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  • Fibrotic
  • Infections Certain medications, e.g. amiodarone, bleomycin (pingyangmycin), busulfan, methotrexate, apomorphine, and nitrofurantoin Radiation therapy to the chest Pulmonary fibrosis involves gradual exchange of normal lung parenchyma with fibrotic tissue. (wikipedia.org)
  • cystic
  • 1983: First successful long-term single lung transplant (Tom Hall) by Joel Cooper (Toronto) 1986: First successful long-term double lung transplant (Ann Harrison) by Joel D. Cooper (Toronto) 1988: First successful long-term double lung transplant for cystic fibrosis by Joel Cooper (Toronto). (wikipedia.org)
  • There are also certain cases where pre-existing infection is unavoidable, as with many patients with cystic fibrosis. (wikipedia.org)
  • excess fibrous connec
  • Scar formation, the accumulation of excess fibrous connective tissue (the process called fibrosis), leads to thickening of the walls, and causes reduced oxygen supply in the blood. (wikipedia.org)
  • Oxygen
  • Pulmonary function tests (PFTs) will show how much oxygen your body is getting. (drugs.com)
  • The replacement of normal lung with scar tissue causes irreversible decrease in oxygen diffusion capacity, and the resulting stiffness or decreased compliance makes pulmonary fibrosis a restrictive lung disease. (wikipedia.org)
  • Some of these features are due to chronic hypoxemia (oxygen deficiency in the blood), are not specific for IPF, and can occur in other pulmonary disorders. (wikipedia.org)
  • Due to the oxygen sensitive nature of bleomycin, and the theorised increased likelihood of developing pulmonary fibrosis following supplemental oxygen therapy, it has been questioned whether patients should take part in scuba diving following treatment with the drug. (wikipedia.org)
  • abnormal
  • Clubbing of the digits, a disfigurement of the finger tips or toes (see image) Abnormal pulmonary function test results, with evidence of restriction and impaired gas exchange. (wikipedia.org)
  • genetics
  • Researches currently believe that a combination of exposure to lung irritants like certain chemicals, smoking, and infections, along with genetics and immune system activity, play key roles in pulmonary fibrosis. (healthline.com)
  • researchers
  • In an article published online by Frontiers in Endocrinology, researchers at the Medical University of South Carolina report that they have identified a potential therapeutic target for lung fibrosis or scarring. (news-medical.net)
  • 1997
  • In: American Thoracic Society Continuing Education Monograph Series: 'Cytokines and Pulmonary Infection,' Pratter, MR, Nelson, S (eds) 1997. (uptodate.com)