• Chronic infection of the respiratory tract is nearly universal in people with cystic fibrosis, with Pseudomonas aeruginosa, fungi, and mycobacteria all increasingly common over time. (wikipedia.org)
  • Subacute and acute endocarditis due to Pseudomonas cepacia in heroin addicts. (medscape.com)
  • Pseudomonas cepacia endocarditis treated with co-trimoxazole and kanamycin. (medscape.com)
  • Age, sex, p.F508del mutation, percentage of baseline forced expiratory volume in the first second, baseline body mass index Z-score, chronic Pseudomonas aeruginosa, methicillin-resistant Staphylococcus aureus and Burkholderia cepacia complex colonization (Leeds criteria), percentage of cystic fibrosis-related diabetes, and recovery of baseline forced expiratory volume in the first second were recorded. (ox.ac.uk)
  • In the 1980s it was discovered that some relatives of the bacterium Burkholderia cepacia (formerly Pseudomonas cepacia) were able to form close relationships with plant roots, and also make a range of antimicrobials capable of killing plant pathogens. (thesciencebreaker.org)
  • Patients with cystic fibrosis periodically experience pulmonary exacerbations. (nih.gov)
  • Progressive lung disease secondary to chronic airway infection and inflammation is the leading cause of morbidity and mortality in cystic fibrosis (CF) [ 1 ]. (ersjournals.com)
  • To determine risk factors for acquiring Burkholderia cepacia complex among patients with cystic fibrosis (CF). (nih.gov)
  • The other part discusses diverse sensors that have been developed and used for the detection of respiratory diseases ( e.g. chronic obstructive pulmonary disease, asthma, lung cancer, pulmonary arterial hypertension, tuberculosis, cystic fibrosis, obstructive sleep apnoea syndrome and pneumoconiosis) by analysis of VOCs in exhaled breath. (ersjournals.com)
  • B cepacia ordinarily is not a pathogen in the ambulatory setting, but it may colonize and/or infect the respiratory tract of patients with cystic fibrosis or bronchiectasis. (medscape.com)
  • According to the US Cystic Fibrosis Foundation's 2021 National Patient Registry , 1.4% percent of all persons with cystic fibrosis were infected with B cepacia complex compared to 2.6% in 2012. (medscape.com)
  • Mortality and morbidity are highest in those with impaired pulmonary function (eg, cystic fibrosis, bronchiectasis, chronic granulomatosis disease). (medscape.com)
  • Transplantation of patients with underlying cystic fibrosis (CF), whose native airways and sinuses are chronically infected with virulent bacterial pathogens, initially raised unique concerns about the potential excessive risk of postoperative infections. (ersjournals.com)
  • Risk factors associated with pulmonary exacerbations in pediatric patients with cystic fibrosis. (ox.ac.uk)
  • INTRODUCTION: Cystic fibrosis patients develop pulmonary exacerbations (PEs) that require intravenous treatment. (ox.ac.uk)
  • 7%), a therapeutic intervention for patients with CF, is believed to target a direct consequence of cystic fibrosis transmembrane conductance regulator (CFTR) dysfunction, airway surface dehydration, and has previously been shown to increase mucociliary clearance, improve FEV 1 and decrease the number of pulmonary exacerbations. (bmj.com)
  • The Burkholderia cepacia complex (Bcc) is a group of Gram-negative opportunistic pathogens causing infections in people with cystic fibrosis (CF). Bcc is highly antibiotic resistant, making conventional antibiotic treatment problematic. (cnr.it)
  • Of 8,479 pulmonary exacerbations, 25% failed to recover to baseline FEV(1). (nih.gov)
  • R. paucula and R. gilardii have zation of the large airways, leading to exacerbations of pulmo- only sporadically been isolated from human clinical samples, nary infection, is the major cause of illness and death in CF including cerebrospinal fluid, bone marrow, wounds, and the patients. (cdc.gov)
  • In multivariate analyses, hospitalization for pulmonary exacerbations, living with a B cepacia complex-positive person, attending a CF summer camp, and direct contact with a B cepacia complex-colonized CF person outside of camp and home were associated with B cepacia complex acquisition. (nih.gov)
  • The findings show a significantly slower disease progression with an 18% increase in people with mild lung disease and 19% fewer hospitalizations or home intravenous antibiotics for pulmonary exacerbations. (cysticfibrosis.ca)
  • However, in some other indications, including chronic obstructive pulmonary disease (COPD), this remains less clear because a substantial improvement in quality of life may not be matched by an increase in overall survival. (ersjournals.com)
  • The causes of growth failure are multi-factorial and include chronic lung infection, poor absorption of nutrients through the gastrointestinal tract, and increased metabolic demand due to chronic illness. (blogspot.com)
  • This control group thus consists of patients with chronic Bcc infection and act as case controls for patients with acute infection. (medscape.com)
  • Three of the four control patients were also previously maintained on inhaled tobramycin for chronic PsA infection. (medscape.com)
  • How Accurate Is the Diagnosis of "Chronic Obstructive Pulmonary Disease" in Patients Hospitalized with an Acute Exacerbation? (huji.ac.il)
  • Because of the history and types of infection, a work-up for immunodeficiency was undertaken and the child was found to have chronic granulomatous disease. (mhmedical.com)
  • Chronic granulomatous disease (CGD) is the result of impaired intracellular microbial killing by phagocytes leading to formation of granulomata and recurrent infections with bacteria and fungi. (mhmedical.com)
  • causes bacterial meningitis, fulminating septicaemia, pulmonary and ophthalmic infections, chronic synovitis (joint pain/inflammation), skin diseases, wound infections and postoperative urinary tract infections. (microgeninc.com)
  • These opportunistic anaerobic bacteria may also cause bed sores, pressure sores, aspiration pneumonia, chronic otitis media (ear infection), chronic sinusitis, and osteomyelitis (bone infection). (microgeninc.com)
  • Environmental opportunistic pathogens, including B. cepacia complex, might be included in regular surveillance as indicator organisms for monitoring environmental contamination. (cdc.gov)
  • are the pathogens most frequently cultured from CF airway samples and are associated with pulmonary decline [ 2 ]. (ersjournals.com)
  • Signs and symptoms of B cepacia infections are related to the organ system involved and are indistinguishable from infections with other pathogens. (medscape.com)
  • A diverse range of pathogens were encountered, including the Burkholderia cepacia complex (BCC). (ncl.ac.uk)
  • This term reflects the inability to determine with certainty where the pathogen is acquired since patients may be colonized with or exposed to potential pathogens outside of the healthcare setting, before receiving health care, or may develop infections caused by those pathogens when exposed to the conditions associated with delivery of healthcare. (cdc.gov)
  • Other gram-adverse pathogens (eg, Enterobacter species, Serratia species, Stenotrophomonas maltophilia, Burkholderia cepacia) not often cause CAP in sufferers with out underlying lung disease or immunosuppression. (sneakersaleoutlet.com)
  • The most frequently identified pathogens in polymicrobial infections had been S pneumoniae, respiratory viruses, and P aeruginosa. (sneakersaleoutlet.com)
  • Infection-adapted emergency hematopoiesis promotes visceral leishmaniasis PLoS Pathogens , vol. 13 , nº 8: e1006422. (inrs.ca)
  • A detailed past medical history reveals several recurrent infections including pneumonia and lymph node abscesses growing Staphylococcus aureus and Burkholderia cepacia . (mhmedical.com)
  • To determine the proportion of patients treated for a pulmonary exacerbation that does not recover to spirometric baseline, and to identify factors associated with the failure to recover to spirometric baseline. (nih.gov)
  • We randomly selected one pulmonary exacerbation treated with intravenous antibiotics per patient and compared the best FEV(1) in the 3 months after treatment with the best FEV(1) in the 6 months before treatment. (nih.gov)
  • For a randomly selected pulmonary exacerbation, 25% of patients' pulmonary function did not recover to baseline after treatment with intravenous antibiotics. (nih.gov)
  • Microbiota communities were distinct in CF compared with disease controls, but did not differ based on pulmonary exacerbation status in CF. (ersjournals.com)
  • these patients were treated based on guidelines for pulmonary exacerbation and were considered as contemporaneous controls. (medscape.com)
  • B cepacia nosocomial pneumonia has rarely been reported, usually in patients treated with fluoroquinolones and ceftazidime. (medscape.com)
  • Moisturizing body milk as a reservoir of Burkholderia cepacia: outbreak of nosocomial infection in a multidisciplinary intensive care unit. (medscape.com)
  • The term nosocomial infection is retained to refer only to infections acquired in hospitals. (cdc.gov)
  • Acinetobacter baumannii is an opportunistic pathogen that causes serious nosocomial infection in intensive care units. (biomedcentral.com)
  • Acinetobacter baumannii , a Gram-negative coccobacillus, is an important global nosocomial pathogen species that causes infections such as bacteremia, pneumonia, urinary tract infections, wound infections, and meningitis in critically immunocompromised patients in intensive care units (ICUs) [ 5 ]. (biomedcentral.com)
  • It is one of the major causes of infection persistence especially in nosocomial settings through indwelling devices. (biomedcentral.com)
  • Although the lungs are generally histologically normal at birth, most patients develop pulmonary disease beginning in infancy or early childhood. (msdmanuals.com)
  • By using next-generation sequencing, we documented a polyclonal B. cepacia complex outbreak affecting peritoneal dialysis patients in Hong Kong that was caused by contaminated chlorhexidine solutions. (cdc.gov)
  • Characteristics and outcome predictors of patients involved in an outbreak of Burkholderia cepacia complex. (medscape.com)
  • Outbreak of Burkholderia cepacia complex among ventilated pediatric patients linked to hospital sinks. (medscape.com)
  • In March 2018, the US Food and Drug Administration (FDA), US Centers for Disease Control and Prevention, California Department of Public Health, Los Angeles County Department of Public Health and Pennsylvania Department of Health initiated an investigation of an outbreak of Burkholderia cepacia complex (Bcc) infections. (cdc.gov)
  • Although passive transfer of occult infection with the transplanted organ is an additional concern, the presence of organisms on Gram stain of donor bronchial washings is not predictive of subsequent pneumonia in the recipient 4 . (ersjournals.com)
  • Composition of pulmonary microbiome of patients with severe pneumonia is poorly known. (bvsalud.org)
  • In certain patients admitted to the ICU, the microbial etiology of pneumonia could also be complex. (sneakersaleoutlet.com)
  • This study is the first report to compare in vivo evaluations ( G. mellonella larvae and a mouse acute pneumonia model) of the therapeutic efficacy of a phage against CRAB infections. (biomedcentral.com)
  • If an intravenous infusate contains high numbers of B cepacia , direct injection into the bloodstream may result in gram-negative bacteremia. (medscape.com)
  • Clinical characteristics and outcomes of patients with Burkholderia cepacia bacteremia in an intensive care unit. (medscape.com)
  • Lung infections are treated with antibiotics which may be given intravenously, inhaled, or by mouth. (wikipedia.org)
  • This typically begins as a prolonged respiratory infection that continues until treated with antibiotics. (wikipedia.org)
  • 1] Difficulty breathing is the most serious symptom and results from frequent lung infections that are treated with, though not cured by, antibiotics and other medications. (blogspot.com)
  • Patients receiving oral antibiotics could also be admitted for hospital companies (eg, pulmonary bathroom and additional diagnostic tests) that aren't obtainable on an outpatient basis. (sneakersaleoutlet.com)
  • Despite being on antibiotics, and being completely asymptomatic, he seeded the infection to his vascular graft. (escientificpublishers.com)
  • Carbapenems have been the most effective antibiotics against the serious infections caused by Acinetobacter spp. (biomedcentral.com)
  • Therefore, biofilm matrix gives the additional resistance power to bacteria which makes them to not only tolerate harsh conditions but also resistant to antibiotics which lead to the emergence of bad bugs infections like multi drug resistant, extensively drug resistant and totally drug resistant bacteria. (biomedcentral.com)
  • Of these compounds some are already approved by official agencies, some are still in study, but the need of new antibiotics still does not cover the increasing prevalence of antibiotic-resistant bacterial infections. (biomedcentral.com)
  • Lung disease is characterized by recurrent and alternative cycles of airway infection and inflammation, leading to bronchiectasis and subsequently to respiratory failure where lung transplantation may constitute the ultimate therapeutic option [ 2 ]. (biomedcentral.com)
  • A case-control study was conducted with active surveillance for B cepacia complex colonization/infection among patients at 21 CF centers from April 1986 to March 1989 (study period). (nih.gov)
  • A case-patient was defined as any CF patient with B cepacia complex colonization for the first time during the study period. (nih.gov)
  • CF sputum samples are now known to contain complex bacterial communities, including facultative and obligate anaerobic organisms [ 10 - 12 ]. (ersjournals.com)
  • Indeed, these species xylosoxidans , B. gladioli, and R. pickettii have been recovered are frequently misidentified as P. fluorescens or B. cepacia from sputum cultures of CF patients as well (2,3). (cdc.gov)
  • The current picture mirrors early reports of MDR tuberculosis in HIV infection in that mortality is very high among HIV-infected patients: In the original South African study from KwaZulu Natal, survival was less than 3 weeks from the time of receipt of the first sputum sample. (clinicalgate.com)
  • Concurrently, with his acute presentation, he was found to have an underlying infection, diagnosed to be from Burkholderia Pseudomallei. (escientificpublishers.com)
  • Changes in acute pulmonary vascular responsiveness to hypoxia during a progressive ascent to high altitude (5300 m). (cmdm.tw)
  • R. pickettii has been associated with noso- by the referring microbiology laboratory as B. cepacia com- comial outbreaks caused by contaminated solutions used for plex or a related species or were not identified to the species patient care and with pseudoepidemics caused by contami- level. (cdc.gov)
  • Conclusion: Lung transplantation is an important therapeutic option in patients with CF even in those with more complex microbiology. (ncl.ac.uk)
  • Yilmaz T, Celik I, Cihangiroglu M, Yildirim S, Akbulut A. Burkholderia cepacia: An unusual cause of postoperative endophthalmitis. (medscape.com)
  • In contrast, the presence of Burkholderia cepacia has been associated with a high risk of severe and often lethal postoperative infections, and consequently, with inferior survival rates. (ersjournals.com)
  • 15][16] Inflammation and infection will cause injury and structural changes to the lungs, leading to a variety of symptoms. (blogspot.com)
  • Association of air pollution sources and aldehydes with biomarkers of blood coagulation, pulmonary inflammation, and systemic oxidative stress. (cmdm.tw)
  • Therefore, as these tests, they simply ignore critical characteristics of real-life infections when at the site of infection, for example in the lungs, the lead pathogen is surrounded by dozens of other bacteria that interact with them. (consultant360.com)
  • Background: The most common 'second strike' in mechanically ventilated patients is a pulmonary infection caused by the ease with which bacteria can invade and colonize the lungs due to mechanical ventilation. (bvsalud.org)
  • To reduce the development of drug-resistant bacteria and maintain the effectiveness of RECARBRIO and other antibacterial drugs, RECARBRIO should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria. (nih.gov)
  • described the show of ac tive P. aeruginosa and B. cepacia lipases about the surface of E. coli through co expression of lipase as well as the Lif protein within a single fusion protein. (pkainhibitors.com)
  • The type and reference strains of Ralstonia , Pandoraea , Burkholderia , Alcaligenes , and Bordetella species have been described (9-14). (cdc.gov)
  • Pseudoalteromonas haloplanktis produces methylamine, a volatile compound active against Burkholderia cepacia complex strains. (cmdm.tw)
  • Patients with BCC infection had poorer outcomes and represented the majority of those who had a septic death. (ncl.ac.uk)
  • In late adolescence or adulthood, people begin to develop severe signs of lung disease: wheezing, digital clubbing, cyanosis, coughing up blood, pulmonary heart disease, and collapsed lung (atelectasis or pneumothorax). (wikipedia.org)
  • CF) and the role of these species in CF pulmonary disease are not well documented. (cdc.gov)
  • Although CF is a multisystemic disease, the clinical picture is generally dominated by pulmonary involvement, the main cause of morbidity and mortality in this disease. (biomedcentral.com)
  • Danai Khemasuwan, MD, FCCP, is an assistant professor in the Department of Internal Medicine in the Division of Pulmonary Disease and Critical Care Medicine at Virginia Commonwealth University in Richmond, VA. (consultant360.com)
  • Long-term issues include difficulty breathing and coughing up mucus as a result of frequent lung infections. (wikipedia.org)
  • This leads to the buildup of thick, sticky mucus, which can lead to infections in the lungs and damage to the pancreas. (cysticfibrosis.ca)
  • Results: Compared to groups C and SV, critical pathological changes in pulmonary lesions occurred in the MV group after 6 h (p (bvsalud.org)
  • Results Construction in the plasmid for autodisplay of lipase By analyzing the amino acid sequence of B. cepacia ATCC 21808 lipase employing the SignalP personal computer program, a classical signal peptide was recognized at its N terminus. (pkainhibitors.com)
  • The pathophysiology of B cepacia infection mirrors that of other nonfermentative aerobic gram-negative bacilli. (medscape.com)
  • causes severe respiratory infections in the immunocompromised. (microgeninc.com)
  • Polymicrobial infection was common in individual recipients. (ncl.ac.uk)
  • Infections in CF patients are considered to be polymicrobial [ 3 ]. (biomedcentral.com)
  • Two recent series from North American centres with extensive experience in transplantation of CF patients have documented 1-yr survival rates of 50% versus 83% and 67% versus 96% among CF patients with and without B. cepacia , respectively 7 , 8 . (ersjournals.com)
  • When successful, the procedure is also associated with a marked improvement in quality of life and a proven survival advantage in patients with CF, idiopathic pulmonary fibrosis and pulmonary hypertension. (ersjournals.com)
  • In the evaluation of its therapeutic potential against CRAB clinical isolates using two in vivo models, phage Βϕ-R2096 increased the survival rates of both G. mellonella larvae (from 0 to 50% at 24 h) and mice (from 30% with MOI = 0.1 to 100% with MOI = 10 for 12 days) in post-infection of CRAB. (biomedcentral.com)
  • Burkholderia cepacia is the type species of the genus Burkholderia and is a ubiquitous multidrug-resistant, motile, non-glucose-fermenting, gram-negative organism found in water and soil ( 1 ). (cdc.gov)
  • R. mannitoli- lytica and R. pickettii in particular may be misidentified as other closely related species, particularly those of the Burkholderia cepacia complex. (cdc.gov)
  • 5-7), but the clinical importance of infection with these other species is less clear. (cdc.gov)
  • Complicated urinary tract infections, including pyelonephritis (cUTI) in patients who have limited or no alternative treatment options. (nih.gov)
  • Other signs and symptoms may include sinus infections, poor growth, fatty stool, clubbing of the fingers and toes, and infertility in most males. (wikipedia.org)
  • A multitude of other symptoms, including sinus infections, poor growth, diarrhea, and infertility result from the effects of CF on other parts of the body. (blogspot.com)
  • These recommendations evolved from observations during the SARS epidemic that failure to implement basic source control measures with patients, visitors, and healthcare personnel with signs and symptoms of respiratory tract infection may have contributed to SARS coronavirus (SARS-CoV) transmission. (cdc.gov)
  • In addition, patients with atypical CAP may present with more subtle pulmonary findings, nonlobar infiltrates on radiography, and various extrapulmonary manifestations (eg, diarrhea, otalgia). (medscape.com)
  • Bacterial infections of the lower respiratory tract comprise the majority of infectious complications and have a bimodal temporal distribution. (ersjournals.com)
  • Garlic ( Allium sativum ), a popular food spice and flavoring agent, has also been used traditionally to treat various ailments especially bacterial infections for centuries in various cultures around the world. (frontiersin.org)
  • Based on phenotypic and genotypic analyses, B cepacia is divided into 9 genomovars that constitute the B cepacia complex (BCC). (medscape.com)
  • In other instances, the tests can be more invasive (endoscopy, pulmonary catheterisation, biopsy and bone marrow tests) and, therefore, run the risk of complications to the patients screened and/or require special facilities (such as CT) with healthcare professionals operating the instruments [ 8 ]. (ersjournals.com)
  • Diagnostic bronchoalveolar lavage and serological tests confirmed the presence of invasive pulmonary aspergillosis and the patient was placed on appropriate antifungal treatment. (mhmedical.com)
  • Infection is an ever-present threat to the well-being of the lung transplant recipient and is a leading cause of both early and late mortality. (ersjournals.com)
  • causes a rare infection of the lungs and is associated with asthma. (microgeninc.com)
  • Originally described in South Africa in association with HIV infection, XDR tuberculosis has now been identified worldwide. (clinicalgate.com)
  • Randomized Clinical Trial: Esomeprazole, Bismuth, Levofloxacin, and Amoxicillin or Cefuroxime as First-Line Eradication Regimens for Helicobacter pylori Infection. (cmdm.tw)
  • Burkholderia cepacia is an aerobic gram-negative bacillus found in various aquatic environments. (medscape.com)