• Chronic Obstructive Pulmonary Disease (COPD) Chronic obstructive pulmonary disease is persistent narrowing (blocking, or obstruction) of the airways occurring with emphysema, chronic obstructive bronchitis, or both disorders. (merckmanuals.com)
  • GAAPP has joined a group of multi-stakeholder international partners to celebrate Pulmonary Rehabilitation Week and raise awareness on the importance of the practice for patients living with COPD, FPI, and other chronic respiratory conditions. (gaapp.org)
  • 3 COPD and fibrotic lung disease such as idiopathic pulmonary fibrosis (IPF ) have no known cure and are associated with significant suffering and disabling symptoms. (gaapp.org)
  • Pulmonary Rehabilitation (PR) is the standard of care for persons with COPD and IPF and is associated with improved physical function, symptoms, mood, and quality of life. (gaapp.org)
  • Pulmonary rehabilitation for COPD. (gaapp.org)
  • Pulmonary rehabilitation utilization in older adults with COPD, 2003 to 2012. (gaapp.org)
  • Association between initiation of pulmonary rehabilitation after hospitalization for COPD and 1-year survival among Medicare beneficiaries. (gaapp.org)
  • What is less clear is the evidence for a role of macrolides in the treatment of other chronic inflammatory airway diseases, e.g. cystic fibrosis, bronchiectasis, asthma, obliterative bronchiolitis, chronic obstructive pulmonary disease (COPD) and chronic rhinosinusitis. (ersjournals.com)
  • Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide. (e-trd.org)
  • Therapies such as inhaled corticosteroids and azithromycin may modulate the airway microbiome or its metabolites in patients with COPD. (e-trd.org)
  • This paper provides an up-to-date overview of the airway microbiome and its importance in the pathophysiology of COPD and as potential therapeutic target in the future. (e-trd.org)
  • Chronic obstructive pulmonary disease (COPD) is the third leading cause of mortality, responsible for 3.23 million deaths per year worldwide [ 1 ]. (e-trd.org)
  • however, modern genomic technology has unveiled a rich and diverse microbial communities in the airways from the nose to the alveoli, which become perturbed in COPD, causing dysbiosis. (e-trd.org)
  • In this review, we will review our current understanding of the airway microbiome (microbiota) in health and disease and discuss the impact of dysbiosis on morbidity and mortality of patients with COPD. (e-trd.org)
  • Using search terms "COPD," "chronic obstructive pulmonary disease," "microbiome," and "bacteria," PubMed was interrogated to January 1, 2023 to identify relevant papers on this topic. (e-trd.org)
  • RONS and calpain play important roles in the development of airway and pulmonary vascular remodeling in COPD. (elsevierpure.com)
  • Establishment of a mouse model is important for investigating the mechanism of chronic obstructive pulmonary disease (COPD). (biomedcentral.com)
  • Compared with the single CS exposure method, the CS + LPS exposure method is a more suitable model of COPD in airway remodeling research. (biomedcentral.com)
  • Chronic obstructive pulmonary disease (COPD) is a chronic progressive lung disease characterized by a persistently limited airflow, chronic airway inflammation, airway remodeling and emphysema [ 1 ]. (biomedcentral.com)
  • Lung cancer and obstructive pulmonary disease share multiple etiological factors, such as cigarette smoking, occupational inhalation hazards, and air pollution, and 50-70% of lung cancer patients present with co-existing COPD or airflow obstruction 6 . (nature.com)
  • Ginsenoside Rg1 may suppress cigarette smoke-induced airway fibrosis in pulmonary fibroblasts and COPD rats. (greenmedinfo.com)
  • A prevailing theory is that it is caused by airway obstruction. (medscape.com)
  • Pulmonary effects of exposure to fine fiberglass: irregular opacities and small airways obstruction. (bmj.com)
  • Objective: We and others have observed significant hyperinflation and airflow obstruction after the surgical repair of pulmonary atresia and ventricular septal defect. (elsevierpure.com)
  • one had changes in pulmonary function consistent with reversible airway obstruction (5). (cdc.gov)
  • Here, we show that expression of SPDEF or FOXA3 in airway epithelial cells in neonatal mice caused goblet cell differentiation, spontaneous eosinophilic inflammation, and airway hyperresponsiveness to methacholine. (nih.gov)
  • SPDEF was required for goblet cell differentiation and pulmonary Th2 inflammation in response to house dust mite (HDM) extract, as both were decreased in neonatal and adult Spdef(-/-) mice compared with control animals. (nih.gov)
  • The neutralization of IL-17 greatly reduces pulmonary neutrophilia, underscoring a key role for IL-17 in promoting chronic airway inflammation. (elsevierpure.com)
  • These findings emphasize the role of IL-17 in mediating neutrophil-driven pulmonary inflammation and highlight a new mouse model that may be used for the development of novel therapies targeting Th17 cells in asthma and other chronic pulmonary diseases. (elsevierpure.com)
  • Macrolides are postulated to reduce airway inflammation via several mechanisms. (ersjournals.com)
  • Ocular and pulmonary exposure may cause incapacitating inflammation, systemic absorption and death. (cdc.gov)
  • Moreover, the mice in the CS + LPS group exhibited more severe inflammation and airway remodeling than the mice in the CS group, but the two treatments induced similar levels of emphysema. (biomedcentral.com)
  • To compare the effectiveness of continuous positive airway pressure (CPAP) with standard pharmacologic treatment in the management of prehospital acute pulmonary edema. (unboundmedicine.com)
  • TY - JOUR T1 - Effectiveness of prehospital continuous positive airway pressure in the management of acute pulmonary edema. (unboundmedicine.com)
  • For instance, bilevel positive airway pressure may be more appropriate than continuous positive airway pressure (CPAP) for the treatment of sleep apnea in the individual with concomitant restrictive pulmonary impairment. (springer.com)
  • Obstructive sleep apnea syndrome (OSAS) has been associated with increased morbidity and mortality, principally from cardiovascular disease, but the impact of nasal continuous positive airway pressure (CPAP) therapy is unclear. (medscape.com)
  • [ 3 ] Continuous positive airway pressure (CPAP) is an effective therapy and is the most widely used modality in patients with moderate-to-severe disease. (medscape.com)
  • Cite this: Long-Term Effects of Nasal Continuous Positive Airway Pressure Therapy on Cardiovascular Outcomes in Sleep Apnea Syndrome - Medscape - Jun 01, 2005. (medscape.com)
  • Laima Kondratavičienė successfully defended a doctoral dissertation "Effect of short-term continuous positive airway pressure on pulmonary and heart function, quality of life in patients with obstructive sleep apnea" at the open session of the Medical Research Council of the Lithuanian University of Health Sciences on June 1, 2023. (pulmoalerg.lt)
  • Treated pulmonary tuberculosis is a cause of significant chronic obstructive airways disease. (nih.gov)
  • Advance lung diseases include: Interstitial lung diseases (primary idiopathic pulmonary fibrosis), chronic obstructive lung diseases, cystic fibrosis, and bronchiolitis obliterans. (wustl.edu)
  • A number of studies were identified that showed short-term beneficial outcomes or the potential for such outcomes in cystic fibrosis, bronchiectasis, chronic obstructive pulmonary disease, asthma and post-transplant obliterative bronchiolitis. (ersjournals.com)
  • The aim of this review is to examine the current literature for the most recent updates on health effects of specific air pollutants and their impact on asthma, chronic obstructive pulmonary disease, lung cancer, and respiratory infection. (cdc.gov)
  • Asthma, chronic obstructive pulmonary disease, lung cancer, and respiratory infections all seem to be exacerbated because of exposure to a variety of environmental air pollutants with the greatest effects because of particulate matter, ozone, and nitrogen oxides. (cdc.gov)
  • Congenital pulmonary airway malformation (CPAM), formerly known as congenital cystic adenomatoid malformation (CCAM), is a congenital disorder of the lung similar to bronchopulmonary sequestration. (wikipedia.org)
  • citation needed] Very large cystic masses might pose a danger during birth because of the airway compression. (wikipedia.org)
  • Congenital pulmonary airway malformations , or CPAM , is a cystic lung disease that is congenital (present at birth). (massgeneral.org)
  • Cystic fibrosis pulmonary guidelines: airway clearance therapies. (musc.edu)
  • The chance finding that erythromycin treatment radically improved the clinical outcome of a patient with diffuse panbronchiolitis rekindled interest in the use of macrolides as a potential treatment in other inflammatory airway disorders, e.g. cystic fibrosis 8 . (ersjournals.com)
  • Epithelial cells that line the conducting airways provide the initial barrier and innate immune responses to the abundant particles, microbes, and allergens that are inhaled throughout life. (nih.gov)
  • The transcription factors SPDEF and FOXA3 are both selectively expressed in epithelial cells lining the conducting airways, where they regulate goblet cell differentiation and mucus production. (nih.gov)
  • The goal of the core is to provide primary cells and cultured airway epithelial cell preparations from human, mouse and other species for the study of epithelial cells, lung biology and lung diseases. (wustl.edu)
  • Core procedures and capabilities: The airway epithelial cell core provides investigators with primary culture preparations of mouse and human airway epithelial cells differentiated at air-liquid interface to provide a model of normal airways including ciliated and secretory cells. (wustl.edu)
  • Normal human airway epithelial cells can be obtained as de-identified tissues and exempted from specific human research. (wustl.edu)
  • The core also has experience with the culture of airway epithelial cells from rats and pigs. (wustl.edu)
  • What is a congenital pulmonary airway malformation? (massgeneral.org)
  • Congenital pulmonary airway malformations (CPAMs) are lung lesions that result from disordered development of the lower respiratory tract. (medscape.com)
  • Sonographic images of fetal congenital pulmonary airway malformation. (medscape.com)
  • A) Microcystic congenital pulmonary airway malformation, with ultrasound showing a solid echogenic mass. (medscape.com)
  • Charcot-Marie-Tooth disease can be associated with several disorders that may be encountered by the pulmonary physician, including restrictive pulmonary impairment, sleep apnea, restless legs, and vocal cord dysfunction. (springer.com)
  • Pulmonary rehabilitation is the use of supervised exercise, education, support, and behavioral intervention to improve how people with chronic lung disease function in daily life and to enhance their quality of life. (merckmanuals.com)
  • Pulmonary rehabilitation is a program designed for people who have chronic lung disease. (merckmanuals.com)
  • Pulmonary rehabilitation programs may be used before a person's lung disease becomes severe. (merckmanuals.com)
  • Purpose To investigate whether microstructural imaging metrics from in-vivo hyperpolarized 3He DW MRI are sensitive to longitudinal changes in a cohort of participants with idiopathic pulmonary fibrosis (IPF) and to evaluate the reproducibility of these metrics and their correlation with existing clinical measures of IPF disease severity. (whiterose.ac.uk)
  • Treatment of Nontuberculous Mycobacterial Pulmonary Disease: An Official ATS/ERS/ESCMID/IDSA Clinical Practice Guideline. (nih.gov)
  • Among the various emergency diseases in children, acute pulmonary and airway disease are common clinical conditions encountered by radiologists, and the first imaging modality is chest radiography. (elsevierpure.com)
  • In this article, we review pneumonia and mimickers of acute pulmonary disease. (elsevierpure.com)
  • The lower airways contain a rich and diverse microbiome, which may play a significant regulatory role in both health and disease. (e-trd.org)
  • Airway -invasion-associated CT presentations at early stages of the disease are characteristic of IPA in non- immunocompromised hosts . (bvsalud.org)
  • 2019 updated consensus statement on the diagnosis and treatment of pediatric pulmonary hypertension: The European Pediatric Pulmonary Vascular Disease Network (EPPVDN), endorsed by AEPC, ESPR and ISHLT. (medscape.com)
  • Disentangling the role of pulmonary impairment in lung cancer development is important from an etiological perspective, for refining disease susceptibility mechanisms, and for informing precision prevention and risk stratification strategies. (nature.com)
  • Considerable past evidence suggests that air pollution is an important factor that enhances pulmonary disease, while also causing greater harm in susceptible populations, such as children, the elderly, and those of low socio-economic status worldwide. (cdc.gov)
  • Summary: Continued vigilance will be essential to lessen the effects of air pollution on human health and pulmonary disease. (cdc.gov)
  • Pulmonary function tests, including diffusing capacity of the lungs for carbon monoxide and forced vital capacity, were performed at each examination. (whiterose.ac.uk)
  • Conclusion Helium 3 diffusion-weighted MRI-derived mean diffusive length scale demonstrates longitudinal changes in lungs affected by idiopathic pulmonary fibrosis. (whiterose.ac.uk)
  • Pulmonary hypertension is a condition in which blood pressure in the arteries of the lungs (the pulmonary arteries) is abnormally high. (msdmanuals.com)
  • Blood travels from the right side of the heart through the pulmonary arteries into the small blood vessels of the lungs (the capillaries) where carbon dioxide is removed from the blood and oxygen is added. (msdmanuals.com)
  • Normally, the pressure in the pulmonary arteries is low, allowing the right side of the heart to be less muscular than the left side (because relatively little muscle and effort are needed to push the blood through the lungs via the pulmonary arteries). (msdmanuals.com)
  • Persistent Pulmonary Hypertension of the Newborn Persistent pulmonary hypertension of the newborn is a serious disorder in which the arteries to the lungs remain narrowed (constricted) after delivery, thus limiting the amount of blood flow. (msdmanuals.com)
  • World-renowned specialists in Cleveland Clinic Florida's Department of Pulmonary Medicine, Critical Care and Sleep Medicine treat patients with disorders relating to the lungs, breathing and sleep. (clevelandclinic.org)
  • Your airways are tubes that allow oxygen to flow into the lungs and waste products (carbon dioxide) to flow out. (clevelandclinic.org)
  • Vascular pulmonary conditions are disorders that affect the blood vessels in your lungs and how blood travels between your heart and lungs. (clevelandclinic.org)
  • Lung transplantation-related pathology encompasses a spectrum of disorders that include, but are not limited to, indications for lung transplantation (seen in explanted lungs), surgical complications (airway anastomotic and vascular complications), ischemia-reperfusion injury, rejection (acute and chronic), infections, and posttransplantation lymphoproliferative disorders (PTLDs). (medscape.com)
  • To study the relationship between transpulomnary [sic] pressure (Ptp), intravascular pressure (Pv), and the pulmonary arterial tree structure, morphometric measurements of pulmonary arterial trees were made in intact lungs from Sprague-Dawley rats. (marquette.edu)
  • We also commonly use thin section scanning for fine detailed examination of the lungs and pulmonary vessels. (ohsu.edu)
  • Pulmonary arterial hypertension can be caused by numerous different disorders. (msdmanuals.com)
  • A number of drugs and toxins have been identified as risk factors for pulmonary arterial hypertension such as fenfluramine (and other related weight-loss drugs), amphetamines, protein kinase inhibitors (such as dasatinib ), cocaine , and selective serotonin reuptake inhibitors (SSRIs). (msdmanuals.com)
  • The largest pulmonary arteries have small yellow atherosclerotic plaques in pulmonary arterial hypertension. (medscape.com)
  • Genetics and other omics in pediatric pulmonary arterial hypertension. (medscape.com)
  • Idiopathic pulmonary arterial hypertension in childhood. (medscape.com)
  • FUTURE-2: Results from an open-label, long-term safety and tolerability extension study using the pediatric FormUlation of bosenTan in pUlmonary arterial hypeRtEnsion. (medscape.com)
  • STARTS-2: long-term survival with oral sildenafil monotherapy in treatment-naive pediatric pulmonary arterial hypertension. (medscape.com)
  • Lung transplantation in children with idiopathic pulmonary arterial hypertension. (medscape.com)
  • Women are affected by idiopathic pulmonary hypertension twice as often as men, and the average age at which the diagnosis is made is about 35 years. (msdmanuals.com)
  • Priorities are given to members of the Asthma and Allergic Diseases Cooperative Research Centers, and the lung research community with established relationships to the Pulmonary and Critical Care Division. (wustl.edu)
  • A clinical diagnosis of asthma and an objective assessment of airway hyperresponsiveness were determined by means of an asthma inventory scale and methacholine challenge testing, respectively. (elsevierpure.com)
  • The most successful rehabilitation programs are those in which services are provided by a respiratory or physical therapist, a nurse, a doctor, a psychologist or social worker, and a dietitian working as the pulmonary rehabilitation team to coordinate complex medical services. (merckmanuals.com)
  • I'm the author of Whitten's Step-by-Step Guides, a series of books teaching airway management, intubation, and respiratory care: Anyone Can Intubate, A Step-by-Step Guide to Intubation and Airway Management 5th edition, and Pediatric Airway Management: a Step-by-Step Guide. (airwayjedi.com)
  • These results provide a basis to anticipate persistent respiratory difficulties after operations in patients with pulmonary atresia and ventricular septal defect. (elsevierpure.com)
  • Paramedics adapt Matchbox Twenty song 3 a.m. to describe respiratory compromise from cardiogenic pulmonary edema. (ems1.com)
  • Pulmonary function tests and respiratory samples were collected prospectively in persons with CF before and after treatment for pulmonary exacerbations. (lww.com)
  • Airway diseases are conditions that affect this network of tubes. (clevelandclinic.org)
  • Genetic pulmonary conditions, or inherited lung conditions, are rare lung diseases linked to conditions that run in families. (clevelandclinic.org)
  • Expert pulmonologists at Cleveland Clinic Florida offer prompt diagnosis of all pulmonary diseases. (clevelandclinic.org)
  • We perform detailed anatomic, functional, and physiologic imaging of the coronary arteries, myocardium, cardiac chambers, valves, aorta, pulmonary arteries, and pericardium using cardiac magnetic resonance imaging (MRI) and computed tomography (CT) in adults and pediatric patients suffering from a broad range of congenital and acquired cardiac diseases. (ohsu.edu)
  • Furthermore, reverse causality remains a concern since pulmonary symptoms may be early manifestations of lung cancer or acquired lung diseases in patients whose immune system has already been compromised by undiagnosed cancer. (nature.com)
  • Many disorders can cause pulmonary hypertension. (msdmanuals.com)
  • If the pressure of the blood in the pulmonary arteries increases to a sufficiently high level, the condition is called pulmonary hypertension. (msdmanuals.com)
  • In pulmonary hypertension, the right side of the heart must work harder to push the blood through the pulmonary arteries. (msdmanuals.com)
  • Cor Pulmonale Cor pulmonale is enlargement and thickening of the ventricle on the right side of the heart resulting from an underlying lung disorder that causes pulmonary hypertension (high pressures in the. (msdmanuals.com)
  • The actual mechanism by which these inherited genetic mutations cause pulmonary hypertension is not yet known. (msdmanuals.com)
  • Because many of the symptoms of idiopathic pulmonary artery hypertension (IPAH) are nonspecific and the disorder is relatively rare, the diagnosis may be somewhat difficult to make. (medscape.com)
  • Go to Primary Pulmonary Hypertension and Persistent Newborn Pulmonary Hypertension for more complete information on these topics. (medscape.com)
  • Wilkes J. AHA/ATS Release Guidelines on the Diagnosis and Treatment of Pediatric Pulmonary Hypertension. (medscape.com)
  • Pediatric Pulmonary Hypertension: Guidelines From the American Heart Association and American Thoracic Society. (medscape.com)
  • Pulmonary artery hypertension and sleep-disordered breathing: ACCP evidence-based clinical practice guidelines. (medscape.com)
  • Barst R, Long W, Gersony W. Long-term vasodilator treatment improves survival in children with primary pulmonary hypertension. (medscape.com)
  • This study sought to objectively characterize this problem and determine the prevalence of airway hyperresponsiveness in these patients. (elsevierpure.com)
  • Overall, 66.7% (22/33) met criteria for a clinical diagnosis of airway hyperresponsiveness: 62% (8/13) from the microdeletion genotype and 70% (14/20) from the nonsyndromic group. (elsevierpure.com)
  • Conclusions: We have identified an extremely strong association between pulmonary atresia and ventricular septal defect and persistent airway hyperresponsiveness. (elsevierpure.com)
  • Haploinsufficiency at chromosome 22q11.2 did not contribute to this predilection for airway hyperresponsiveness. (elsevierpure.com)
  • Moreover, this at-risk patient population may yield unique insights into fundamental mechanisms involved in the pathogenesis of airway hyperresponsiveness. (elsevierpure.com)
  • RESULTS: Wild type mice developed a greater degree of airway hyperresponsiveness to MCh at 1 day post exposure to Cl2 compared with TCR-delta-/- mice. (cdc.gov)
  • Upper airway biopsy is surgery to remove a small piece of tissue from the nose, mouth, and throat area. (medlineplus.gov)
  • This test may be done if your provider thinks there is a problem with your upper airway. (medlineplus.gov)
  • The upper airway tissues are normal, with no abnormal growths. (medlineplus.gov)
  • The apparent diffusion coefficient (ADC) and stretched exponential model-derived mean diffusive length scale (LmD) from DW MRI was compared with baseline CT fibrosis scores and pulmonary function tests by using Spearman rank correlation coefficient. (whiterose.ac.uk)
  • Patchy fibrosis with greater involvement of the lower lobes and subpleural regions is readily apparent in idiopathic pulmonary fibrosis. (medscape.com)
  • Diffuse alveolar injury and progression to pulmonary fibrosis are pathological features of ARDS. (medscimonit.com)
  • The present study sought to determine how puerarin influences the inflammatory response caused by pulmonary fibrosis in ARDS in infants. (medscimonit.com)
  • Puerarin regulated the proliferation and apoptosis of pulmonary fibrosis cells, and affected the secretion of inflammatory cytokines. (medscimonit.com)
  • Thus, puerarin alleviated the inflammatory response resulting from pulmonary fibrosis by regulating the TGF-β1/Smad3 pathway in infants with ARDS. (medscimonit.com)
  • Inhaled phosgene oxime is extremely irritating to the upper airways and causes pulmonary edema. (cdc.gov)
  • Restrictive pulmonary impairment has been described in association with phrenic nerve dysfunction, diaphragm dysfunction, or thoracic cage abnormalities. (springer.com)
  • If a bad forest fire smoke causes some small airway impairment, 500mg of ReMag takes care of it within 20 minutes and it lasts, unlike a prescription inhaler. (windinmyface.com)
  • These findings support a causal role of pulmonary impairment in lung cancer etiology. (nature.com)
  • Barbareschi M, Mengoli MC, Cavazza A. Nonneoplastic pathology of the large and small airways. (medlineplus.gov)
  • The ReMag magnesium I've been taking has my small airways working as good as they have in a decade. (windinmyface.com)
  • Pulmonary rehabilitation programs are usually conducted in an outpatient setting (in other words, the person has regular appointments in an office or clinic) or in the person's home. (merckmanuals.com)
  • Sometimes pulmonary rehabilitation is combined with cardiac rehabilitation. (merckmanuals.com)
  • can be used in conjunction with pulmonary rehabilitation. (merckmanuals.com)
  • ATS/ERS Task Force on Pulmonary Rehabilitation. (gaapp.org)
  • An official ATS/ERS statement: key concepts and advances in pulmonary rehabilitation. (gaapp.org)
  • An international comparison of pulmonary rehabilitation: a systematic review. (gaapp.org)
  • Mortality occurred in 66 (0.5%) participants, and 2311 patients (16.3%) had a composite outcome of postoperative pulmonary complications, major morbidity, or 30-day mortality. (pulmonologyadvisor.com)
  • Recent findings: A total of 52 publications were reviewed to establish new insights as to how air pollution is associated with pulmonary morbidity and mortality. (cdc.gov)
  • Absorption through the skin can cause pulmonary edema. (cdc.gov)
  • Inhalation and systemic absorption may cause pulmonary edema, necrotizing bronchiolitis and pulmonary thrombosis. (cdc.gov)
  • Seventy-one subjects who had previously been treated for tuberculosis up to 16 years before underwent pulmonary function assessment. (nih.gov)
  • Longitudinal changes in DW MRI and pulmonary function test measurements were assessed with Friedman tests and post hoc Dunn test. (whiterose.ac.uk)
  • Assistance with live imaging of cilia function and models of airway clearance are available using core instruments including videomicroscopy. (wustl.edu)
  • Significant symptom reduction and improved pulmonary function have also been achieved 11 - 14 . (ersjournals.com)
  • The two treatments induced emphysema and airway remodeling and decreased lung function. (biomedcentral.com)
  • Conducting airways of the lung are lined by a highly specialized epithelium whose composition and function varies along the proximal to distal axis. (bioinbrief.com)
  • Our objectives were to investigate the effect of broad (BS) versus narrow (NS) spectrum antianaerobic antibiotic activity on lung microbiome diversity and pulmonary function, hypothesizing that BS antibiotics would cause greater change in microbiome diversity without a significant improvement in lung function. (lww.com)
  • Standard pulmonary function tests were also performed. (researchgate.net)
  • Integrative analyses reveal that pulmonary function instruments, including 73 novel variants, influence lung tissue gene expression and implicate immune-related pathways in mediating the observed effects on lung carcinogenesis. (nature.com)
  • In this study we comprehensively assess the shared genetic basis of impaired lung function and lung cancer risk by conducting genome-wide association analyses in the UK Biobank cohort to identify genetic determinants of three pulmonary phenotypes, forced expiratory volume in 1s (FEV 1 ), forced vital capacity (FVC), and FEV 1 /FVC. (nature.com)
  • We examine the genetic correlation between pulmonary function phenotypes and lung cancer, followed by Mendelian randomization (MR) using novel genetic instruments to formally test the causal relevance of impaired pulmonary function, using the largest available dataset of 29,266 lung cancer cases and 56,450 controls from the OncoArray lung cancer collaboration 16 . (nature.com)
  • In March 1985, NIOSH conducted a follow-up medical evaluation consisting of pulmonary function tests, skin-stick tests for sensitivity to egg protein, determinations of serum IgE and IgG antibodies to egg protein (whole egg, egg yolk, egg white, and egg fractions), and physical examinations and clinical histories by a physician trained in internal and occupational medicine. (cdc.gov)
  • The Laboratory of Chronic Airway Infection, led by Dr. Kenneth Olivier, focuses on bronchiectasis, a condition that damages the body's ability to clear mucus from the airways and increases risk of severe lung infections by nontuberculous mycobacteria (NTM), which commonly are found in wet environments such as streams, rivers, and marshes. (nih.gov)
  • Dr. Olivier's research focuses on bronchiectasis , a condition that damages the body's ability to clear mucus from the airways and increases risk of severe lung infections by nontuberculous mycobacteria (NTM), which commonly are found in wet environments such as streams, rivers, and marshes. (nih.gov)
  • The multicenter, observational study evaluated the association between dynamic driving pressure and postoperative pulmonary complications among adults who underwent a major abdominal surgical procedure ( mechanical ventilation ≥120 min). (pulmonologyadvisor.com)
  • METHODS: C57Bl/6J (wild type) and TCR-delta-/- mice exposed to Cl2 (400 ppm) for 5 minutes underwent measurements of airway responses to i.v. methacholine (MCh) at 1, 3, and 5 days after exposure. (cdc.gov)
  • Commitment from the pulmonary epithelium to bronchial and bronchiolar airway lineages occurs through the changeover from pseudoglandular to cannalicular stages of lung advancement suggesting that regional variations exist with regards to the identification of stem and progenitor cells that donate to epithelial maintenance in adulthood. (bioinbrief.com)
  • We conclude that basal cells stand for an alternative solution multipotent progenitor cell human population of bronchial airways which progenitor cell selection can be dictated by the type WK23 of airway injury. (bioinbrief.com)
  • 14 16 Bronchial airways harbor a minimum of two distinct progenitor cell populations also. (bioinbrief.com)
  • Both basal and nonciliated secretory cell varieties of bronchial airways have already been shown to show proliferative capability.8 9 11 12 20 21 47 Nevertheless the relative contribution of secretory basal progenitor cell populations to epithelial maintenance and regeneration following injury continues to be controversial. (bioinbrief.com)
  • The role of gamma delta T cells in airway epithelial injury and bronchial responsiveness after chlorine gas exposure in mice. (cdc.gov)
  • An emergent surgical airway can be accomplished by using one of several different methods, including a surgical cricothyrotomy, needle cricothyrotomy with jet oxygenation, or percutaneous cricothyrotomy using the Seldinger technique. (medscape.com)
  • For children younger than 12 years, needle cricothyrotomy with percutaneous transtracheal (jet) ventilation is the surgical airway of choice. (medscape.com)
  • Methods: We performed a prospective study of children and young adults with pulmonary atresia and ventricular septal defect between June 1996 and December 1998. (elsevierpure.com)
  • A cricothyrotomy is indicated when a patient's airway cannot be secured using nonsurgical methods or when other devices or rescue techniques (ie, intubating laryngeal mask airway, fiberoptic scope, lighted stylet) have failed or are not available. (medscape.com)
  • Manipulation and genetic modification of primary cells: The core has extensive experience with the manipulation of airway cells using growth factors, cytokines and specific culture conditions, as well as genetic manipulation using recombinant viral vectors. (wustl.edu)
  • These effects include reduced airway mucus secretion 17 and anti-inflammatory properties, including decreased airway neutrophil accumulation through a reduction in expression of pro-inflammatory cytokines, e.g. interleukin (IL)-8, and adhesion molecule production, e.g. macrophage adhesion molecule-1 18 - 20 . (ersjournals.com)
  • Chest x-rays, electrocardiography (ECG), and echocardiography give clues to the diagnosis, but measurement of blood pressure in the right ventricle and the pulmonary artery is needed for confirmation. (msdmanuals.com)
  • The European Organization for Research and Treatment of Cancer / Mycoses Study Group (EORTC/ MSG ) criteria are widely used in the diagnosis of invasive pulmonary aspergillosis (IPA), but they only apply to immunocompromised patients . (bvsalud.org)
  • Although rare, pulmonary embolism, infections, or neoplasms in the allograft may be diagnosed in this manner, which would affect the decision to use the donor lung. (medscape.com)
  • Pulmonary complications post abdominal surgery were more common among patients who were approximately 60 years of age or older and male. (pulmonologyadvisor.com)
  • Airway driving pressure, but not tidal volume or positive end-expiratory pressure (PEEP), is associated with an increased risk for postoperative pulmonary complications after major abdominal surgery, researchers reported in BJA Open . (pulmonologyadvisor.com)
  • Because of the association between adverse outcomes in critically ill patients receiving mechanical ventilation and high airway driving pressure, investigators hypothesized that increased driving pressure would be linked to postoperative pulmonary complications in patients following major abdominal surgery. (pulmonologyadvisor.com)
  • The primary outcome was a composite of postoperative pulmonary complications, which included at least 1 of the following occurring within 30 days postoperatively: pneumonia, requirement of ventilatory support for any reason (unplanned tracheal intubation, failure to wean from ventilator support within 48 hours from the end of surgery), or both. (pulmonologyadvisor.com)
  • P =.452) were not associated with postoperative pulmonary complications. (pulmonologyadvisor.com)
  • Future studies, including RCTs, will be required to provide further insight into the relationship between driving pressure and postoperative pulmonary complications, including a potential causal mechanism and whether modifications in driving pressure reduce the risk for postoperative pulmonary complications. (pulmonologyadvisor.com)
  • Of the cohort, 389 (2.7%) patients had a postoperative pulmonary complication, and 2202 (15.5%) had a nonrespiratory complication. (pulmonologyadvisor.com)
  • [ 1 , 14 ] Another theory is that imbalance between cell proliferation and apoptosis during airway branching morphogenesis may lead to CPAM. (medscape.com)
  • CONCLUSION: The severity of airway epithelial injury after Cl2 is greater in TCR-delta-/- mice but the inflammatory response and the change in airway responsiveness to methacholine are reduced. (cdc.gov)
  • Emphysema was induced after 1 month of exposure to CS or CS + LPS, while airway remodeling was induced after 2 months of exposure to CS + LPS and 3 months of exposure to CS. (biomedcentral.com)
  • BACKGROUND: Acute exposure to chlorine (Cl2) gas causes epithelial injury and airway dysfunction. (cdc.gov)
  • Diffuse panbronchiolitis is a progressive inflammatory disorder of lung airways found almost exclusively in Japan. (ersjournals.com)
  • Cardiothoracic Imaging works closely with many clinical departments, such as the Knight Cardiovascular Institute, Pulmonary Medicine and the Knight Lung Cancer team. (ohsu.edu)
  • We used this model to investigate the effects of IL-17 activity on airway epithelium and identified CXCL5 and MIP-2 as important factors in neutrophil recruitment. (elsevierpure.com)
  • Despite a growing appreciation of mechanisms contributing to branching morphogenesis and lineage specification in the developing lung it is still unclear how a complex epithelium such as that present in the conducting airway is established and maintained through adulthood. (bioinbrief.com)
  • gammadelta T cells are present in the mucosal surface of the airways and may contribute to the injury/repair response of the epithelium. (cdc.gov)
  • My books, as well as my training videos on intubation and airway management, are used in training programs both nationally and internationally. (airwayjedi.com)
  • [ 1 ] This percentage may be driven even lower by increasing adoption of rapid sequence intubation techniques, increased use of video-assisted intubation and other "difficult airway" devices, and increased prevalence of residency-trained emergency practitioners. (medscape.com)
  • A cricothyrotomy is indicated when an airway is required immediately in a patient who is not a candidate for orotracheal or nasotracheal intubation (ie, in the case of severe facial trauma). (medscape.com)
  • An example of a task in which the borders are often incomplete or invisible is the segmentation of the pulmonary lobes. (diagnijmegen.nl)
  • In this paper, a fully automatic segmentation of the pulmonary lobes in chest CT scans is presented. (diagnijmegen.nl)
  • Using a nonrandomized control group design, all consecutive patients presenting to two participating emergency medical services (EMS) systems with a field impression of acute pulmonary edema between July 1, 2004, and June 30, 2005, were included in the study. (unboundmedicine.com)
  • Inhalation and systemic absorption may result in pulmonary edema, necrotizing bronchiolitis, and pulmonary thrombosis. (cdc.gov)