AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentHealth Care
Pulmonary AspergillosisAspergillosisLung Diseases, FungalHemoptysisAspergillosis, Allergic BronchopulmonaryThoracoplastyAspergillus fumigatusNeuroaspergillosisPulmonary Surgical ProceduresParanasal Sinus DiseasesAspergillusAntigens, FungalLung AbscessItraconazoleAntibodies, FungalCranial Fossa, AnteriorPneumonectomyInfusions, IntralesionalMycetomaOrbital DiseasesAspergillus flavusBronchiectasisHydroxycorticosteroidsBronchogenic CystAntifungal AgentsUreterostomyOpportunistic InfectionsAmphotericin BTuberculosis, PulmonaryBronchoscopyRadiography, ThoracicTomography, X-Ray ComputedTreatment OutcomeLungRetrospective StudiesPostoperative ComplicationsImmunoglobulin G
AspergillosisTuberculosisInvasiveFungusHemoptysisFungalInfectionColonizationCases of aspergillomaDiagnosis of pulmonaryClinicalBronchiectasisBronchialCOPDLesionABPAOccursInterstitialGranulomatous inflammationLungsSignificant morbidityOutcomesIntracavitaryAcuteCavityHypertensionComputed tomographyIdiopathicFibrosisBronchoscopySevereDiseaseSarcomaNodulesSymptomaticSarcoidosisPathologyFindings
Aspergillosis30
Tuberculosis15
  • [1] Aspergilloma occurs in 10-15% of patients with cavitating lung diseases like tuberculosis, sarcoidosis, bronchiectasis, cysts and bullae. (atmph.org)
  • She had suffered from pulmonary tuberculosis 3 years back for which she received complete course of antitubercular therapy. (atmph.org)
  • Aspergilloma mainly affects people with underlying cavitary lung disease such as tuberculosis, sarcoidosis, bronchiectasis, cystic fibrosis and systemic immunodeficiency. (wikipedia.org)
  • citation needed] Treatment of diseases which increase the risk of aspergilloma, such as tuberculosis, may help to prevent their formation. (wikipedia.org)
  • The ERR contains state-of-the-art review articles, editorials and correspondence, in addition to summaries of the most important recent research findings and published studies in topics such as COPD, asthma, pulmonary hypertension, interstitial lung disease, lung cancer, tuberculosis and pulmonary infections. (ers-education.org)
  • Initial infections that are not contained may cause either progressive local disease (primary progressive pulmonary tuberculosis), or may disseminate hematogenously to seed other organs such as kidney, CNS, or bones, occasionally causing miliary tuberculosis. (medscape.com)
  • Primary pulmonary tuberculosis results from initial infection with tubercle bacilli. (medscape.com)
  • Pulmonary lesions progress to tuberculous pneumonia, cavitate, and can shed tubercle bacilli into bloodstream and result in miliary tuberculosis. (medscape.com)
  • A lower body mass index, interstitial lung disease, prior pulmonary tuberculosis, larger clinical target volume, history of lung cancer surgery or radiation pneumonitis, and use of inhaled corticosteroids were independent risk factors for CPI development. (e-crt.org)
  • With decreasing incidence of tuberculosis, surgery is now less challenging for aspergilloma, with improved outcome, during past three decades. (ijsurgery.com)
  • Presenting here is a case of giant aspergilloma involving the left upper and middle lobe, which had been progressively increasing since 15 years, in a patient with no history of tuberculosis, with two more cases, along with symptoms and signs, operative and perioperative management, as well as literature review of this rare, clinically important entity. (ijsurgery.com)
  • In India where tuberculosis (TB) is rampant (second highest in Asia), post tuberculosis patient presenting with aspergilloma is common in our scenario. (jmas.in)
  • The symptoms include fever, cough, chest pain, or breathlessness, which also occur in many other illnesses such as tuberculosis or chronic obstructive pulmonary disease (COPD) , but with otherwise healthy immune systems. (moldsafeinspections.com)
  • Tuberculosis and pulmonary candidiasis co-infection present in a previously healthy patient. (vestnikdv.ru)
  • Patients who already have lung damage and cavities, most frequently as a result of a previous case of tuberculosis or sarcoidosis, are more likely to develop aspergilloma or mycetoma. (sifisheriessciences.com)
Invasive1
Fungus8
  • Aspergillus species can colonize preexisting pulmonary cavities, resulting in an intracavitary fungus ball (aspergilloma). (johnshopkins.edu)
  • Aspergilloma/Aspergillous mycetoma is the saprophytic colonization of the fungus in a pre-existing cavity of the lung. (atmph.org)
  • 4 Aspergilloma is also called a "fungus ball. (cdc.gov)
  • Aspergilloma, also called fungus ball, is a clump of fungus growing in a cavity, in the lung or a sinus, often a maxillary sinus. (biomedcentral.com)
  • Aspergilloma is aspergillus fungus overgrowth, most frequently in upper respiratory passages or lung, in a spatial configuration. (ijsurgery.com)
  • The fungus mixes with mucus and cellular debris within the lungs to form a aspergilloma or fungal ball. (moldsafeinspections.com)
  • Focal infections, typically in the lung, sometimes form a fungus ball (aspergilloma), a characteristic growth of tangled masses of hyphae, with fibrin exudate and few inflammatory cells, typically encapsulated by fibrous tissue. (msdmanuals.com)
  • Aspergilloma, or fungus ball: Aside from breathing problems, you may also see blood when you cough. (techswizz.net)
Hemoptysis4
  • Bronchoscopy is performed to determine the site of bleeding in persistent hemoptysis associated with aspergilloma or to rule out an alternate cause such as bronchogenic carcinoma. (johnshopkins.edu)
  • In cases complicated by severe hemoptysis or other associated conditions such as pleural empyema or pneumothorax, surgery may be required to remove the aspergilloma and the surrounding lung tissue by doing a lobectomy or other types of resection and thus stop the bleeding. (wikipedia.org)
  • Complications of fibrotic pulmonary sarcoidosis include pulmonary hypertension from capillary obliteration and chronic aspergillus disease, with hemoptysis a common and potentially life-threatening manifestation. (livingwithsarcoidosis.org)
  • hemorrhage arising from the pulmonary microcirculation (e.g., alveolar capillaries , arterioles , and/or venules ) that manifests clinically with hypoxemia , alveolar infiltrates on imaging, and possible hemoptysis. (amboss.com)
Fungal2
  • Pulmonary aspergilloma is a mass caused by a fungal infection. (mountsinai.org)
  • Pulmonary infectious granulomatous inflammation is encountered in fungal, mycobacterial, parasitic and bacterial infections (see below). (medscape.com)
Infection8
  • This study aimed to investigate cumulative incidence and risk factors associated with chronic pulmonary infection (CPI) development after radiotherapy for lung cancer. (e-crt.org)
  • Background: The most common 'second strike' in mechanically ventilated patients is a pulmonary infection caused by the ease with which bacteria can invade and colonize the lungs due to mechanical ventilation. (bvsalud.org)
  • To provide a reference for preventing and treating bacterial flora imbalance and pulmonary infection injury caused by mechanical ventilation of tracheal intubation. (bvsalud.org)
  • At initial stages of SARS-CoV-2 infection, no important alterations in the pulmonary microbiome were observed. (bvsalud.org)
  • Depending on the patient's underlying immunological status, the burden of the organisms, and the underlying condition of the lungs, a pulmonary aspergillus infection might present itself in a number of different ways. (sifisheriessciences.com)
  • In this article, we correlate the radiologic findings of the various pulmonary manifestations of Aspergillus infection with their pathologic aspects to get a deeper comprehension of the disease process and a better understanding of the imaging patterns that are associated with it. (sifisheriessciences.com)
  • 1 serious opportunistic infection other than PML: one had aspergilloma and an atypical mycobacterial infection, and the other had cryptococcal fungemia and cryptococcal meningitis. (tysabrihcp.com)
  • However, chronic pulmonary infection tends to progress and disseminated infections can be fatal. (medscape.com)
Colonization2
Cases of aspergilloma2
  • Most cases of aspergilloma do not require treatment. (wikipedia.org)
  • This study included 26 cases of aspergilloma, over period of 4 years between 2013 and 2017 in TB Hospital Erranum, Hyderabad in the of Department of Car-dio-thoracic Surgery. (jmas.in)
Diagnosis of pulmonary2
  • With a diagnosis of pulmonary aspergilloma, the patient was referred to a higher center for further management. (atmph.org)
  • Diagnosis of pulmonary aspergilloma is usually made based on chest X-ray findings, and the Aspergillus precipitin antibody test results (ie, for IgG) are usually positive. (moldsafeinspections.com)
Clinical4
  • Clinical manifestations and treatment outcomes of pulmonary aspergilloma. (ijsurgery.com)
  • Clinical profile and surgical outcome for pulmonary aspergilloma: a single center experience. (ijsurgery.com)
  • Most patients with pulmonary sarcoidosis undergo clinical remission with minimal residual organ impairment and favorable long-term outcomes. (livingwithsarcoidosis.org)
  • CLINICAL FEATURES - Patients with granulomatosis with polyangiitis (GPA) typically have both upper airway and pulmonary involvement, although a minority may have just one or the other [ 1 ]. (medilib.ir)
Bronchiectasis1
  • The risk factors for CPI include fibronodular lesions on chest images, the presence of bronchiectasis or chronic obstructive pulmonary disease (COPD), and sequelae of PTB [ 6 - 8 ]. (e-crt.org)
Bronchial1
  • Chronic cavitatory or cystic parenchymal disease, causing damage to bronchial tree, predisposes to aspergilloma. (ijsurgery.com)
COPD3
  • These non-specific respiratory symptoms can lead to a delay in diagnosis or a misdiagnosis of asthma or chronic obstructive pulmonary disease (COPD). (pharmaceutical-journal.com)
  • Question 3 - Which treatment of chronic obstructive pulmonary disease (COPD) increases the long-term prognosis in. (passmed.uk)
  • Oxygen administration reduces mortality rates in patients with advanced COPD because of the favourable effects on pulmonary hemodynamics. (passmed.uk)
Lesion4
  • This x-ray shows a single lesion (pulmonary nodule) in the upper right lung (seen as a light area on the left side of the picture). (mountsinai.org)
  • This CT scan shows a single lesion (pulmonary nodule) in the right lung. (mountsinai.org)
  • However, with the culture report and a fibrocavity lesion of the lung, a diagnosis of aspergilloma was made. (atmph.org)
  • [3] The natural history of aspergilloma varies from a stable lesion to progression and even spontaneous regression in about 5% of the cases. (atmph.org)
ABPA1
Occurs2
  • [4] Aspergilloma predominantly occurs in the upper lobes, indicating the predilection for cavity formation at this site. (atmph.org)
  • Pulmonary hypertension occurs in 1-6% of cases of pulmonary sarcoidosis and can occur in the absence of significant pulmonary fibrosis. (pharmaceutical-journal.com)
Interstitial2
  • The development and worsening of interstitial fibrosis leading to respiratory failure is an uncommon but significant complication in pulmonary sarcoidosis and is a considerable cause of morbidity and premature mortality. (pharmaceutical-journal.com)
  • Microscopic polyangiitis (MPA) is a necrotizing vasculitis without granulomatous inflammation that predominantly affects small vessels (ie, capillaries, venules, or arterioles) and can present with pulmonary capillaritis or in the context of interstitial lung disease [ 3 ]. (medilib.ir)
Granulomatous inflammation1
  • Although most patients enter remission and have good long-term outcomes, up to 20% develop fibrotic lung disease, whereby granulomatous inflammation evolves to pulmonary fibrosis. (livingwithsarcoidosis.org)
Lungs1
  • Findings on chest X-ray suggestive of aspergilloma include a well demarcated, round, soft tissue mass located inside an air space cavity of the lungs . (wikidoc.org)
Significant morbidity1
Outcomes3
  • Mesenchymal cystic hamartoma is a rare pulmonary neoplasm, which occasionally presents with severe symptoms such as pneumothorax or hemothorax, and shows favorable outcomes following surgical resection. (biomedcentral.com)
  • Mesenchymal cystic hamartoma (MCH) of the lung is a rare pulmonary neoplasm that has favorable outcomes following surgical resection, although it occasionally presents with severe symptoms such as pneumothorax and hemothorax. (biomedcentral.com)
  • Good long-term outcomes after surgical treatment of simple and complex pulmonary aspergilloma. (ijsurgery.com)
Intracavitary1
  • An intracavitary aspergilloma is seen in the anterior segment of the LUL (Circles). (cider-yale.org)
Acute1
  • In otherwise healthy persons, acute pulmonary and primary mucocutaneous symptomatic lesions may resolve without treatment. (medscape.com)
Cavity4
  • The diagnosis of aspergilloma is most commonly based on the chest X-ray showing a cavity with an air-crescent sign and by histopathological examination of the resected tissue. (atmph.org)
  • [4] We report here a case of pulmonary aspergilloma due to A. fumigatus in a pre-existing tubercular cavity that was primarily diagnosed by sputum culture. (atmph.org)
  • The diagnosis of aspergilloma is mainly based on the presence of radiological opacity in the cavity with an air-crescent sign. (atmph.org)
  • An aspergilloma is a clump of mold which exists in a body cavity such as a paranasal sinus or an organ such as the lung. (wikipedia.org)
Hypertension2
  • Pulmonary fibrosis is also a significant risk factor for the development of aspergilloma and pulmonary hypertension [4] . (pharmaceutical-journal.com)
  • Potential signs of pulmonary hypertension include breathlessness (out of proportion with the extent of pulmonary disease), palpitations, or feeling faint on exertion or leaning forward. (pharmaceutical-journal.com)
Computed tomography1
  • Among 550 RA patients treated with TNFα antagonists, six (1.1%) had symptomatic maxillary aspergilloma diagnosed by computed tomography before or during TNFα antagonist therapy. (biomedcentral.com)
Idiopathic1
  • However, unlike in idiopathic pulmonary fibrosis (IPF), in sarcoidosis there is little evidence to suggest that fibrotic activity, once initiated, continues inexorably. (livingwithsarcoidosis.org)
Fibrosis5
  • Pulmonary function testing often demonstrates restriction from parenchymal involvement, although airflow obstruction from airway-centric fibrosis is also recognized. (livingwithsarcoidosis.org)
  • However, up to 20% develop pulmonary fibrosis as a response to inflammation. (livingwithsarcoidosis.org)
  • It is not clear that the risk of developing pulmonary fibrosis, or stage IV disease, varies by ancestry. (livingwithsarcoidosis.org)
  • Even when the extent of fibrosis is anatomically limited and pulmonary function remains normal, a pathologic fibrotic response results in some degree of permanent alteration of pulmonary architecture. (livingwithsarcoidosis.org)
  • The main risk factors are the presence of pulmonary fibrosis and possibly male sex [5] . (pharmaceutical-journal.com)
Bronchoscopy1
Severe2
  • Lung transplantation should be considered for patients with severe fibrotic pulmonary sarcoidosis, as mortality is high in these patients. (livingwithsarcoidosis.org)
  • Composition of pulmonary microbiome of patients with severe pneumonia is poorly known. (bvsalud.org)
Disease1
  • Although these alterations meet the definition for radiographic stage IV disease, for the purpose of this review we use the term fibrotic pulmonary sarcoidosis, as it is descriptive, applies also to CT imaging and histopathology, and avoids the implications of "staging. (livingwithsarcoidosis.org)
Sarcoma2
  • Preoperative diagnosis of MCH is reportedly difficult due to similar radiographic features as other cystic neoplasms, such as pleuropulmonary blastoma, pulmonary metastasis of endometrial stromal sarcoma, lymphangiomyomatosis (LAM), and cystic adenomatoid malformation (CAM) [ 2 ]. (biomedcentral.com)
  • Primary pulmonary leiomyosarcomas is a subtype of pulmonary sarcoma, accounting for less than 0.5% of all malignant pulmonary neoplasms. (panafrican-med-journal.com)
Nodules1
  • CT findings commonly include pulmonary nodules with a surrounding ground-glass halo, and pleural-based, wedge-shaped areas of consolidation. (cider-yale.org)
Symptomatic2
  • The purpose of this study was to describe symptomatic sinus aspergilloma in RA patients treated with TNFα antagonists. (biomedcentral.com)
  • Retrospective descriptive study of symptomatic cases of sinus aspergilloma in patients with RA followed in three French university hospitals. (biomedcentral.com)
Sarcoidosis3
  • We designate this phenotype fibrotic pulmonary sarcoidosis. (livingwithsarcoidosis.org)
  • Although the pathophysiology of fibrotic pulmonary sarcoidosis remains poorly understood, augmented transforming growth factor-β activity, macrophage phenotype switching, and a Th1 to Th2 transition may be important features (11-14). (livingwithsarcoidosis.org)
  • The exuberance of the response in fibrotic pulmonary sarcoidosis suggests that this program is dysregulated. (livingwithsarcoidosis.org)
Pathology1
Findings1
  • Diagnosis of aspergilloma is made on the basis of characteristic radiographic findings, positive serum precipitins against Aspergillus species, and culture of the organism from sputum. (johnshopkins.edu)