LeishmaniasisGenusTrypanosomaBraziliensisParasite Leishmania majorSpecies of leishmania parasitesAmazonensisParasitic protozoanTropicaInfantumMexicanaCutaneousChagasPanamensisCaused by protozoan parasitesVitroInfectionsCruziIntracellularDonovani infectionPathogensMajorIsolatesVirulence factorAntiparasiticMacrophageOrganismsLife cycleDiseaseBiteMiceHumansProteinGeneTherapeuticHumanResearchWorld
Leishmaniasis27
- Leishmaniasis is caused by a tiny parasite called leishmania protozoa. (medlineplus.gov)
- Leishmania species: visceral (kala-azar), cutaneous, and mucosal leishmaniasis. (medlineplus.gov)
- Leishmaniasis is a neglected infectious disease caused by several different species of protozoan parasites of the genus Leishmania . (hindawi.com)
- The human parasite Leishmania is the causative agent of leishmaniasis. (unil.ch)
- After malaria, leishmaniasis stands as the most important protozoan parasitic disease in the world, with 350 million people at risk on 5 continents in 98 countries and steadfastly listed in the top 10 most debilitating infectious diseases in the world (according to DALY units). (unil.ch)
- Leishmaniasis is a vector-borne disease caused by protozoan parasites of the genus Leishmania. (degruyter.com)
- In several protozoans, the status of this mechanism remains elusive, such as in Leishmania , the causative agent of the disease leishmaniasis in humans and a wide array of vertebrate animals. (mdpi.com)
- A study reported in the journal Antibiotics shows that treatment of leishmaniasis by photodynamic therapy in conjunction with curcumin, an active component of turmeric ( Curcuma longa ), can reduce parasite load and even eliminate Leishmania parasites completely. (eurekalert.org)
- Cutaneous leishmaniasis is a parasitic disease that can be caused by more than 15 species of the protozoan Leishmania . (dndi.org)
- Leishmaniasis is a protozoan disease responsible for significant morbidity and mortality. (strath.ac.uk)
- In this study, transgenic Leishmania tarentolae expressing gamma glutamyl cysteine synthetase (γGCS) from three pathogenic species were produced and their ability to protect against infection determined using models of cutaneous and visceral leishmaniasis. (strath.ac.uk)
- Leishmania is a protozoan that causes a disease called leishmaniasis. (osmosis.org)
- A new study suggests that transmission of a protozoan parasite from insects may also cause leishmaniasis-like symptoms in people. (sciencedaily.com)
- Leishmaniasis Parasitic Disease - (Alternative - leishmaniosis) - A disease caused by protozoan parasites of the genus Leishmania and spread by the bite of certain types of sandflies. (disabled-world.com)
- Leishmaniasis is a vector-borne disease caused by an obligate intracellular protozoa of genus Leishmania and is transmitted by the bite of a female phlebotomine sand fly ( Figure 1 ). (intechopen.com)
- Leishmaniasis, a neglected tropical disease that is caused by protozoan parasites from the genus Leishmania, is not well understood. (healthinternetwork.org)
- Different species of Leishmania parasites can cause leishmaniasis. (healthinternetwork.org)
- We have determined the X-ray structures of CYP51s from three protozoan parasites, Trypanosoma brucei (sleeping sickness) [3g1q, 3g9o, ] Trypanosoma cruzi (Chagas disease) and Leishmania infantum (visceral leishmaniasis), in the ligand-free state and complexed with different ligands including clinical antifungal and experimental azoles, non-azole inhibitors and a substrate analog. (vanderbilt.edu)
- Visceral leishmaniasis (VL), commonly known as kala-azar, from the Hindu vernacular, is a human systemic disease caused by parasitic protozoan species of the genus Leishmania . (plos.org)
- Cutaneous leishmaniasis is a self-limited infection of the skin caused by Leishmania tropica, a protozoan parasite transmitted by Phlebotomus sandfly. (koreamed.org)
- Leishmaniasis is a very serious group of diseases, and are caused by more than 20 species of protozoan parasites belonging to the genus of Leishmania . (databasefootball.com)
- Leishmaniasis is caused by 20 or more species of the protozoa Leishmania . (msdmanuals.com)
- Medications used to treat the infection depend on the clinical form of leishmaniasis, the status of the person's immune system, which species of Leishmania is causing the infection, and where the infection was acquired. (msdmanuals.com)
- The natural products pulchrol and pulchral, isolated from the roots of the Mexican plant Bourreria pulchra, have previously been shown to possess an antiparasitic activity toward Trypanosoma cruzi, Leishmania braziliensis and L. amazonensis, protozoa responsible for the Chagas disease and leishmaniasis. (lu.se)
- Leishmaniasis represents a serious public health problem in Brazil and abroad, being endemic in 88 countries and the second most important disease caused by protozoan with medical relevance, exceeded only by malaria. (bvsalud.org)
- Epidemiolog'ia de la leishmaniasis mucocut'anea en el foco natural del Bajo Calima, Buenaventura, Colombia / by Enrique Loyola. (who.int)
- Estudios sobre la leishmaniasis en el nuevo mundo y su transmisi'on, con especial referencia al Ecuador / editado por Yoshihisa Hashiguchi. (who.int)
Genus3
- Protozoan parasites of the genus Leishmania undergo a complex life cycle involving transmission by biting sand flies and replication within mammalian macrophage phagolysosomes. (pasteur.fr)
- Leishmania is a genus of flagellate protozoa. (aao.org)
- Leishmaniosis in Dogs The leishmaniases are spectral diseases caused by protozoan parasites of the genus Leishmania . (merckvetmanual.com)
Trypanosoma6
- Based on previous reports about the antileishmanial activity of dihydropyridine-CCBs, this work aimed to investigate whether the in vitro anti- Leishmania infantum and anti- Trypanosoma cruzi activities of this therapeutic class would be shared by other non-dihydropyridine-CCBs. (hindawi.com)
- Additionally, the in vitro antiparasitic activity of eight clinically used dihydropyridines (azelnidipine, amlodipine, cilnidipine, lercanidipine, nicardipine, nifedipine, nimodipine, and nitrendipine) was demonstrated against a panel of Leishmania species and Trypanosoma cruzi [ 6 , 7 ]. (hindawi.com)
- I returned to the field of parasitology in 2000 to join the research group of Debbie Smith at Imperial College London and from 2004 at the University of York, studying the cell biology of the protozoan parasites Leishmania major and Trypanosoma brucei . (keele.ac.uk)
- Caused by the protozoan Trypanosoma cruzi , Chagas disease is endemic in 21 countries in the Americas, although the migration of people who carry the illness can take it to other parts of the world. (dndi.org)
- [ 2 ] Trypanosoma cruzi, a protozoan hemoflagellate, is the parasite that causes this disease. (medscape.com)
- Chagas disease, also known as American trypanosomiasis, is caused by infection with the protozoan parasite Trypanosoma cruzi . (medscape.com)
Braziliensis2
- This image depicted a dorsoposterior view of a hamster's back, in the region of the pelvis, which had been shaved in order to reveal the presence of what had been an intradermal leishmanial lesion, caused by the parasitic protozoan, Leishmania braziliensis . (cdc.gov)
- Cell-mediated and humoral immune responses to Leishmania braziliensis panamensis in the owl monkey (Aotus trivirgatus / by Ricardo Lujan-Lunsford. (who.int)
Parasite Leishmania major3
- The causative agent of CL, a protozoan parasite, Leishmania major has a digenetic lifecycle and lives in two hosts, sandfly and human, in the form of flagellated promastigotes and non-flagellated amastigotes, respectively. (frontiersin.org)
- 1] "Identification and characterization of a polyamine permease from the protozoan parasite Leishmania major. (tcdb.org)
- 2] "The genome of the kinetoplastid parasite, Leishmania major. (tcdb.org)
Species of leishmania parasites1
- Overall, infection in people is caused by more than 20 species of leishmania parasites that are spread by 30 or so species of phlebotomine sand flies. (disabled-world.com)
Amazonensis1
- Amazonian Phlebovirus (Bunyaviridae) potentiates the infection of Leishmania (Leishmania) amazonensis: Role of the PKR/IFN1/IL-10 axis. (unil.ch)
Parasitic protozoan1
- The effect of tubulozoles on the parasitic protozoan Leishmania was tested. (researchwithrutgers.com)
Tropica1
- Each photosensitizer is activated protozoa, Leishmania major and L. tropica . (who.int)
Infantum5
- The aim of this study was to determine the seroprevalence of Leishmania infantum and Toxoplasma gondii among household dogs in Shanghai (the most important industrial and commercial city in China), and to assess the possible risk factors associated with the infection. (aaem.pl)
- Domestic dog ownership in Iran is a risk factor for human infection with Leishmania infantum. (aaem.pl)
- MGenetic homogeneity among Leishmania (Leishmania) infantum isolates from dog and human samples in Belo Horizonte Metropolitan Area (BHMA), Minas Gerais, Brazil. (aaem.pl)
- Coura-Vital W, Marques MJ, Veloso VM, Roatt BM, Aguiar-Soares RD, Reis LE, Braga SL, Morais MH, Reis AB, Carneiro M. Prevalence and Factors Associated with Leishmania infantum infection of dogs from an urban area of Brazil as identified by molecular methods. (aaem.pl)
- Belo VS, Struchiner CJ, Werneck GL, Barbosa DS, de Oliveira RB, Neto RG, da Silva.ESA systematic review and meta-analysis of the factors associated with Leishmania infantum infection in dogs in Brazil. (aaem.pl)
Mexicana1
- Investigating the functions of the BBSome protein complex in Leishmania mexicana using molecular, cellular and proteomic techniques. (keele.ac.uk)
Cutaneous2
- More than 20 well-recognized Leishmania species are known to infect humans and cause visceral (VL), cutaneous (CL) and mucocutaneous (ML) forms of the disease. (degruyter.com)
- Amphotericin B is recommended as patients with confirmed cutaneous leishmaf secondfline treatment.The most dangerous niasis ( Leishmania sore in arm, forearm or sidefeffect of amphotericin B is kidney leg) were selected: 3 patients had 1 lesion damage [ 4-6 ]. (who.int)
Chagas1
- Chagas disease is caused by T. cruzi protozoa and affects nearly 6 million persons in Latin America countries. (cdc.gov)
Panamensis1
- In the research, larvae were infected with Leishmania (Viannia) panamensis promastigotes and the immunological response of the larvae was followed by using analytical techniques like electrophoresis and chromatography. (databasefootball.com)
Caused by protozoan parasites1
- The leishmaniases are a group of diseases caused by protozoan parasites from more than 20 Leishmania species. (who.int)
Vitro5
- Infections of susceptible mice and macrophages in vitro showed that these lpg(-) Leishmania were highly attenuated. (pasteur.fr)
- Fong, D 1993, ' Effect of the anti-microtubule compound tubulozole on Leishmania protozoan parasites in vitro ', FEMS Microbiology Letters , vol. 107, no. 1, pp. 95-99. (researchwithrutgers.com)
- For this, the in vitro activity of four non-dihydropyridine agents (amrinone, fendiline, mibefradil, and lidoflazine) was tested against different Leishmania species and their cytotoxicity to mammalian cells was evaluated. (hindawi.com)
- The processed hemolymph samples were fractionated by reverse-phase HPLC and each fraction was evaluated against Leishmania in vitro cultures. (databasefootball.com)
- Using mass spectrometry, two peptides were identified in the active fraction: a fragment from the Anionic peptide 2 and Cecropin-D. Both peptides were synthesized and evaluated against Leishmania in vitro cultures with promising antiparasitic activity. (databasefootball.com)
Infections3
- Parasitic infections caused by Plasmodium species, Toxoplasma, Leishmania and Trypanosomes cause significant morbidity and mortality worldwide. (umassmed.edu)
- As a result, the CYP51 reaction is the major target for clinical and agricultural antifungals and is very likely to become a successful target for treatment of human infections with protozoan pathogens. (vanderbilt.edu)
- Infections by protozoan parasites, such as Plasmodium falciparum or Leishmania donovani, have a significant health, social and economic impact and threaten billions of people living in tropical and sub-tropical regions of developing countries worldwide. (imperial.ac.uk)
Cruzi1
- Our preliminary data suggest that the derivative of this compound, designed to fill the deepest portion of the CYP51 substrate binding cavity, has even higher antiparasitic potency, especially in the drug-resistant strains of T. cruzi and in Leishmania . (vanderbilt.edu)
Intracellular1
- Das, Pijush K. (2006) Regulation of guanylyl cyclase by intracellular Ca 2+ in relation to the infectivity of the protozoan parasite, Leishmania donovani International Journal of Biochemistry & Cell Biology, 38 (8). (ias.ac.in)
Donovani infection1
- Hypergammaglobulinemia sustains the development of regulatory responses during chronic Leishmania donovani infection in mice. (inrs.ca)
Pathogens1
- Hipoxia inducible factor 1 alpha: A critical factor fro the immune response to pathogens and Leishmania . (inrs.ca)
Major4
- A major component of the Leishmania surface coat is the glycosylphosphatidylinositol (GPI)-anchored polysaccharide called lipophosphoglycan (LPG). (pasteur.fr)
- To study truly lpg(-) parasites, we generated Leishmania major lacking the gene LPG1 [encoding a putative galactofuranosyl (Gal(f)) transferase] by targeted gene disruption. (pasteur.fr)
- note = "Funding Information: We thank Dr. Max Grogl for the gift of Leishmania major, Drs. Marion Man-Ying Chan and Robert Herman for helpful comments, Ms. Chiann-Chyi Chen for technical assistance, and Mrs. Lynn Weingart for manuscript preparation. (researchwithrutgers.com)
- 6 The majority of these persons were infected with Leishmania major in urban areas of Iraq after a median period of deployment of 60 days. (aafp.org)
Isolates1
- The purpose of this study was to develop a robust, standardized method for comparative expression profiling and molecular characterization of Leishmania donovani clinical isolates. (cambridge.org)
Virulence factor1
- Royal Society research grant (PI), Functions & interactions of BBS1, novel virulence factor in the human pathogen Leishmania . (keele.ac.uk)
Antiparasitic1
- Dihydropyridines have been considered promising antiparasitic hits, especially against protozoan parasites. (hindawi.com)
Macrophage1
- Leishmania parasites possess an exceptional oxidant and chemical defense mechanism, involving a very unique small molecular weight thiol, trypanothione (T[SH] 2 ), that helps the parasite to manage its survival inside the host macrophage. (frontiersin.org)
Organisms3
- Protozoa are one-celled organisms. (medlineplus.gov)
- I performed molecular studies to validate the enzyme N -myristoyltransferase (NMT) as a drug target and used protozoa as genetically tractable model organisms to study the functions of proteins implicated in human genetic and autoimmune diseases. (keele.ac.uk)
- Leishmania protozoa (single-cell infectious organisms) are usually spread through the bite of infected sand flies. (msdmanuals.com)
Life cycle1
- The Life Cycle of Leishmania spp. (plos.org)
Disease5
- Here, we identify 5 protozoan parasites with demonstrated presence in seminal fluid, only 1 of which has been identified as a sexually transmitted disease among humans. (cdc.gov)
- Acanthamoeba species are protozoa (unicellular eukaryotes) that can cause an isolated infection of the human cornea as their primary disease in humans. (aao.org)
- As veterans of infection, Leishmania guyanensis parasites have been plaguing humankind for centuries, provoking a deleterious hyper-inflammatory immune response, destroying host tissue and forming the ulcerating lesions, which typify most forms of the disease. (unil.ch)
- Innate immune B cell activation by Leishmania donovani exacerbates disease and mediates hypergammaglobulinemia. (inrs.ca)
- To determine the cause of disease, researchers cultured parasites taken from the patient's bone marrow and skin lesions, sequenced their genomes, and discovered that the parasites were not closely related to known disease-causing Leishmania parasites. (sciencedaily.com)
Bite2
- Tiny infected sand flies spread Leishmania when they bite people or animals, such as dogs or rodents. (msdmanuals.com)
- After the protozoa enter the body through a bite in the skin, they may remain in the skin or spread to the mucous membranes of the nose, mouth, and throat, or to internal organs including the bone marrow, liver, and spleen. (msdmanuals.com)
Mice1
- The in vivo oral efficacy of amlodipine and lacidipine has been shown in the treatment of Leishmania (L.) donovani infected mice [ 5 ]. (hindawi.com)
Humans1
- Trichomonas vaginalis is a protozoan parasite recognized as sexually transmissible among humans ( 2 ). (cdc.gov)
Protein1
- In this review we summarize the latest insights into protein lipidation in protozoan parasites. (imperial.ac.uk)
Gene1
- Gene expression profiling of Leishmania (Leishmania). (cambridge.org)
Therapeutic1
- Many therapeutic agents are being used in Leishmania treatment, but the only effective treatment is achieved with current pentavalent antimonials. (intechopen.com)
Human1
- Leishmania parasites invade human cells and are able to escape the host's immune system. (eurekalert.org)
Research3
- As an independant researcher of the Dr. Max Cloëtta Research Foundation, he had the opportunity to establish his own group investigating the molecular and cellular biology of protozoan parasites. (unil.ch)
- In the past years, our research has centered around immunotyping the response to metastatic Leishmania guyanensis. (unil.ch)
- MRC New Investigator Research grant (PI), BBSome trafficking: investigating a novel pathway associated with virulence in Leishmania . (keele.ac.uk)
World2
- T. vaginalis protozoa are the most common nonviral STI in the world, and incidence is increasing ( 11 ). (cdc.gov)
- Leishmania species are classified into Old World species and New World species. (osmosis.org)