AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsInformation ScienceHealth Care
AdenocarcinomaJaagsiekte sheep retrovirusMucinsPulmonary Adenomatosis, OvineLung NeoplasmsAdenocarcinoma, Bronchiolo-AlveolarMesotheliomaPulmonary Surfactant-Associated Protein AKeratin-7Gastric MucinsProteolipidsImmunohistochemistryTumor Markers, BiologicalSolitary Pulmonary NodulePulmonary SurfactantsPneumonectomyLungKeratinsSheepImmunoenzyme TechniquesReceptor, Epidermal Growth FactorPrognosisAdenocarcinoma, MucinousTomography, X-Ray ComputedTumor Cells, CulturedGene Expression Regulation, NeoplasticNuclear ProteinsPancreatic NeoplasmsEpithelial CellsEsophageal NeoplasmsTranscription FactorsMutationAdenocarcinoma, PapillaryBarrett EsophagusCarcinoma, Pancreatic DuctalStomach NeoplasmsSensitivity and SpecificityMucin-5BMucin-1CardiaColonic NeoplasmsMucin-4Esophagogastric JunctionMucin-6Cell Line, TumorNeoplasm StagingMucin-3MetaplasiaCarcinoma, Squamous CellPrecancerous ConditionsGoblet CellsEndometrial NeoplasmsIntestinal NeoplasmsNeoplasms, Multiple PrimaryCarcinoma, Signet Ring CellProstatic NeoplasmsNeoplasm InvasivenessMammary Neoplasms, ExperimentalDuodenal NeoplasmsGastric MucosaCarcinoma, EndometrioidCecal NeoplasmsColorectal NeoplasmsAdenocarcinoma, Clear CellAntigens, Tumor-Associated, CarbohydrateRectal NeoplasmsRNA, MessengerMucusNeoplasm ProteinsSialomucinsAdenomaAntigens, NeoplasmKeratin-20Ampulla of VaterTissue Array AnalysisGenes, rasCommon Bile Duct NeoplasmsIntestinal MucosaCarcinoma, AdenosquamousIleal NeoplasmsCarcinoembryonic AntigenColonReverse Transcriptase Polymerase Chain ReactionNeoplasm MetastasisDNA, NeoplasmPancreaticoduodenectomyNeoplasm TransplantationSurvival RateLymphatic MetastasisCarcinoma, Acinar CellJejunal NeoplasmsEsophagusDisease ProgressionCarcinoma, Non-Small-Cell LungMolecular Sequence DataPeriodic Acid-Schiff ReactionMice, NudeBiopsySurvival AnalysisRetrospective Studies
IdiopathicMUC1CarcinomaAirwayDisulfideCOPDMucusPrimary pulmonaryDiagnosisMetastaticTransmembraneMUC5BEmboliInfarctionParenchymalTumor cellsAbundantMalignantSecretionProteinNeuroendocrineHeavily glycosylated proteinsMucinousDepositionCommonlyAggregatesNodulesEmbolusPancreaticAngiographyMetastasesGenesPrecursorChestSerumCarcinomasTissueMolecularCancersProteinsProcessesProstateGobletRefersHumanLeftFindingsFunctionsCells
Idiopathic8
  • atypical adenomatous hyperplasia and diffuse idiopathic pulmonary neuroendocrine cell hyperplasia. (ersjournals.com)
  • In addition of the categories of squamous dysplasia and carcinoma in situ , two additional lesions were added to the group of pre-invasive lesions: atypical adenomatous hyperplasia (AAH) and diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH). (ersjournals.com)
  • Idiopathic pulmonary hemosiderosis. (radiopaedia.org)
  • The pathology of chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF) and most lung cancers involves the small airway epithelium (SAE), the single continuous layer of cells lining the airways ≥ 6th generations. (biomedcentral.com)
  • The clinical manifestations are renal disease, idiopathic pulmonary fibrosis (IPF), heart failure, end-stage liver diseases, and so on ( Bataller and Brenner, 2005 ). (frontiersin.org)
  • Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, fibrosing interstitial lung disease (ILD) of unknown aetiology, with a median survival of 2-4 years from the time of diagnosis. (encyclopedia.pub)
  • Among them, idiopathic pulmonary fibrosis (IPF) is a rare lung disease with an unknown cause and a median survival of 2-4 years from the time of diagnosis. (encyclopedia.pub)
  • The role of T-cell immunoglobulin- and mucin-domain-containing molecule-3 polymorphisms in idiopathic thrombocytopenic purpura. (cdc.gov)
MUC13
  • Overexpression of the mucin proteins, especially MUC1, is associated with many types of cancer. (wikipedia.org)
  • Some EGF-like mucins, plus MUC1 and MUC16, carry SEA domains, a vertebrate invention. (wikipedia.org)
  • Krebs von den Lungen-6 (KL-6) is now classified as a human MUC1 mucin protein, and regenerating type II pneumocytes are the primary cellular source of KL-6/MUC1 in the affected lungs of patients with interstitial lung diseases (ILD). (e-trd.org)
Carcinoma7
  • [ 3 , 4 ] The term "pseudomesotheliomatous carcinoma" was first applied by Harwood and colleagues in 1976 to 6 cases of peripheral lung adenocarcinoma that closely mimicked mesothelioma. (medscape.com)
  • Another change is the subclassification of adenocarcinoma: the definition of bronchioalveolar carcinoma has been restricted to noninvasive tumours. (ersjournals.com)
  • As compared to the previous edition, changes include a better definition of pre-invasive lesion, a reclassification of adenocarcinoma, the description of two new tumour types as variants of large cell carcinoma, large cell neuroendocrine carcinoma (LCNEC) and basaloid carcinoma, and a new class called pleomorphic carcinoma. (ersjournals.com)
  • The differential diagnosis includes glandular differentiation of transitional cell carcinoma and direct extension or metastatic spread of adenocarcinoma arising primarily from the colon, prostate, appendix or endometrium. (biomedcentral.com)
  • Microscopically, early gastric carcinoma is a typical glandular adenocarcinoma, usually well-differentiated. (poznayka.org)
  • Microscopically, it may be an adenocarcinoma or signet-ring cell carcinoma, extensively infiltrating the stomach wall, but due to marked desmoplasia cancer cells may be difficult to find. (poznayka.org)
  • carcinoma contains abundant pools of mucin in which are seen a small number of tumor cells, sometimes having signet-ring appearance. (poznayka.org)
Airway4
  • This technique provides functional vascular and airway detail, and it may aid in targeting pulmonary angiograms in the abnormal lung or lobe. (medscape.com)
  • The identification of the genes associated with increased airway mucin production in humans should be useful in understanding the pathogenesis of airway mucus hypersecretion and identifying therapeutic targets. (biomedcentral.com)
  • Little is known about the gene networks associated with the synthesis and secretion of mucins in the human small airway epithelium. (biomedcentral.com)
  • Despite small molecular mucolytics having the ability to break the disulfide bonds of mucins, offering a potential way to overcome the airflow obstruction and airway infection, these mucolytics have limited therapeutic effects in vivo. (biomed.news)
Disulfide2
  • The cysteine residues participate in establishing disulfide linkages within and among mucin monomers. (wikipedia.org)
  • The positively charged nanogels effectively inhibit the formation of large aggregates of mucin in vitro, probably thanks to the formation of an ionic interaction between CS-Arg and mucin, as well as the breakage of disulfide bonds in mucin by the reductive TCEP. (biomed.news)
COPD2
  • Cigarette smoke exposure causes various diseases involving changes in miRNA expressions in the pathogenesis of atherosclerosis, chronic obstructive pulmonary disease (COPD) and lung cancer (12-15). (researchsquare.com)
  • Mucus hypersecretion contributes to the morbidity and mortality of smoking-related lung diseases, especially chronic obstructive pulmonary disease (COPD), which starts in the small airways. (biomedcentral.com)
Mucus2
  • Although some mucins are membrane-bound due to the presence of a hydrophobic membrane-spanning domain that favors retention in the plasma membrane, most mucins are secreted as principal components of mucus by mucous membranes or are secreted to become a component of saliva. (wikipedia.org)
  • This novel strategy enabled identification of a 73 "MUC5AC-associated core gene" list with 9 categories, which control a series of processes from mucin biosynthesis to mucus secretion. (biomedcentral.com)
Primary pulmonary1
  • [ 12 ] Rare cases of primary pulmonary or pleural DSRCT have subsequently been identified. (medscape.com)
Diagnosis5
  • The most common classification used for PE is the Prospective Investigation of Pulmonary Embolism Diagnosis (PIOPED) criteria, which are based on the largest study of PE. (medscape.com)
  • Diagnosis of pulmonary hemosiderosis by MR imaging. (radiopaedia.org)
  • Formal diagnosis of NSF is usually made with a deep skin biopsy, which may show thickened collagen bundles with surrounding clefts, mucin deposition, and proliferation of fibroblasts and elastic fibers. (medscape.com)
  • During further follow ups she had developed bone and pulmonary metastasis and died shortly after the diagnosis of metastasis. (biomedcentral.com)
  • Differential diagnosis includes lymphoma, lymphadenitis associated with systemic lupus erythematosus, and even adenocarcinoma. (medscape.com)
Metastatic1
  • As malignant cells have a tendency to round up in body fluids these non-epithelial neoplasms can therefore mimic reactive mesothelial cells and metastatic adenocarcinoma. (cytojournal.com)
Transmembrane1
  • It is unclear whether this points to a common origin among these transmembrane mucins. (wikipedia.org)
MUC5B3
  • MUC5B, the predominant mucin in the mouth and female genital tract, has been shown to significantly reduce attachment and biofilm formation of Streptococcus mutans, a bacterium with the potential to form cavities. (wikipedia.org)
  • Similar effects of MUC5B and other mucins have been demonstrated with other pathogens, such as Candida albicans, Helicobacter pylori, and even HIV. (wikipedia.org)
  • Among them, the most studied and validated genetic risk factor is represented by the single nucleotide polymorphism in the promoter region of the mucin 5B (MUC5B) responsible for sporadic and familial IPF [ 12 ] . (encyclopedia.pub)
Emboli1
Infarction2
  • This is consistent with pulmonary infarction caused by pulmonary embolism. (medscape.com)
  • 2. Chang C & Davis W. A Roentgen Sign of Pulmonary Infarction. (radiopaedia.org)
Parenchymal2
  • Ventilation/perfusion (V/Q) mismatches and/or perfusion defects connote pulmonary parenchymal (related to airways) and vascular pathology (see the images below). (medscape.com)
  • 4. Woolley K, Stark P. Pulmonary parenchymal manifestations of mitral valve disease. (radiopaedia.org)
Tumor cells2
  • Lung adenocarcinoma: Positive for cytoplasm of tumor cells. (nichireibiosciences.com)
  • Adenocarcinoma ex-goblet cell carcinoid (AdexGCC) was considered a neuroendocrine adenocarcinoma, despite majority of tumor cells being negative for conventional neuroendocrine markers such as chromogranin and synaptophysin. (gastrores.org)
Abundant2
  • Mucin genes encode mucin monomers that are synthesized as rod-shaped apomucin cores that are post-translationally modified by exceptionally abundant glycosylation. (wikipedia.org)
  • The cells have basally located and benign looking nucleoli with abundant intracytoplasmic mucin. (radiologycases.my)
Malignant5
Secretion1
  • Upon stimulation, MARCKS (myristylated alanine-rich C kinase substrate) protein coordinates the secretion of mucin from mucin-filled vesicles within the specialized epithelial cells. (wikipedia.org)
Protein3
  • Sialylated HEG1 is a mucin-like membrane protein with many sialylated O-linked glycans linked to the serine/threonine rich region in the extracellular domain. (nichireibiosciences.com)
  • Identification of mesothelioma-specific sialylated epitope recognized with monoclonal antibody SKM9-2 in a mucin-like membrane protein HEG1. (nichireibiosciences.com)
  • Recently, insulinoma-associated protein 1 (INSM1) has been identified as a novel neuroendocrine marker that is more sensitive than chromogranin, synaptophysin, and CD56 in pulmonary neuroendocrine tumors. (gastrores.org)
Neuroendocrine1
  • Appendiceal goblet cell carcinoid (GCC) and adenocarcinoma ex-goblet cell carcinoid (AdexGCC) have previously been described as two entities in a spectrum of neoplasms showing both glandular/mucinous and neuroendocrine differentiation [ 1 ]. (gastrores.org)
Heavily glycosylated proteins1
  • Mucins (/ˈmjuːsɪn/) are a family of high molecular weight, heavily glycosylated proteins (glycoconjugates) produced by epithelial tissues in most animals. (wikipedia.org)
Mucinous5
  • Transitional cell and squamous cell carcinomas are the most common but there are three reported cases of mucinous adenocarcinoma. (biomedcentral.com)
  • We report a 57-year-old Caucasian man presenting with penile discharge for 30 years following ileal conduit surgery for neurogenic bladder, and who was found to have primary mucinous adenocarcinoma of his defunctionalized bladder. (biomedcentral.com)
  • The histologic appearance of bladder adenocarcinoma can be enteric, signet ring, mucinous, clear cell, hepatoid and mixed types. (biomedcentral.com)
  • We describe the fifth case of primary mucinous adenocarcinoma arising in a longstanding defunctionalized bladder. (biomedcentral.com)
  • Prostate biopsies showed mucinous adenocarcinoma in six of eight cores with large collections of mucin dissecting the prostatic parenchyma. (biomedcentral.com)
Deposition2
  • Pulmonary hemosiderosis (PH) refers to iron deposition within the lung. (radiopaedia.org)
  • Although the term " siderosis " strictly just means any deposition of surplus iron in the body, when used as a stand-alone term it usually refers to pulmonary siderosis. (radiopaedia.org)
Commonly4
  • These modalities are the methods most commonly used to study the pulmonary circulation, although central pulmonary arterial pathology may be seen with chest radiography and transesophageal echocardiography. (medscape.com)
  • Although meningiomas commonly arise in locations where meningothelial cells are found, the embryonic origin of intraventricular and pulmonary meningiomas are intriguing. (medscape.com)
  • Most cases of paraneoplastic AN involve an adenocarcinoma,[5] most commonly one arising in the gastrointestinal tract (stomach or liver[3] ) and less commonly in the lungs, ovaries, uterus, breasts, kidneys, prostate or bladder. (medscape.com)
  • Microscopically, fungating or polypoid carcinomas are well-differentiated adenocarcinomas, commonly papillary type. (poznayka.org)
Aggregates1
  • Mucins are secreted as massive aggregates of proteins with molecular masses of roughly 1 to 10 million Da. (wikipedia.org)
Nodules1
Embolus2
  • CT image obtained after the intravenous administration of contrast material shows a large embolus at the distal aspect of the right pulmonary artery, with extension into its branches. (medscape.com)
  • It is one of several described signs of pulmonary embolus on chest radiographs . (radiopaedia.org)
Pancreatic1
  • The compact extracellular matrix (ECM) of pancreatic ductal adenocarcinoma (PDAC) is the major physical barrier that hinders the delivery of anti-tumor drugs, leading to strong inherent chemotherapy resistance as well as establishing an immunosuppressive tumor microenvironment (TME). (biomed.news)
Angiography1
  • Radiologic modalities used for assessment include lung scintigraphy, digital subtraction pulmonary angiography (DSPA), pulmonary computed tomography angiography (PCTA), and pulmonary magnetic resonance angiography (PMRA). (medscape.com)
Metastases1
  • She initially improved but 6 months after her operation during a routine follow ups she complained of left shoulder pain and further investigation found lytic lesions in her left proximal humerus and multiple pulmonary metastases. (biomedcentral.com)
Genes1
Precursor2
  • Many studies now justify that AAH is a precursor to adenocarcinoma 4 - 14 . (ersjournals.com)
  • Concomitant cystitis glandularis occurs in the majority of cases, but is not considered a definitive precursor lesion since adenocarcinoma can develop in the absence of cystitis glandularis and only a small number of bladders with cystitis glandularis actually develop malignancies [ 2 ]. (biomedcentral.com)
Chest1
  • Patients were further assessed based on chest high-resolution computed tomography (HRCT), pulmonary function test, 6-minute walk test, echocardiography, bronchioalveolar lavage, and/or transbronchial biopsy. (e-trd.org)
Serum2
  • Studied predictive use of mucin 1 (KL-6) serum level as a biomarker in development of bronchopulmonary dysplasia in preterm infants. (cusabio.com)
  • Neoplasms containing cyst-like formations or producing mucin or serum. (lookformedical.com)
Carcinomas1
  • Macroscopically, ulcerative carcinomas are poorly-differentiated adenocarcinomas, which invade deeply into the stomach wall. (poznayka.org)
Tissue1
  • Of these mucins, the following classes have been defined by localization: Secreted mucins in humans, with their chromosomal location, repeat size in amino acids (aa), whether they are gel-forming (Y) or not (N), and their tissue expression. (wikipedia.org)
Molecular1
  • Recent research has also revealed clinical, radiologic, and pathologic correlates, leading to greater knowledge in molecular profiling and targeted therapeutics, as well as an emphasis on the rising incidence of adenocarcinoma histology. (scienceopen.com)
Cancers1
Proteins1
  • In the mouth, mucins can also recruit anti-microbial proteins such as statherins and histatine 1, which further reduces risk of infection. (wikipedia.org)
Processes1
  • The pulmonary vascular tree processes the entire volume of the body's blood circulation. (medscape.com)
Prostate1
  • Transgenic mice bearing PB promoter fused to simian virus 40 large tumor antigen gene all consistently develop prostate adenocarcinoma [ 13 ]. (hindawi.com)
Goblet1
  • Eleven mucins are expressed by the eye surface epithelia, goblet cells and associated glands, even though most of them are expressed at very low levels. (wikipedia.org)
Refers1
  • The Chang sign refers to the dilatation and abrupt change in caliber of the main pulmonary artery due to pulmonary embolism 1 . (radiopaedia.org)
Human1
  • Synthesized peptide derived from the C-terminal region of Human Mucin 1. (cusabio.com)
Left2
  • Embolic disease is also present in the left pulmonary artery. (medscape.com)
  • The potential for adenocarcinoma to develop in the defunctionalized bladder that is left in-situ at the time of urinary diversion is rare [ 3 - 5 ]. (biomedcentral.com)
Findings1
  • Examinations are prolonged, and the findings are most often nondiagnostic for pulmonary embolism (PE). (medscape.com)
Functions1
  • Mucins have been found to have important functions in defense against bacterial and fungal infections. (wikipedia.org)
Cells1
  • Banal appearing columnar cells lined these mucous lakes, and nests of these cells were seen floating in the mucin (Figure 1 ). (biomedcentral.com)