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Vidarabine PhosphateAntimetabolitesPurinesPurine NucleotidesAntimetabolites, AntineoplasticPurine NucleosidesInosine MonophosphateTetrahydrouridineHypoxanthinesHypoxanthinePhosphoribosyl PyrophosphateTrabeculectomyPurine-Nucleoside PhosphorylaseFloxuridineXanthineAdenosine DeaminaseInosine6-MercaptopurinePurine-Pyrimidine Metabolism, Inborn ErrorsLesch-Nyhan SyndromeFluorouracilAdenylosuccinate LyaseUric AcidMethotrexateSurgical Sponges5'-NucleotidaseMitomycinHypoxanthine PhosphoribosyltransferaseAdenineThioguanineLeukemia L1210CytarabineAdenine PhosphoribosyltransferaseAdenosine Deaminase InhibitorsGuanine DeaminaseRibose-Phosphate PyrophosphokinaseDeoxycytidineUrate OxidaseGMP ReductaseNucleotidases6-AminonicotinamideGoutAntineoplastic AgentsIMP DehydrogenaseXanthinesPantothenic AcidAdenosineFolic Acid AntagonistsDrug SynergismRibonucleosidesXanthine DehydrogenaseNorleucineGuanineAdenosine KinaseTumor Cells, CulturedNeoplasmsAdenosine MonophosphateCell SurvivalFormatesAdenine NucleotidesCell DivisionAminoimidazole CarboxamideEnergy MetabolismXanthine OxidaseCell LinePhosphonoacetic AcidThymidylate SynthaseAzathioprineLipid MetabolismPhosphotransferasesKineticsHyperuricemiaPentosyltransferases

AntineoplasticNucleotideNucleotidesBiosynthesisSynthesisAzathioprineInhibitCancerDrugActs as an antimetaboliteAntineoplastic agentMercaptopurineDrugsIdentificationTermFormTreatmentFunctionsTherapy

Antineoplastic3

• An antimetabolite antineoplastic agent with immunosuppressant properties. (lookformedical.com)
• An antineoplastic compound which also has antimetabolite action. (lookformedical.com)
• Capecitabine is a fluoropyrimidine carbamate belonging to the class of antineoplastic agents called antimetabolites. (targetmol.com)

Nucleotide2

• 6-MP is further metabolized by hypoxanthine-guanine phosphoribosyltransferase (HGPRT) into 6-thioguanosine-5′-phosphate (6-thio-GMP) and 6-thioinosine monophosphate (6-thio-IMP), both inhibit nucleotide conversions and de novo purine synthesis. (illnesshacker.com)
• A purine nucleotide which has hypoxanthine as the base and one phosphate group esterified to the sugar moiety. (lookformedical.com)

Nucleotides2

• The key substance in the biosynthesis of histidine, tryptophan, and purine and pyrimidine nucleotides. (lookformedical.com)
• Nucleotides are very important as cosubstrates in metabolism. (heresy.is)

Biosynthesis1

• Immunosuppression likely occurs because of the ability of the drug to inhibit purine biosynthesis. (illnesshacker.com)

Synthesis8

• Azathioprine is converted into 6-mercaptopurine in the body where it blocks purine metabolism and DNA synthesis. (illnesshacker.com)
• Azathioprine antagonizes purine metabolism and may inhibit synthesis of DNA, RNA, and proteins. (illnesshacker.com)
• Azathioprine acts to inhibit purine synthesis necessary for the proliferation of cells, especially leukocytes and lymphocytes. (illnesshacker.com)
• Azathioprine inhibits DNA synthesis and, as a purine antimetabolite, exerts its effect on activated lymphocytes, which requires purines during their proliferative phase. (illnesshacker.com)
• It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia. (lookformedical.com)
• Purine bases related to hypoxanthine, an intermediate product of uric acid synthesis and a breakdown product of adenine catabolism. (lookformedical.com)
• An antimetabolite that is converted to deoxyuridine triphosphate during DNA synthesis. (targetmol.com)
• It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in. (targetmol.com)

Azathioprine4

• febuxostat increases levels of azathioprine by decreasing metabolism. (medscape.com)
• allopurinol increases levels of azathioprine by decreasing metabolism. (medscape.com)
• Azathioprine is a purine analog with cytotoxic and immunosuppressive activity. (illnesshacker.com)
• Azathioprine (AZA), one of the antimetabolite drugs, is a purine analog that is more potent than the prototype 6-mercaptopurine, as an inhibitor of cell replication. (illnesshacker.com)

Inhibit1

• It may also interfere with cellular metabolism and inhibit mitosis. (illnesshacker.com)

Cancer1

• Antimetabolites that are useful in cancer chemotherapy. (lookformedical.com)

Drug1

• An immunosuppressive antimetabolite pro-drug. (illnesshacker.com)

Acts as an antimetabolite2

• A nucleoside that substitutes for thymidine in DNA and thus acts as an antimetabolite. (lookformedical.com)
• It also acts as an antimetabolite on some simpler organisms. (nih.gov)

Antineoplastic agent2

• An antimetabolite antineoplastic agent with immunosuppressant properties. (bvsalud.org)
• Nelarabine is a purine nucleoside analog and antineoplastic agent used for the treatment of with acute T-cell lymphoblastic leukemia and T-cell lymphoblastic lymphoma with inadequate clinical response to prior chemotherapeutic treatments. (drugbank.com)

Mercaptopurine2

• It is a derivative of mercaptopurine (2-amino-6-mercaptopurine) and, like its parent molecule, inhibits purine metabolism, thus blocking DNA, RNA and subsequent protein synthesis. (nih.gov)
• ALT elevations as well as myelotoxicity have been linked to higher levels of methyl-mercaptopurine, a product of one of the metabolic pathways of thioguanine metabolism. (nih.gov)

Drugs1

• It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia. (bvsalud.org)

Identification1

• Identification of genetic variations that affect activation and metabolism may permit the development of individualized therapy that optimize effectiveness and minimize toxicity. (basicmedicalkey.com)

Term1

• The term metabolism refers to the many chemical reactions that take place in our bodies. (cancerquest.org)

Form2

• 14 Nelarabine preferentially accumulates in T-cells since T-cells have a higher expression of enzymes that convert nelarabine to the active purine analog form, making them effective against T-cells malignancies. (drugbank.com)
• The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability. (lookformedical.com)

Treatment1

• Many of the antimetabolites used in the treatment of cancer interfere with the production of the nucleic acids, RNA and DNA. (cancerquest.org)

Functions1

• The presence of the 'decoy' antimetabolites prevents the cells from carrying out vital functions and the cells are unable to grow and survive. (cancerquest.org)

Therapy1

• Thioguanine (also referred to as 6-thioguanine and as tioguanine) is a purine analogue that is used in the therapy of acute and chronic myelogenous leukemias. (nih.gov)