Pseudomonas aeruginosa pao1. Medical search. Frequent questions

Quantitative genomic DNA from Pseudomonas aeruginosa strain PAO1-LAC can be used for assay development, verification, and validation as well as monitoring of day-to-day test variation and lot-to-lot performance of molecular-based assays. (atcc.org)
To download a certificate of analysis for Quantitative Genomic DNA from Pseudomonas aeruginosa strain PAO1-LAC ( 47085DQ ), enter the lot number exactly as it appears on your product label or packing slip. (atcc.org)
The certificate of analysis for that lot of Quantitative Genomic DNA from Pseudomonas aeruginosa strain PAO1-LAC ( 47085DQ ) is not currently available online. (atcc.org)
In our lab we discovered a distinct and novel anti-predation behavior in Pseudomonas aeruginosa strain 01. (kennesaw.edu)
This distinct evasion response was not observed in another P. aeruginosa strain, PA14, nor in other closely related pseudomonads we tested. (kennesaw.edu)
In a genetically engineered P. aeruginosa strain where alginate biosynthesis is under arabinose control, we found that AlgL is required for cell viability and maintaining membrane integrity during alginate production. (rcsb.org)
PAO1 strain and its derivatives are widely used to study the biology of this bacterium, however recent studies demonstrated differences in the genomes and phenotypes of derivatives from different laboratories. (waw.pl)
Results: Here we report the genome sequence of P. aeruginosa PAO1161 laboratory strain, a leu-, Rif R , restriction- modification defective PAO1 derivative, described as the host of IncP-8 plasmid FP2, conferring the resistance to mercury. (waw.pl)
Species aggregate of Pseudomonas aeruginosa strain UPM P3 was shown to have potential as a biocontrol agent against Ganoderma boninense , the causal agent of Basal Stem Rot (BSR) of oil palm. (thescipub.com)
The objective of this study was to carry out DNA fingerprinting for strain differentiation to differentiate between pathogenic and non-pathogenic forms of P. aeruginosa strain UPM P3. (thescipub.com)
RFLP results showed that strain UPM P3 has close similarity with strain PAO1 of Pseudomonas aeruginosa . (thescipub.com)
Strain PAO1 is commonly associated with strains of medical, human or plant pathogens and agricultural environment. (thescipub.com)
Thus the use of Pseudomonas aeruginosa strain UPMP3 as a biological control candidate in agriculture has to be monitored. (thescipub.com)
Laboratory reference strain PAO1 and P. aeruginosa NDTH6412, which belongs to high-risk international sequence type 235, were used as controls. (cdc.gov)
B) Virulence was determined by using Kaplan-Meier survival curves of mice intraperitoneally challenged with 1 × 10 7 CFUs of strain ZY94 or ZY1214, hypervirulent strain PA14, or nonvirulent P . aeruginosa strain ATCC9027. (cdc.gov)
Bismuth and cefiderocol showed synergistic effect both in vitro and in vivo (lung infectious model) against PAO1, a strain of Pseudomonas aeruginosa, as a metallo-sideromycin complex transported actively into bacterial cells. (hku.hk)
Mu transposition complexes were used for transposon mutagenesis of Pseudomonas aeruginosa strain PA68. (microbiologyresearch.org)
A PA0171 mutant and a PA1822 mutant were constructed by gene replacement in the P. aeruginosa PAO1 strain. (microbiologyresearch.org)
The Calu-3 cell line and the isogenic CFTR knock down cell line (cftr-) infected apically with P. aeruginosa strain PAO1 showed a progressive reduction in transepithelial resistance during 24 h. (unige.ch)
The complete sequence of the genome of P aeruginosa strain, PAO1, is noted for its large size and diverse metabolic capacity. (medscape.com)

This study is the first to characterize the spaceflight-induced global transcriptional and proteomic responses of Pseudomonas aeruginosa, an opportunistic pathogen that is present in the space habitat. (sckcen.be)
However, P. aeruginosa is also an opportunistic pathogen. (thescipub.com)
1] "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen. (tcdb.org)
The problematic opportunistic pathogen Pseudomonas aeruginosa is a major cause of infection in patients with underlying or immunocompromising conditions. (elifesciences.org)
Pseudomonas is a clinically significant and opportunistic pathogen, often causing nosocomial infections. (medscape.com)
Pseudomonas aeruginosa is an opportunistic pathogen that often causes nosocomial infections resistant to treatment. (who.int)

Pseudomonas aeruginosa is an opportunistic human pathogen and a leading cause of chronic infection in the lungs of individuals with cystic fibrosis. (rcsb.org)
Background: Pseudomonas aeruginosa is a cause of nosocomial infections, especially in patients with cystic fibrosis and burn wounds. (waw.pl)
These P. aeruginosa cell clusters are in vitro models of the chronic P. aeruginosa infections in cystic fibrosis patients which display recalcitrance to antibiotic treatments , leading to exacerbated morbidity and mortality . (bvsalud.org)
The pathogenesis of Pseudomonas aeruginosa infection in cystic fibrosis (CF) is a complex process attributed to specific characteristics of both the host and the infecting organism. (jci.org)
Hence, phage-antibiotic combination should be a safe and promising anti-Pseudomonas therapy for future clinical trials potentially including cystic fibrosis patients. (unige.ch)

From the phylogenetic tree, UPM P3 has more than 90% similarity with Pseudomonas aeruginosa strains: PAM7, PAO1, UCBPP-PA14 and PA7. (thescipub.com)

This study envisages on the anti-QS properties of ethanolic extract of P. betle leaf (PbLE) using P. aeruginosa PAO1 as a model organism. (scite.ai)

P. aeruginosa is also an ESKAPE pathogen, which are leading causes of nosocomial infections throughout the world, and they are often multi-drug resistant. (kennesaw.edu)

Pseudomonas aeruginosa colonization reportedly occurs in more than 50% of humans, and P aeruginosa is the most common pseudomonal species. (medscape.com)

The regulation of the neuraminidase gene nanA was examined in Pseudomonas and as cloned and expressed in Escherichia coli. (jci.org)

The study investigates colonization, competition, and translocation of biotechnology agents following intranasal challenge by sublethal doses of the environmental isolates Pseudomonas maltophilia (BC6) and Pseudomonas aeruginosa (BC16, BC17, BC18, AC869). (epa.gov)
Two clinical Pseudomonas aeruginosa isolates (PAO1, DG1), are included for comparison. (epa.gov)
P. aeruginosa isolates referred to the ARSP, epidemic clone. (who.int)

The ICEPae1161 was transferred to Pseudomonas putida cells, where it integrated in the genome and conferred the mercury resistance. (waw.pl)
For this purpose, the non-pathogenic production host P. putida KT2440 containing the rhlAB genes with the native P. aeruginosa 5′-UTR region was used. (springer.com)

We showed that strains of Pseudomonas aeruginosa with increased mutation rates (caused by deletion of genes involved in DNA mismatch repair) produced more biofilm biomass in laboratory experiments. (southampton.ac.uk)

cerPAC reduced the production of QS-regulated virulence determinants and protected D. melanogaster from fatal infection by P. aeruginosa PA14. (nature.com)

Treatment of P. aeruginosa in the affected patients has become difficult because of its ability to develop resistant strains against most of the conventional therapeutic antibiotics. (ijpsr.com)
Strains BC6, AC869, DG1, and PAO1 were detectable in all three intestinal region 14 d following treatment. (epa.gov)
A) Carbapenem-resistant P . aeruginosa strains ZY94 and ZY1214 isolated from hospital patients in China were evaluated for desiccation tolerance. (cdc.gov)

If you have used this database, please ensure that you acknowledge this most recent Pseudomonas Genome Database publication rather than just the website URL. (pseudomonas.com)
Enhanced annotations and features for comparing thousands of Pseudomonas genomes in the Pseudomonas genome database. (pseudomonas.com)
An interactive web-based Pseudomonas aeruginosa genome database: discovery of new genes, pathways and structures. (microbiologyresearch.org)

This effect correlated with increased adherence of PAO1 to epithelial cells after exposure to PAO1 neuraminidase and was consistent with in vitro studies demonstrating Pseudomonas adherence to asialoganglioside receptors. (jci.org)
Mu DNA transposition complexes were assembled with MuA transposase and an artificial mini-Mu transposon in vitro , and introduced into Pseudomonas aeruginosa by electroporation. (microbiologyresearch.org)

N -acylhomoserine lactone (AHL)-mediated quorum sensing (QS) tightly regulates the expression of multiple virulence factors in the opportunistic pathogenic bacterium Pseudomonas aeruginosa . (nature.com)
Quorum sensing plays a crucial role in the virulence nature of P. aeruginosa as it helps the bacteria to produce virulence factors and biofilm formation. (ijpsr.com)
These findings indicate a new anti-infective and alternative therapeutic approaches to combat the virulence factors of Pseudomonas aeruginosa and explore further the potential of fungal secondary metabolites from other saprophytic fungi colonizing decaying substrata of medicinal plants. (ijpsr.com)

The current classification of the genus Pseudomonas is divided into 5 groups based on ribosomal RNA (rRNA)/DNA homology. (medscape.com)

Pseudomonas aeruginosa is one of the most emerging multidrug-resistant opportunistic pathogens, which poses a threat to immunocompromised patients. (ijpsr.com)

Three rhamnosyltransferases responsible for assembly of the A-band D-rhamnan polysaccharide in Pseudomonas aeruginosa: a fourth transferase, WbpL, is required for the initiation of both A-band and B-band lipopolysaccharide synthesis. (pseudomonas.com)

A model for antibiotic accumulation in bacterial biofilm microcolonies utilizing heterogenous porosity and attachment site profiles replicated the periphery sequestration reported in prior experimental studies on Pseudomonas aeruginosa PAO1 biofilm cell clusters. (bvsalud.org)

After colonization, P. aeruginosa often undergoes a phenotypic conversion to mucoidy, characterized by overproduction of the alginate exopolysaccharide. (rcsb.org)
In this study, the properties of the PAO1 neuraminidase were examined to determine its potential role in facilitating Pseudomonas colonization of the respiratory epithelium. (jci.org)
The 3 stages of Pseudomonas infections are (1) bacterial attachment and colonization, (2) local infection, and (3) bloodstream dissemination and systemic disease. (medscape.com)

P. aeruginosa is an opportunistic and nosocomial pathogen responsible for 10% of all hospital acquired infections. (kennesaw.edu)
P seudomonas aeruginosa is an opportunistic P. aeruginosa infections are often resistant to pathogen that often causes nosocomial infections treatment, 4 and carbapenem use has been strongly as- (e.g. pneumonia, bacteraemia and urinary sociated with resistance. (who.int)
were the reported increasing rates of resistance to antibiotics used second most common pathogen isolated from device- to treat P. aeruginosa infections, such as carbapenems associated HA infections in a study of intensive care and extended-spectrum cephalosporins ( Fig. 1A-B ). In units in Philippine hospitals. (who.int)

These findings provide insights into the underlying mechanisms of action of a cerPAC to restrict the virulence of P. aeruginosa and can have implications in the development of alternative approaches to control infections. (nature.com)
Gram-negative bacterial infections, such as those caused by Pseudomonas aeruginosa , pose significant challenges in treatment due to their complicated structure. (hku.hk)
Gram-negative bacteria, including Pseudomonas aeruginosa , can cause a range of infections in humans. (hku.hk)

Transcriptional and proteomic responses of Pseudomonas aeruginosa PAO1 to spaceflight conditions involve Hfq regulation and reveal a role for oxygen. (sckcen.be)
P. aeruginosa responded to spaceflight conditions through differential regulation of 167 genes and 28 proteins, with Hfq as a global transcriptional regulator. (sckcen.be)
In Pseudomonas the osmotic regulation of neuraminidase production was dependent upon algR1 and algR2, genes involved in the transcriptional activation of algD, which is responsible for the mucoid phenotype of Pseudomonas and pathognomonic for chronic infection in CF. Under the hyperosmolar conditions postulated to exist in the CF lung, nanA is likely to be expressed to facilitate the initial adherence of Pseudomonas to the respiratory tract. (jci.org)

Here we describe a novel predation resistance response observed in PAO1 and we aim to frame this predation response in the context of predation resistance responses seen in prey bacteria. (kennesaw.edu)
We found that subpopulations of biofilm bacteria undergo cell death and lysis as a feature of the Pseudomonas aeruginosa biofilm life cycle. (southampton.ac.uk)
For example, the high resistance of P. aeruginosa against conventional antibiotics can be attributed in part to the limited permeability of the outer membrane (OM) and the expression of 'efflux pump', specialised proteins within bacteria that actively remove antibiotics, thus reducing their effectiveness. (hku.hk)

In this study, we demonstrate an anti-virulence activity of a cranberry extract rich in proanthocyanidins (cerPAC) against P. aeruginosa in the model host Drosophila melanogaster and show this is mediated by QS interference. (nature.com)

The PAO1 neuraminidase was 1000-fold more active than the Clostridium perfringens enzyme in releasing sialic acid from respiratory epithelial cells. (jci.org)
We conclude that combination of phage and ciprofloxacin efficiently protects wild type and cftr- epithelial cells from infection by P. aeruginosa and emergence of phage resistant mutants without inducing an inflammatory response. (unige.ch)

Today, mainly heterologous production systems are targeted due to the advantage of non-pathogenic hosts as well as uncoupling from complex quorum sensing regulatory networks compared to their natural producer Pseudomonas aeruginosa . (springer.com)
Quorum sensing (QS) plays an important role in virulence of Pseudomonas aeruginosa, blocking of QS ability are viewed as viable antimicrobial chemotherapy and which may prove to be a safe anti-virulent drug. (scite.ai)

In addition to this, a significant inhibition in the motility factors of P. aeruginosa such as swimming, swarming, twitching was also observed. (ijpsr.com)

IS406 and IS407, two gene-activating insertion sequences for Pseudomonas cepacia. (pseudomonas.com)

thus, efflux pump inhibitors are thought to be useful in reducing the invasiveness and antimicrobial resistance of P aeruginosa and may be promising as new anti-infectious agents. (medscape.com)
In addition, long-read sequencing of one representative XDR ST235 isolate identified an integron carrying multiple resistance genes (including bla VIM-2), with differences in gene composition and synteny from the P. aeruginosa class 1 integrons described previously. (who.int)
Philippines reporting P. aeruginosa as the most common Antimicrobial Resistance Surveil ance Program (ARSP) etiological agent. (who.int)

Pseudomonas brassicacearum subsp. (pseudomonas.com)

2] "Gene cloning and properties of the RND-type multidrug efflux pumps MexPQ-OpmE and MexMN-OprM from Pseudomonas aeruginosa. (tcdb.org)

The population of P. aeruginosa was diverse, with clonal expansions of XDR genomes belonging to MLSTs ST235, ST244, ST309 and ST773. (who.int)

Further work has shown the importance of this phage in the P. aeruginosa biofilm lifecycle and virulence. (southampton.ac.uk)
Here we studied in an ex vivo human airway epithelial cell line model the efficacy of phage and ciprofloxacin alone and in combination to treat infection by Pseudomonas aeruginosa. (unige.ch)

Production of the Pseudomonas aeruginosa neuraminidase is increased under hyperosmolar conditions and is regulated by genes involved in alginate expression. (jci.org)

Whether the observed changes in pathogenesis-related gene expression in response to spaceflight culture could lead to an alteration of virulence in P. aeruginosa remains to be determined and will be important for infectious disease risk assessment and prevention, both during spaceflight missions and for the general public. (sckcen.be)

However, under the same conditions PAO1 showed no reduction in surviving cells when compared to non-predation controls. (kennesaw.edu)

groES genes are involved in the cellular response to heat shock, but it is not thought that the Pseudomonas-groES RNA motif is involved in heat shock regulation. (wikipedia.org)

Comparison of PAO1161 genome with PAO1-UW sequence revealed lack of an inversion of a large genome segment between rRNA operons and 100 nucleotide polymorphisms, short insertions and deletions. (waw.pl)
Conclusions: The high-quality P. aeruginosa PAO1161 genome sequence provides a reference for further research including e.g. investigation of horizontal gene transfer or comparative genomics. (waw.pl)
Desiccation tolerance and virulence analyses of Pseudomonas aeruginosa high-risk sequence type 463 co-producing KPC-2 and AFM-1 carbapenemases, China, 2020-2022. (cdc.gov)
1] "Cloning and nucleotide sequence of the gene braB coding for the sodium-coupled branched-chain amino acid carrier in Pseudomonas aeruginosa PAO. (tcdb.org)
Identification of a gene, pilV , required for type 4 fimbrial biogenesis in Pseudomonas aeruginosa , whose product possesses a pre-pilin-like leader sequence. (microbiologyresearch.org)

In the recent past, the presence and function of a ROSE-like RNA-thermometer located in the 5′UTR of the rhamnosyltransferase genes rhlAB has been reported in wild type P. aeruginosa . (springer.com)

Methicillin-sensitive S. aureus , Streptococcus pneumoniae , and Haemophilus influenzae are most commonly implicated when pneumonia develops within 4 to 7 days of hospitalization, whereas P. aeruginosa , MRSA, and enteric gram-negative organisms become more common with increasing duration of intubation or hospitalization. (msdmanuals.com)

The major P. aeruginosa virulence-related genes induced in spaceflight were the lecA and lecB lectin genes and the gene for rhamnosyltransferase (rhlA), which is involved in rhamnolipid production. (sckcen.be)
The pilG gene product, required for Pseudomonas aeruginosa pilus production and twitching motility, is homologous to the enteric, single-domain response regulator CheY. (microbiologyresearch.org)

Pseudomonas aeruginosa has been used in agriculture as biological agents. (thescipub.com)

Heterogenous biofilm mass-transport model replicates periphery sequestration of antibiotics in Pseudomonas aeruginosa PAO1 microcolonies. (bvsalud.org)

Although P aeruginosa is a common human saprophyte, it rarely causes disease in healthy persons. (medscape.com)

Together, our study demonstrates the role of AlgL in alginate biosynthesis, explains the discrepancies observed previously across other P. aeruginosa ΔalgL genetic backgrounds, and clarifies the existing divergent data regarding the function of AlgL as an alginate degrading enzyme. (rcsb.org)
Role of a new filamentous prophage Pf4 in Pseudomonas aeruginosa biofilm development. (southampton.ac.uk)

Anatomy5

Organisms18

Diseases11

Chemicals and Drugs81

Analytical, Diagnostic and Therapeutic Techniques and Equipment15

Phenomena and Processes37

Information Science3

Health Care1

Strain20

Opportunistic pathogen6

Cystic fibrosis5

UCBPP-PA141

Organism1

Leading causes of nosocomial1

Species1

Escherichia1

Isolates3

Putida2

Mutation1

PA141

Strains3

Genome Database3

Vitro2

Virulence factors3

Classification1

Pathogens1

Polysaccharide1

Antibiotic1

Colonization3

Pathogen3

Infections3

Transcriptional3

Bacteria3

Drosophila1

Epithelial cells2

Quorum2

Inhibition1

Cepacia1

Resistance3

Subsp1

Efflux1

Genomes1

Phage2

Genes involved1

Infectious1

Reduction1

Regulation1

Sequence5

Type1

Organisms1

Production2

Biological1

Model1

Human1

Role2