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  • Overexpression
  • Overexpression of BCL6 and Bcl-xL confer a high proliferative capacity and fixed differentiation phenotype to peripheral blood CD27 + IgG + memory B cells ( a ) Flow cytometry identification of BCL6-transduced (ΔNGFR + ), Bcl-xL-transduced (GFP + ) and BCL6+Bcl-xL transduced (GFP + ΔNGFR + ) CD19 + B cells in culture with CD40L-L cells and IL-21 four days post transduction. (nih.gov)
  • Concurrently, overexpression of HO-1 was associated with a decrease in the expression of c-fos and p53, an increase in the activation of p38 and bcl-2, and preserved the expression of c-FLIP. (arvojournals.org)
  • molecular
  • The immune system is controlled by a molecular "internet" of protein messages called cytokines. (gabriellesangels.org)
  • The current study determines the possible association between telomerase activity, the expression of both molecular forms of estrogen receptor (ERα and ERβ) and the protein bcl-2, and their relative associations with clinical parameters. (beds.ac.uk)
  • BCL6
  • CD27 + memory peripheral blood cells acquire a stable GC-like phenotype following transduction with BCL6 and Bcl-xL and subsequent culture. (nih.gov)
  • a ) Phenotype of BCL6+Bcl-xL transduced CD27 + memory B cells (6XL, black histogram line) compared to tonsil GC cells (GC, CD38 + CD20 + , shaded grey), tonsil naïve and memory cells (N/M, CD38 − CD20 low , red histogram), and tonsil plasma cells (PC, CD38 ++ CD20 low , blue histogram). (nih.gov)
  • BCL6+Bcl-xL transduced monoclonal cell lines show an identical phenotype (not shown). (nih.gov)
  • caspase
  • Here, we describe a human Jurkat-derived cell line (JB-6) that is deficient in caspase 8. (pubmedcentralcanada.ca)
  • BA enhances the levels of BAX and BCL-2 proteins but does not alter the levels of BCL-x S or BCL-x L . Ectopic expression of BCL-2 prevents BA-induced caspase activation, DNA fragmentation, and cell death. (aspetjournals.org)
  • The generation of reactive oxygen species is blocked by BCL-2 and requires new protein synthesis but is unaffected by caspase inhibitors, suggesting that BA toxicity sequentially involves new protein synthesis, formation of reactive oxygen species, and activation of crm-A-insensitive caspases. (aspetjournals.org)
  • monoclonal
  • The staining with monoclonal antibodies against CD8 and Bcl-2 was performed within 2 hours after collection, and followed with flow cytometry acquisition and analysis. (aaem.pl)
  • cytokines
  • We demonstrate herein that IL-6 and TNF family cytokines, TNFα, BAFF and APRIL, but not IGF-1 cooperatively enhance the expression of the serine/threonine kinase Pim-2 in MM cells. (biomedsearch.com)
  • Activation of STAT3 downstream of cell surface receptors for cytokines and growth factors, by oncogenes or by chemical carcinogens in the microenvironment of many tumor types drives their transformation, survival, proliferation, invasion and dissemination. (mdpi.com)
  • nuclear
  • The proteins are found on mitochondrial, microsomal, and NUCLEAR MEMBRANE sites within many cell types. (rush.edu)
  • human
  • Bars show mean ± standard error of the mean (SEM) from at least 6 human tonsils. (nih.gov)
  • A generalized combinatorial approach for detecting gene-by-gene and gene-by-environment interactions with application to nicotine dependence," The American Journal of Human Genetics , vol. 80, no. 6, pp. 1125-1137, 2007. (hindawi.com)