AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesInformation Science
Protein CPorphyrinsOncogene Proteins v-sisOncogene Protein tpr-metOncogene Protein v-mafProtein C DeficiencyOncogene Protein gp140(v-fms)Oncogene Proteins v-mosProtein C InhibitorOncogene Protein p55(v-myc)Oncogene Protein p65(gag-jun)Oncogene Proteins v-rafOncogene Proteins v-fosActivated Protein C ResistanceOncogene Protein v-crkOncogene Proteins v-mybOncogene Protein v-cblOncogene Proteins v-erbBOncogenesOncogene Proteins v-ablOncogene Proteins v-relProtein SOncogene Proteins v-erbAThrombomodulinOncogene ProteinsOncogene Protein p21(ras)Blood Coagulation FactorsPulmonary Surfactant-Associated Protein CGenes, sisFactor VOncogene Protein pp60(v-src)Factor VaThrombinHSP40 Heat-Shock ProteinsOncogene Proteins, ViralBlood CoagulationOncogene Proteins, FusionGenes, rasOncogene Protein v-aktProthrombinCell Transformation, NeoplasticProtein S DeficiencyMolecular Sequence DataReceptors, Cell SurfaceReceptors, ThrombinBase SequenceAmino Acid SequenceThrombophiliaBlood Coagulation DisordersMutationPartial Thromboplastin TimeReceptor, PAR-1AnticoagulantsRecombinant ProteinsShoulder Impingement SyndromeProto-Oncogene ProteinsFactor Xa1-Carboxyglutamic AcidGlycoproteinsProto-OncogenesBlood Coagulation TestsDisseminated Intravascular CoagulationCell LineProtein BindingAntithrombin IIIThrombosisThrombophlebitisFactor V DeficiencyFactor XGenes, mycTransfectionGene AmplificationAntithrombinsProto-Oncogene Proteins c-mycProto-Oncogene Proteins p21(ras)HemostasisRNA, MessengerEnzyme ActivationGene Expression Regulation, NeoplasticSepsisFactor VIIIaSarcoma Virus, Woolly MonkeyCells, CulturedBinding SitesPurpura FulminansAntithrombin III DeficiencyRetroviridae Proteins, OncogenicCell Line, TransformedKineticsTranscription, GeneticSignal TransductionFibrinolysisThromboplastinGene Expression RegulationCarrier ProteinsHeat-Shock ProteinsPoint MutationCell Transformation, ViralMice, TransgenicCell Line, Tumor
Platelet-DeriveGenesAmino AcidsPDGFBTumorPhosphorylationReceptorsMutationChromosomeReceptorMitogen-activaTranscription FactorsMAPKTumorigenesisKinaseGTPaseTransmembranePathwaysHER2MeshChromatidKinasesHeat shock proteinGenomeOncogenicStabilityEnzymesDefectiveActivityRich proteinSpindleMutantNoteBreastFamilyChainCell cyclePublicationsForm
Platelet-Derive1
  • Platelet Derived Growth Factor-BB Recombinant Protein has been tested by biological activity and is suitable as a control for polyclonal or monoclonal anti-Platelet Derived Growth Factor-BB in immunological assays. (rockland.com)
Genes10
  • Cellular DNA-binding proteins encoded by the sis gene ( GENES, SIS ). (nih.gov)
  • These rearrangements fuse the collagen type I alpha 1 ( COL1A1 ) and the PDGF-beta chain ( PDGFB , c-sis proto-oncogene) genes. (medscape.com)
  • Cellular proteins encoded by the H-ras, K-ras and N-ras genes. (uchicago.edu)
  • The current models for CIN involve telomere dysfunction, defective spindle assembly, sister chromatid cohesion, DNA double-strand breaks (DSB) repair, genes involved in the cell cycle, and epigenetic regulators. (encyclopedia.pub)
  • Genes whose protein products stimulate or enhance the division and viability of cells. (cancerquest.org)
  • Genes whose protein products can directly or indirectly prevent cell division or lead to cell death. (cancerquest.org)
  • The normal versions of genes in the first group are called proto-oncogenes. (cancerquest.org)
  • The mutated or otherwise damaged versions of these genes are called oncogenes. (cancerquest.org)
  • Numerous genes have been identified as proto-oncogenes. (cancerquest.org)
  • As stated in the introduction to this section, the defective versions of these genes, known as oncogenes, can cause a cell to divide in an unregulated manner. (cancerquest.org)
Amino Acids1
  • Transmembrane region of proteins is likely to have a stretch of hydrophobic amino acids. (medicosplexus.com)
PDGFB2
  • The collagen promoter drives COL1A1 and PDGFB fusion protein production. (medscape.com)
  • However, unlike oncogenes such as PDGFB or ras, Wnt-1 and -2 failed to induce detectable transformed foci following transfection, and stable NIH3T3 transfectants lacked tumor forming capacity. (tau.ac.il)
Tumor4
  • The fusion protein is then processed into functional PDGF-B and subsequently interacts with the PDGF receptor on the cell surface of DFSP tumor cells. (medscape.com)
  • Its ability to ubiquitinate p53 is regulated by TUMOR SUPPRESSOR PROTEIN P14ARF. (umassmed.edu)
  • DNA from a parathyroid tumor from the sister revealed a loss of heterozygosity in which the mutant allele was retained. (ox.ac.uk)
  • A useful analogy to consider when thinking about tumor suppressors and oncogenes is an automobile. (cancerquest.org)
Phosphorylation3
  • Mdm2 Phosphorylation Regulates Its Stability and Has Contrasting Effects on Oncogene and Radiation-Induced Tumorigenesis. (umassmed.edu)
  • Newborn mice lacking Pptc7 exhibit aberrant mitochondrial protein phosphorylation, suffer from a range of metabolic defects, and fail to survive beyond one day after birth. (bvsalud.org)
  • Overall, our work reveals a significant role for PPTC7 in the mitophagic response and furthers the growing notion that management of mitochondrial protein phosphorylation is essential for ensuring proper organelle content and function. (bvsalud.org)
Receptors2
  • Many of these proteins are similar in structure to known NUCLEAR RECEPTORS but appear to lack a functional ligand-binding domain, while in other cases the specific ligands have yet to be identified. (nih.gov)
  • There are various kinds of invasive cancers with cells lacking progesterone and estrogen receptors and no increase in the protein named HER2 on the surface. (healthresource4u.com)
Mutation1
  • In addition, another unreported heterozygous missense germline MEN1 mutation, Trp220Leu, was identified in an unrelated male patient with FIHP, whose mother and sister also had primary hyperparathyroidism. (ox.ac.uk)
Chromosome1
  • ERBB2 , a known proto-oncogene , is located at the long arm of human chromosome 17 (17q12). (iiab.me)
Receptor4
  • Receptor tyrosine-protein kinase erbB-2 , also known as CD340 (cluster of differentiation 340), proto-oncogene Neu , Erbb2 (rodent), or ERBB2 (human), is a protein that in humans is encoded by the ERBB2 gene. (iiab.me)
  • STRAP (Serine/Threonine Kinase Receptor Associated Protein) is a Protein Coding gene. (inamericawithgrace.com)
  • A broad category of receptor-like proteins that may play a role in transcriptional-regulation in the CELL NUCLEUS . (nih.gov)
  • 19 normal healthy in- receptor protein (CD117) that is structurally dividuals were recruited as a control group. (who.int)
Mitogen-activa1
  • The kinases of this family that have been suggested to play a role in apoptosis are the mitogen-activated protein kinase (MAPK) family, specifically p42/44 ERK, p38 MAPK and c-Jun N-terminal kinase (JNK), cyclic AMP-dependent protein kinase (PKA), protein kinase B (PKB), or Akt and protein kinase C (PKC). (inamericawithgrace.com)
Transcription Factors1
  • Although OSM and IL-6 induced STAT (signal transducers and activators of transcription) factors to bind a high affinity Sis-inducible element DNA probe, binding to homologous TIMP-1 promoter sequences was not detected. (uea.ac.uk)
MAPK1
  • Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. (inamericawithgrace.com)
Tumorigenesis3
  • Overexpression of c-sis causes tumorigenesis. (nih.gov)
  • ADP-ribosylation factor-like protein 13B (ARL13B), a regulatory GTPase and guanine exchange factor (GEF), enriches in primary cilia and promotes tumorigenesis in part by regulating Smoothened (SMO), GLI, and Sonic Hedgehog (SHH) signaling. (bvsalud.org)
  • Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation and thus providing a selective advantage in tumorigenesis (PubMed:15528381, PubMed:1825810, PubMed:31548394). (inamericawithgrace.com)
Kinase5
  • Inside the opinion in the authors, the platelet gel as a reproducible, low-cost and minimally invasive method FES Proto-Oncogene, Tyrosine Kinase Proteins Species comprises an efficient alternative to myocutaneous flaps. (scdinhibitor.com)
  • Protein kinase Cd and c-Abl kinase are required for transforming growth factor ß induction of endothelial-mesenchymal transition in vitro. (jefferson.edu)
  • V-Raf murine sarcoma viral oncogene homolog B1 ( B-RAF) is a gene that codes a protein B-Raf, which is a serine/ threonine-protein kinase. (inamericawithgrace.com)
  • A topological analysis predicted PknB, the serine/threonine protein kinase of S. The serine/threonine-specific protein kinase Akt (protein kinase B), when phosphorylated by phosphotidylinositol-3-kinase, is a key mediator of tolerance. (inamericawithgrace.com)
  • Akt is a serine/threonine-specific protein kinase that plays a critical role in controlling the balance between survival and death pathways in cells. (inamericawithgrace.com)
GTPase1
Transmembrane1
  • Substitution of a valine for a glutamic acid in the transmembrane domain can result in the constitutive dimerisation of this protein in the absence of a ligand. (iiab.me)
Pathways3
  • These findings establish that both Wnt signaling and pattern of growth alterations differ from those of oncogenes which activate proliferative signaling pathways in NIH3T3 cells. (tau.ac.il)
  • A protein with a myriad of effects on various important signaling pathways that is expressed in microglia is the Src Homology 2 (SH2) domain-containing Inositol 5' Phosphatase 1 (SHIP1) protein. (bvsalud.org)
  • Serine/threonine (S/T) protein kinases are crucial components of diverse signaling pathways in eukaryotes, including the model filamentous fungus Neurospora crassa. (inamericawithgrace.com)
HER21
  • HER2 is colocalised and most of the time, coamplified with the gene GRB7, which is a proto-oncogene associated with breast, testicular germ cell, gastric, and esophageal tumours. (iiab.me)
Mesh4
  • Proto-Oncogene Proteins c-mdm2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (umassmed.edu)
  • Proto-Oncogene Proteins p21(ras)" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uchicago.edu)
  • Immunoglobulin J Recombination Signal Sequence-Binding Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
  • Factor For Inversion Stimulation Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (childrensmercy.org)
Chromatid1
Kinases1
  • Regarded as constitutively active enzymes, known to participate in many, diverse biological processes, the intracellular regulation bestowed on the CK1 family of serine/threonine protein kinases is critically important, yet poorly understood. (inamericawithgrace.com)
Heat shock protein1
Genome1
  • ERBB is abbreviated from erythroblastic oncogene B, a gene isolated from avian genome. (iiab.me)
Oncogenic1
Stability1
  • Inside a pilot study inside a group of 11 individuals who received HIV Integrase Proteins Storage & Stability filgrastim in the perioperative period (7 days in total) in the every day dose of 300 lg subcutaneously, the authors observed a reduction inside the prices of postoperative dehiscence of inguinal and vulvar wounds as in comparison with a historical control group. (scdinhibitor.com)
Enzymes1
  • A small Ca++ binding protein that modifies activity of many enzymes and other proteins in response to changes of Ca++ concentration is known as Calmodulin. (medicosplexus.com)
Defective2
  • A defective oncogene would be analogous to a gas pedal that is stuck in the 'on' position. (cancerquest.org)
  • We have two copies of each gene and for oncogenes, a single defective copy is enough to cause a cell to divide. (cancerquest.org)
Activity2
  • In normal cells, both internal and external signals control the activity of the oncogenes. (cancerquest.org)
  • A key feature of oncogene activity is that a single altered copy leads to unregulated growth. (cancerquest.org)
Rich protein2
Spindle1
Mutant1
  • The mutant proteins often retain some of their capabilities but are no longer sensitive to the controls that regulate the normal form of the protein. (cancerquest.org)
Note1
  • Note that by convention gene names are italicized and the proteins they make are not. (cancerquest.org)
Breast2
  • Amplification or over-expression of this oncogene has been shown to play an important role in the development and progression of certain aggressive types of breast cancer . (iiab.me)
  • In recent years the protein has become an important biomarker and target of therapy for approximately 30% of breast cancer patients. (iiab.me)
Family1
Chain1
  • It has been shown that the sis oncogene is derived from the PDGF B-chain gene. (wikipedia.org)
Cell cycle1
Publications7
  • This is a "connection" page, showing publications James Liao has written about Proto-Oncogene Proteins c-sis. (uchicago.edu)
  • This graph shows the total number of publications written about "Proto-Oncogene Proteins c-mdm2" by people in this website by year, and whether "Proto-Oncogene Proteins c-mdm2" was a major or minor topic of these publications. (umassmed.edu)
  • Below are the most recent publications written about "Proto-Oncogene Proteins c-mdm2" by people in Profiles. (umassmed.edu)
  • Below are the most recent publications written about "Proto-Oncogene Proteins p21(ras)" by people in Profiles. (uchicago.edu)
  • This graph shows the total number of publications written about "Immunoglobulin J Recombination Signal Sequence-Binding Protein" by people in Harvard Catalyst Profiles by year, and whether "Immunoglobulin J Recombination Signal Sequence-Binding Protein" was a major or minor topic of these publication. (harvard.edu)
  • Below are the most recent publications written about "Immunoglobulin J Recombination Signal Sequence-Binding Protein" by people in Profiles. (harvard.edu)
  • Below are the most recent publications written about "Factor For Inversion Stimulation Protein" by people in Profiles. (childrensmercy.org)
Form1
  • Rel frequently combines with other related proteins (NF-KAPPA B, I-kappa B, relA) to form heterodimers that regulate transcription. (childrensmercy.org)