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  • tuberous scleros
  • In her case, LAM was not associated with tuberous sclerosis complex. (springer.com)
  • LAM can occur in women with tuberous sclerosis complex (TSC) or in women who have [no signs of TSC (sporadic LAM). (grantome.com)
  • LAM occurs in about one third of women with tuberous sclerosis complex (TSC), an autosomal dominant syndrome characterized by hamartoma-like tumor growths in various organs, cerebral calcifications, seizures, and mental retardation, that occurs in one of 5800 live births. (atlasgeneticsoncology.org)
  • PLCH
  • Check-valve obstruction with subsequent distal over-inflation is one of the most widely known pathways leading to CLD and has been linked to diseases such as FB, metastatic neoplasm, pneumatocele, LAM, and PLCH [ 6 - 10 ]. (kjim.org)
  • LAM, PLCH, and light chain deposit disease (LCDD) are representative diseases that develop via this mechanism. (kjim.org)
  • Although PLCH has generally been considered an acquired benign disorder, recent evidence suggests that at least a subset of these patients have a clonal proliferative disorder of mutated cells including the BRAF V600E mutation. (oncologynurseadvisor.com)
  • interstitium
  • To be accurate, however, ILD comprises a broader range of lung diseases which involves the pulmonary interstitium, including drug-induced pneumonitis and eosinophilic pneumonia, etc. (intechopen.com)
  • The lymphatic vascular system serves key physiological functions: it maintains fluid homeostasis by absorbing water and macromolecules from the interstitium, enables uptake of dietary lipids and vitamins in the intestine, and serves as a trafficking route for immune cells. (rupress.org)
  • A) The lymphatic vasculature resorbs fluid, macromolecules, and cells from the interstitium. (rupress.org)
  • Free overlapping cell edges anchored on each side by these junctions form "flap valves" ( Fig. 1, B and C ) through which fluid flows unidirectionally along pressure gradients from the interstitium into the capillary lumen. (rupress.org)
  • fibrosis
  • Smad3 Deficiency Attenuates Bleomycin-induced Pulmonary Fibrosis in Mice American Journal of Physiology. (jove.com)
  • Using mice without Smad3 gene expression, we investigated whether Smad3 could regulate bleomycin-induced pulmonary fibrosis in vivo. (jove.com)
  • Furthermore, loss of Smad3 greatly attenuated morphological fibrotic responses to bleomycin in the mouse lungs, suggesting that Smad3 is implicated in the pathogenesis of pulmonary fibrosis. (jove.com)
  • angiomyolipoma
  • To determine whether LAM cells and angiomyolipoma cells have identical clonality patterns. (grantome.com)
  • A natural corollary of this goal is to test the hypothesis that LAM and angiomyolipoma cells are derived from the same precursor cell. (grantome.com)
  • LAM usually presents with progressive breathlessness or with spontaneous recurrent pneumothorax, chylous effusions (chylothorax and ascites), or hemorrhage within an angiomyolipoma. (atlasgeneticsoncology.org)
  • patients
  • Up to 20% of patients may have normal pulmonary function tests at presentation. (oncologynurseadvisor.com)
  • The primary focus of my laboratory is to understand alterations in the immune system (natural killer cells, T cells, dendritic cells and macrophage) of smokers and COPD patients and how these alterations in immunity affect susceptibility to exacerbations. (uc.edu)
  • Autologous administration of bone marrow mononuclear cells (BMMC) has been performed in over 2000 cardiac patients without adverse effects, for stimulation of angiogenesis/regeneration. (biomedcentral.com)
  • Our upcoming Clinical Trial to Examine Drug Combination as Treatment for LAM Patients was reported in the Office of Public Relations. (uc.edu)
  • sirolimus
  • Due to pulmonary function alterations, sirolimus was also reinitiated in 2017 in conjunction with nivolumab, without any undesirable effects and a major partial response continuing up to May 2018. (springer.com)
  • endothelial cells
  • Nanomaterials are known to translocate into the circulation and could thus directly affect vascular endothelial cells (ECs), causing vascular injury that might be responsible for the development of atherosclerosis. (physiology.org)
  • Key to this response is production of nitric oxide (NO) from endothelial cells and nonadrenergic noncholinergic (NANC) postganglionic parasympathetic neurons, as well as responsiveness to this. (biomedcentral.com)
  • Oak leaf-shaped endothelial cells are connected by discontinuous buttonlike junctions. (rupress.org)
  • predominantly
  • IL-17A was predominantly secreted by γδT cells (especially the Vγ4 + γδT subset), but not CD4 + Th and CD8 + Tc cells at the early stage of infection, and IL-1β and/or IL-23 were sufficient to induce IL-17A production by γδT cells. (pubmedcentralcanada.ca)
  • antibodies
  • PD-1 blocking antibodies constitute an essential treatment option for advanced non-small-cell lung cancer (NSCLC). (springer.com)
  • Both types of cells react with antibodies against smooth muscle cell-specific antigens (e.g., smooth muscle a-actin, vimentin , desmin) (Figure 5). (atlasgeneticsoncology.org)
  • We have developed unique transgenic mouse models, reporter-cell lines and antibodies as part of our research. (uc.edu)
  • systemic
  • The bone marrow serves as a continuous supply of circulating endothelial progenitor cells (EPC) for the systemic vasculature. (biomedcentral.com)