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  • antigens
  • These techniques, employing various molecular methods involving recombinant antigens, have not delivered as expected and attention is once again focusing on the potential of irradiated vaccines. (springer.com)
  • The sequencing of T. cruzi genome ( 3 ) and the development of approaches to produce recombinant proteins at low cost have made it feasible to produce, deliver, and test the efficacy of a variety of recombinant T. cruzi antigens as potential vaccine candidates in experimental models of infection and disease. (frontiersin.org)
  • Nevertheless, the importance of adjuvants still is not fully realized by many researchers working in the vaccine field, who are involved mostly in the search for better target antigens. (scielo.br)
  • In other words, vaccine adjuvants are capable of enhancing, sustaining and directing the immunogenicity of antigens, thereby effectively modulating appropriate immune responses, reducing the amount of antigen and/or number of required immunizations, and improving the efficacy of vaccines, which is of increased relevance for vaccination strategies aimed at newborns, elderly, or immune-compromised individuals (5). (scielo.br)
  • However, vaccine history has traditionally focused on the identification of particular antigens and more restrictedly single epitopes to induce protection. (scielo.br)
  • Vaccines made from antigens arising from any of the four strains of Plasmodium which cause malaria in humans, or from P. berghei which causes malaria in rodents. (curehunter.com)
  • We show that these properties can be exploited to both protect and adjuvant vaccine antigens for oral administration. (nature.com)
  • Proteins
  • Subsequent analysis of the E. tenella complete coding sequences identified 25 putative secretory and 60 putative surface proteins, all of which are now rational candidates for development as recombinant vaccines or drug targets in the effort to control avian coccidiosis. (biomedcentral.com)
  • Intestinal and free-living protozoa, such as Giardia lamblia , express a dense coat of variant-specific surface proteins (VSPs) on trophozoites that protects the parasite inside the host's intestine. (nature.com)
  • humans
  • The early-branching eukaryote Giardia lamblia is perhaps the only protozoan capable of colonizing the lumen of the upper small intestine of many vertebrates, including humans 6 . (nature.com)
  • Hantavirus vaccine is a vaccine that protects in humans against hantavirus infections causing Hantavirus hemorrhagic fever with renal syndrome (HFRS) or hantavirus pulmonary syndrome (HPS). (wikipedia.org)
  • Field trial of an inactivated vaccine against hemorrhagic fever with renal syndrome in humans. (wikipedia.org)
  • Antibody responses in humans to an inactivated hantavirus vaccine (Hantavax). (wikipedia.org)
  • organisms
  • The review outlines the extensive use of radiation attenuation in attempts to create vaccines for a multiplicity of pathogenic organisms and how the technology is being re-examined in the light of recent advances in irradiation techniques and cryopreservation/lyophilization that might obviate some of the problems of maintenance of viable, attenuate vaccines and their transport and use in the field. (springer.com)
  • Horses can develop EPM when they ingest feed and water contaminated with Sarcocystis neurona , one-celled organisms called protozoa, that are spread by opossums and carried by other wildlife. (equisearch.com)
  • For a long time, only live or attenuated organisms and vaccines containing aluminum salts (alum) have proven successful. (scielo.br)
  • Eimeria
  • Compared with other protozoan viruses, Eimeria viruses are more closely related to mycoviruses (fungal viruses), indicating a different evolutionary branch. (biomedcentral.com)
  • Having the eimeria genome sequences provides a tool set of immense value to the development of subunit or recombinant vaccines, which would make vaccines more affordable for use with broilers and in developing countries," he suggested. (fwi.co.uk)
  • Ebola
  • Biodistribution of DNA plasmid vaccines against HIV-1, Ebola, Severe Acute Respiratory Syndrome, or West Nile virus is similar, without integration, despite differing plasmid backbones or gene inserts. (semanticscholar.org)
  • development
  • We review here some of the advances and challenges for the development of DNA vaccines against these diseases. (semanticscholar.org)
  • So scientist have concentrated on vaccine development for viruses rather than chemicals to kill/disable them. (cattletoday.com)
  • Because of these talented individuals, today CureVac is a group of 120 dedicated employees, and we continue to advance the research and development and commercial potential of RNA-based vaccines. (medgadget.com)
  • Cattle
  • I had a discussion with a veterinarian in Missouri who is skeptical of some of the cattle vaccines for Bacteria (bacterins not toxoids). (cattletoday.com)
  • The catch is that drug companies have marketed vaccines against bacteria in cattle, for example the vaccines against Moraxella (primary cause of pinkeye), that may have little or no effectiveness. (cattletoday.com)
  • infections
  • The vaccine is considered important as acute hantavirus infections are responsible for significant morbidity and mortality worldwide. (wikipedia.org)
  • viruses
  • This is somewhat of a generalization but Vaccines are more effective against viruses than they are against bacteria. (cattletoday.com)
  • The primary reason vaccines are more effective against viruses is because viruses are simple. (cattletoday.com)
  • However the vaccine is thought not to be effective against European hantaviruses including Puumala (PUUV) and Dobrava-Belgrade (DOBV) viruses. (wikipedia.org)
  • effective
  • To date, no universally effective and safe vaccine has been developed for general human use. (nih.gov)
  • With poultry production expansion predicted to continue for at least the next 30 years, developing a new generation of cheap effective vaccines will be a major contribution to global food security. (fwi.co.uk)
  • In those already infected the vaccines are not effective. (wikipedia.org)
  • formulations
  • Adjuvants have been considered for a long time to be an accessory and empirical component of vaccine formulations. (scielo.br)
  • One major current question in the vaccinology field is whether adjuvants are additional or essential components of vaccine formulations. (scielo.br)
  • disease
  • A vaccine typically contains an agent that resembles a disease-causing microorganism, and is often made from weakened or killed forms of the microbe or its toxins. (wikipedia.org)
  • research
  • Rodent models have been used in research on vaccines against T. gondii over the past decades. (nih.gov)
  • Additional vaccine candidate research is occurring for next generation products to extend protection against additional HPV types. (wikipedia.org)
  • Cells
  • A fraction of vaccine-induced CD4 + T cells exhibited iTreg phenotype responsible for aversion of self-injurious immune responses. (frontiersin.org)