• MYB proto-oncogene like 1 is a protein that in humans is encoded by the MYBL1 gene. (wikipedia.org)
  • This gene encodes a nucleolar transcriptional regulator that was first identified by its ability to bind specifically to the Myb proto-oncogene protein. (nih.gov)
  • Cellular DNA-binding proteins encoded by the rel gene (GENES, REL). (bvsalud.org)
  • High trait specificity is found for the R2R3-MYB factors such that one specific R2R3-MYB gene regulates each trait [ 3 ]. (biomedcentral.com)
  • Non-nuclear oncogenes and the regulation of gene expression in transformed cells. (musc.edu)
  • Analysis of the v-myb structural components important for transactivation of gene expression. (musc.edu)
  • Most interestingly, the c-myb gene in lpr L3T4-, Lyt-2- T cells is hypomethylated compared with normal controls. (aai.org)
  • This suggests that a regulatory mechanism, rather than the structural alteration of the gene, is responsible for elevated expression of c-myb in these L3T4-, Lyt-2- cells. (aai.org)
  • Myc proto-oncogene encodes nuclear DNA-binding phosphoproteins that are involved in the regulation of gene expression and DNA replication during cell growth and differentiation. (sigmaaldrich.com)
  • Researchers have noted an MYB-NFIB gene fusion, which provides a new genetic link between dermal cylindroma and adenoid cystic carcinoma. (medscape.com)
  • Our studies have demonstrated that several of the proteins encoded by cellular oncogenes function in fundamental aspects of gene regulation. (stanford.edu)
  • Note that by convention gene names are italicized and the proteins they make are not. (cancerquest.org)
  • As an example TP 53 refers to the gene and p53 refers to the protein. (cancerquest.org)
  • We have two copies of each gene and for oncogenes, a single defective copy is enough to cause a cell to divide. (cancerquest.org)
  • Opposing actions of c-ets/PU.1 and c-myb protooncogene products in regulating the macrophage-specific promoters of the human and mouse colony-stimulating factor-1 receptor (c-fms) genes. (musc.edu)
  • Cellular proteins encoded by the H-ras, K-ras and N-ras genes. (uchicago.edu)
  • To identify YpdB-regulated genes, we compared the transcriptomes of E. coli cells overproducing either YpdB or a control protein. (cipsm.de)
  • In contrast to sporadic cylindromas, according to one study, the fusion of MYB-NFIB genes was absent for CYLD -defective tumors in inherited disorders. (medscape.com)
  • Genes whose protein products stimulate or enhance the division and viability of cells. (cancerquest.org)
  • Genes whose protein products can directly or indirectly prevent cell division or lead to cell death. (cancerquest.org)
  • The normal versions of genes in the first group are called proto-oncogenes. (cancerquest.org)
  • The mutated or otherwise damaged versions of these genes are called oncogenes. (cancerquest.org)
  • Numerous genes have been identified as proto-oncogenes. (cancerquest.org)
  • As stated in the introduction to this section, the defective versions of these genes, known as oncogenes, can cause a cell to divide in an unregulated manner. (cancerquest.org)
  • Cellular- oncogenes, anti-oncogene and DNA repair genes are major types of genes that contribute to this process. (biomedcentral.com)
  • Differentially expressed genes and proteins can be screened from the level of genes and proteins, respectively. (biomedcentral.com)
  • Screening differential molecules can be accomplished in two ways: screening from protein expression data or using RNA-Seq data to detect differentially expressed genes. (biomedcentral.com)
  • 120 different translocations, resulting in the generation of MLL-fusion proteins encompassing more than 75 different partner genes 5 . (nature.com)
  • While it is routine to detect structural viral proteins in vitro for diagnostic purposes, it previously remained impossible to directly and dynamically visualize HIV in living cells without genetic modification of the virus. (cipsm.de)
  • The encoded protein is thought to play a role in many cellular processes including response to nucleolar stress, tumor suppression and synthesis of ribosomal DNA. (nih.gov)
  • Regulation and function of Myb-binding protein 1A (MYBBP1A) in cellular senescence and pathogenesis of head and neck cancer. (nih.gov)
  • Since the c-myb protein is presumably the effector molecule that affects cellular functions, it is important to determine whether increased levels of this c-myb protein are produced. (aai.org)
  • ADP-ribosylation is a post-translational modification of proteins that occurs mostly in response to cellular stress and is catalysed by members of the diverse poly-ADP-ribose (PAR) polymerase (PARP/ARTD) family. (cipsm.de)
  • These results also suggest that in addition to its established role in invasion and angiogenesis, ETS1 may support malignant cellular Narlaprevir growth via regulation of CIP2A expression and protein phosphatase 2A inhibition. (researchassistantresume.com)
  • A cellular transcriptional coactivator that was originally identified by its requirement for the stable assembly IMMEDIATE-EARLY PROTEINS of the HERPES SIMPLEX VIRUS. (rush.edu)
  • Rel frequently combines with other related proteins (NF-KAPPA B, I-kappa B, relA) to form heterodimers that regulate transcription. (bvsalud.org)
  • In A. thaliana TTG1 acts together with R2R3-MYB and bHLH proteins (called MBW complex) to regulate different aspects of epidermal cell differentiation including the production of proanthocyanidin, anthocyanidin, seed coat mucilage, trichomes and root hairs [ 5 - 12 ]. (biomedcentral.com)
  • This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. (novusbio.com)
  • In addition to binding to RNA, nuclear factor 90 proteins form heterodimeric complexes that regulate GENETIC TRANSCRIPTION and may play a role in T-CELL activation. (ouhsc.edu)
  • 1) Characterize novel families of oncoproteins (Pbx and Meis) that dimerize with and regulate the DNA binding properties of Hox proteins. (stanford.edu)
  • Some proto-oncogenes work to regulate cell death. (cancerquest.org)
  • The mutant proteins often retain some of their capabilities but are no longer sensitive to the controls that regulate the normal form of the protein. (cancerquest.org)
  • Proto-oncogene proteins that negatively regulate RECEPTOR PROTEIN-TYROSINE KINASE signaling. (nih.gov)
  • These genetic alterations often results in overexpression or activity of proto-oncogenes and inhibition of the function of tumor suppressor [1], [2].Therefore, understanding of the mechanisms by which the activity of both proto-oncogenes and tumor suppressors is usually altered in malignancy is usually crucially important both academically, and for development of new approaches to target malignancy cells for therapy. (researchassistantresume.com)
  • A useful analogy to consider when thinking about tumor suppressors and oncogenes is an automobile. (cancerquest.org)
  • Macrophage colony-stimulating factor promotes cell survival through Akt/protein kinase B. (musc.edu)
  • ets-2 is a target for an akt (Protein kinase B)/jun N-terminal kinase signaling pathway in macrophages of motheaten-viable mutant mice. (musc.edu)
  • Protein kinase Cd and c-Abl kinase are required for transforming growth factor ß induction of endothelial-mesenchymal transition in vitro. (jefferson.edu)
  • death associated protein kinase 1 [Sou. (gsea-msigdb.org)
  • The multifunctional protein fused in sarcoma (FUS) is a coactivator of microphthalmia-associated transcription factor (MITF). (musc.edu)
  • We are investigating how Pbx and Meis proteins contribute to the specificity of Hox function in development and how disruption of their activities leads to neoplasia. (stanford.edu)
  • Progress has been made to better understand about effect of regulons (AREB/ABF, DREB, MYB, and NAC) under abiotic stresses and a number of regulons reported for stress responsive and used as a better transgenic tool of Arabidopsis and Rice. (scielo.br)
  • Progresso foi feito para entender melhor sobre o efeito dos regulons (AREB / ABF, DREB, MYB e NAC) sob estresses abióticos e uma série de regulons relatados como responsivos ao estresse e usados ​​como uma melhor ferramenta transgênica de Arabidopsis e Rice. (scielo.br)
  • In Arabidopsis thaliana ( A. thaliana ) the WD40 protein TRANSPARENT TESTA GLABRA1 (TTG1) controls five traits relevant for the adaptation of plants to environmental changes including the production of proanthocyanidin, anthocyanidin, seed coat mucilage, trichomes and root hairs. (biomedcentral.com)
  • The carboxy-terminal catalytic domain of the GTPase-activating protein inhibits nuclear signal transduction and morphological transformation mediated by the CSF-1 receptor. (musc.edu)
  • A broad category of receptor-like proteins that may play a role in transcriptional-regulation in the CELL NUCLEUS . (nih.gov)
  • Many of these proteins are similar in structure to known NUCLEAR RECEPTORS but appear to lack a functional ligand-binding domain, while in other cases the specific ligands have yet to be identified. (nih.gov)
  • Using lysate-based single-molecule motility assays and live-cell imaging in primary neurons, we show that JNK-interacting proteins 3 (JIP3) and 4 (JIP4) are activating adaptors for dynein that are regulated on autophagosomes and lysosomes by the small GTPases ARF6 and RAB10. (bvsalud.org)
  • It has been linked to malignancy since its identification as an oncogenic fusion with the product of c-Myb proto-oncogene in the. (researchassistantresume.com)
  • Families of related leukemia fusion proteins that share genomic and biological properties represent unique opportunities to study how the combination of distinct functional protein modules can drive oncogenic transformation. (nature.com)
  • It has therefore been proposed that the oncogenic activity of MLL-fusion proteins depends on chromatin targeting functions exerted by the MLL N-terminus in combination with other functional properties encoded by the fusion partners 6 . (nature.com)
  • A ubiquitously expressed sequence-specific transcriptional repressor that is normally the target of signaling by NOTCH PROTEINS. (harvard.edu)
  • This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. (novusbio.com)
  • These are frequently activated by fusion to other transcriptional proteins resulting in chimeric transcription factors. (stanford.edu)
  • We are studying the effects and consequences of protein fusion on the transcriptional and transforming activities of these proteins using in vitro and animal models. (stanford.edu)
  • We demonstrate here that GSK-3 maintains the MLL leukemia stem cell transcriptional program by promoting the conditional association of CREB and its coactivators TORC and CBP with homedomain protein MEIS1, a critical component of the MLL-subordinate program, which in turn facilitates HOX-mediated transcription and transformation. (stanford.edu)
  • Proto-Oncogene Proteins c-mdm2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (umassmed.edu)
  • Immunoglobulin J Recombination Signal Sequence-Binding Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
  • Proto-Oncogene Proteins p21(ras)" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uchicago.edu)
  • Nuclear Factor 90 Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (ouhsc.edu)
  • Factor For Inversion Stimulation Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (childrensmercy.org)
  • Cytoskeletal motor proteins are essential molecular machines that hydrolyze ATP to generate force and motion along cytoskeletal filaments. (bvsalud.org)
  • Molecular basis of elevated c-myb expression in the abnormal L3T4-, Lyt-2- T lymphocytes of autoimmune mice. (aai.org)
  • However, it is unclear whether these molecular mechanisms pertain to the entire family of MLL-fusions or if they specifically affect the leukemogenicity of isolated MLL-fusion proteins. (nature.com)
  • Several different variants of the bcr-abl fusion proteins occur depending upon the precise location of the chromosomal breakpoint. (jefferson.edu)
  • This graph shows the total number of publications written about "Fusion Proteins, bcr-abl" by people in this website by year, and whether "Fusion Proteins, bcr-abl" was a major or minor topic of these publications. (jefferson.edu)
  • Below are the most recent publications written about "Fusion Proteins, bcr-abl" by people in Profiles. (jefferson.edu)
  • In instances in which no positive result is found for fusion, MYB activation may be enough to manifest a subset of sporadic cylindromas. (medscape.com)
  • We present the first comprehensive survey of protein-protein interactions of seven distantly related MLL-fusion proteins. (nature.com)
  • MLL-fusion proteins are found in acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML) and are often associated with adverse prognosis, particularly in pediatric patients 3 . (nature.com)
  • For instance, the CxxC-domain is essential for DNA binding of MLL-fusion proteins 7 . (nature.com)
  • Furthermore, the MLL-interacting protein Menin links MLL-fusion proteins with LEDGF, and the H3K36me3-binding PWWP domain of LEDGF is critical for the function of MLL-fusions 8 . (nature.com)
  • Myc encodes a protein of 65 kDa which is expressed in almost all normal and transformed cells. (sigmaaldrich.com)
  • Cancerous inhibitor of protein phosphatase 2A (CIP2A) is usually a recently characterized human oncoprotein. (researchassistantresume.com)
  • Sequences of the Myc oncogene have been highly conserved throughout evolution, from Drosophila to vertebrates. (sigmaaldrich.com)
  • Different cancer types tend to depend on a limited number of 'driver' oncogene mutations. (cancerquest.org)
  • With the use of immunoprecipitation with an anti-v-myb reagent, we found high levels of c-myb protein in the lymph nodes of lpr mice. (aai.org)
  • It helps to open up the chromatin by neutralizing the positive charge of histone lysine residues and providing binding platforms for "reader" proteins. (omicsdi.org)
  • The bromodomain (BRD) has long been thought to be the sole protein module that recognizes acetylated histones. (omicsdi.org)
  • Detailed analysis showed that the c-myb protein is primarily expressed by an abnormal T lymphocyte population that does not express the mature T cell markers, L3T4 and Lyt-2. (aai.org)
  • transport is driven by the microtubule motor protein cytoplasmic dynein, with motor activity regulated by a sequential series of adaptors. (bvsalud.org)
  • MORF4L1 may also participate in the formation of NuA4 related complexes which lack the HTATIP/TIP60 catalytic subunit, but which include the SWI/SNF related protein SRCAP. (novusbio.com)
  • The protein expressions of epithelial marker, E-cadherin and mesenchymal marker, N-cadherin were evaluated using western blot. (aging-us.com)
  • Understanding the underlying mechanisms and behaviors of motor proteins is critical to provide better strategies for the treatment of motor protein-related diseases. (bvsalud.org)