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  • Genes
  • CRC arises from the colorectal epithelium as a result of the accumulation of genetic alterations in defined oncogenes and tumour suppressor genes (TSG). (kegg.jp)
  • The gene induction kinetics of c-fos, c-jun and two other IE genes, core promoter element binding protein (CPBP) and MAP kinase phosphatase 1 (MKP1), was examined (Figure 6B). (nih.gov)
  • Gene expression assays are becoming practical tools for quantitating the effect of a drug or drugs on a large fraction of genes and/or proteins in a cell culture. (google.com)
  • Moreover, the spacing and relative orientation of the Elk1 binding site to the SRE is rather flexible, suggesting that the SRE-regulated early genes other than c-fos could be targets of Elk1. (wikipedia.org)
  • For example, by forming stable heterodimers with c-Jun, the bZIP region of v-Fos increases the binding of c-Jun to target genes whose activation is involved in the differentiation of chicken embryo fibroblasts (CEF). (wikipedia.org)
  • Mice
  • Effects of MDP (3 mg/kg), LPS (0.83 mg/kg) and MDP + LPS on c-Fos expression 3 h after treatment of male mice. (nih.gov)
  • dorsal
  • Pretreatment with D-CPPene (2 mg/kg) reversed CCK (2 microg/kg)-induced inhibition of sucrose intake, and attenuated CCK-induced Fos-Li in the dorsal hindbrain. (biomedsearch.com)
  • regulatory
  • The human protein 26S proteasome non-ATPase regulatory subunit 14 is 37 kDa in size and composed of 324 amino acids. (wikipedia.org)
  • The 19S regulatory particles can recognize ubiquitin-labeled protein as degradation substrate, unfold the protein to linear, open the gate of 20S core particle, and guide the substate into the proteolytic chamber. (wikipedia.org)
  • According to the protein interaction and topological characteristics of this multisubunit complex, the 19S regulatory particle is composed of a base and a lid subcomplex. (wikipedia.org)
  • The eukaryotic proteasome recognizes degradable proteins, including damaged proteins for protein quality control purpose or key regulatory protein components for dynamic biological processes. (wikipedia.org)
  • gene induction
  • We produced high-resolution comparative maps of the distribution and dynamics of H3K4me3, H3K36me3, H3K79me2 and H3K9ac across c-fos and c-jun upon gene induction in murine fibroblasts. (nih.gov)
  • substrate
  • This unique structure design prevents random encounter between proteolytic active sites and protein substrate, which makes protein degradation a well-regulated process. (wikipedia.org)
  • inhibitors
  • p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors. (uniprot.org)
  • cells
  • Addressing molecular mechanisms involved, we find that Huntingtin-interacting protein HYPB/Setd2 is responsible for virtually all global and transcription-dependent H3K36 trimethylation, but not H3K36-mono- or dimethylation, in these cells. (nih.gov)
  • D) Cells were transfected and stimulated as in (A) and cellular protein was isolated from the same TRIzolĀ® reagent preparations used for RNA extraction. (nih.gov)
  • kappa
  • This protein functions as a transcriptional coactivator that activates through its association with NF-kappa B homodimers. (wikipedia.org)
  • The NF-kappa B precursor p105 and the proto-oncogene product Bcl-3 are I kappa B molecules and control nuclear translocation of NF-kappa B". EMBO J. 12 (1): 213-22. (wikipedia.org)
  • accumulation
  • Such protein accumulation may contribute to the pathogenesis and phenotypic characteristics in neurodegenerative diseases, cardiovascular diseases, inflammatory responses and autoimmune diseases, and systemic DNA damage responses leading to malignancies. (wikipedia.org)
  • Such protein accumulation has become phenotypic characteristics of neurodegenerative diseases, cardiovascular diseases, and systemic DNA damage responses. (wikipedia.org)