• Isolates from pseudorabies virus epidemics in swine herds were characterized. (cdc.gov)
  • Iglesias G., Pijoan C., Molitor T., Interactions of pseudorabies virus with swine alveolar macrophages I: virus replication, Arch. (vetres.org)
  • Both viruses are highly contagious and fatal to the animals," it added, without specifying how many swine were infected or whether some died from other causes. (straitstimes.com)
  • Rapid detection of African swine fever virus "We have identified a cell line that can be used to isolate and detect a live virus," said ARS scientist Dr. Douglas Gladue. (heolabs.com)
  • In a previous study we obtained and characterized in vitro a novel pseudorabies virus (PRV) variant named gIp2 with a TK, gI/gE, 11k and 28k negative phenotype and a duplication of PK gene. (csic.es)
  • Deletion of the gene encoding glycoprotein (G protein) in rabies limits the spread of the virus strictly to cells that were initially infected. (wikipedia.org)
  • Transsynaptic spread of the virus can be limited to monosynaptic transmission to a neuron of origin by pseudotyping the G protein and putting the gene under Cre-control. (wikipedia.org)
  • Promoter activity of the 5'-flanking region of the pseudorabies virus (PRV) early protein 0 (EP0) gene was analysed by transient transfection assays employing chloramphenicol acetyl transferase (CAT) reporter constructs. (elsevierpure.com)
  • Brideau A.D., Banfield B.W., Enquist L.W., The Us9 gene product of pseudorabies virus, an alphaherpesvirus, is a phosphorylated tail-anchored type II membrane protein, J. Virol. (vetres.org)
  • Fuchs W., Klupp B.G., Granzow H., Osterrieder N., Mettenleiter T.C., The interacting UL31 and UL34 gene products of pseudorabies virus are involved in egress from the host-cell nucleus and represent components of primary enveloped but not of mature virions, J. Virol. (vetres.org)
  • Fuchs W., Klupp B.G., Granzow H., Mettenleiter T.C., Essential function of the pseudorabies virus UL36 gene product is independent of its interaction with the UL37 protein, J. Virol. (vetres.org)
  • In this study, we deleted and genes based on a / / triple gene-deleted pseudorabies virus and tested its efficacy in pigs as a vaccine candidate. (engineering.org.cn)
  • Rapid Diagnostic Tests as a Source of Dengue Virus RNA for Envelope Gene Amplification: A Proof of Concept. (cdc.gov)
  • Alignment the partial sequences of glycoprotein (g) C (A), gD (B), and gE (C) genes of pseudorabies virus at the nucleotide level. (cdc.gov)
  • Recombinant Glycoprotein E (gE) of Pseudorabies Virus produced in E. coli. (creativebiomart.net)
  • Pseudorabies virus glycoprotein E (PRV gE) has been recognized as a suitable diagnostic antigen for pseudorabies. (creativebiomart.net)
  • Kit S., Kit M., Bartkoski M.J., Dees G., Genetically engineered pseudorabies virus vaccine with deletions in thymidine kinase and glycoprotein genes, Cold Spring Harbor Symposium Vaccines 87, Pseudorabies Vaccines, 1987, pp. 345-349. (vetres.org)
  • The herpes simplex virus type 1 (HSV-1) glycoprotein N (gN/UL49.5) is a type I transmembrane protein conserved throughout the herpesvirus family. (mdpi.com)
  • However, pigs have been confirmed to be the primary hosts and reservoir of this virus ( 6 - 8 ). (cdc.gov)
  • Necropsy specimens from pigs infected with pseudorabies virus. (cdc.gov)
  • Baskerville A., The histopathology of pneumonia produced by aerosol infection of pigs with a strain of Aujeszky's disease virus, Res. (vetres.org)
  • De Wind N., Berns J., Gielkens A.L., Kimman T.G., Ribonucleotide reductase-deficient mutants of pseudorabies virus are avirulent for pigs and induce partial protective immunity, J. Gen. Virol. (vetres.org)
  • However, vaccination could not provide protection against virulent pseudorabies virus challenge since vaccinated pigs showed clinical pseudorabies-specific syndromes. (engineering.org.cn)
  • Animal disease investigators found a "pseudo-rabies virus" - which is related to the herpes virus, rather than rabies - and also the virus that causes blue ear disease, "which likely killed the pigs", the report said. (straitstimes.com)
  • We do not advise the use of raw pork in the recipes because pigs may carry many disease causing pathogens including Trichinella and the virus that causes Pseudorabies (Aujeszky's disease). (felineinstincts.com)
  • Thus, both the virus in the vaccine and the super-virulent wild-type strain can establish latency within the same animal ( 13 - 15 ). (cdc.gov)
  • Deletion of three key membrane protein genes in the PRV-Bartha strain of pseudorabies blocks anterograde spread of the virus and allows for additional manipulations to the viral DNA such as fluorescence to be added, allowing for retrograde circuit tracing. (wikipedia.org)
  • The rescued virus showed similar growth properties and plaque size as its parent strain. (engineering.org.cn)
  • Strain Cvilin [18] isolated in North Moravia near Ostrava is closely related or identical with CIP virus. (cdc.gov)
  • ipRGCs can be transsynaptically labeled through the pupillary-reflex circuit with the derivatives of the Bartha strain of the alphaherpesvirus pseudorabies virus(PRV) [4, 5] that express GFP [6-12]. (nih.gov)
  • A new strain of Covid-19 virus has been found in Bavaria, southern Germany, and preliminary evidence suggests that the strain is different from what is known. (heolabs.com)
  • The membrane proteins gI and gE of Pseudorabies virus (PRV) are required for viral invasion and spread through some neural pathways of the rodent central nervous system. (princeton.edu)
  • Favoreel H.W., Nauwynck H.J., Halewyck H.M., Van Oostveldt P., Mettenleiter T.C., Pensaert M.B., Antibody-induced endocytosis of viral glycoproteins and major histocompatibility complex class I on pseudorabies virus-infected monocytes, J. Gen. Virol. (vetres.org)
  • Hanssens F.P., Nauwynck H.J., Pensaert M.B., Involvement of membrane-bound viral glycoproteins in adhesion of pseudorabies virus-infected cells, J. Virol. (vetres.org)
  • As virulence-determining genes, and encode the small subunit and large subunit of viral ribonucleotide reductase (RR) in pseudorabies virus which have been extensively studied in mice. (engineering.org.cn)
  • Unlike non-viral tracers, which have many limitations, genetically modified viruses can target specific cell types. (2bscientific.com)
  • Recently, an increasing number of studies have shown that long noncoding RNAs (lncRNAs) are involved in host metabolism after infection with pseudorabies virus (PRV). (bvsalud.org)
  • Following infection of the rat retina with wild-type PRV, virus replicates in retinal ganglion neurons and anterogradely spreads to infect all visual centers in the brain. (princeton.edu)
  • Comparison of Respiratory Specimen Collection Methods for Detection of Influenza Virus Infection by RT-PCR: A Literature Review. (cdc.gov)
  • Bitsch V., Correlation between the pathogenicity of field strains of Aujeszky's disease virus and their ability to cause cell fusion - syncytia formation - in cell cultures, Acta Vet. (vetres.org)
  • Elford W.J., Galloway I.A., The size of the virus of Aujeszky's disease ("pseudo-rabies", "infectious bulbar paralysis", "mad itch") by ultrafiltration analysis, J. Hyg. (vetres.org)
  • Kaliman A.V., Boldogkoi Z., Fodor I., Large and small subunits of the Aujeszky's disease virus ribonucleotide reductase: nucleotide sequence and putative structure, Biochim. (vetres.org)
  • Kimman T.G., Pol J.M., de Wind N., Oei-Lie N., Berns A.J., Gielkens A.L., Role of different genes in the virulence and pathogenesis of Aujeszky's disease virus, Vet. (vetres.org)
  • In conclusion, the use of gIp2 in piglets as a vaccine virus is safe and induces an immunity comparable to that exerted by commercially available vaccines. (csic.es)
  • As members of the Herpesviridae virus family, there are two strains of the herpes simplex virus, HSV-1, which is responsible for cold sores, and HSV-2, which is responsible for genital herpes. (eol.org)
  • We sought to identify neural populations that project from the CNS indirectly through multisynaptic pathways to liver and epididymal white fat in mice using pseudorabies virus strains expressing different reporters together with BAC transgenesis and immunohistochemistry. (mssm.edu)
  • Viruses have the advantage of self-replication over molecular tracers. (2bscientific.com)
  • Molecular characterization of measles viruses in China: Circulation dynamics of the endemic H1 genotype from 2011 to 2017. (cdc.gov)
  • Berthomme H., Monahan S.J., Parris D.S., Jacquemont B., Epstein A.L., Cloning, sequencing and functional characterization of the two subunits of the pseudorabies virus DNA polymerase holoenzyme: evidence for specificity of interaction, J. Virol. (vetres.org)
  • Two weeks post-stroke, mice received intramuscular injections of pseudorabies virus (PRV-152), a trans-synaptic retrograde herpes virus driving expression of green fluorescent protein (GFP), into the affected contralesional forelimb to label neurons in descending tracts to the forelimb musculature. (frontiersin.org)
  • Fuchs W., Granzow B.G., Klupp B.G., Kopp M., Mettenleiter T.C., The UL48 tegument protein of pseudorabies virus is critical for intracytoplasmic assembly of infectious virus, J. Virol. (vetres.org)
  • Fuchs W., Klupp B.G., Granzow H., Hengartner C., Brack A., Mundt A., Mettenleiter T.C., Physical interaction between envelope glycoproteins E and M of pseudorabies virus and the major tegument protein UL49, J. Virol. (vetres.org)
  • Pseudorabies virus (PRV), also called Aujeszky disease virus or suid herpesvirus type 1, is a member of the Alphaherpesvirinae subfamily within the family Herpesviridae . (cdc.gov)
  • A member of the herpesviridae family, the pseudorabies virus spreads through the CNS in both a retrograde and anterograde fashion, moving up the neural axon into the soma and dendrites in the retrograde application. (wikipedia.org)
  • This negatively-stained transmission electron micrograph (TEM) revealed the presence of numerous herpes simplex type-2 virions, members of the Herpesviridae virus family. (eol.org)
  • Additionally, the inoculation of gIp2 induced an immune response able to provide clinical and virological protection against pseudorabies virus after challenge. (csic.es)
  • The original articles mentioned in this collection are surprisingly diverse, including studies related to newly invented virological methods, basic virology, surveillance work, virus evolution and bioinformatic analyses. (biomedcentral.com)
  • NT among Kemerovo group viruses by ic route in mice (data of J. Casals). (cdc.gov)
  • Connections from these same sites to the PVH were evident after direct injection of virus into the PVH, suggesting that these regions lie upstream of the PVH in a common pathway to liver and adipose tissue (two metabolically active organs). (mssm.edu)
  • Test kit is used for the rapid detection of monkeypox virus antigens in human specimens,making it a valuable tool in the early diagnosis and control of monkeypox infections. (mapperbio.com)
  • 130 "Biohazard":110 page document produced by National Anti-vivi -section Society in London in 1987.Quotes over 1000 scien -tific papers relating to deliberate transmission of lethal viruses from species to spe -cies in US primate centres in the 1960's and 1970's. (globalchange.com)
  • Genome-wide analysis of long noncoding RNA profiles in pseudorabies-virus-infected PK15 cells. (bvsalud.org)
  • These experiments provide additional proof that the retinal ganglion cells projecting to the superior colliculus are susceptible and permissive to gE and gI mutant viruses. (princeton.edu)
  • Porcine NK Cells Stimulate Proliferation of Pseudorabies Virus-Experienced CD8 and CD4CD8 T Cells. (sciensano.be)
  • Neurons common to both circuits were identified in subpopulations of the paraventricular nucleus of the hypothalamus (PVH) by double labeling with markers expressed in viruses injected in both sites. (mssm.edu)
  • In an animal study, the virus could elicit humoral immune responses shown by generation of gB-specific antibodies and virus neutralizing antibodies. (engineering.org.cn)
  • Evidence confirmed that the pathogenic pseudorabies virus was the etiologic agent of this epidemic. (cdc.gov)
  • Pseudorabies virus (PRV) can infect multiple hosts and lead to fatal encephalitis. (biomedcentral.com)
  • The deficiency in protection may due to the generation of late and low levels of gB antibodies and virus neutralizing antibodies. (engineering.org.cn)
  • In the wildtype rabies virus, the virus will continue to replicate and spread throughout the central nervous system until it has systemically infected the entire brain. (wikipedia.org)
  • Thirdly, the articles in this series cover a wide range of viruses circulating in different hosts. (biomedcentral.com)
  • Since viruses have the ability to jump across synapses they can spread very quickly and degrade neural tissue. (2bscientific.com)
  • The detachment of the SARS-CoV-2 receptor-binding domain from hACE2 increased as the BE concentration increased, allowing the release of the virus from hACE2 for early diagnosis. (1bp1.com)
  • CD112 functions as a receptor for α-herpes viruses HSV-1 and pseudorabies virus (PRV). (biolegend.com)