SwineNovel pseudorabiesVaccineViralPigsSuid herpesvirusGeneGlycoproteinInfectionClinicalVirolProteinEvidenceCellsResultsDogsUniversityAujeszky's DiseaseInfected with pseudorabies virusAttenuated Pseudorabies VirusVaccinesEradicationAlphaherpesvirusAujeszky DiseaseGenesAbstractIsolatesPathogenesisSwine industryAntibodyEpidemiologyViral diseaseCharacterizationDiagnosisHerdSpecimensStrainDiseaseTransmissionControlNaturalTest
Swine11
- Aujeszky's disease, usually called pseudorabies in the United States, is a viral disease in swine that is endemic in most parts of the world. (wikipedia.org)
- The assessment is levied to promote the control and eradication of pseudorabies in swine. (arkansas.gov)
- Isolates from pseudorabies virus epidemics in swine herds were characterized. (cdc.gov)
- Pseudorabies, also known as Aujezsky's disease, mad itch, and infectious bulbar paralysis, is a highly contagious disease of swine that can also be fatal in domestic species. (tamu.edu)
- The prevalence of pseudorabies in Texas feral swine populations averages between 8-13% based on opportunistic sampling of adults done by the USDA/APHIS/Wildlife Services. (tamu.edu)
- Pseudorabies does not appear to have a detrimental effect on the feral swine population. (tamu.edu)
- In summary, pseudorabies should be considered a differential diagnosis for neurologic disease of domestic animals exposed to feral swine populations. (tamu.edu)
- Iglesias G., Pijoan C., Molitor T., Interactions of pseudorabies virus with swine alveolar macrophages I: virus replication, Arch. (vetres.org)
- Vaccines or candidate vaccines used to prevent PSEUDORABIES (Aujeszky's disease), a herpesvirus of swine and other animals. (nih.gov)
- No swine vaccinated against Pseudorabies are allowed entry into Georgia. (georgia.gov)
- Pseudorabies is a highly contagious disease of swine that kills piglets. (miwildlife.org)
Novel pseudorabies1
- In a previous study we obtained and characterized in vitro a novel pseudorabies virus (PRV) variant named gIp2 with a TK, gI/gE, 11k and 28k negative phenotype and a duplication of PK gene. (csic.es)
Vaccine2
- Kit S., Kit M., Bartkoski M.J., Dees G., Genetically engineered pseudorabies virus vaccine with deletions in thymidine kinase and glycoprotein genes, Cold Spring Harbor Symposium Vaccines 87, Pseudorabies Vaccines, 1987, pp. 345-349. (vetres.org)
- In this study, we deleted and genes based on a / / triple gene-deleted pseudorabies virus and tested its efficacy in pigs as a vaccine candidate. (engineering.org.cn)
Viral6
- Histologically, pseudorabies lesions are characterized by non-suppurative inflammation with intranuclear herpesvirus-type viral inclusion bodies (Figure 1). (tamu.edu)
- however, these findings are not specific for pseudorabies and are only suggestive of a viral infection. (tamu.edu)
- Favoreel H.W., Nauwynck H.J., Halewyck H.M., Van Oostveldt P., Mettenleiter T.C., Pensaert M.B., Antibody-induced endocytosis of viral glycoproteins and major histocompatibility complex class I on pseudorabies virus-infected monocytes, J. Gen. Virol. (vetres.org)
- Hanssens F.P., Nauwynck H.J., Pensaert M.B., Involvement of membrane-bound viral glycoproteins in adhesion of pseudorabies virus-infected cells, J. Virol. (vetres.org)
- The membrane proteins gI and gE of Pseudorabies virus (PRV) are required for viral invasion and spread through some neural pathways of the rodent central nervous system. (princeton.edu)
- As virulence-determining genes, and encode the small subunit and large subunit of viral ribonucleotide reductase (RR) in pseudorabies virus which have been extensively studied in mice. (engineering.org.cn)
Pigs3
- Necropsy specimens from pigs infected with pseudorabies virus. (cdc.gov)
- De Wind N., Berns J., Gielkens A.L., Kimman T.G., Ribonucleotide reductase-deficient mutants of pseudorabies virus are avirulent for pigs and induce partial protective immunity, J. Gen. Virol. (vetres.org)
- However, vaccination could not provide protection against virulent pseudorabies virus challenge since vaccinated pigs showed clinical pseudorabies-specific syndromes. (engineering.org.cn)
Suid herpesvirus2
- Pseudorabies virus (PRV), also called Aujeszky disease virus or suid herpesvirus type 1, is a member of the Alphaherpesvirinae subfamily within the family Herpesviridae . (cdc.gov)
- Pseudorabies is caused by suid herpesvirus 1. (tamu.edu)
Gene4
- Promoter activity of the 5'-flanking region of the pseudorabies virus (PRV) early protein 0 (EP0) gene was analysed by transient transfection assays employing chloramphenicol acetyl transferase (CAT) reporter constructs. (elsevierpure.com)
- Brideau A.D., Banfield B.W., Enquist L.W., The Us9 gene product of pseudorabies virus, an alphaherpesvirus, is a phosphorylated tail-anchored type II membrane protein, J. Virol. (vetres.org)
- Fuchs W., Klupp B.G., Granzow H., Osterrieder N., Mettenleiter T.C., The interacting UL31 and UL34 gene products of pseudorabies virus are involved in egress from the host-cell nucleus and represent components of primary enveloped but not of mature virions, J. Virol. (vetres.org)
- Fuchs W., Klupp B.G., Granzow H., Mettenleiter T.C., Essential function of the pseudorabies virus UL36 gene product is independent of its interaction with the UL37 protein, J. Virol. (vetres.org)
Glycoprotein3
- Alignment the partial sequences of glycoprotein (g) C (A), gD (B), and gE (C) genes of pseudorabies virus at the nucleotide level. (cdc.gov)
- Recombinant Glycoprotein E (gE) of Pseudorabies Virus produced in E. coli. (creativebiomart.net)
- Pseudorabies virus glycoprotein E (PRV gE) has been recognized as a suitable diagnostic antigen for pseudorabies. (creativebiomart.net)
Infection2
- Recently, an increasing number of studies have shown that long noncoding RNAs (lncRNAs) are involved in host metabolism after infection with pseudorabies virus (PRV). (bvsalud.org)
- In May, the Michigan Department of Agriculture (MDA) confirmed pseudorabies virus (PRV) infection in wild boars on four privately-owned game ranches in Saginaw, Gladwin (2 ranches), and Cheboygan Counties. (miwildlife.org)
Clinical4
- Based on the clinical signs and history of exposure to feral hogs, the submitting veterinarian strongly suspected a diagnosis of pseudorabies. (tamu.edu)
- As the name implies, pseudorabies causes clinical neurological signs that mimic those of rabies. (tamu.edu)
- The most characteristic clinical sign of pseudorabies is intense pruritis, which is why the disease is also known colloquially as "mad itch. (tamu.edu)
- Additionally, the inoculation of gIp2 induced an immune response able to provide clinical and virological protection against pseudorabies virus after challenge. (csic.es)
Virol3
- Berthomme H., Monahan S.J., Parris D.S., Jacquemont B., Epstein A.L., Cloning, sequencing and functional characterization of the two subunits of the pseudorabies virus DNA polymerase holoenzyme: evidence for specificity of interaction, J. Virol. (vetres.org)
- Fuchs W., Granzow B.G., Klupp B.G., Kopp M., Mettenleiter T.C., The UL48 tegument protein of pseudorabies virus is critical for intracytoplasmic assembly of infectious virus, J. Virol. (vetres.org)
- Fuchs W., Klupp B.G., Granzow H., Hengartner C., Brack A., Mundt A., Mettenleiter T.C., Physical interaction between envelope glycoproteins E and M of pseudorabies virus and the major tegument protein UL49, J. Virol. (vetres.org)
Protein1
- Two weeks post-stroke, mice received intramuscular injections of pseudorabies virus (PRV-152), a trans-synaptic retrograde herpes virus driving expression of green fluorescent protein (GFP), into the affected contralesional forelimb to label neurons in descending tracts to the forelimb musculature. (frontiersin.org)
Evidence1
- Evidence confirmed that the pathogenic pseudorabies virus was the etiologic agent of this epidemic. (cdc.gov)
Cells1
- Genome-wide analysis of long noncoding RNA profiles in pseudorabies-virus-infected PK15 cells. (bvsalud.org)
Results1
- The pseudorabies PCR results were positive. (tamu.edu)
Dogs1
- This past spring, pseudorabies was diagnosed in a group of hog-hunting dogs from southern Texas. (tamu.edu)
University1
- Once rabies testing was deemed negative, brain samples were sent to the Texas A&M Veterinary Medical Diagnostic Laboratory (TVMDL) for histopathology and to the Iowa State University Veterinary Diagnostic Laboratory for pseudorabies PCR. (tamu.edu)
Aujeszky's Disease5
- Aujeszky's disease, usually called pseudorabies in the United States, is a viral disease in swine that is endemic in most parts of the world. (wikipedia.org)
- The IDEXX PRV/ADV gE Ab Test is an immunoassay for the detection of antibodies in swine serum to the gE antigen of pseudorabies virus (PRV/Aujeszky's disease). (idexx.co.uk)
- Pseudorabies virus (PRV/Aujeszky's disease) is caused by a type 1 porcine herpesvirus. (idexx.co.uk)
- Examples are the PRRS vaccine, aujeszky's disease (pseudorabies) vaccines and classical swine fever vaccines. (thepigsite.com)
- All the pigs will test positive which has obvious implications for an eradication programme based on blood tests, for example the eradication of swine fever or aujeszky's disease (pseudorabies). (thepigsite.com)
Infected with pseudorabies virus1
- Necropsy specimens from pigs infected with pseudorabies virus. (cdc.gov)
Attenuated Pseudorabies Virus1
- A Novel Strategy of US3 Codon De-Optimization for Construction of an Attenuated Pseudorabies Virus against High Virulent Chinese Pseudorabies Virus Variant. (bvsalud.org)
Vaccines1
- Our discussion on the use of biotechnologically engineered vaccines and diagnostics in pseudorabies (PR) eradication will focus mainly on selected characteristics of these two vectors (adenoviruses and vaccinia) and their application in the development of PR vaccines. (usda.gov)
Eradication2
- This differential test is intended for use in herd management and pseudorabies eradication applications. (idexx.co.uk)
- The widely used pseudorabies virus (PRV) Bartha-K61 vaccine has played a key role in the eradication of PRV. (cdc.gov)
Alphaherpesvirus2
- In this report, we demonstrate that pseudorabies virus (PRV), a distantly related alphaherpesvirus, shows a distinctive set of defects after infection of gro29 cells. (princeton.edu)
- The serine protease-specific inhibitor AEBSF inhibited penetration of the basement membrane by the porcine alphaherpesvirus pseudorabies virus (PRV) by 88.1% without affecting lateral spread. (biomedcentral.com)
Aujeszky Disease1
- Pseudorabies virus (PRV), also called Aujeszky disease virus or suid herpesvirus type 1, is a member of the Alphaherpesvirinae subfamily within the family Herpesviridae . (cdc.gov)
Genes1
- Alignment the partial sequences of glycoprotein (g) C (A), gD (B), and gE (C) genes of pseudorabies virus at the nucleotide level. (cdc.gov)
Abstract1
- Abstract - Pseudorabies virus (PRV) is an alpha herpesvirus that causes Aujezsky disease in the pig. (vetres.org)
Pathogenesis1
- Pseudorabies Virus: From Pathogenesis to Prevention Strategies. (nih.gov)
Swine industry1
Antibody1
- during the first month of these outbreaks, 50% of samples were positive for pseudorabies gE antibody. (cdc.gov)
Epidemiology1
- Molecular epidemiology of outbreak-associated pseudorabies virus (PRV) strains in central China. (nih.gov)
Viral disease1
- Pseudorabies is an acute, often fatal, viral disease with a worldwide distribution. (merckvetmanual.com)
Characterization1
- Genomic characterization of pseudorabies virus strains isolated in Italy. (nih.gov)
Diagnosis1
- The findings confirm the diagnosis of pseudorabies in swine. (chula.ac.th)
Herd2
- 2. The swine originate from a qualified pseudorabies negative herd or a qualified pseudorabies negative grow-out herd in this state. (wisconsin.gov)
- 3. The exhibitor documents that non-breeding swine originate from a qualified pseudorabies negative herd or qualified negative pseudorabies grow-out herd in this state. (wisconsin.gov)
Specimens1
- Specimens were taken from a brain of swine suspected of pseudorabies. (chula.ac.th)
Strain2
- Only one serotype of pseudorabies virus is recognized, but strain differences have been identified, particularly in China, where a highly virulent type has been reported. (merckvetmanual.com)
- In a further experiment, an eGFP expressing pseudorabies virus based on the attenuated Bartha strain (PRV-152) was stereotactically injected into the IC and was able to retrogradely infect the nuclei of the auditory brain stem in juvenile and adult Mongolian gerbils. (uni-muenchen.de)
Disease3
- Pseudorabies is an acute, frequently fatal disease with a worldwide distribution that affects swine primarily and other domestic and wild animals incidentally. (merckvetmanual.com)
- The pseudorabies virus has re-emerged as a significant foreign animal disease pathogen in the USA because of the emergence of highly virulent strains in China. (merckvetmanual.com)
- A biosecurity concern in 2006 from the Henshaw's wild boar livestock that included concerns of pseudorabies and brucellosis, a zoological disease that could potentially be spread to people, necessitated a quarantine for the Carters and their livestock, Robert and Valerie said. (farmvilleherald.com)
Transmission1
- Interspecies Transmission, Genetic Diversity, and Evolutionary Dynamics of Pseudorabies Virus. (nih.gov)
Control1
- These results demonstrate clearly the high potential of transgenic strategy in control of pseudorabies. (elsevierpure.com)
Natural1
- Membrane fusion, potential threats, and natural antiviral drugs of pseudorabies virus. (nih.gov)
Test2
- 1. The swine tested negative for pseudorabies in a pseudorabies test performed not more than 30 days before the person moves the swine to the fair or exhibition. (wisconsin.gov)
- 2. The exhibitor documents that the swine tested negative for pseudorabies in a test performed within 30 days before the swine are exhibited. (wisconsin.gov)