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  • histologically
  • The 1999 World Health Organization classification system defined MCACL as a cystic adenocarcinoma with copious mucin production that, histologically, resembles (the more common) mucus-producing cystadenocarcinomas originating in the ovary, breast and pancreas. (wikipedia.org)
  • tumor cell
  • The histopathological ( microscopic ) diagnosis of adenocarcinoma of the lung requires observation of tumor gland formation or mucin secretion within tumor cell cytoplasm. (icnet.uk)
  • Resulting hybridomas were screened for the production of antibodies that bound to the immunizing line, tumor cell lines, and tumor tissues, with relative lack of binding to normal tissue ( 3 ). (aacrjournals.org)
  • precursor
  • Foci of squamous metaplasia and dysplasia may be present in the epithelium proximal to adenocarcinomas, but these are not the precursor lesions for this tumor. (wikipedia.org)
  • It is sometimes considered to be a precursor to pulmonary carcinoid tumours . (radiopaedia.org)
  • The trisaccharide is a precursor to the Lewis blood group antigens, but RAAG12 is distinct from those antigen structures and is not one of the previously described mucin antigens ( 3 ). (aacrjournals.org)
  • stain
  • Most of these markers, such as BerEP4, CD15, the thyroid transcription factor (TTF-1) and carcinoembryonic antigen (CEA) stain adenocarcinomas whereas calretinin and CK5/6 are positive in both benign Correspondence: Professor M-C Copin, Service d Anatomie et Cytologie Pathologiques, Hôpital Calmette, CHRU, Bd J. Leclercq, Lille Cedex, France. (docplayer.net)
  • Poorly differentiated adenocarcinoma will not resemble the normal glands (high grade) and will be detected by seeing that they stain positive for mucin (which the glands produce). (wikipedia.org)
  • microscopic
  • Electron microscopic studies in 3 cases described intracytoplasmic mucin, convoluted oval nuclei, prominent nucleoli, homogeneous euchromatin with peripheral chromatin condensation, microvilli, junctional complexes, and primitive lumen formation. (wikipedia.org)
  • nodules
  • It is characterised by a generalised proliferation of scattered single cells, small nodules or linear proliferations of pulmonary neuroendocrine cells (enterochromaffin cells, "Kulchitsky cells") 9 . (radiopaedia.org)
  • Can also present as a pulmonary nodule , mass or a cluster of diffuse nodules 1,2 . (radiopaedia.org)
  • malignant
  • 4 Unitat de Biologia Cellular i Molecular, Institut Municipal d Investigacio Medica, Barcelona, Spain and 5 Department of Biochemistry and Molecular Biology, UNMC/Eppley Cancer Center, University of Nebraska Medical Center, NE, USA The distinction between pleural malignant mesothelioma and pleural infiltration by adenocarcinomas has complex therapeutic and medicolegal implications. (docplayer.net)
  • MUC4 is a membrane-bound mucin that has been suggested to be implicated in malignant progression in humans and rats. (docplayer.net)
  • 3,16 MOC-31 immunostaining is also a useful marker of lung adenocarcinomas although positive immunostaining in a limited number of cells has been described in malignant mesotheliomas. (docplayer.net)
  • detect
  • Histochemical stains, such as mucicarmine, Alcian Blue (AB) or Periodic Acid-Schiff (PAS) detect mucin within cells and extracellularly. (icnet.uk)
  • occur
  • It can sometimes occur within a pulmonary bronchocele, and this tumor entity should be kept in mind after identification of a bronchocele with suspicious or non-prototypical imaging characteristics. (wikipedia.org)
  • small
  • Thymidylate synthase, the main target of pemetrexed, was found to be differentially expressed among the histotypes of lung cancer, being lower in adenocarcinoma and higher in SCC and small-cell lung cancer. (cancernetwork.com)
  • antibodies
  • Although the panel of adenocarcinoma-associated antibodies and one or two mesothelioma markers is useful in this purpose, most of these antibodies are not totally specific. (docplayer.net)
  • 3 8 An appropriate panel of antibodies is useful to differentiate between mesothelioma and adenocarcinoma. (docplayer.net)