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  • zebrafish
  • To investigate the fate of lmo2-expressing cells and the transcriptional regulation of lmo2 in vivo, we generated stable transgenic zebrafish that express green fluorescent protein (EGFP) or DsRed under the control of an lmo2 promoter. (zfin.org)
  • This element contains critical ETS-binding sites conserved between zebrafish and pufferfish. (zfin.org)
  • SPDEF
  • Taken together, to the best of our knowledge, these studies are the first demonstrating requirement of SPDEF for expression of E-cadherin, an essential epithelial cell junction protein. (nih.gov)
  • Etv2
  • Furthermore, Gata2 is initially activated by Fli1 but later maintained by another ETS factor, Etv2. (ox.ac.uk)
  • motif
  • Finally, we show that FOX:ETS motifs are present in many known endothelial-specific enhancers and that this motif is an efficient predictor of endothelial enhancers in the human genome. (ox.ac.uk)
  • Etv6
  • Thus, the two ETS factors Fli1 and Etv6, which drives the VEGFA expression in both somites and the DLP, sit at the top of the adult haemangioblast gene regulatory network (GRN). (ox.ac.uk)
  • The ETS variant gene 6 (ETV6)-neurotrophin receptor 3 (NTRK3) rearrangement (ETV6-NTRK3) was identified by RNA-Seq in a tumor from a patient who received a high (131) I dose. (nih.gov)
  • expression
  • Scope includes mutations and abnormal protein expression. (cancerindex.org)
  • Opposing effects of Ets and Id proteins on p16INK4a expression during cellular senescence. (openrepository.com)
  • Here we used an outlier meta-analysis (meta-COPA) to identify SPINK1 outlier expression exclusively in a subset of ETS rearrangement-negative cancers ( approximately 10% of total cases). (ox.ac.uk)
  • We validated the mutual exclusivity of SPINK1 expression and ETS fusion status, demonstrated that SPINK1 outlier expression can be detected noninvasively in urine, and observed that SPINK1 outlier expression is an independent predictor of biochemical recurrence after resection. (ox.ac.uk)
  • We identified the aggressive 22RV1 cell line as a SPINK1 outlier expression model and demonstrate that SPINK1 knockdown in 22RV1 attenuates invasion, suggesting a functional role in ETS rearrangement-negative prostate cancers. (ox.ac.uk)
  • progression
  • In this review we focus on the roles of Ets-1 for tumour development and progression with special emphasis on tumour vascularization and invasion. (ox.ac.uk)
  • activation
  • In this paper we demonstrate that the distal region of the human immunodeficiency virus-1 (HIV-1) enhancer, which contains DNA-binding sites for LEF-1 and Ets-1, also provides a functional context for activation by LEF-1. (ac.be)
  • cancers
  • The role of SPINK1 in ETS rearrangement-negative prostate cancers. (ox.ac.uk)
  • however, the key molecular alterations in ETS-negative cancers are unclear. (ox.ac.uk)
  • Factor
  • en] Lymphoid enhancer-binding factor 1 (LEF-1) is a regulatory high mobility group (HMG) protein that activates the T cell receptor alpha (TCR alpha) enhancer in a context-restricted manner in T cells. (ac.be)