• The Parathyroid Hormone-Related Peptide (PTH-RP) Plasma Test measures the PTH-RP hormone levels in the blood to help diagnose hypercalcemia. (walkinlab.com)
  • Molecular determinants of tuberoinfundibular peptide of 39 residues (TIP39) selectivity for the parathyroid hormone-2 (PTH2) receptor. (wikipedia.org)
  • In addition to OPG, the stimulation of osteoclastic bone resorption by RANKL is opposed by activation of the gamma interferon receptor (INFR) by gamma interferon (INF) production by activated lymphocytes and by the peptide hormone, calcitonin. (endotext.org)
  • Hypercalcemia is a paraneoplastic syndrome that occurs secondary to malignant cell production of a parathyroid hormone-related peptide (PTH-rp). (vin.com)
  • Parathyroid hormone related peptide (PTHrP) was first described in 1985 as a new compound with parathyroid hormone (PTH)-like bioactivity that accounted for the discrepancy between human umbilical cord and maternal PTH levels ( 1 ). (frontiersin.org)
  • Hypercalcaemia is a prevalent complication in malignancies as a consequence of tumor secretion of parathyroid hormone related peptide (PTHrP). (endocrine-abstracts.org)
  • Synthetic peptide corresponding to aa146-169 of human PTH/PTHrP Receptor [RRCDRNGSWELVPGHNRTWANYSE]. (covalab.com)
  • Parathyroid hormone (PTH) regulates calcium homeostasis via the type I PTH/PTH-related peptide (PTH/PTHrP) receptor (PTH1R). (duke.edu)
  • Identification of a novel parathyroid hormone-like peptide. (medscape.com)
  • The parathyroid hormone-related protein (PTH-rP) test measures the level of a hormone in the blood, called parathyroid hormone-related protein. (medlineplus.gov)
  • Parathyroid hormone-related protein (PTHrP) and malignancy. (nih.gov)
  • Parathyroid Hormone-Related Protein (PTHrP): An Emerging Target in Cancer Progression and Metastasis. (nih.gov)
  • The cloning of cDNA and genomic DNA encoding the PTH/parathyroid hormone-related protein (PTHrP) receptor. (massgeneral.org)
  • In this study, we examined the roles of parathyroid hormone-related protein (PTHrP) in the development of bisphosphonate- and calcitonin-refractory HHM. (unboundmedicine.com)
  • Harvard Medical School Professor Bruce Spiegelman was among the researchers who demonstrated that symptoms of cachexia in mice with lung tumors improved or were prevented when they were given an antibody that blocked the effects of a protein, PTHrP, secreted by the tumor cells. (harvard.edu)
  • In the July 13 advanced online edition of Nature, scientists led by Bruce Spiegelman , the Stanley J. Korsmeyer Professor of Cell Biology and Medicine at Harvard Medical School, reported that symptoms of cachexia in mice with lung tumors improved or were prevented when the mice were given an antibody that blocked the effects of a protein, PTHrP, secreted by the tumor cells. (harvard.edu)
  • PTHrP, which stands for parathyroid hormone-related protein, is known to be released from many types of cancer cells. (harvard.edu)
  • Before trying the anti-PTHrP antibody in human patients, he said, "clinicians would probably first want to find out if the protein is elevated in certain cancers, and determine which patients would be good candidates for a clinical trial. (harvard.edu)
  • Additionally, saikosaponins A and D inhibited mRNA expression of parathyroid hormone-related protein as well as cell viability and invasion in metastatic human breast cancer cells. (hindawi.com)
  • In endochondral bone formation, parathyroid hormone-related protein (PTHrP)-expressing RZSCs are the source of growth plate chondrocytes, which give rise to bone-forming osteoblasts as well as bone marrow skeletal stem cells 1 . (nature.com)
  • PTH1R (parathyroid receptor-1) is a 7-transmembrane receptor that expressed in bone, kidney and other tissues where its ligands, PTH (parathyroid hormone) and PTHrP (PTH-related protein), are found. (rndsystems.com)
  • Measurement of parathyroid hormone related protein (PTHrp) to aid in the diagnosis of hypercalcemia due to malignancy. (tamu.edu)
  • The company intends to use the proceeds to fund Phase 3 clinical development of the subcutaneous injection form of BA058, its novel, proprietary PTHrP (parathyroid hormone-related protein) analog, for the treatment of osteoporosis. (finsmes.com)
  • Parathyroid hormone-related protein (PTHrP) is an autocrine/paracrine regulator in many tissues, including bone and mammary glands. (edu.au)
  • Production and characterisation of gilthead sea bream (Sparus auratus) recombinant parathyroid hormone related protein. (ualg.pt)
  • The production and purification of gilthead sea bream recombinant parathyroid hormone related protein [sbPTHrP(1-125)] using an Escherichia coli system and one step purification process with continuous elution gel electrophoresis is reported. (ualg.pt)
  • Assessment of the immunological reactivity of the isolated protein by Western blot revealed it cross-reacts with antisera specific for the N-terminal and C-terminal region of PTHrP. (ualg.pt)
  • Scholars@Duke publication: Distinct beta-arrestin- and G protein-dependent pathways for parathyroid hormone receptor-stimulated ERK1/2 activation. (duke.edu)
  • Furthermore, stimulation of hPTH1R with PTH analogues, [Trp1]PTHrp-(1-36) and [d-Trp12,Tyr34]PTH-(7-34), selectively activated G(s)/PKA-mediated ERK1/2 activation or G protein-independent/beta-arrestin-dependent ERK1/2 activation, respectively. (duke.edu)
  • No detectable (or minimal) parathyroid hormone-related protein (PTHrP) is normal. (medscape.com)
  • Moseley JM, Gillespie MT. Parathyroid hormone-related protein. (medscape.com)
  • Hypercalcemia secondary to gastrointestinal stromal tumors: parathyroid hormone-related protein independent mechanism? (medscape.com)
  • When malignancy is considered, parathyroid hormone-related protein (PTHrP) levels are often measured. (bvsalud.org)
  • Unlike other protein hormones, its production and secretion are stimulated by decreased intracellular calcium concentrations, which reflect serum calcium concentrations. (medscape.com)
  • Demonstration that the formerly puzzling Jansen-type metaphyseal osteochondrodystrophy is a disease of the PTH/PTHrP receptor. (massgeneral.org)
  • Detailed analysis of the modes of activation of the PTH/PTHrP receptor by PTH and PTHrP analogs. (massgeneral.org)
  • PTH-rP resembles PTH in as much as they bind to the same type 1 PTH/PTHrP receptor and induce a similar response in the body. (medscape.com)
  • Since PTHrP has the same N-terminal as PTH, it can bind to the same receptor and stimulate the action of PTH. (medscape.com)
  • Hypoparathyroidism results from defective synthesis or secretion of parathyroid hormone (PTH), end-organ resistance, or inappropriate regulations that result from the activated or antibody-stimulated calcium-sensing receptor (CaSR). (medscape.com)
  • Genetically inherited forms arise from defects of parathyroid gland development, defects in the parathyroid hormone (PTH) gene, defects in the calcium-sensing receptor gene, defects in PTH action, defects in the autoimmune regulator gene, and genetic syndromes. (medscape.com)
  • Because high blood levels of PTHrP were detected in the LC-6 rats, those that developed alendronate-refractory HHM were treated with an anti-PTHrP antibody. (unboundmedicine.com)
  • Administration of anti-PTHrP antibody to animals that received repeated administration of alendronate, thereby developing alendronate-refractory HHM, resulted in an increase in fractional excretion of calcium and a marked decrease of blood calcium level. (unboundmedicine.com)
  • Administration of the anti-PTHrP antibody, but not of alendronate, effectively reduced the blood calcium of the animals that developed elcatonin-refractory HHM. (unboundmedicine.com)
  • Thus, blockage of PTHrP functions by a neutralizing antibody against PTHrP would benefit patients who develop bisphosphonate- or calcitonin-refractory HHM. (unboundmedicine.com)
  • In one, they administered a polyclonal antibody that specifically neutralizes PTHrP and found that it almost completely prevented the wasting, while untreated animals became mildly cachexic. (harvard.edu)
  • C-terminal PTHrP levels accumulate with CKD and can be elevated in normocalcemic CKD patients who lack malignancy. (bvsalud.org)
  • The identification and cloning of the PRAD 1 gene, a novel cyclin gene overexpressed in a subset of parathyroid and other tumors. (massgeneral.org)
  • The scientists said their findings were the first to explain in detail how PTHrP from tumors switches on a thermogenic (heat-producing) process in fatty tissues, resulting in unhealthy weight loss. (harvard.edu)
  • A novel FAK Tyr397 inhibitor suppresses osteoblast proliferation and differentiation, as well as osteoclast formation, via PTHrP-induced RANKL expression in murine bone stromal ST2 cells [twenty]. (acthreceptor.com)
  • High levels of circulating PTHrP and the resulting augmentation of renal calcium reabsorption is one of the major causes of the emergence of osteoclast inhibitor-refractory HHM. (unboundmedicine.com)
  • Major phosphaturic hormones that regulate renal phosphate handling are PTH and FGF23. (frontiersin.org)
  • Mice with conditional deletion of PTHrP in the osteoblast lineage showed an osteopenic phenotype, and low bone formation levels by the age of 6 weeks, suggesting a paracrine role for PTHrP in promoting bone formation. (edu.au)
  • These results showed that PTHrP acts as an autocrine/paracrine factor in osteocytes to regulate mineralisation and bone formation. (edu.au)
  • These two sets of experiment showed that deletion of endogenous osteocytic PTHrP (in both heterozygous- and homozygous-bred Dmp1Cre.Pthlhf/f mice) had no impact on PTH-induced bone formation. (edu.au)
  • SHH stimulates osteoclast formation with PTHrP in a co-lifestyle technique consisting of ST2 cells and murine CD11b+ bone marrow cells [ten]. (acthreceptor.com)
  • For this purpose, I have developed an in vitro model of PTHrP (gene: Pthlh) knockdown by using shRNA in a new osteocytic cell line, Ocy454 cells. (edu.au)
  • Other studies believe that IDD is closely related to hormone regulation, especially the decrease of estrogen level in menopausal women may lead to the occurrence of IDD [ 8 ]. (hindawi.com)
  • Also, significant discoveries including new embryological molecular genetic transcription factors, the role of active placental mineral transport, and hormone regulation factors have changed the understanding of calcium and phosphate homeostasis in the fetus and the newborn. (frontiersin.org)
  • Growth, metabolism, and differentiation of chondrocytes, which are the key cellular players in this process, are regulated by systemic hormones, local factors, and cellular signaling pathways. (pfmjournal.org)
  • The bioactivity of recombinant sbPTHrP(1-125) assessed using an in vitro scale bioassay was found to be equipotent to PTHrP(1-34) in stimulating cAMP accumulation. (ualg.pt)
  • It may turn out that the PTHrP mechanism is responsible for cachexia in a subset of cancer patients, but not all, Spiegelman suggested. (harvard.edu)
  • Thus, the role of PTHrP "is definitely not the whole answer" to the riddle of cachexia, noted Spiegelman, but it may be a necessary part, with other factors also involved. (harvard.edu)
  • Hormones and growth factors play a role in these different stages of mammary development and are also implicated in breast cancer. (biologists.com)
  • PTHrP Drives Pancreatic Cancer Growth and Metastasis and Reveals a New Therapeutic Vulnerability. (nih.gov)
  • Do not worry about cancer until you have checked your parathyroids--high blood calcuim is due to a parathyroid problem almost 100% of the time! (parathyroid.com)
  • Twenty-five years of PTHrP progress: from cancer hormone to multifunctional cytokine. (medscape.com)
  • Hens JR, Dann P, Zhang JP, Harris S, Robinson GW, Wysolmerski J. BMP4 and PTHrP interact to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction. (medscape.com)
  • My results showed recombination of Pthlh in mammary tissues, however there was no difference in milk PTHrP content of Dmp1Cre.Pthlhf/f mothers, compared to controls. (edu.au)
  • You would have expected, based on our first experiments in cell culture, that blocking PTHrP in the mice would reduce browning of the fat," said Spiegelman. (harvard.edu)
  • Next, I generated 10kb-Dmp1Cre.Pthlhf/f mice, which had conditional deletion of PTHrP in osteocytes, from heterozygous breeders. (edu.au)
  • My results demonstrating that Dmp1Cre.Pthlhf/f mice showed no significant differences in cortical or trabecular bone structure compared to Dmp1Cre.Pthlhw/w littermates at 6 weeks of age, indicate that osteocytic PTHrP is not essential for skeletal development in growing mice. (edu.au)
  • DiGeorge syndrome (ie, hypoparathyroidism, absence of thymus gland [T-cell abnormalities], cardiac anomalies) is associated with abnormal development of the third and fourth pharyngeal pouches from which the parathyroids derive embryologically and represents an example of a defect in parathyroid gland development. (medscape.com)
  • You enter your test results and the app will tell you if you have a parathyroid problem and what your risks are. (parathyroid.com)
  • The amino and carboxy termini of PTHrP are of functional relevance. (bvsalud.org)
  • The existence of amino (N)-terminal and carboxy (C)-terminal PTHrP assays and how their concentrations are impacted by CKD are reviewed herein. (bvsalud.org)
  • Growth hormone (GH), sex hormone, thyroid hormone, as well as glucocorticoids affect chondrocyte proliferation and hypertrophy. (pfmjournal.org)
  • Since PTHrP is also expressed in osteocytes, I sought to determine the role of osteocytic PTHrP in bone. (edu.au)
  • These findings indicate that osteocyte-derived PTHrP is required to maintain trabecular bone mass and material strength of adult bones. (edu.au)
  • High blood calcium can lead to many serious health problems and should almost always be treated with an operation to remove the parathyroid tumor. (parathyroid.com)
  • Over 99% of all people who have a blood test that shows too much calcium will have a parathyroid problem. (parathyroid.com)
  • A subsequent N-terminal PTHrP assay returned within the normal range. (bvsalud.org)
  • Many commercial labs run the C-terminal PTHrP assay as their first-line test. (bvsalud.org)
  • If you have high calcium, the first thing you need to look for is parathyroid disease. (parathyroid.com)
  • If you have high calcium, you should start at the beginning of this site and read about your parathyroid problem. (parathyroid.com)