellar long-term depression (LTD) at parallel fiber (PF)-Purkinje cell synapses are known to be induced when PF activation precedes climbing fiber (CF) activation by 50-200 ms, consistent with cerebellar learning theories. (jneurosci.org)
  • pause
  • Previous studies have shown that an eyeblink conditioning protocol can make cerebellar Purkinje cells learn to pause in response to the conditioned stimulus. (springer.com)
  • The present paper argues that the learned Purkinje cell pause response is the memory trace and main driver of the overt conditioned blink and that it explains many well-known behavioural phenomena. (lu.se)
  • microelectrode
  • We have developed a method for isolation of single canine Purkinje cells and studied their basic electrophysiological properties using conventional single and double microelectrode techniques. (ahajournals.org)
  • inhibitory
  • Montarolo PG, Palestini M, Strata P (1982) The inhibitory effect of the olivocerebellar input on the cerebellar Purkinje cells in the rat. (springer.com)
  • SLC26A11 (KBAT) in Purkinje Cells Is Critical for Inhibitory Transmission and Contributes to Locomotor Coordination. (nih.gov)
  • To address the question of whether inhibitory environmental cues along the axon could exert a negative, tonic downregulation of growth-associated genes, we have examined adult rat Purkinje cells, which are endowed with poor regenerative capabilities. (jneurosci.org)
  • pathway
  • For many years it had been thought that the resting discharge of cerebellar PCs is produced by the sustained postsynaptic depolarization of the cells by ongoing transmission along the MF-PF pathway, but there has long been good reason to doubt this. (jneurosci.org)