Pubertal development amenorrhea. Medical search. Frequent questions

Although skeletal maturation is delayed, the rate of linear growth is usually normal except for the absence of a distinct pubertal growth spurt. (beds.ac.uk)
Pubertal maturation in girls and the relationship to anthropometric changes: pathways through puberty. (human-biology-and-public-health.org)
The Tanner scale (5 stages) of sexual maturity rating allows for accurate classification of physical pubertal maturation. (browsegrades.net)
and absent, incomplete, or partial pubertal maturation. (medscape.com)
Endogenous testosterone is responsible for sexual maturation at all stages of development throughout life. (empowerpharmacy.com)
Normally, endogenous androgens stimulate RNA polymerase, resulting in an increased protein production.These proteins are responsible for normal male sexual development, including the growth and maturation of the prostate, seminal vesicle, penis, and scrotum. (empowerpharmacy.com)

Primary amenorrhoea is often a feature. (gponline.com)
Amenorrhea (the absence of menstruation) can be primary or secondary. (msdmanuals.com)
Primary amenorrhea is failure of menses to occur by age 15 years in patients with normal growth and secondary sexual characteristics. (msdmanuals.com)
However, absence of menarche and of any breast development by age 13 should prompt evaluation for primary amenorrhea. (msdmanuals.com)
General references Amenorrhea (the absence of menstruation) can be primary or secondary. (msdmanuals.com)
Gonadal dysgenesis and congenital reproductive tract anomalies cause primary amenorrhea. (msdmanuals.com)
Primary or secondary amenorrhea may be due to endocrinologic disorders. (msdmanuals.com)
Pregnancy could be the cause for primary amenorrhea. (medscape.com)
Primary ovarian insufficiency (POI) (premature ovarian failure, premature menopause, or early menopause) is a condition characterized by amenorrhea, hypoestrogenism, and elevated serum gonadotropin levels in women younger than 40 years. (medscape.com)
There is a possibility of growth stop, delayed pubertal development, and primary amenorrhea in children and adolescents. (healthypilipinas.ph)
Adult females have little or no breast development and primary amenorrhea. (beds.ac.uk)
Some girls develop oligomenorrhea (infrequent menstrual periods) which is usually only intermittent spotting, but primary amenorrhea (absent menstruation) is slightly more common. (pws.org.nz)
Older patients with mild defects in 3-beta-hydroxysteroid dehydrogenase activity (late-onset or nonclassic variant) may present with premature pubic hair development, hirsutism, irregular menstrual cycles or primary amenorrhea. (naqlafshk.com)
The DSM-IV-TR does not consider primary amenorrhea (i.e., failure of menses to start by age 15 while secondary sex characteristics such as breast development and growth of body hair are present, or within three years of the onset of secondary sexual characteristics) as part of the criteria for females with AN [ 11 ]. (biomedcentral.com)
2017 described a girl with a profound congenital hearing impairment and primary amenorrhea, like in Perrault Syndrome that also present additional features like progressive retinal degeneration, agenesis of the corpus callosum, and liver disease. (biomedcentral.com)
The most frequent complaint is primary amenorrhea, accompanied by the absence or reduction of pubic and axillary hairiness, dyspareunia, no acne and no voice change at puberty 6 . (bvsalud.org)
All materials presented in the article are part of the dissertation "Prognosis, diagnosis and prevention of primary dysmenorrhea in patients of pubertal age with different somatotypes. (reproduct-endo.com)
Medicine of the future will be preventive, aimed to identify predictors of pathology, factors influencing the development of nosology, and individual characteristics of teenage girls, which may lead to etiological and pathogenic impulse of clinical progression of primary dysmenorrhea. (reproduct-endo.com)
Chaika, G.V., Markevych, B.O. "Features of sexual development in adolescent girls of different somatotypes with primary dysmenorrhea. (reproduct-endo.com)

Older children may present with absent or delayed puberty, although about 30% of cases have some spontaneous pubertal development. (gponline.com)
Dr Thangesweran said the common gynaecological conditions during adolescence are abnormal pubertal development (delayed puberty, abnormal facial hair), dysmenorrhea (painful period), menstrual disorders (abnormal bleeding), amenorrhea (absence of period) and leucorrhoea (white discharge). (sunwaymedical.com)
McGlacken-Byrne and coauthors discuss management of three girls with delayed puberty and hypergonadotropic amenorrhea of different etiologies. (endocrine.org)
On page 6, Ali Abbara and Waljit Dhillo review our understanding of kisspeptin's role in puberty, with exciting potential developments in its therapeutic and diagnostic use. (eurospe.org)
The function of androgens in male development begins in the fetus, is crucial during puberty, and continues to play an important role in the adult male. (empowerpharmacy.com)
During puberty, androgens cause a sudden increase in growth and development of muscle, with redistribution of body fat. (empowerpharmacy.com)
Puberty is completed with beard development and growth of body hair. (empowerpharmacy.com)

However, the penis and testes rarely reach full development and menstruation in girls either does not start, is sporadic, or is very delayed, sometimes starting much later in adulthood. (pws.org.nz)
If there is a pattern of amenorrhea or irregular menstruation, when there is no normal (early or late) pubertal development or there is some age-related abnormality: excessive growth of the breasts, testicles or penis and growth of hair around the genital organs in childhood. (dailyzum.com)

These phenotypic variations are also difficult to estimate, as cases of the latter are often detected later in infancy, childhood, or even in adolescence due to unusual pubertal development and/or infertility. (e-apem.org)
13 By contrast, pubertal delay or secondary amenorrhoea may herald sub/infertility in girls whose options are more limited. (bmj.com)

It has to be investigated using the clinical history of the patient: occurrence of menarche, menstrual cyclicity, time and modality of amenorrhea, and it has to be excluded any endocrine disease or any metabolic (i.e., diabetes) and systemic disorders. (researchgate.net)
An adequate history includes childhood growth and development and other areas, including height and weight charts and age at thelarche and menarche. (medscape.com)
Needs change as a female enters her pubertal years (beginning of menarche), during her conceptive years and during pregnancy, and afterward at the stage that denotes the finish of multiplication (menopause). (ntierdesign.com)

Some present later with abnormal pubertal development. (orpha.net)
An absence of any breast development or pubertal growth spurt by age 13-14 years in girls is distinctly abnormal and requires investigation. (medscape.com)

and no menses within 3 years of the onset of breast development. (contemporaryobgyn.net)
Minimal breast development and delayed menses - Turner syndrome may be the cause in girls with short stature, cubitus valgus, shortened fourth metacarpals, short neck, high arched palate, neurosensory hearing loss, scoliosis, and Madelung deformity. (contemporaryobgyn.net)
Breast development and no menses - Causes can include androgen insensitivity, anatomical anomalies, or Mayer-Rokitansky-Kuster-Hauser syndrome, which may require surgical interventions. (contemporaryobgyn.net)
It has been shown that pre-pubertal weight can be a useful tool to determine the weight at which resumption of menses (ROM) is likely to occur in adolescents with AN, highlighting the need to return to a weight trajectory preceding weight loss [ 18 ]. (biomedcentral.com)

Signs include: lower abdominal pain, gynecomastia, inguinal hernia, an inguinoscrotal mass, cryptorchidism or amenorrhea/periodic hematuria depending on sex assignment. (orpha.net)
Investigation of CAIS should be standard in pre-pubertal girls with bilateral inguinal hernia, genetic techniques involving X chromatin or Y chromosome tests present the best choices. (bvsalud.org)

1, 5 Obesity in adulthood is recognised as an independent risk factor for the development of type 2 diabetes, and obesity in adolescence increases the risk of insulin resistance and glucose intolerance. (bmj.com)

Breast development, pubertal growth spurt, and adrenarche are delayed or absent in girls with hypothalamic pituitary failure. (medscape.com)
A distinguishing factor in the case of isolated ovarian insufficiency or failure is that adrenarche occurs normally, while estrogen-dependent breast development and the pubertal growth spurt are absent or delayed. (medscape.com)

In girls, disturbances in menstrual function and galactorrhea may be seen, whereas in boys, delayed pubertal development and hypogonadism are often present. (mayocliniclabs.com)
[ 3 ] In addition, mutations of the gene encoding chromodomain-helicase DNA-binding protein 7 ( CHD7 ) have been found in some patients with Kallmann syndrome or idiopathic hypogonadotropic hypogonadism, some of whom have features of the CHARGE syndrome (characterized by delayed growth and development, congenital cardiac defects, dysmorphic ears, hearing loss, coloboma of the eyes). (medscape.com)

However, amenorrhea can occur when ovulation is normal, as occurs when genital anatomic abnormalities (eg, congenital anomalies causing outflow obstruction, intrauterine adhesions [Asherman syndrome]) prevent normal menstrual flow despite normal hormonal stimulation. (msdmanuals.com)
Secondary amenorrhea may be caused by acquired anatomic reproductive tract abnormalities that interfere with menstrual function or obstruct the menstrual flow. (msdmanuals.com)
Amenorrhea can be due to pregnancy, anatomic defects of the outflow tract, ovarian disorders, and pituitary or hypothalamic disorders. (medscape.com)

HA occurs generally after severe stressed conditions/situations such as dieting, heavy training, or intense emotional events, all situations that can induce amenorrhea with or without body weight loss and HA is a secondary amenorrhea with a diagnosis of exclusion. (researchgate.net)

Disorders of sex development (DSDs) are a genetically and clinically heterogeneous group of congenital conditions of the urogenital tract and reproductive system. (e-apem.org)

However, on average, children with PWS reach a stage called pubarche (development of pubic hair) earlier than is typical, but premature pubarche (usually caused by premature adrenarche) can happen as early as before the ages of 8 or 9 in 14-30% of children with PWS. (pws.org.nz)

All individuals with a suspected disorders of sex development need to undergo a thorough diagnostic evaluation, including extensive whole-body and genital physical examinations, biochemical and genetic investigations, and imaging studies. (e-apem.org)
46,XY and 46,XX DSDs can be further subdivided into the subclasses of disorders of gonadal development, disorders of androgen biosynthesis and excess, and unclassified. (e-apem.org)
Amenorrhea, defined as the lack of three consecutive menstrual periods in postmenarchal females, is one of four criteria for AN in the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition Text revision (DSM-IV-TR) [ 9 ] and is currently considered a key clinical feature of AN. (biomedcentral.com)

Siderius-type syndromic intellectual developmental disorder (MRXSSD) is an X-linked disorder in which affected males have mildly impaired intellectual development, mild dysmorphic features, and bilateral or unilateral cleft lip/palate (summary by Koivisto et al. (nih.gov)

Patients with classic salt-losing 3-beta-hydroxysteroid dehydrogenase require initial replacement of glucocorticoids and mineralocorticoid, plus the addition of sex steroids at appropriate, pubertal age. (naqlafshk.com)
Additionally, studies have shown that ileostomy patients have an increased risk for the development of uric acid stones. (passmed.uk)
Treatment has been continued in patients treated with gonadotrophin-releasing hormone (GnRH) analogues for metastatic prostate cancer where there has been a development of castrate-resistant prostate cancer. (medscape.co.uk)
Treatment is usually continued in patients treated with GnRH analogues for metastatic prostate cancer where there has been a development of castrate-resistant prostate cancer. (medscape.co.uk)
In these patients, GnRH deficiency and anosmia are believed to be secondary to abnormalities of neuronal migration during development. (medscape.com)

These conditions may be caused by numerical or structural variations in sex chromosomes as well as autosomes, variations in genes involved in gonadal and/or genital development, and changes in gonadal and/or adrenal steroidogenesis. (e-apem.org)

This is not related to actual pubertal onset. (pws.org.nz)

In some cases, hormonal contraception itself may be the cause of the amenorrhea. (medscape.com)

Ovulatory dysfunction is the most common cause of amenorrhea, particularly secondary amenorrhea. (msdmanuals.com)

find that disrupting the slow-wave sleep of pubertal children with sound had no effect on growth hormone pulse amplitude or basal growth hormone secretion. (endocrine.org)

Taking a careful patient history is paramount in deciphering potential etiologies of secondary amenorrhea. (medscape.com)

It is known as functional hypothalamic amenorrhea (FHA), and it is associated with metabolic, physical, or psychological stress (after severe dieting, heavy training, intense emotional events, or a combination of them) [4, 5] with or without body weight loss [6]. (researchgate.net)
Functional hypothalamic amenorrhea (FHA) is a relatively frequent disease due to the combination of metabolic, physical, or psychological stressors. (researchgate.net)
Functional hypothalamic amenorrhea: An Endocrine Society clinical practice guideline. (msdmanuals.com)

Pregnancy is the most common cause of amenorrhea. (medscape.com)

Testosterone therapy for boys and oestrogen therapy for girls can be used for promoting and maintaining pubertal development. (pws.org.nz)

As a foundation for understanding müllerian duct anomalies, the first part of this article discusses the epidemiology and classification of müllerian duct defects as well as normal embryologic development of the female reproductive tract. (medscape.com)

Eighty-four adolescents (Mean age = 15.1, SD = 2.2) with a DSM-IV diagnosis of AN, presenting with secondary amenorrhea were identified. (biomedcentral.com)

In addition, developments in assisted reproductive technology allow some women with müllerian duct anomalies to conceive and deliver healthy babies. (medscape.com)
8 The Guideline Development Group (GDG) included representatives from paediatric haematology, oncology, endocrinology, reproductive medicine, cardiology, general paediatrics and general practice, as well as a survivor. (bmj.com)
Epidemiological investigations have shown increasing evidence of altered development and detrimental effects on reproductive health during the past 50 years associated with endocrine disruptors affecting the HPG axis. (intechopen.com)

We selected three of the reviewed dosing regimens for their pharmacokinetics (PK) characteristics and their exposure-response relationship in three gestational age groups of preterm neonates (28, 32 and 36 gestational age weeks) at risk for development of severe NAS (defined as an umbilical cord methadone concentration of ≤60 ng/mL, following fetal exposure). (academic-accelerator.com)

Deficiency of Purkinje cells is one of the most consistently identified neuroanatomical abnormalities in brains from autistic individuals 18 , 19 and RORα is critical in development of the Purkinje cells. (epiphanyasd.com)

Among secondary amenorrheas, hypothalamic amenorrhea (HA) is the one with no evidence of endocrine/systemic causal factors. (researchgate.net)
Endogenous or exogenous (maternal) and possibly endocrine disruptors may also interfere with genital development. (e-apem.org)

A rare disorder of sex development (DSD) characterized by histologically confirmed testicular and ovarian tissue in an individual with a 46,XX karyotype. (orpha.net)
Development of external genitalia ranges from apparent female to male genitalia with hypospadias or isolated bilaterally undescended ovotestes (gonads containing ovarian and testicular elements). (orpha.net)
In Endocrinology , Guo and co-workers describe research providing insights into the role of casein kinase 1α in testicular development and steroidogenesis. (endocrine.org)

There are no published reports documenting the development in obese white children in the UK. (bmj.com)

When endogenous androgens are unavailable, use of exogenous androgens are necessary for normal male growth and development. (empowerpharmacy.com)

Sexual development in PWS is affected by the diminished or disrupted production of sex hormones. (pws.org.nz)

Anatomy9

Organisms3

Diseases25

Chemicals and Drugs20

Analytical, Diagnostic and Therapeutic Techniques and Equipment13

Psychiatry and Psychology7

Phenomena and Processes25

Anthropology, Education, Sociology and Social Phenomena1

Health Care7

Geographicals1

Maturation6

Primary19

Puberty7

Menstruation2

Infertility2

Menarche3

Abnormal2

Menses4

Inguinal hernia2

Adolescence1

Absent2

Hypogonadism2

Anatomic3

Induce1

Congenital1

Adrenarche1

Disorders3

Bilateral1

Patients5

Gonadal1

Onset1

Hormonal1

Dysfunction1

Growth hormone1

Etiologies1

Functional3

Pregnancy1

Girls1

Defects1

Diagnosis1

Reproductive3

Severe1

Abnormalities1

Endocrine2

Testicular3

Children1

Normal1

Sexual1