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  • replication
  • Antimetabolites generally impair DNA replication machinery, either by incorporation of chemically altered nucleotides or by depleting the supply of deoxynucleotides needed for DNA replication and cell proliferation. (wikipedia.org)
  • Because of this mode of action, most antimetabolites have high cell cycle specificity and can target arrest of cancer cell DNA replication. (wikipedia.org)
  • treat
  • Antimetabolites, particularly mitomycin C (MMC), are commonly used in America and Japan as an addition to trabeculectomy , a surgical procedure to treat glaucoma . (wikipedia.org)
  • shown
  • Notably recent studies have shown that the ABC transporter ABCG2 [which is expressed in many tumor types ( 22 )] exports both purine nucleoside monophosphates and nucleosides ( 18 , 23 ).This suggests an ABC transporter could affect the intracellular nucleoside monophosphate concentration by reducing both the amount of nucleoside available for phosphorylation as well as the amount phosphorylated. (aacrjournals.org)