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  • gene
  • What does this gene/protein do? (cancerindex.org)
  • Análise de mutações do gene KIT em pacientes com melanoma de mucosa de cabeça e pescoço. (usp.br)
  • Além disso, a mutação do gene KIT foi identificada em melanomas, indicando a possibilidade de benefícios terapêuticos com o uso dos inibidores de tirosino-quinase. (usp.br)
  • avaliar a relação entre a presença de mutação ativadora do gene KIT e evolução clínica dos pacientes tratados em relação ao estadiamento, sobrevida livre de doença e sobrevida global. (usp.br)
  • What pathways are this gene/protein implicaed in? (cancer-genetics.org)
  • The c-kit gene is encoded on the q12 locus of chromosome 4. (wikipedia.org)
  • url=http://www.genecards.org/cgi-bin/carddisp.pl?gene=KIT&keywords=C-kit Fairley JA, Pentland AP, Voorhees JJ (1984). (wikipedia.org)
  • The product of this gene belongs to a small family of adaptor proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. (wikipedia.org)
  • In the case of Noonan syndrome, mutations are broadly distributed throughout the coding region of the gene but all appear to result in hyper-activated, or unregulated mutant forms of the protein. (wikipedia.org)
  • The Cox-2 gene catalyses the production of prostaglandins-it overexpresses in several cancers, and is stabilized by the binding of CUGBP2 RNA-binding protein to ARE Chen, Chyi-Ying A. (wikipedia.org)
  • adapter protein
  • His research has also shown that a mutant form of an immune adapter protein termed ADAP can block the infection of T-cells by the Human Immunodeficiency Virus (HIV-1), and has pioneered the use of small molecule inhibitors (SMIs) of glycogen synthase kinase-3 (GSK-3) in the down-regulation of the co-receptor programmed cell death-1 (PD-1) in immunotherapy. (wikipedia.org)
  • mice
  • Here we generated two genetic approaches in mice to examine whether endogenous c-kit(+) cells contribute differentiated cardiomyocytes to the heart during development, with ageing or after injury in adulthood. (nih.gov)
  • A complementary DNA encoding either Cre recombinase or a tamoxifen-inducible MerCreMer chimaeric protein was targeted to the Kit locus in mice and then bred with reporter lines to permanently mark cell lineage. (nih.gov)
  • Assessing the fidelity and specificity of the Kit-Cre knock-in allelea, Histological sections from the indicated tissues of Kit+/Cre × R-GFP mice at 4 weeks of age. (nih.gov)
  • b, Immunohistochemistry for endogenous c-kit expression (red) in the mouse ileum at 4 weeks of age from Kit+/Cre mice that contain the IRES-eGFPnls cassette (but without the × R-GFP reporter allele) so that eGFP expression can be monitored in real time. (nih.gov)
  • c, Immunohistochemistry for endogenous c-kit expression (red) in quadriceps muscle of Kit+/Cre mice at 4 weeks of age versus nuclear eGFP (green) from the Kit+/Cre allele. (nih.gov)
  • While lineage tracing in Kit+/Cre × R-GFP mice, which is cumulative, showed abundant endothelial cells throughout the skeletal muscle (a), instantaneous c-kit expressing cells are rare in skeletal muscle, and when identified, are always mononuclear (inset box). (nih.gov)
  • e, Immunohistochemistry in the hearts of Kit+/Cre × R-GFP mice for endogenous c-kit expression (red) versus all the cells that underwent recombination throughout development and the first 4 weeks of life, shown in green. (nih.gov)
  • biological
  • The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 0.25ng/ml-8ng/ml in biological research samples containing CRAF, with an estimated sensitivity of 0.1ng/ml. (mybiosource.com)
  • This kit is NOT suitable for assaying non-biological sources of substances. (mybiosource.com)
  • No real ARE consensus sequence has been determined yet, and these categories are based neither on the same biological functions, nor on the homologous proteins. (wikipedia.org)
  • Severity
  • It has been previously reported that there is an association between Wnt5a mRNA and protein expression and histopathological severity of human atherosclerotic lesions as well as co-expression of Wnt5a and TLR4 in foam cells/macrophages of murine and human atherosclerotic lesions. (wikipedia.org)
  • Inhibitors
  • In this review, we discuss the role of KIT in the context of mast cells in these disease states and how recent advances in the development of inhibitors of KIT activity and function may offer novel therapies for the treatment of these disorders. (forskningsdatabasen.dk)
  • Peptides
  • The classical SH3 domain is usually found in proteins that interact with other proteins and mediate assembly of specific protein complexes, typically via binding to proline-rich peptides in their respective binding partner. (wikipedia.org)
  • Cytokines
  • Two cytokines that down modulate FLT3 activity (& block FLT3-induced hematopoietic activity) are: TNF-Alpha (Tumor necrosis factor-alpha) TGF-Beta (Transforming growth factor-beta) TGF-Beta especially, decreases FLT3 protein levels and reverses the FLT3L-induced decrease in the time that hematopoietic progenitors spend in the G1-phase of the cell cycle. (wikipedia.org)
  • AREs) are found in the 3' untranslated region (UTR) of many messenger RNAs (mRNAs) that code for proto-oncogenes, nuclear transcription factors, and cytokines. (wikipedia.org)
  • histone
  • Depending on cell type and cell cycle, mediating factors such as DNA-binding proteins like chromatin, composed of DNA tightly wound around histone proteins, and other environmental conditions and stresses affect the dynamic formation of quadraplexes. (wikipedia.org)
  • D816V
  • The D816V+ allele fraction represents a quantitative measure which allows KIT D816V-positivity to be analyzed as a continuous variable instead of a categorical variable (negative/positive) as previously described. (forskningsdatabasen.dk)
  • stem
  • We evaluated mature peripheral blood eosinophils for their expression of the surface tyrosine kinase, c-kit, the receptor for the stromal cell-derived cytokine, stem cell factor (SCF). (nih.gov)
  • Stem cell factor (SCF)-dependent activation of KIT is critical for mast cell homeostasis and function. (forskningsdatabasen.dk)
  • Chromosome
  • In chronic myelogenous leukemia, the Philadelphia chromosome leads to a fusion protein of abl with bcr (breakpoint cluster region), termed bcr-abl. (wikipedia.org)
  • MET proto-oncogene (GeneID: 4233) has a total length of 125,982 bp, and it is located in the 7q31 locus of chromosome 7. (wikipedia.org)
  • mRNA
  • In vitro, endometrial side population (ESP) cell apoptosis models were built, and apoptosis was quantified by fluorescence-activated cell sorter (FACS) analysis, pou5f1, and c-kit mRNA was detected by qPCR. (nih.gov)
  • Pou5f1and c-kit mRNA was examined by qPCR. (nih.gov)
  • In the in vitro endometrial SP (ESP) cells apoptosis model, we found that the apoptotic rate was gradually increased with time, prolonging the expression of TERT, and c-kit mRNA was gradually decreased. (nih.gov)
  • AUF1 is also known to interact with the translation initiation factor eIF4G and with poly(A)-binding protein, indicating that AUF1 senses the translational status of mRNA and decays accordingly through the excision of the poly(A) tail. (wikipedia.org)
  • MET is transcribed into a 6,641 bp mature mRNA, which is then translated into a 1,390 amino-acid MET protein. (wikipedia.org)
  • encode
  • HuRs are involved in genotoxic response-they accumulate in the cytoplasm in response to UV exposure and stabilize mRNAs that encode proteins involved in DNA repair. (wikipedia.org)
  • yeast
  • SH3 interactomes, revealed that worm SH3 interactome resembles the analogous yeast network because it is significantly enriched for proteins with roles in endocytosis. (wikipedia.org)