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  • lesions
  • We found that the majority of cases of histiocytic and dendritic cell neoplasms, including histiocytic sarcoma, follicular dendritic cell sarcoma, Langerhans cell histiocytosis, and interdigitating dendritic cell sarcoma, show strong EZH2 expression by immunohistochemical staining, in contrast to benign histiocytic lesions and normal cellular counterparts, which did not show EZH2 expression, suggesting that this molecule may function as an oncogenic protein in these neoplasms. (readbyqxmd.com)
  • Biopsy
  • An aetiological investigation was performed, and a bone marrow (BM) biopsy and aspirate showed a hypercellular marrow with hypereosinophilia without dysmorphia or abnormal elements, and the BM and inguinal node's immunophenotyping denied any presence of abnormal lymphoid cell population. (readbyqxmd.com)
  • PLCH
  • Although PLCH has generally been considered an acquired benign disorder, recent evidence suggests that at least a subset of these patients have a clonal proliferative disorder of mutated cells including the BRAF V600E mutation. (oncologynurseadvisor.com)