• Neutralization of beta-lactam antibiotics in an environmental monitoring medium. (nih.gov)
  • Penicillin-resistant Streptococcus pneumoniae is usually cross-resistant to beta-lactam antibiotics. (druglib.com)
  • Beta-lactams are antibiotics that have a beta-lactam ring nucleus. (merckmanuals.com)
  • In vitro inactivation of aminoglycoside antibiotics by beta-lactam antibiotics is well doc-umented. (elephantcare.org)
  • Marabotti, A. Bifunctional Beta-Lactam Antibiotics. (encyclopedia.pub)
  • Bifunctional Beta-Lactam Antibiotics" Encyclopedia , https://encyclopedia.pub/entry/7047 (accessed December 02, 2023). (encyclopedia.pub)
  • The molecular structure of β-lactam antibiotics can be modified either to introduce another β-lactam ring (the pharmacophore conferring bactericidal activities to these molecules), or to add other pharmacophores that modify their pharmacological properties and spectrum of action. (encyclopedia.pub)
  • The serendipitous discovery of the first representative of the β-lactam antibiotics, penicillin G, is generally attributed to Alexander Fleming in 1929 [ 1 ] , although there are pieces of evidence that, about fifteen years before, an Italian physician, Vincenzo Tiberio, had already identified in molds a "principle with bactericidal action" [ 2 ] . (encyclopedia.pub)
  • The other classes of β-lactam antibiotics, namely carbapenems and monobactams, were discovered more recently [ 7 ] [ 8 ] , in an effort to identify new members of this broad group of molecules. (encyclopedia.pub)
  • This resistance is caused by the development of many different "escape strategies", such as the alteration of the target, the development of pumps to export the antibiotics outside the microbial cell, and in particular for β-lactam antibiotics, the widespread diffusion of β-lactamases, enzymes able to inactivate their pharmacophoric core by hydrolysis of the β-lactam ring [ 11 ] . (encyclopedia.pub)
  • Pseudomonas pseudomallei resistance to beta-lactam antibiotics due to alterations in the chromosomally encoded beta-lactamase. (burkholderia.com)
  • Pseudomonas aeruginosa is one of the most important pathogenic bacteria because of its resistance to beta lactam antibiotics. (ac.ir)
  • For initial antimicrobial treatment of infected wounds, beta-lactam antibiotics with anti-staphylococcal activity (cephalexin, dicloxacillin, ampicillin/sulbactam etc.) and clindamycin are recommended options. (cdc.gov)
  • Infections caused by this organism will not respond to treatment with beta-lactam antibiotics and should be considered in patients who fail to respond to this therapy. (cdc.gov)
  • Results: Clinical cure of the infection due to pandrug-resistant ( PDR) Gram-negative bacteria, namely Pseudomonas aeruginosa or Klebsiella pneumoniae was observed in 4 out of 6 patients with combination of colistin and beta lactam antibiotics. (illinois.edu)
  • Conclusion: Colistin, in combination with beta lactam antibiotics, may be a useful agent for the management of pandrug-resistant Gram-negative bacterial infections. (illinois.edu)
  • In addition it's able to make beta-lactamases that degrade beta-lactam antibiotics as well as aminoglycoside-modifying enzymes that alter aminoglycoside antibiotics - rendering them ineffective. (osmosis.org)
  • Staphylococcus intermedius is usually susceptible to beta-lactamase resistant antibiotics and first or third generation cephalosporins, whereas most anaerobic organisms can be treated with penicillins, metronidazole, clindamycin or the second generation cephalosporins. (vin.com)
  • Antibiotics with time-dependent killing (beta lactams and most bacteriostatic drugs) work best with continual exposure to drug concentrations above the MIC. (vin.com)
  • Two major factors responsible for this kind of infection are use of mechanical ventilation and use of beta-lactam antibiotics. (clickpress.com)
  • Belongs to the penicillin group of beta-lactam antibiotics, ampicillin is able to penetrate Gram-positive and some Gram-negative bacteria. (standardofcare.com)
  • Worldwide dissemination of the Klebsiella pneumoniae , VIM, OXA, and New Delhi metallo-Beta-lactamase type carbapenemases among humans has been facilitated by intercontinental passenger travel, but the role of the global food trade in this dissemination has not been investigated. (cdc.gov)
  • MBLs can be chromosomally encoded in some organisms, such as the L1 MBL of Stenotrophomonas maltophilia , or can be acquired as can occur with a variety of gram-negative organisms including Klebsiella , Pseudomonas , and Acinetobacter species. (merckmanuals.com)
  • Plasmid-encoded AmpC expression is also constitutive and may be spread among bacteria usually lacking this beta-lactamase, such as Escherichia coli , Klebsiella pneumoniae , and Proteus mirabilis . (merckmanuals.com)
  • Staphylococcus aureus (40), Acinetobacter spp (28), Pseudomonas spp (22), Enterobacter spp (20), et Klebsiella spp (17). (who.int)
  • They are found in gram-negative organisms such as Klebsiella, E Coli, Enterobacter, and Pseudomonas. (sinaiem.org)
  • 6. Burgess D.S., Hall R.G. In vitro killing of parenteral beta-lactams against standard and high inocula of extended-spectrum beta-lactamase and non-ESBL producing Klebsiella pneumoniae. (cmac-journal.ru)
  • Cefepime and the inoculum effect in tests with Klebsiella pneumoniae producing plasmid-mediated AmpC-type beta-lactamase. (cmac-journal.ru)
  • Effects of inoculum and beta-lactamase activity in AmpC- and extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli and Klebsiella pneumoniae clinical isolates tested by using NCCLS ESBL methodology. (cmac-journal.ru)
  • Cross-class resistance to non-beta-lactam antimicrobials in extended-spectrum beta-lactamase-producing Klebsiella pneumoniae. (cmac-journal.ru)
  • Russian Klebsiella pneumoniae isolates that express extended-spectrum beta-lactamases. (cmac-journal.ru)
  • Epidemiology of ciprofloxacin resistance and its relationship to extended-spectrum beta-lactamase production in Klebsiella pneumoniae isolates causing bacteremia. (cmac-journal.ru)
  • Molecular epidemiology of extended-spectrum beta-lactamase-producing, fluoroquinolone-resistant isolates of Klebsiella pneumoniae in Taiwan. (cmac-journal.ru)
  • Common gram-negative pathogens include Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumonia, Enterobacter aerogenes and Acinetobacterbaumannii. (clickpress.com)
  • All Pseudomonas species and most strains of Klebsiella and Aerobacter are considered resistant. (standardofcare.com)
  • CIPRO® HC OTIC is indicated for the treatment of acute otitis externa in adult and pediatric patients, one year and older, due to susceptible strains of Pseudomonas aeruginosa, Staphylococcus aureus, and Proteus mirabilis. (globalrph.com)
  • A new cephalosporin with a highly reactive beta-lactam ring was found to give an immediate color change in the presence of beta-lactamases from many bacteria, including staphylococci, Bacillus species, Enterobacteriaceae, and Pseudomonas. (nih.gov)
  • Although in the bacteria only beta-lactamases produce this color change, it was found that serum and tissues from experimental animals also rapidly produced the colored breakdown product, which was then excreted in the urine. (nih.gov)
  • Beta-lactamases are a diverse class of enzymes produced by bacteria that break open the beta-lactam ring, inactivating the beta-lactam antibiotic. (merckmanuals.com)
  • The BETA-LACTAMASES hydrolyze the beta lactam ring, accounting for BETA-LACTAM RESISTANCE of infective bacteria. (lookformedical.com)
  • has been identified as the 2nd most consensus (ERIC) sequences which · 60 environmental samples were tak- frequent organism causing ventilator- are common to Gram-negative enteric en throughout the ICU, including associated pneumonia, the 4th most bacteria [11,12]. (who.int)
  • Therefore, the present study aimed to evaluate frequency of existence of OXA, PER, CTX-M1, CTX-M2 and CTX-M genes in pathogenic Pseudomonas aerugionsa isolates from different hospitals in Shiraz, Iran.Methods: The pathogenic bacteria were isolated from hospitals in Shiraz during six months. (ac.ir)
  • Afterward, DNA of the isolates was extracted and the genes amplified by PCR method.Findings: Out of 728 bacteria isolated from the clinical samples obtained from the patients of the hospitals in Shiraz, 62 Pseudomonas aeruginosa isolates harbored ESBL genes. (ac.ir)
  • 1. Finegold S.M. In vitro efficacy of beta-lactam/ beta-lactamase inhibitor combinations against bacteria involved in mixed infections. (cmac-journal.ru)
  • Tazobactam-piperacillin compared with sulbactam-ampicillin, clavulanic acid-ticarcillin, sulbactam-cefoperazone, and piperacillin for activity against beta-lactamase-producing bacteria isolated from patients with complicated urinary tract infections. (cmac-journal.ru)
  • Cómo se contagia la bacteria Pseudomonas aeruginosa? (consejosparati.com.mx)
  • Similar to other beta-lactams, the carbapenems inhibit cell wall synthesis by binding to and inhibiting penicillin-binding proteins. (wustl.edu)
  • BCC resistance to β-lactams has developed by means of an inducible chromosomal β-lactamase and altered penicillin-binding proteins. (cdc.gov)
  • Pseudomonas infection can be treated with a combination of an antipseudomonal beta-lactam (eg, penicillin or cephalosporin) and an aminoglycoside. (consejosparati.com.mx)
  • Because this organism is patented, it is not officially recognized as a legitimate Pseudomonas species, and therefore has no type strain. (wikipedia.org)
  • Novel SHV-derived extended-spectrum beta-lactamase, SHV-57, that confers resistance to ceftazidime but not cefazolin. (nih.gov)
  • Fosfomycin for the treatment of multidrug-resistant, including extended-spectrum beta-lactamase producing, Enterobacteriaceae infections: a systematic review. (sinaiem.org)
  • B. multivorans PenA is an inhibitor-resistant carbapenemase, whereas the B. pseudomallei PenA is an extended spectrum beta-lactamase (PMID:27620956). (burkholderia.com)
  • 8. Thomson K.S., Moland E.S. Cefepime, piperacillin-tazobactam, and the inoculum effect in tests with extended-spectrum beta-lactamase-producing Enterobacteriaceae. (cmac-journal.ru)
  • 16. Graffunder E.M., Preston K.E., Evans A.M., Venezia R.A. Risk factors associated with extended-spectrum {beta}-lactamase-producing organisms at a tertiary care hospital. (cmac-journal.ru)
  • Hence, empirical antimicrobial therapy that lacks anti-pseudomonal activity could be harmful in case of pseudomonas bacteremia. (biomedcentral.com)
  • Age over 90 years, healthcare-associated infection, indwelling central venous catheter, indwelling urinary device, and antimicrobial therapy within the previous 30 days, have been reported to be clinical predictors of pseudomonas infection. (biomedcentral.com)
  • Occurrence of extended-spectrum beta-lactamases in members of the family Enterobacteriaceae in Italy: implications for resistance to beta-lactams and other antimicrobial drugs. (cmac-journal.ru)
  • Most beta-lactam have poor CNS penetration (exception ceftriaxone). (vin.com)
  • For patients with CAP requiring ICU admission, a non-pseudomonal beta-lactam (cefotaxime, ceftriaxone, or amoxicillin-clavulanic acid) plus a macrolide (azithromycin or clarithromycin) should be preferred if there are no risk factors for Pseudomonas aeruginosa infection. (medicaldialogues.in)
  • Comparison of the activity of imipenem and beta-lactams combined with sulbactam and clavulanic acid in beta-lactamase-producing strains of Bacteroides fragilis. (nih.gov)
  • Although the organism was not extensively resistant, it was resistant to all Beta-lactam drugs tested, including ertapenem. (cdc.gov)
  • Of the exoU strains, all except one were resistant to fluoroquinolones, 100% were resistant to beta-lactams. (monash.edu)
  • Beta-lactamase production is among the most clinically important mechanisms of resistance for gram-negative bacterial pathogens. (merckmanuals.com)
  • Understanding the most common types of beta-lactamases produced by different pathogens can help with susceptibility interpretation, therapeutic decision making, and infection control practices. (merckmanuals.com)
  • Pseudomonas aeruginosa and other members of this group of gram-negative bacilli are opportunistic pathogens that frequently cause hospital-acquired infections, particularly in ventilator patients, burn patients, and patients with neutropenia or chronic debility. (msdmanuals.com)
  • Other important hospital-acquired pathogens formerly classified as Pseudomonas include Burkholderia cepacia and Stenotrophomonas maltophilia . (msdmanuals.com)
  • The reaction is confined to organisms producing beta-lactamases, but it is sufficiently sensitive to indicate the presence of this enzyme is small amounts in strains previously considered not to produce it. (nih.gov)
  • Virulent strains of Pseudomonas aeruginosa are often associated with an acquired cytotoxic protein, exoenzyme U (ExoU) that rapidly destroys the cell membranes of host cells by its phospholipase activity. (monash.edu)
  • In addition, exoU strains had mutations at K76Q, A110T, and V126E in ampC, Q155I and V356I in ampR and E114A, G283E, and M288R in mexR genes that are associated with higher beta-lactamase and efflux pump activities. (monash.edu)
  • Mohammadzadeh A, Mardaneh J, Ahmadi R, Adabi J. Evaluation of the Virulence Features and Antibiotic Resistance Patterns of Pathogenic Pseudomonas aeruginosa Strains Isolated from Hospitalized Patients in Gonabad, Iran. (brieflands.com)
  • This study was performed to detect risk factors for Pseudomonas aeruginosa bacteremia in patients with liver cirrhosis. (biomedcentral.com)
  • Thus, it is important for clinicians to be aware of the risk factors for pseudomonas bacteremia. (biomedcentral.com)
  • However, no studies have focused on the clinical predictors or outcomes of pseudomonas bacteremia in patients with liver cirrhosis. (biomedcentral.com)
  • The aim of this study was therefore to identify predictive factors and clinical outcomes of pseudomonas bacteremia in patients with liver cirrhosis. (biomedcentral.com)
  • We performed a case-control study to identify risk factors associated with pseudomonas bacteremia in cirrhotic patients. (biomedcentral.com)
  • Two antipseudomonal drug combination therapy (eg, a beta-lactam antibiotic with an aminoglycoside) is usually recommended for the initial empiric treatment of a pseudomonal infection, especially for patients with neutropenia, bacteremia, sepsis, severe upper respiratory infections (URIs), or abscess formation. (consejosparati.com.mx)
  • مقدمه: مقاومت باکتـــری‌های بیماری‌زا مانند سودومونــاس آئروژینـــوزا به آنتــی‌بیوتیک‌های بتــالاکتام به علـــت ژن‌های ESBL (Extended-spectrum beta-lactamases) است که توسط ترانسپوزون‌ها و پلاسمیدها و یا موتاسیون در باکتری‌های سودوموناس ایجاد می‌شود. (ac.ir)
  • This character in Pseudomonas aerugionsa occurs because of extended spectrum β lactamase (ESBL) genes, which carry by transposons, plasmids and mutation. (ac.ir)
  • In addition, ESBL genes in Pseudomonas aerugionsa were tested by disk double diffusion. (ac.ir)
  • The results of in vitro susceptibility testing of ESBL producers indicate that the activity of non-β-lactam agents (amikacin and ciprofloxacin) significantly decreased during the time period of the study. (cmac-journal.ru)
  • Antibiotic therapy should be individualized to cover the commonly implicated organisms according to risk factors, including Pseudomonas, ESBL producing Enterobacteriaceae or MRSA. (medicaldialogues.in)
  • Des infections microbiennes ont été observées chez 30% (155/519) de l'ensemble des malades admis au service de soins intensifs pour adultes de l'Hôpital universitaire de Jordanie à Amman en 1993. (who.int)
  • In the treatment of beta-haemolytic streptococcal infections, a therapeutic dose should be administered for at least 10 days. (medthority.com)
  • Pseudomonas aeruginosa are quite a common cause of hospital-acquired infections. (japsonline.com)
  • Fluoroquinolones are given at high doses in the treatment of Pseudomonas infections. (vin.com)
  • The global emergence of carbapenemase-producing organisms is a public health emergency because these enzymes confer resistance to nearly all Beta-lactam drugs and are often associated with multidrug or pandrug resistance. (cdc.gov)
  • Pseudomonas aeruginosa , or P. aeruginosa , is a gram-negative bacterium that is abundant in the environment. (osmosis.org)
  • Ertapenem is a unique member of this class, with a narrower spectrum that lacks reliable activity against Pseudomonas and Enterococcus. (wustl.edu)
  • Similar to other beta-lactams, ertapenem exhibits time-dependent killing. (wustl.edu)
  • Jacoby, GA. Extended-spectrum beta-lactamases. (sinaiem.org)
  • A beta-lactam antibiotic that is part of the aminopenicillin family and is roughly equivalent to its successor, amoxicillin in terms of spectrum and level of activity. (standardofcare.com)
  • Their resistance to beta-lactamases including AmpC and extended-spectrum beta-lactamases enhances their usefulness. (wustl.edu)
  • Sulfazecin, a novel beta-lactam antibiotic of bacterial origin. (wikipedia.org)
  • Beta-lactamase enzyme is responsible for degrading ampicillin and related drugs. (standardofcare.com)
  • Probability of target attainment (PTA) was assessed for 4× the epidemiological cut-off values for Enterobacterales (4 × 0.25 mg/L) and Pseudomonas spp. (springeropen.com)
  • Here, we have investigated the resistance profiles and genes associated with resistance for fluoroquinolone and beta-lactams. (monash.edu)
  • Pseudomonas aeruginosa, Moraxella catarrhalis, Aeromonas spp. (wellmedpharm.uz)
  • Beta 2-microglobulin is present in small amounts in serum, csf, and urine of normal people, and to a much greater degree in the urine and plasma of patients with tubular proteinemia, renal failure, or kidney transplants. (lookformedical.com)
  • En Égypte, des isolats prélevés sur les tubulures d'appareils d'aspiration et de respiration artificielle (A8) et sur les cuvettes (A7) étaient liés à ceux prélevés chez les patients ayant ces antibiotypes. (who.int)
  • En Égypte, les isolats des patients étaient de types ERIC VII, VIII et IX et correspondaient à ceux des tubulures des appareils d'aspiration et de respiration artificielle et des cuvettes. (who.int)
  • For Pseudomonas , high doses or continuous infusion are required to reach PTA in ACLF patients. (springeropen.com)
  • Ecthyma gangrenosum is known as a characteristic lesion of Pseudomonas aeruginosa sepsis and is usually seen in immunocompromised patients. (biomedcentral.com)
  • Since almost all beta-lactams are excreted by the kidneys, some patients with renal failure may require a dose adjustment. (vin.com)
  • Pseudomonas is ubiquitous and favors moist environments. (msdmanuals.com)
  • Pseudomonas aeruginosa is a ubiquitous microorganism, which is present in diverse environmental niches and is seldom a member of normal human microbiota community. (brieflands.com)
  • Pseudomonas acidophila is a Gram-negative soil bacterium that produces the beta-lactam antibiotic, sulfazecin, as well as bulgecins. (wikipedia.org)
  • Pseudomonas aeruginosa is an aerobic, gram-negative, rod-shaped bacterium commonly found in the environment, such as in soil, in the home, and in hospitals. (osmosis.org)
  • Classes A, C, and D have a serine residue at the active site, whereas class B enzymes have zinc at the active site, ie, metallo-beta-lactamases (MBLs). (merckmanuals.com)
  • These enzymes are not inhibited by currently available beta-lactamase inhibitors. (merckmanuals.com)
  • Resistance caused by hyperproduction of chromosomal beta-lactamase in Pseudomonas aeruginosa]. (nih.gov)