• The pathogenesis of this organism is multifactorial and involves various toxins and proteases (eg, exotoxin A, lecithinase) and the glycocalyx "slime. (medscape.com)
  • Its neutralizing action on certain toxins, exotoxins, virus infections, endotoxins and histamine is in direct proportion to the amount of the lethal factor involved and the amount of ascorbic acid given. (health-matrix.net)
  • Introduction of Exotoxins and Endotoxins Numerous bacteria produce toxins, enzymes, and pigments. (medicallabnotes.com)
  • Toxins are of two types- Differences Between Exotoxins and Endotoxins The differences between exotoxins and endotoxins are as follows- S. No Exotoxins Endotoxins 1. (medicallabnotes.com)
  • Lumoxiti (moxetumomab pasudotox-tdfk) is a CD22-directed cytotoxin composed of a recombinant murine immunoglobulin genetically fused to truncated Pseudomonas exotoxin (PE38). (geisinger.org)
  • The heavy chain variable domain is fused to a shortened form of the pseudomonas exotoxin, PE38, that inhibits protein synthesis. (fda.gov)
  • Pseudomonas is a clinically significant and opportunistic pathogen, often causing nosocomial infections. (medscape.com)
  • The 3 stages of Pseudomonas infections are (1) bacterial attachment and colonization, (2) local infection, and (3) bloodstream dissemination and systemic disease. (medscape.com)
  • A team of scientists from Singapore has discovered the secret recipe for 'antidotes' that could neutralize the deadly plant toxin Ricin, widely feared for its bioterrorism potential, as well as the Pseudomonas exotoxin responsible for the tens of thousands of hospital-acquired infections in immune-compromised patients all over the world. (sciencedaily.com)
  • Pseudomonas aeruginosa and P maltophilia account for 80 percent of opportunistic infections by pseudomonads. (tdmuv.com)
  • Phagocytosis by polymorphonuclear leukocytes is important in resistance to Pseudomonas infections. (tdmuv.com)
  • Pseudomonas aeruginosa can cause severe corneal infections following eye surgery or injury. (tdmuv.com)
  • These consisted of chemically linking numerous Pfs25 molecules to each other and to other proteins: Pseudomonas aeruginosa exotoxin A, a protein from a species of bacteria that infects people with weakened immune systems, and ovalbumin, a protein found in egg whites. (infectioncontroltoday.com)
  • Modulation of apoptotic response of a radiation-resistant human carcinoma by Pseudomonas exotoxin-chimeric protein. (uchicago.edu)
  • Recombinant immunotoxins were made by Rising the Fab domain of monoclonal antibody (MAb) B3 to PE38M, a truncated mutant form of Pseudomonas exotoxin (PE). (korea.ac.kr)
  • Pseudomonas aeruginosa colonization reportedly occurs in more than 50% of humans, and P aeruginosa is the most common pseudomonal species. (medscape.com)
  • Pseudomonas species are Gram-negative, aerobic bacilli measuring 0.5 to 0.8, m by 1.5 to 3.0 m. (tdmuv.com)
  • Pseudomonas species normally inhabit soil, water, and vegetation and can be isolated from the skin, throat, and stool of healthy persons. (tdmuv.com)
  • The genus Pseudomonas contains more than 140 species, most of which are saprophytic. (tdmuv.com)
  • Cultures revealed gram-negative Pseudomonas species and Bacteroides fragilis. (medscape.com)
  • SB: Abhi, there are important safety issues with moxetumomab pasudotox-tdfk attributed to the nature of the pseudomonas-derived toxin payload. (fda.gov)
  • Among the bacterial diseases of plants, the most widespread and destructive losses are caused by the Gram-negative bacteria of the genus, Erwinia, Pseudomonas, and Xanthomonas.The genus Xanthomonas is of great economic importance because of its broad host range. (discoverdctours.com)
  • Pseudomonas aeruginosa , or P. aeruginosa , is a gram-negative bacterium that is abundant in the environment. (osmosis.org)
  • An alginate is antiphagocytic, and most strains isolated produce toxin A, a diphtheria-toxin-like exotoxin. (tdmuv.com)
  • The current classification of the genus Pseudomonas is divided into 5 groups based on ribosomal RNA (rRNA)/DNA homology. (medscape.com)
  • It consists of an N-terminal single-chain antibody fragment (scFv), genetically linked to truncated Pseudomonas exotoxin A (ETA). (uni-frankfurt.de)
  • In the human pathogen Pseudomonas aeruginosa, the GltR regulator is required for glucose transport, whereas GtrS is a sensor kinase that plays a key role in mediating bacteria-host interaction and pathogen dissemination in the host. (nih.gov)
  • The bacteria Pseudomonas aeruginosa that secretes PE toxin is a common cause of HAIs in vulnerable individuals, including those with burn injuries or receiving intensive care. (sciencedaily.com)
  • Pseudomonas aeruginosa is an aerobic, gram-negative, rod-shaped bacterium commonly found in the environment, such as in soil, in the home, and in hospitals. (osmosis.org)
  • The effects of exotoxin A (EXA) from Pseudomonas aeruginosa on polymorphonuclear leucocytes (PMNLs) were studied in a mouse model and in vitro. (nih.gov)
  • This immunotoxin was achieved by conjugating/fusing the Anti-CD22 monoclonal antibody to Pseudomonas exotoxin. (creativebiolabs.net)
  • Roche is currently terminating its Pseudomonas exotoxin conjugate programs, including antibody and DARPin-based projects. (molecularpartners.com)
  • The aim of this study was to produce anti-VEGFR2/rPE (Pseudomonas exotoxin) 38 IT to test its cytotoxic activity and mechanism of action. (celljournal.org)
  • 4. Armstrong S., Yates S. P., Merrill A. R. Insight into the Catalytic Mechanism of Pseudomonas aeruginosa Exotoxin A studies of toxin interaction with eukaryotic elongation factor-2 // Journal of Biological Chemistry. (medline.ru)
  • It consists of the human epidermal growth factor (EGF) as binding domain and a de-immunized variant of Pseudomonas Exotoxin A (PE), called PE24mutΔREDLK, as toxin domain. (bvsalud.org)
  • The present study examined the ability of the tumor cell surface receptor, interleukin (IL)‑13 receptor α2 (IL13Rα2)‑ and epidermal growth factor receptor (EGFR)‑targeted pseudomonas exotoxin (PE) to sensitize TRAIL‑resistant GBM cells and assessed the dual effects of interleukin 13‑PE (IL13‑PE) or EGFR nanobody‑PE (ENb‑PE) and TRAIL for the treatment of a broad range of brain tumors with a distinct TRAIL therapeutic response. (spandidos-publications.com)
  • Pseudomonas aeruginosa exotoxin (Pseudomonas Aeruginosa Exotoxin A, PE) is a cell toxin produced by P. aeruginosa. (creativebiolabs.net)
  • Pseudomonas can be cultured on most general-purpose media and identified with biochemical media. (tdmuv.com)