• gene
  • The purine riboswitch can become saturated at concentrations as low as 5 nM, which reflects the need for gene expression to respond quickly and dynamically to changes in purine concentration. (wikipedia.org)
  • The pbuE gene encodes a purine base efflux pump. (wikipedia.org)
  • The disorder is caused by a mutation of the purine nucleoside phosphorylase (PNP) gene, located at chromosome 14q13.1. (wikipedia.org)
  • pyrimidine nucleotides
  • Previous prebiotic syntheses of nucleotides had attempted to form them through assembly of their constituent parts, a nucleobase, sugar, and phosphate, but with only limited efficacy for purine nucleotides, and no success for pyrimidine nucleotides. (wikipedia.org)
  • derivatives
  • To be viable, organisms possess a number of (deoxy)purine phosphohydrolases, which hydrolyze these purine derivatives removing them from the active NTP and dNTP pools. (wikipedia.org)