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  • enzymes
  • Whether or not a nucleotide synthase ribozyme had measurable nucleobase binding affinity, all families of nucleotide synthetase ribozymes were extremely sensitive to nucleobase modification and showed surprising parallels to the substrate preferences of highly evolved protein nucleotide synthase enzymes. (nih.gov)
  • These changes in the activity of enzymes, involved in purine catabolism can beregarded as increased functional relationships between T and B lymphocytes in hypothyroidism. (msk.ru)
  • guanosine
  • The N K-edge X-ray absorption near edge structure (XANES) spectra of the purine-containing nucleotide, guanosine 5{sup ′}-monophosphate (GMP), in aqueous solution are measured under various pH conditions. (osti.gov)
  • adenosine
  • The experimental spectra are compared with theoretical spectra calculated by using density functional theory for GMP and the other purine-containing nucleotides, adenosine 5{sup ′}-monophosphate, and adenosine 5{sup ′}-triphosphate. (osti.gov)
  • In eukaryotes the second, third, and fifth step are catalyzed by trifunctional purine biosynthetic protein adenosine-3 , which is encoded by the GART gene. (rug.nl)
  • uracil
  • For example, the family A pyrimidine nucleotide synthetase ribozyme was ~10,000 times slower with uracil than with 4-thiouracil and reactivity with 2-thiocytosine, 2-thiopyrimidine, 2-thiopyridine and 5-carboxy-2-thiouracil could not be detected (Figure 3). (nih.gov)
  • intracellular
  • Effect of the msb3msb4 double mutation on the intracellular pool of purine nucleotides in the yeast Saccharomyces cerevisiae: application to the study of the biological activity of the oncogenic human protein oncTre210p. (ac.be)
  • Reference : Effect of the msb3msb4 double mutation on the intracellular pool of purine nucleotide. (ac.be)
  • nitrogen
  • The source of the carbon and nitrogen atoms of the purine ring, 5 and 4 respectively, come from multiple sources. (rug.nl)
  • Formyl groups build carbon-2 and carbon-8 in the purine ring system, which are the ones acting as bridges between two nitrogen atoms. (rug.nl)
  • Purines consist of a six-membered and a five-membered nitrogen-containing ring, fused together. (utah.edu)
  • Carbon 1 of the sugar is attached to nitrogen 9 of a purine base or to nitrogen 1 of a pyrimidine base. (utah.edu)
  • atoms
  • The N K-edge XANES spectra for all of these nucleotides are classified by the numbers of N atoms with particular chemical bonding characteristics in the purine moiety. (osti.gov)
  • decrease
  • Our studies of the membranous ubiquinone reduction level in mitochondria demonstrate that activation of UCP1 leads to a purine nucleotide-sensitive decrease in the ubiquinone redox state. (ac.be)
  • reaction
  • The arrows point to reaction efficiencies for ribozymes with the indicated substrate molecule: red arrows indicate the MA purine nucleotide synthetase ribozyme reaction efficiencies, purple indicates the RA purine nucleotide synthetase ribozyme, blue indicates the Family A pyrimidine nucleotide synthethase ribozyme and green indicates the improved a15 ribozyme derived from the Family A ribozyme by reselection. (nih.gov)
  • redox
  • Results obtained for non-phosphorylating and phosphorylating mitochondria, as the endogenous ubiquinone redox state was gradually varied by a lowering rate of the ubiquinone-reducing or ubiquinol-oxidizing pathways, indicate that the endogenous ubiquinone redox state has no effect on non-esterified fatty acid-induced UCP1 activity in the absence of GTP, and can only regulate this activity through sensitivity to inhibition by the purine nucleotide. (ac.be)