• Although oncogenic versions of c-Myb were first associated with leukemias, over expression or rearrangement of the c- myb gene is common in several types of solid tumors, including breast cancers. (biomedcentral.com)
  • Our results show that c-Myb associates with a surprisingly large number of promoters in human cells. (biomedcentral.com)
  • The results also suggest that estradiol stimulation leads to large-scale, genome-wide changes in c-Myb activity and subsequent changes in gene expression in human breast cancer cells. (biomedcentral.com)
  • By studying a panel of these targets to validate the results, we found that estradiol stimulation triggered the association of c-Myb with promoters and that association correlated with increased target gene expression. (biomedcentral.com)