• Unlike the protozoan Leishmania major , Toxoplasma parasites avoid destruction by preventing fusion of the phagosome with the lysosome and live permanently in a unique parasitophorous vacuole, a specialized structure within the cytoplasm that is entirely segregated from the endocytic system of the host cell. (ppdictionary.com)
  • I returned to the field of parasitology in 2000 to join the research group of Debbie Smith at Imperial College London and from 2004 at the University of York, studying the cell biology of the protozoan parasites Leishmania major and Trypanosoma brucei . (keele.ac.uk)
  • Leishmaniasis Parasitic Disease - (Alternative - leishmaniosis) - A disease caused by protozoan parasites of the genus Leishmania and spread by the bite of certain types of sandflies. (disabled-world.com)
  • Overall, infection in people is caused by more than 20 species of leishmania parasites that are spread by 30 or so species of phlebotomine sand flies. (disabled-world.com)
  • The leishmaniases are a group of neglected tropical diseases caused by protozoan parasites from more than 20 Leishmania species. (immunopaedia.org.za)
  • A striking feature of these diseases is the ability of a single group of parasites - the genus Leishmania - to cause a spectrum of different diseases in human infections. (immunopaedia.org.za)
  • One critical factor in the different presentations of leishmaniasis is clearly the parasite, as different presentations are generally associated with different species of Leishmania and different host immune response. (immunopaedia.org.za)
  • Leishmaniasis is caused by protozoan Leishmania parasites that are transmitted through female sandfly bites. (ac.ir)
  • Advances in understanding underlying immune mechanisms are feasibale using a variety of candidate antigens, including attenuated live parasites, crude antigens, pure or recombinant Leishmania proteins, Leishmania genes encoding protective proteins, as well as immune system activators from the saliva of parasite vectors. (ac.ir)
  • Heterologous immunization with defined RNA and subunit vaccines enhances T cell responses that protect against Leishmania donovani. (ac.ir)
  • Leishmaniasis are vector-borne diseases caused by the intracellular protozoan parasite Leishmania, which cause significant morbidity and mortality worldwide and therefore constitute an important public health problem. (fiocruz.br)
  • The human parasite Leishmania is the causative agent of leishmaniasis. (unil.ch)
  • As veterans of infection, Leishmania guyanensis parasites have been plaguing humankind for centuries, provoking a deleterious hyper-inflammatory immune response, destroying host tissue and forming the ulcerating lesions, which typify most forms of the disease. (unil.ch)
  • Our lab has recently shown that a virus within metastatic Leishmania parasites (Leishmania RNA virus: LRV) can act as an independently immunogenic entity, where its RNA-based nucleic acid acted as a potent innate immunogen, triggering a destructive hyper-inflammatory cascade through Toll-Like-Receptor 3 recognition. (unil.ch)
  • Viral Double-Stranded RNA Detection by DNase I and Nuclease S1 digestions in Leishmania parasites. (unil.ch)
  • A sandfly vector of Leishmania parasites taking a blood meal through human skin. (who.int)
  • Leishmaniasis is caused by a tiny parasite called leishmania protozoa. (medlineplus.gov)
  • We also found that mice infected with the rodent malaria parasite P. yoelii 17XNL succumbed to otherwise non-lethal infection when mice were co-infected with an intestinal helminth Heligmosomoides polygyrus 10 . (nature.com)
  • 2019). Parasiticide Screening: Volume 1: In Vitro and In Vivo Tests with Relevant Parasite Rearing and Host Infection/Infestation Methods. (researchgate.net)
  • Although neither a vaccine against infection nor a completely effective treatment for chronic Chagas disease currently exists ( 2 , 9 ), treatment is now recommended for acute infections, congenital infections, infections in immunosupressed persons, and infections in children ( 10 ). (cdc.gov)
  • There is no recommended vaccine to protect against infection. (strath.ac.uk)
  • In contrast, immunisation with wild type L. tarentolae, using the same immunisation protocol, had no effect on parasite burdens compared to infection controls. (strath.ac.uk)
  • These findings have provided a foundation for producing a vaccine that could help to prevent the initial establishment of infection in the intestinal wall. (qxmd.com)
  • The structure of the lectin has been defined, and the heavy subunit with its cysteine-rich region has been demonstrated in animal models to have some efficacy as a possible vaccine agent for prevention of amebic infection. (qxmd.com)
  • These researchers wrote, 'Several population-based studies have suggested a link between herpes zoster infection or vaccine against shingles and dementia. (precisionvaccinations.com)
  • I am interested in the infection biology of protozoan parasites of livestock. (ed.ac.uk)
  • I am particularly attracted to integrated approaches where we can learn about both host and parasite processes that are key to infection/disease progression - especially in the clinically relevant host, the cow. (ed.ac.uk)
  • Protozoa can multiply in their human hosts, increasing in number to cause overwhelming infection. (merckmanuals.com)
  • While the disease is effectively treated with the drug praziquantel, reinfection occurs so rapidly that public health officials desperately need a vaccine to control this infection. (lifespan.org)
  • Mucosal leishmaniasis may be a consequence of infection with some of the species of the parasite that cause cutaneous leishmaniasis in parts of Latin America. (disabled-world.com)
  • There are no drugs or vaccines available to prevent leishmaniasis infection. (disabled-world.com)
  • We develop and use modern molecular approaches to understand fundamental parasite cell and molecular biology, the response of the host to this infection, and the mechanisms by which host and parasite interact. (striepenlab.org)
  • To screen for additional vaccine candidate antigens of Plasmodium pre-erythrocytic stages, fourteen P. falciparum proteins were selected based on expression in sporozoites or their role in establishment of hepatocyte infection. (ox.ac.uk)
  • All fourteen chimeric parasites produced sporozoites but sporozoites of eight lines failed to establish a liver infection, indicating a negative impact of these P. falciparum proteins on sporozoite infectivity. (ox.ac.uk)
  • Protective immunogenicity was determined by analyzing parasite liver load and prepatent period of blood stage infection after challenge. (ox.ac.uk)
  • Malaria is infection of red blood cells with one of five species of the protozoa Plasmodium . (msdmanuals.com)
  • Doctors diagnose the infection by identifying the protozoa (single-cell infectious organisms) in a sample of blood or by doing other blood tests, or both. (msdmanuals.com)
  • Malaria is a protozoa infection that is spread by the bite of an infected female mosquito. (msdmanuals.com)
  • This review focuses on the strategies currently employed for the development of vaccines against visceral and cutaneous experimental leishmaniasis and the recent findings obtained in experimental models of infection. (fiocruz.br)
  • The use of live attenuated preparations as candidate vaccines is very promising because they most closely mimic the natural course of infection and may therefore elicit similar immune responses. (bioxorio.com)
  • Primaquine should be added to the main treatment to prevent relapses of infection with the P. vivax and P. ovale parasites. (who.int)
  • Chagas disease, also known as American trypanosomiasis, is caused by infection with the protozoan parasite Trypanosoma cruzi . (medscape.com)
  • Malaria caused by protozoan parasites of the genus Plasmodium is the most prevalent infectious disease in tropical and subtropical regions. (nature.com)
  • Malaria occurs when parasitic protozoa of the genus Plasmodium get into your bloodstream. (everydayhealth.com)
  • With the development of latest transcriptomic and proteomic tools, recently a great dearth of information has been generated with respect to understanding the Plasmodium biology resulting in discovery of new vaccine candidate antigens and drug targets. (icgeb.org)
  • Background Malaria is a mosquito-borne disease caused by protozoan parasites of the genus Plasmodium. (genbioconsortium.africa)
  • Malaria is a mosquito-borne infectious disease caused by protozoan parasites belonging to the genus Plasmodium. (who.int)
  • Leishmaniasis is a protozoan disease responsible for significant morbidity and mortality. (strath.ac.uk)
  • The results of this study provide further proof that γGCS should be considered a candidate vaccine for leishmaniasis. (strath.ac.uk)
  • In several geographic areas where leishmaniasis is found in people, infected people are not needed in order to maintain the transmission cycle of the parasite. (disabled-world.com)
  • However, there is still no vaccine against different types of human leishmaniasis. (ac.ir)
  • A third generation vaccine for human visceral leishmaniasis and post kala azar dermal leishmaniasis: First-in-human trial of ChAd63-KH. (ac.ir)
  • After malaria, leishmaniasis stands as the most important protozoan parasitic disease in the world, with 350 million people at risk on 5 continents in 98 countries and steadfastly listed in the top 10 most debilitating infectious diseases in the world (according to DALY units). (unil.ch)
  • To date a couple of no tested vaccines against any type of leishmaniasis. (bioxorio.com)
  • In clinical trials in humans whole killed vaccines with BCG as an adjuvant failed to confer protection against cutaneous leishmaniasis (42 58 or visceral leishmaniasis (33). (bioxorio.com)
  • Cutaneous leishmaniasis is a disease that is caused by a protozoa parasite. (who.int)
  • WHO promotes research on effective cutaneous leishmaniasis control, including in the areas of safe, effective and affordable medicines, diagnostic tools and vaccines. (who.int)
  • There are no vaccines or medicines that prevent leishmaniasis. (medlineplus.gov)
  • The innate immune response is a powerful mechanism to eliminate infections caused by bacteria, viruses, parasites, and fungi. (umassmed.edu)
  • Researchers in the PII are focused on understanding how the innate immune system recognizes and responds to pathogenic fungi and applying this knowledge to develop immunotherapies and preventive vaccines. (umassmed.edu)
  • The same thing is happening with other causes of infections in humans: fungi, viruses and parasites. (theconversation.com)
  • Overview of Intestinal Protozoan and Microsporidia Infections Protozoa is a loose term for certain nucleated, unicellular organisms (eukaryotes) that lack a cell wall and are neither animals, plants, nor fungi. (merckmanuals.com)
  • are intracellular spore-forming organisms that used to be classified as protozoa, but genetic analysis indicates that they are fungi or closely related to them. (merckmanuals.com)
  • Antimicrobial resistance (AMR) threatens the effective prevention and treatment of an ever-increasing range of infections caused by bacteria, parasites, viruses and fungi. (who.int)
  • AMR occurs when bacteria, viruses, fungi and parasites change over time and no longer respond to medicines making infections harder to treat and increasing the risk of disease spread, severe illness and death. (who.int)
  • Coccidiosis is a disease of the intestinal lining, produced by the invasion of the mucosal cells by a very prolific protozoan parasite of the genus Eimeria. (zootecnicainternational.com)
  • Surveillance was conducted for the occurrence of protozoan parasites of the genus Cryptosporidium in European hedgehogs (Erinaceus europaeus) in Great Britain. (worktribe.com)
  • Screening of viral-vectored P. falciparum pre-erythrocytic candidate vaccine antigens using chimeric rodent parasites. (ox.ac.uk)
  • Also, extensive evidence from studies in experimental models indicates that solid protection can be achieved by immunization with parasite and/or vector antigens. (fiocruz.br)
  • Using the mouse model analysts have tested several methods to develop secure nonlive vaccines against using recombinant antigens including GP63 (41 74 Absence (26) PSA-2 (28) TSA/LmSTI1 SNX-5422 (59) PFR2 (55) A2 (22) and HASPB1 (64) DNA-based vaccines (13 26 38 39 43 52 66 or a cDNA manifestation library (37). (bioxorio.com)
  • The most important intestinal protozoan pathogens. (merckmanuals.com)
  • claim that the usage of like a live vaccine vector may represent a guaranteeing approach for enhancing the performance and protection of Nrp2 applicant live vaccines against attacks and possibly additional intracellular pathogens that T-cell mediated reactions are crucial for the introduction of protecting immunity. (bioxorio.com)
  • are obligate intraerythrocytic protozoans parasites that undergo a number of developmental stages in the vertebrate host and mosquito vectors. (icgeb.org)
  • Live recombinant vectors are central in the development of new vaccine strategies. (bioxorio.com)
  • However utilization of bacterial or viral recombinant vectors as candidate vaccines in humans is hampered due to problems of either preexisting immunity or inefficient antigen delivery and safety issues. (bioxorio.com)
  • parasites had been transfected with manifestation vectors including either the luciferase gene (gene (9 54 by electroporation as previously referred to (49). (bioxorio.com)
  • SCD patients should also receive counselling on hygiene, barrier protection against vectors, routine chemoprophylaxis for locally endemic diseases, and immunization for vaccine-preventable infections as a long-term preventive strategy against IAH. (bvsalud.org)
  • Epimastigotes are an extracellular and noninfective form of the parasite found in the midgut of insect vectors, where they multiply by binary fission. (medscape.com)
  • The trypomastigote is the infective flagellated form of the parasite found in the blood of the mammalian hosts (blood trypomastigote) and in the hindgut of vectors (metacyclic trypomastigote). (medscape.com)
  • Researchers in the PII program are examining how these parasites interact with and evade the immune system, to develop new therapies to treat these infections. (umassmed.edu)
  • Theo Schetters is director of ProtActivity, a company that focuses on vaccine development against ticks and tick-borne protozoal infections, and coordinator of CATVAC a consortium that works on the development of a vaccine against Rhipicephalus microplus ticks. (researchgate.net)
  • The Witola laboratory's research interests are in protozoan and nematode parasites of medical and veterinary significance, with the goal of identifying, characterizing, and validating novel molecular targets for anti-parasite drug and vaccine development, as well as deciphering host innate immune molecular mechanisms that are important in resistance to parasitic infections. (illinois.edu)
  • Parasitic infections due to protozoa and helminths are responsible for substantial morbidity and mortality worldwide. (merckmanuals.com)
  • The characteristics of protozoan and helminthic infections vary in important ways. (merckmanuals.com)
  • With rare exceptions, protozoan infections do not cause eosinophilia. (merckmanuals.com)
  • Overview of Parasitic Infections A parasite is an organism that lives on or inside another organism (the host) and benefits (for example, by getting nutrients) from the host at the host's expense. (msdmanuals.com)
  • Infections or infestations with PARASITES. (bvsalud.org)
  • Coccidiosis in poultry is a parasitic disease of the gastrointestinal tract caused by a single cell protozoan parasite of the family Eimeria . (bri.cz)
  • Live vaccines of either virulent or attenuated lines of Eimeria are currently used throughout the world with the exception of Europe, where virulent vaccines are not allowed. (bri.cz)
  • Coccidiosis, caused by Eimeria species parasites, has long been recognised as an economically significant disease of chickens. (huvepharma.com)
  • Eimeria are protozoan parasites that can cause the enteric disease coccidiosis in all major livestock species. (huvepharma.com)
  • A recombinant vaccine against nodaviruses is under development. (int-res.com)
  • He is inventor of a recombinant vaccine against Babesia canis and B. divergens. (researchgate.net)
  • Our current research activities are focused on the innovation of live attenuated coccidiosis vaccines ( LIVACOX ® T and LIVACOX ® Q ) and development of new immunobiologicals - i.e. recombinant coccidiosis vaccines for domestic fowl and vaccines for other avian species. (bri.cz)
  • There are much more common parasites which can infect your body and brain and ways you can minimise your risks of being infected with one. (theconversation.com)
  • T. gondii has a very broad host specificity, such that this parasite can infect and become encysted in the tissues of virtually any warm-blooded animal. (ppdictionary.com)
  • As with other parasites that infect both mammalian and insect hosts, the life cycle of T cruzi is complex (see image below). (medscape.com)
  • it depends on parasite growth and host immunity to malaria parasites. (nature.com)
  • When using a coccidiosis vaccine, achieving early and uniform immunity (within the first 3-4 weeks of a chick's life) is essential for ensuring long-lasting protection. (zootecnicainternational.com)
  • The just successful immunization technique in human beings continues to be leishmanization which is dependant on the introduction of long lasting immunity after recovery from disease at a selected site generally the arm with practical nonattenuated parasites (25 32 47 The usage of this technique continues to be restricted or deserted entirely however because of safety SNX-5422 worries. (bioxorio.com)
  • I run a research group focusing on kinetoplastid parasites and co-lead the NIHR-funded ECLIPSE research programme with Professor Lisa Dikomitis . (keele.ac.uk)
  • varieties are kinetoplastid protozoa and obligatory intracellular parasites that are sent to human beings from the bite of the infected phlebotomine fine sand soar. (bioxorio.com)
  • Chagas disease (CD) is a disease caused by the protozoan flagellates of the Kinetoplastid order Trypanosoma cruzi . (bvsalud.org)
  • Chagas disease (CD) is a disease caused by the protozoan flagellate of the Kinetoplastid order Trypanosoma cruzi , whose vector is an insect belonging to the Reduviidae family and subfamily Triatominae popularly known as barber 1 . (bvsalud.org)
  • This disease is caused by the protozoan parasite Trypanosoma cruzi , which is transmitted to humans by blood-sucking insects of the family Reduviidae (Triatominae). (cdc.gov)
  • The epimastigote form of Trypanosoma cruzi is the multiplying stage of the parasite that grows in the gut of the insect vector and also in cell-free culture medium as shown here. (medscape.com)
  • Through Rhode Island Hospital's Center for International Health Research (CIHR)- for which Kurtis is the founder and director and Friedman the director of clinical studies- the pair works to understand the mechanisms that cause tropical infectious diseases, specifically malaria and schistosomiasis, and to harness this knowledge to design improved treatments and vaccines. (lifespan.org)
  • In today's study we utilized a lizard parasitic protozoan that's not pathogenic to human beings could elicit a protecting immune system response against infectious problem. (bioxorio.com)
  • As a malaria researcher, I used to dream of the day we would have a safe and effective vaccine against malaria. (precisionvaccinations.com)
  • New strategies, including an effective vaccine, are urgently needed-and CIHR is making great strides in bringing this to fruition. (lifespan.org)
  • Hence, it seems that the key to disease control management is the introduction of an effective vaccine, particularly against its cutaneous form. (ac.ir)
  • One such 'noneradication outcome' was the impetus that the members of the ITFDE gave to initiating a demonstration project to control intestinal parasites among schoolchildren in Ghana. (cdc.gov)
  • The parasite invades and multiplies within the intestinal cells several times, and the cycle ends with the shedding of the unsporulated oocysts in the feces. (zootecnicainternational.com)
  • Since the beginning of the COVID-19 global pandemic, our researchers have been integrally involved in studying this emerging disease, as well as testing, potential therapies and vaccines. (umassmed.edu)
  • With the help of the revolutionary new R21/Matrix vaccine the disease could be eradicated by 2040. (theconversation.com)
  • However, a vaccine for amebiasis could make a significant impact on the morbidity and mortality from the disease. (qxmd.com)
  • Malaria can be a life-threatening disease caused by a parasite that's carried by certain mosquitoes in warm climates. (everydayhealth.com)
  • To investigate if the result seen was exclusive to HZ vaccination, we also explored the effect of influenza vaccine and dementia/Alzheimer's disease. (precisionvaccinations.com)
  • My work aims to identify key host-parasite interactions that determine disease outcome, further our understanding of bovine immunobiology, and identify targets for interventions (e.g. drug & vaccine development). (ed.ac.uk)
  • We want to know how these parasites cause disease in the host, when it's most effective to treat, and how to prioritize the limited health care resources in these developing countries," says Kurtis. (lifespan.org)
  • The CIHR team has developed a vaccine for schistosomiasis that works in mice and is showing promise in water buffalo, which are a major transmitter of the disease. (lifespan.org)
  • This disease, caused by a mosquito-transmitted protozoan, is a capricious killer of the innocent. (lifespan.org)
  • Indeed, the ongoing battle between the robust immune response mounted by a host and the counter evasion strategies by the parasite will ultimately decide the fate of the disease. (immunopaedia.org.za)
  • Transmitted by sand flies, the disease is caused by protozoan parasites and has three distinct forms. (affordablemallorca.com)
  • Despite its staggering prevalence and morbidity, it has been categorised as a 'neglected disease', with little clinical research interest, no vaccine and a vastly inadequate therapeutic arsenal. (unil.ch)
  • Understanding the distribution and population structure of these protozoan parasites is of fundamental importance to explain disease epidemiology and develop sustainable control. (worktribe.com)
  • The parasites damage the immune system by decreasing the numbers of disease-fighting cells. (medlineplus.gov)
  • Identified in boxer dogs in 1984, the parasite Neospora caninum is harmless to humans, yet has been shown to be effective against tumour cells in mice. (theconversation.com)
  • These parasites are transmitted to humans by the bites of the infected female phlebotomine sandfly - a tiny - only 2-3 mm long - insect vector. (immunopaedia.org.za)
  • Immune responses to whole parasite/BCG/MPL were studied in Phase I/II through Phase III in Humans. (immunopaedia.org.za)
  • With no vaccine for humans, and a vaccine for animals that is only partially effective, the best protection is prevention. (affordablemallorca.com)
  • Infected insects take blood meals from humans and their domestic animals and deposit parasite-laden feces. (medscape.com)
  • Parasites range in size from tiny, one-celled organisms called protozoa to worms that can be seen with the naked eye. (ahrq.gov)
  • Human parasites are organisms that live on or in a person and derive nutrients from that person (its host). (merckmanuals.com)
  • I performed molecular studies to validate the enzyme N -myristoyltransferase (NMT) as a drug target and used protozoa as genetically tractable model organisms to study the functions of proteins implicated in human genetic and autoimmune diseases. (keele.ac.uk)
  • Protozoa are one-celled organisms. (medlineplus.gov)
  • Genetically modified eimerian parasites expressing heterologous antigenic genes could be used as vaccine delivery vehicles. (jove.com)
  • Normally, in the presence of a competent immune system, the tachyzoite stage is cleared from the tissues while the more slowly dividing form of the parasite, persists within pseudocytes. (ppdictionary.com)
  • Joint treatment with IL-2-producing PODS® enhanced the protective effect of the live vaccine in L. donovani studies. (strath.ac.uk)
  • This is the first Phase III L.donovani vaccine study that was carried out in the World. (immunopaedia.org.za)
  • A myriad of agents can potentially be transmitted through blood transfusions, including bacteria, viruses, and parasites. (medscape.com)
  • Immunogenicity of the other six proteins (SPELD, ETRAMP10.3, SIAP2, SPATR, HT, RPL3) was analyzed by immunization of inbred BALB/c and outbred CD-1 mice with viral-vectored (ChAd63 or ChAdOx1, MVA) vaccines, followed by challenge with chimeric sporozoites. (ox.ac.uk)
  • Entamoeba histolytica is a eukaryotic protozoan parasite and is the causative agent of amebic colitis and amebic liver abscess. (qxmd.com)
  • Furthermore, some genera of microbiota correlated with parasite growth and/or ECM development. (nature.com)
  • Therefore, the elucidation of host protective mechanisms against malaria and parasite-host interactions is essential to strategies to control malaria, including vaccine development. (nature.com)
  • Development of vaccines against ticks and tick borne diseases. (researchgate.net)
  • The definitive host is the cat (both domestic and wild) where parasite sexual development occurs in the small intestine. (ppdictionary.com)
  • Malaria vaccines have been in development since the 1960s, with substantial progress in the last decade, says the World Health Organization (WHO). (precisionvaccinations.com)
  • Our goal is to develop vaccines and drugs that are safe enough for these patients to take to help guard against this parasite, which can undermine children's growth and cognitive development. (lifespan.org)
  • This invention relates to the development of a vaccine against theileria parva, which is a protozoan parasite infecting cattle in Africa. (go.ke)
  • Strategies and Components Parasite development and transfections. (bioxorio.com)
  • Rarely, parasites are transmitted via blood transfusions or shared needles or congenitally from mother to fetus. (merckmanuals.com)
  • This has profound implications for the spread of harmful genes among different strains of this important livestock parasite. (ukri.org)
  • This method is pivotal for investigating the cellular mechanisms of the protection and immunopathogenesis of ZIKV vaccines and is also valuable for their efficacy evaluation. (jove.com)
  • The whole parasite vaccine plus BCG proved to be immunogenic, but its efficacy was not superior to BCG alone with respect leishmanin skin test (LST) conversion. (immunopaedia.org.za)
  • Effects of ethanol and water extracts from Phyllanthus emblica fruits on the growth of bovine Babesia and equine piroplasma parasites in vitro and Babesia microti in mice. (obihiro.ac.jp)
  • A vaccine for malaria has existed for 35 years, but so far it only works in mice," says Kurtis. (lifespan.org)
  • Viruses of protozoan parasites and viral therapy: Is the time now right? (unil.ch)
  • As an independant researcher of the Dr. Max Cloëtta Research Foundation, he had the opportunity to establish his own group investigating the molecular and cellular biology of protozoan parasites. (unil.ch)
  • In the mammalian sponsor multiplies within mononuclear phagocytic cells which leads to medical manifestations of a broad spectrum of illnesses dependant on the parasite varieties and host immune system responses. (bioxorio.com)
  • With the World Health Organization's (WHO) recent recommendation of a second dengue vaccine, this increased access may help reduce dengue outbreaks globally. (precisionvaccinations.com)
  • In collaboration with Professor Somaia Abou-Akkada at Alexandria University, Egypt, we are investigating the prevalence of T. evansi in Egyptian camels and analysing isolated parasites for drug resistance against commonly used anti-trypanocidal drugs. (keele.ac.uk)
  • There is no vaccine and few drugs are available for treatment, while reports of drug resistance are increasing. (ukri.org)
  • Since no prevention method is available, drug therapy is toxic and drug resistance is growing, vaccine developments against this important pathogen is paramount. (fiocruz.br)
  • the Strategy to respond to antimalarial drug resistance in Africa aims to improve detection, delay emergence, and limit selection and spread of resistant parasites. (who.int)
  • When the mosquito bites another person, parasites are injected along with the mosquito's saliva. (msdmanuals.com)
  • When an infected mosquito bites a human, it can introduce the parasite from its saliva into the person's blood. (who.int)
  • Research interests focus on: the study of the interface of the pathogen and host at the level of the host's immune response, the nature of the protective immune response and how the pathogen modulates the host response to ensure its success, the detection, treatment and prevalence of parasites of veterinary importance (including those of zoonotic concern), and the disinfection of wastewater and sewage. (cornell.edu)