• It should be administered under the supervision of a qualified physician who is experienced in allogeneic hematopoietic stem cell transplantation, the use of cancer chemotherapeutic drugs and the management of patients with severe pancytopenia. (nih.gov)
  • The pharmacokinetics of BUSULFEX were studied in 59 patients participating in a prospective trial of a BUSULFEX-cyclophosphamide preparatory regimen prior to allogeneic hematopoietic progenitor stem cell transplantation. (nih.gov)
  • The allogeneic HSCT was the most frequently performed (57.14%) and the most used source of Hematopoietic progenitor cells (HPC) was the peripheral blood (54.29%) and 5.71% of these patients developed the Graft versus Host Disease (GVHD), of which one was affected by acute GVHD and another by chronic GVHD. (bvsalud.org)
  • Sargramostim is a colony stimulating factor that is FDA approved for the treatment of granulocytopenia following induction chemotherapy in acute myelogenous leukemia , mobilization and following transplantation of autologous peripheral blood progentior cells, myeloid reconstitution after autologous bone marrow transplantation, myeloid reconstitution after allogeneic bone marrow transplantation and bone marrow transplantation failure or engraftment delay. (wikidoc.org)
  • Allogeneic hematopoietic transplantation may be curative in some patients with thalassemia major. (medscape.com)
  • Evaluation of the clinical benefits of intralacrimal transplantation of allogeneic mesenchymal stem cells (MSCs) in dogs with mild-moderate and severe KCS was done. (drcremers.com)
  • T cells from these patients responded vigorously to autologous tumour antigens after culture with allogeneic-IgG-loaded DCs, recapitulating our findings in mice. (bioxcell.com)
  • Seven eighty six patients undergoing allogeneic (n=550) or autologous (n=236) BMT were evaluated by physical examination, history, rest and exercise ECG, chest x-ray, two-dimensional echocardiography, and radionuclide ventriculography (RNV) before BMT, and monitored for 5 months thereafter. (slideshare.net)
  • This article contains highlights of "Guidelines for Pre- allogeneic or autologous, depending on the source of venting Opportunistic Infections among Hematopoi- the transplanted hematopoietic progenitor cells. (cdc.gov)
  • For the purposes of this document, HSCT is defined of the CDC, the Infectious Diseases Society of America, as any transplantation of blood or marrow-derived he- and the American Society of Blood and Marrow Trans- matopoietic stem cells, regardless of transplant type plantation," which was published in the Morbidity and (allogeneic or autologous) or cell source (bone marrow, Mortality Weekly Report [1]. (cdc.gov)
  • There pediatric and adult autologous and allogeneic HSCT patients. (cdc.gov)
  • Human endothelial progenitor cells (hEPCs) are adult stem cells, located in the bone marrow and peripheral blood. (intechopen.com)
  • Different phenotypes and subtypes of endothelial progenitor cells (EPCs), such as early and late EPCs, have been described according to their functionality. (intechopen.com)
  • Endothelial progenitor cells (EPCs) contribute to neovascularization and play an important role in the development of these diseases. (hindawi.com)
  • The bone-marrow-derived endothelial progenitor cells (EPCs) provide an alternative source of endothelial cells (ECs) that contributes to neovessel formation in endothelium structure [ 4 , 5 ]. (hindawi.com)
  • We hypothesize that blood-derived endothelial progenitor cells (EPCs) have the required proliferative and vasculogenic activity to create vascular networks in vivo. (ashpublications.org)
  • Peripheral blood progenitor cells and/or bone marrow were infused on day 0. (duke.edu)
  • The etiology of bone marrow failure (BMF) includes defective stem/progenitor cells and/or stroma/accessory cells/growth factors, as well as deficient nonspecific nutrients or, as in the case of acquired aplastic anemia, immune-mediated abnormalities. (medscape.com)
  • Inherited bone marrow failure syndromes (IBMFS) are usually the result of intrinsic stem cell/progenitor defects. (medscape.com)
  • There are many studies involving autologous therapies and some allogenic therapies, based on the recovery of mobilized bone marrow cells, including mesenchymal stem cells (MSCs) and adipose derived stem cells that also include the stromal or adherent cell type that has an MSC phenotype. (biomedcentral.com)
  • Neupogen is indicated for the reduction in the duration of neutropenia and the incidence of febrile neutropenia in patients treated with established cytotoxic chemotherapy for malignancy (with the exception of chronic myeloid leukaemia and myelodysplastic syndromes) and for the reduction in the duration of neutropenia in patients undergoing myeloablative therapy followed by bone marrow transplantation considered to be at increased risk of prolonged severe neutropenia. (medicines.org.uk)
  • Bone Marrow Transplantation. (bvsalud.org)
  • Objectives: To evaluate the safety and feasibility of endobronchial administration of bone marrow autologous MSCs (BM-MSC) in patients with mild-to-moderate IPF. (unav.edu)
  • Supportive measures include folic acid replacement and monitoring for the development of complications such as pulmonary hypertension, osteoporosis, and bone fractures, poor dentition, heart failure, and aplastic crisis with parvovirus B-19 infection. (medscape.com)
  • Patients who undergo bone marrow transplantation are generally immunosuppressed with a dose of cyclophosphamide which is usually calculated based on the patient's weight. (slideshare.net)
  • In conclusion, gene-corrected hematopoietic stem cell transplantation has promising outcomes for SCD, Fanconi anemia, and thalassemia, and it may overcome the limitation of the source of allogenic bone marrow transplantation. (sscb-stembiotech.com)
  • In preclinical and clinical studies, progenitor cell therapy (cord blood and mesenchymal stem cells) has shown promise in reversing the underlying pathology of SNHL, the loss of cochlear sensory hair cells. (intechopen.com)
  • Sadan O, Melamed E, Offen D. Intrastriatal transplantation of neurotrophic factor-secreting human mesenchymal stem cells improves motor function and extends survival in R6/2 transgenic mouse model for Huntington's disease. (jamanetwork.com)
  • Purpose: To determine the tolerability and feasibility of double-cycle, high-dose chemotherapy followed by peripheral blood stem-cell transplantation (PBSCT) after conventional chemotherapy or chemoradiotherapy for small cell lung cancer (SCLC). (the-medical-dictionary.com)
  • Neupogen is indicated for the mobilisation of peripheral blood progenitor cells (PBPCs). (medicines.org.uk)
  • To find new treatments for COPD, researchers have been investigating stem cells, which are capable of differentiating into any cell in the body, and progenitor cells, which are descendants of stem cells and can only differentiate into the cells that belong to the same tissue or organ and are normally used by the body to repair and replace damaged tissue. (earth-news.info)
  • Symmetric division gives rise to two identical daughter stem cells, whereas asymmetric division produces one stem cell and one progenitor cell with limited self-renewal potential. (wikipedia.org)
  • The proliferation and differentiation of pluripotent stem cells give rise to progeny that can populate the entire immunologic and hematopoietic systems through committed progenitors of both the lymphoid and myeloid lineages. (medscape.com)
  • 1 Unique MSC-specific markers have not yet been identified, and MSCs constitute a heterogeneous cell population, including both multipotent (stem) cells and progenitor cells and might even contain pluripotent cell fractions. (bmj.com)
  • All stem cells are undifferentiated cells that exhibit unlimited self-renewal and can generate multiple cell lineages or more restricted progenitor populations that can contribute to tissue homeostasis by replenishing the cells or to tissue regeneration after injury. (biomedcentral.com)
  • His research focus is on haematopoietic stem cell transplantation (HSCT) and translational research of normal and malignant stem cells. (edu.au)
  • Commenting on the study in a statement, Dr Dusko Ilic, reader in stem cell science at King's College London, says: "The basic science research led to the hypothesis that preserving and stimulating autologous stem cells in the eye might promote regeneration of a surgically removed lens. (medscape.com)
  • To take human organ generation via BC and transplantation to the next step, we reviewed current emerging organ generation technologies and the associated efficiency of chimera formation in human cells from the standpoint of developmental biology. (frontiersin.org)
  • Researchers have successfully used patients' own P63+ lung progenitor cells to repair damaged lung tissue in COPD patients, improving their quality of life. (earth-news.info)
  • Researchers have demonstrated the potential to heal injured lung tissue in chronic obstructive pulmonary disease (COPD) patients using their own lung cells for the first time. (earth-news.info)
  • Professor Wei Zuo, of the School of Medicine, Tongji University, Shanghai, China, and chief scientist at Regend Therapeutics Ltd in China, and his colleagues have been investigating whether a type of cell called P63+ lung progenitor cells might be able to regenerate lung tissue damaged by COPD. (earth-news.info)
  • P63+ progenitor cells are known for their ability to regenerate the tissues of the airways, and previously we and other scientists have shown in animal experiments that they can repair the damaged epithelial tissue in the alveoli - the tiny air sacs in the lungs that play a crucial role in the exchange of gases between air breathed in and the blood supply to the lungs. (earth-news.info)
  • In this first phase I clinical trial, the researchers set out to investigate the efficacy and safety of taking P63+ progenitor cells from the lungs of 20 COPD patients, using them to grow millions more in the laboratory, before transplanting them back into the patients' lungs. (earth-news.info)
  • We used a tiny catheter that contains a brush to collect the progenitor cells from the patients' own airways. (earth-news.info)
  • Early fate decisions in hematopoietic stem and progenitor cells. (lu.se)
  • These new cells are called progenitor cells and they start to grow and divide until they form new lung tissue. (guidelinenews.com)
  • Autologous lung transplantation involves using the patient's own healthy cells to replace their damaged lungs. (guidelinenews.com)
  • The mobilisation and apheresis procedures should be performed in collaboration with an oncology-haematology centre with acceptable experience in this field and where the monitoring of haematopoietic progenitor cells can be correctly performed. (medicines.org.uk)
  • Mesenchymal stromal cells: a novel therapy for the treatment of chronic obstructive pulmonary disease? (bmj.com)
  • Myoblasts cultured from satellite cells of adult muscle biopsies survive, develop, and function to revitalize degenerative muscles upon transplantation. (jgc301.com)
  • Independent origins of fetal liver haematopoietic stem and progenitor cells. (u-tokyo-hemat.com)
  • If adequate numbers of progenitor cells are not collected, other mobilization therapy should be considered. (wikidoc.org)
  • The most important difference between SCs and progenitor cells is that SCs can replicate indefinitely, whereas progenitor cells can divide only a limited number of times. (biomedcentral.com)
  • Grafted c-kit + /SSEA1 - eye-wall progenitor cells delay retinal degeneration in mice by regulating neural plasticity and forming new graft-to-host synapses. (stacksdiscovery.com)
  • 2 Examples of this approach include blood vessels and cardiovascular substitutes, where autologous vascular cells have been used for this purpose without immune rejection. (ashpublications.org)
  • The use of human cord blood cells dates back as early as 1974, when it was first proposed that stem cell and progenitor cells were present in human cord blood . (bioinformant.com)
  • I developed specific interest in the immune-modulating properties of Vitamin D, the molecular basis for chronic kidney transplant rejection, complications of organ transplantation and the involvement of cells from the immune system in kidney disease. (universityofgalway.ie)
  • The scientists at the University of California San Diego report on a method of removing cataracts while preserving epithelial stem/progenitor cells (LECs), which have an important role in lens regeneration. (medscape.com)
  • The Hematopoietic stem cell transplantation (HSCT) is used in children as a definitive treatment for various oncological, immune deficiencies, hemoglobinopathy, and malignancies diseases that involve the hematological system, congenital metabolism disorders, among others. (bvsalud.org)
  • This is a quantitative, retrospective, observational, descriptive and analytical quantitative approach approaching the medical records of children and adolescents submitted to HSCT in a referral hospital service for this type of transplantation in the state of Rio Grande do Sul North (RN). (bvsalud.org)
  • Hematopoietic stem cell transplantation not responded to other therapeutic modalities, with (HSCT) is used in children as a definitive treatment an increase in survival after transplantation, for different oncological, immune deficiencies, contributing to its use (YEILIPEK, 2014). (bvsalud.org)
  • For this reason, hematopoietic stem cell transplantation, better known as HSCT, can be a promising treatment approach for a wide range of conditions. (bioinformant.com)
  • are basically 3 phases of immune recovery for HSCT patients, The purposes of the guidelines are (1) to summarize the beginning at day 0, the day of transplantation. (cdc.gov)
  • Scholars@Duke publication: Efficacy and toxicity of a CCNU-containing high-dose chemotherapy regimen followed by autologous hematopoietic cell transplantation in relapsed or refractory Hodgkin's disease. (duke.edu)
  • COPD, or chronic obstructive pulmonary disease, is a serious lung condition that can make it difficult to breathe. (guidelinenews.com)
  • Cigarette smoke (CS) is well known to be a risk factor for pulmonary diseases including chronic obstructive pulmonary disease (COPD), lung cancer, asthma, pulmonary hypertension, and vascular diseases such as atherosclerosis [ 1 ]. (hindawi.com)
  • Transplantation-related issues such as graft versus host disease, graft failure, chronic immunosuppressive therapy, and transplantation-related mortality should be carefully considered prior to proceeding with this approach. (medscape.com)
  • The specific medications administered depend on the choice of therapy and whether it is supportive care only, immunosuppressive therapy, or hematopoietic cell transplantation. (medscape.com)
  • Stem cell and progenitor cell-based regenerative medicine may be the biggest, if not the only, hope to cure COPD," he told the congress. (earth-news.info)
  • After more than 50 years of research, airway transplantation remains a major challenge in the fields of thoracic surgery and regenerative medicine. (biomedcentral.com)
  • Cigarette smoke is a major public health problem associated with multitude of diseases, including pulmonary and vascular diseases. (hindawi.com)
  • We will present a summary of the effect of hearing loss on auditory development, existing preclinical and clinical data on progenitor cell therapy, and its potential role in the (re)habilitation of non-genetic SNHL. (intechopen.com)
  • The clinical presentation of Acute Respiratory Distress (ARDS) is marked by disruptions to the alveolar-capillary complex mediated by inflammation, interalveolar edema primarily caused by protein-rich fluids influx, reduced alveolar clearance, and increased pulmonary resistance. (ceufast.com)
  • Experimental and clinical evidence has demonstrated the effectiveness of MSC transplantation in managing diabetes mellit. (shengsci.com)
  • My interest in transplantation resulted in a research fellowship in basic immunology at the University of Chicago, USA following which I spent 9 years combining clinical transplant medicine with laboratory-based immunology research at Mayo Clinic. (universityofgalway.ie)
  • 9. Clinical complications and outcomes of human kidney and pancreas transplantation. (universityofgalway.ie)
  • Progenitors can go through several rounds of cell division before finally differentiating into a mature cell. (wikipedia.org)
  • Cell Replacement Therapy for Parkinson's Disease - Evaluating the potential of autologous grafting. (lu.se)
  • Progenitor cell therapy may also allow functional reorganization of the auditory pathways including primary auditory cortex (Heschl's gyrus). (intechopen.com)
  • Central venous catheter placement is required before the administration of hematopoietic cell transplantation. (medscape.com)
  • Human Myoblast Genome Therapy (HMGT) is a platform technology of cell transplantation, nuclear transfer, and tissue engineering. (jgc301.com)
  • A progenitor cell is a biological cell that, like an SC, has a tendency to differentiate into a specific type of cell but is already more specific than an SC and is pushed to differentiate into its 'target' cell. (biomedcentral.com)
  • Hematopoietic Stem Cell Transplantation in Refractory Crohn's Disease: Should It Be Considered? (mdpi.com)
  • Impact of Diabetes Mellitus on Human Mesenchymal Stromal Cell Biology and Functionality: Implications for Autologous Transplantation. (shengsci.com)
  • They recommend lower concentrations to prevent stem cell clumping and pulmonary emboli. (drcremers.com)
  • There is 1 report of a family of 3 who had signs & 1 had symptoms (42 yo male with chest pain) of a pulmonary emboli after intravenous stem cell injection. (drcremers.com)
  • The only risk factor this patient had was that his father was a smoker and he had received autologous adipose tissue-derived stem cell therapy for cervical herniated intervertebral disc three times intravenously over 3 months and finished one month before his ER visit. (drcremers.com)
  • 3. Also: Authors write, "The suspicion of IV stem cell therapy as the cause of pulmonary embolism became more solidified when we came to know that his parents had taken the same therapy for treatment of knee osteoarthritis five times. (drcremers.com)
  • Journal of Stem Cell Research and Transplantation is an international, open access, peer reviewed, scholarly journal committed to publish articles in diversified fields of transplantations and applications of stem cell research. (slideshare.net)
  • The aim of the academic journal is to provide a platform for researchers, scientists, physicians, and other health professionals to find latest research information in the areas of stem cell research, transplantations such as stem cell transplantation, transplantation immunology, kidney transplantation and its treatment. (slideshare.net)
  • The Journal of Stem Cell Research and Transplantation publishes latest scientific information, and is generously accessible across the world through internet to go halves the innovations of the researchers for intellectual advancement in this field. (slideshare.net)
  • 184 had no cardiac events after stem cell transplantation. (slideshare.net)
  • Discussion Stem cell transplantation is well and truly underway in South East Asia. (slideshare.net)
  • Human mesenchymal stromal cell transplantation modulates neuroinflammatory milieu in a mouse model of amyotrophic lateral sclerosis. (jamanetwork.com)
  • Depending on the patient's medical condition, a refractory disease patient also requires an on-time selective option, such as less invasive cellular therapy options or curative organ transplantation that can function immediately after transplantation. (frontiersin.org)
  • In some instances, these tumors originate from transformed HSCs that retain the ability to differentiate along multiple lineages, whereas in other instances the origin is a more differentiated progenitor that has acquired an abnormal capacity for self-renewal. (fdocuments.net)
  • Department of Pulmonary and Critical Care Medicine, The Second Affiliated Hospital of Fujian Medical University, Respirology Medicine Centre of Fujian Province, 34 Zhongshanbei Road, Licheng District, Quanzhou, China. (stacksdiscovery.com)
  • 8. Autologous hematopoietic stem cell transplantation in peripheral T-cell lymphoma using a uniform high-dose regimen. (nih.gov)
  • The allogeneic HSCT was the most frequently performed (57.14%) and the most used source of Hematopoietic progenitor cells (HPC) was the peripheral blood (54.29%) and 5.71% of these patients developed the Graft versus Host Disease (GVHD), of which one was affected by acute GVHD and another by chronic GVHD. (bvsalud.org)
  • Articular cartilage regeneration with autologous peripheral blood stem cells versus hyaluronic acid: a randomized controlled trial. (anova-irm.com)
  • 7.Hongeng S., Pakakasama S., Hathirat P., Chaisiripoomkere W., Ungkanont A.Allogeneic peripheral blood stem cell transplantation in a Wiskott-Aldrich syndrome patient [3]. (mahidol.ac.th)
  • PK profile and marked increase of peripheral CD34+ cells after GPC-100 administration support further clinical development of GPC-100 for mobilization of hematopoietic stem/progenitor cells. (gpcr.co.kr)
  • Hematopoietic progenitor cell transplantation is required to prevent potentially fatal complications of the prolonged myelosuppression. (nih.gov)
  • THE "HEAD START 4" Protocol - Newly Diagnosed Children (Less than 10 years Old) with Medulloblastoma and other Central Nervous System Embryonal Tumors: Clinical and Molercular Risk-Tailored Intensive and Compressed Induction Chemotherapy Followed by Consolidation with Either Single Cycle (Low Risk Patients) Or Randomization (High Risk Patients) to Either Single Cycle Or To Thee Tandem Cycles of Marrow-Ablative Chemotherapy with Autologous Hematopoietic Progenitor Cell Rescue. (nicklauschildrens.org)
  • 10. Effect of the dose per body weight of conditioning chemotherapy on severity of mucositis and risk of relapse after autologous haematopoietic stem cell transplantation in relapsed diffuse large B cell lymphoma. (nih.gov)
  • Allogeneic haematopoietic stem-cell transplantation versus gene therapy for haemoglobinopathies. (ucsf.edu)
  • 6. Consolidative involved field radiotherapy after high dose chemotherapy and autologous stem cell transplantation for non-Hodgkin's lymphoma: a case-control study. (nih.gov)
  • Multicenter Long-Term Follow-Up of Allogeneic Hematopoietic Cell Transplantation with Omidubicel: A Pooled Analysis of Five Prospective Clinical Trials. (ucsf.edu)
  • Aetna considers allogeneic hematopoietic cell transplantation medically necessary for the treatment of persons with relapsed NHL (including persons who have relapsed after autologous hematopoietic cell transplantation) or primary refractory (see "Note" below) NHL (low-grade, intermediate-grade, and high-grade) if the person meets the transplanting institution's protocol eligibility criteria. (aetna.com)
  • Aetna considers non-myeloablative allogeneic hematopoietic cell transplantation medically necessary ("mini-transplant", reduced intensity conditioning transplant) for the treatment of persons with relapsed NHL (including persons who have relapsed after ABMT) or primary refractory (see note below) NHL (low-grade, intermediate-grade, and high-grade) when they are eligible for conventional allografting or a reduced intensity regimen is preferred by the transplant center. (aetna.com)
  • 5. Lung function, pulmonary complications, and mortality after allogeneic blood and marrow transplantation in children. (nih.gov)
  • 11. Analysis of risk factors for outcomes after unrelated cord blood transplantation in adults with lymphoid malignancies: a study by the Eurocord-Netcord and lymphoma working party of the European group for blood and marrow transplantation. (nih.gov)
  • Enrollment Lessons from a Biological Assignment Study of Marrow Transplantation versus Standard Care for Adolescents and Young Adults with Sickle Cell Disease: Considerations for Future Gene and Cellular Therapy Trials. (ucsf.edu)
  • These projects cover a broad spectrum of science and new technologies, and have the potential to advance understanding and treatment of common diseases - including diabetes, anemia, corneal and other eye diseases, and chronic skin ulcers -- as well as rare diseases, including idiopathic pulmonary fibrosis, inherited skin diseases, and sickle cell disease. (nih.gov)
  • Microengineered 3D pulmonary interstitial mimetics highlight a critical role for matrix degradation in idiopathic pulmonary fibrosis. (umich.edu)
  • Aetna considers tandem autologous hematopoietic cell transplantion (auto-auto) or tandem autologous hematopoietic cell transplantation followed by allogenic hematopoietic cell transplantation (auto-allo) experimental and investigational for NHL due to a lack of adequate evidence in the peer-reviewed published medical literature of their safety and effectiveness. (aetna.com)
  • Right ventricular (RV) function is well-established as 1 of the main prognostic risk factors in patients with pulmonary arterial hypertension (PAH). (pulmonologyadvisor.com)
  • Althoughthere is evidence that allogeneic transplantation can lead to long-termdisease remissions in patients with aplastic anemia and coincidental autoimmunedisease, given the 20% to 30% treatment-related mortality, it is unlikelythat this approach can be justified for the majority of patients with autoimmunedisease. (cancernetwork.com)
  • Furthermore, the success of clear visualization of the pulmonary veins enabled us to perform epicardial ablation. (biomedcentral.com)
  • There were five treatment related deaths (7%) from pneumonitis (2) and veno-occlusive disease, pulmonary hemorrhage and sepsis (1 each). (nih.gov)
  • and the delineation of immune factors affecting allogeneic transplantation, including prevention and treatment of GVHD. (nih.gov)
  • 3] Sinceapproaches to remove lymphocytes that have little impact on treatment-relatedtoxicity are available,[4] the theoretical benefit from these purging proceduresseems to be warranted if autologous transplantation is used. (cancernetwork.com)
  • The WG was composed of basic and clinical researchers with HIV, CV, pulmonary, and hematologic scientific expertise. (nih.gov)
  • The present study was a randomized controlled trial designed to determine the impact of intracoronary autologous BMC transfer on LV remodeling and functional regeneration in patients after AMI and successful percutaneous coronary intervention (PCI). (medscape.com)
  • As the disease progresses, the "RV remodeling shifts from an adaptive to a maladaptive state that includes RV dilatation, decreased contractility, and VA uncoupling," according to a recent review published in Pulmonary Circulation . (pulmonologyadvisor.com)
  • Since it remains unclear whether allogeneic transplantation will berequired for reversal of human autoimmune diseases, it seems prudent tofirst test its efficacy using the least toxic procedure. (cancernetwork.com)
  • a) The trans-differentiation capacity of MSCs into neuronal and glial lineages both in vitro and in vivo was described as the probable explanation for their beneficial outcome after transplantation into the CNS, although this concept remains still unclear. (anova-irm.com)