RNA sequencing after RBM39 knockdown revealed downregulated PI3K/AKT signaling. (bvsalud.org)
We discovered DA neuron dVGLUT knockdown increased mitochondrial reactive oxygen species in a sexually dimorphic manner in response to depolarization or paraquat-induced stress, males being especially affected. (umassmed.edu)
Protects1
Overall, VGLUT protects DA neurons from PD-associated degeneration by maintaining mitochondrial health. (umassmed.edu)
Small1
In a survey of trafficking regulators required for developmental dendrite pruning in Drosophila sensory neurons, the small GTPase Rab11 was identified as a regulator of recycling endosomes. (sdbonline.org)
Promotes mitochondrial2
Our data suggest that Prune stabilizes TFAM and promotes mitochondrial DNA (mtDNA) replication through downregulation of mitochondrial cAMP signaling. (nih.gov)
One of the major mechanisms of removal is mitophagy, a selective form of autophagy that promotes mitochondrial degradation via the mitolysosomal pathway. (biomedcentral.com)
Biogenesis3
In addition, our work demonstrates the prevalence of mitochondrial cAMP signaling in metazoan and its new role in mitochondrial biogenesis. (nih.gov)
Mitochondrial mass and quality are tightly regulated by two essential and opposing mechanisms, mitochondrial biogenesis (mitobiogenesis) and mitophagy, in response to cellular energy needs and other cellular and environmental cues. (biomedcentral.com)
Mitochondria have circular DNA (mitochondrial DNA, mtDNA), and mitochondrial biogenesis (mitobiogenesis) involves the replication, transcription, and translation of mtDNA-encoded genes, the interorganelle transport of phospholipids, and the import of nuclear-encoded proteins into mitochondria through the protein translocation machinery of the outer and inner membranes [ 14 ]. (biomedcentral.com)
MtDNA1
Knocking down prune in cultured cells reduces mitochondrial transcription factor A (TFAM) and mitochondrial DNA (mtDNA) levels. (nih.gov)
Proteins2
Given that the majority of mitochondrial proteins are nuclear-encoded, the transcription and translation of nuclear and mitochondrial genes must be tightly coordinated to ensure the creation of new mitochondria [ 17 ]. (biomedcentral.com)
Recent studies have examined the therapeutic potential of the sodium-glucose cotransporter 2 (SGLT2) inhibitors in neurodevelopmental diseases, based on their proved anti-inflammatory effects, such as downregulating the expression of several proteins, including the transforming growth factor beta (TGF-β), interleukin-6 (IL-6), C-reactive protein (CRP), nuclear factor κB (NF-κB), tumor necrosis factor alpha (TNF-α), and the monocyte chemoattractant protein (MCP-1). (epiphanyasd.com)
Pathway1
However, regulators of the mitochondrial cAMP pathway, and its broad impact on organelle function, remain to be explored. (nih.gov)
Apoptosis1
The neuroprotective effects of conditioned medium (CM) of hESCs (H9), wt hiPSCs (WTC-11) and the ALS iPSCs, on MN apoptosis and viability, formation and maintenance of neurites, mitochondrial activity and expression of inflammatory genes, were examined. (springer.com)
Response1
In immunofluorescence experiments, GAP and Tid-1 were shown to colocalize at perinuclear mitochondrial membranes in response to epidermal growth factor stimulation. (embl.de)
Expression2
In the model with pathogenic SOD1 mutation, ALS iPSC-CM attenuated all examined hallmarks of ALS pathology, rescued human ALS-MNs from denervation and death, restored mitochondrial health, and reduced the expression of inflammatory genes. (springer.com)
en, decreased risks of cancers in persons with schizophrenia and DSS was used to nd the key genes' opposite inuence of their relatives, suggesting that the familiar/genetic factors survival in glioma and GETx and TCGA were used to contributing to schizophrenia may potentially inhibit tu- evaluate the expression levels of these key genes in dierent morigenesis and lead to the better survival [4-6]. (sagepub.com)