Proto oncogene proteins c abl. Medical search. Frequent questions

c-Src can be activated by many transmembrane proteins that include: adhesion receptors, receptor tyrosine kinases, G-protein coupled receptors and cytokine receptors. (wikipedia.org)
To investigate why 3-substituted benzamide derivatives show dual inhibition of Abl and Lyn protein tyrosine kinases, we determined their inhibitory activities against Abl and Lyn, carried out molecular modeling, and conducted a structure-activity relationship study with the aid of a newly determined X-ray structure of the Abl/Lyn dual inhibitor INNO-406 (formerly known as NS-187) bound to human Abl. (nih.gov)
Non-receptor tyrosine kinases encoded by the C-ABL GENES. (bvsalud.org)
Scholars@Duke publication: Abl family kinases regulate FcγR-mediated phagocytosis in murine macrophages. (duke.edu)
Abl and Arg define a family of nonreceptor tyrosine kinases that regulate actin-dependent processes in a variety of cell types, including those important in the adaptive immune response. (duke.edu)
Using pharmacological inhibition as well as dominant negative and knockout approaches, we demonstrate a role for the Abl family kinases in phagocytosis by macrophages and define a mechanism whereby Abl kinases regulate this process. (duke.edu)
Bone marrow-derived macrophages from mice lacking Abl and Arg kinases exhibit inefficient phagocytosis of sheep erythrocytes and zymosan particles. (duke.edu)
Treatment with the Abl kinase inhibitors imatinib and GNF-2 or overexpression of kinase-inactive forms of the Abl family kinases also impairs particle internalization in murine macrophages, indicating Abl kinase activity is required for efficient phagocytosis. (duke.edu)
Further, Arg kinase is present at the phagocytic cup, and Abl family kinases are activated by FcγR engagement. (duke.edu)
The regulation of phagocytosis by Abl family kinases is mediated in part by the spleen tyrosine kinase (Syk). (duke.edu)
The link between Abl family kinases and Syk may be direct, as purified Arg kinase phosphorylates Syk in vitro. (duke.edu)
Together, these findings reveal that Abl family kinases control the efficiency of phagocytosis in part through the regulation of Syk function. (duke.edu)
instructions for making a protein called fms-like tyrosine kinase 3 (FLT3), which is part of a family of proteins called receptor tyrosine kinases (RTKs). (nih.gov)
6. Activation of Src kinases p53/56lyn and p59hck by p210bcr/abl in myeloid cells. (nih.gov)
8. Selective pyrrolo-pyrimidine inhibitors reveal a necessary role for Src family kinases in Bcr-Abl signal transduction and oncogenesis. (nih.gov)
Here we report that Abl kinases are regulated by a novel microRNA, miR-4723, in prostate cancer. (elsevierpure.com)
Analysis of putative miR-4723 targets showed that miR-4723 targets integrin alpha 3 and Methyl CpG binding protein in addition to Abl1 and Abl2 kinases. (elsevierpure.com)
In conclusion, we have identified a novel microRNA that mediates regulation of Abl kinases in prostate cancer. (elsevierpure.com)
Mitogen-Activated Protein Kinase Kinases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (childrensmercy.org)
This graph shows the total number of publications written about "Mitogen-Activated Protein Kinase Kinases" by people in this website by year, and whether "Mitogen-Activated Protein Kinase Kinases" was a major or minor topic of these publications. (childrensmercy.org)
Below are the most recent publications written about "Mitogen-Activated Protein Kinase Kinases" by people in Profiles. (childrensmercy.org)
Oncogenic forms of src-family kinases can occur through altered regulation or expression of the endogenous protein and by virally encoded src (v-src) genes. (nih.gov)
The present invention describes novel alkynyl derivatives with inhibitory activity on protein kinases and a pharmaceutical composition for preventing or treating diseases involving abnormal cell growth. (justia.com)
Protein kinases are a group of enzymes for phosphorylation of hydroxyl groups in serine, threonine, and tyrosine moieties of protein. (justia.com)
Human protein kinases can be divided into tyrosine protein kinases and serine/threonine protein kinases. (justia.com)
Tyrosine protein kinases can be further divided into receptor and cytoplasma/non-receptor kinases (Manning et al. (justia.com)
A mutation or an overexpression of certain protein kinases may impact the signal transduction in a normal cell resulting in the imbalance of homeostasis in body. (justia.com)
Gleevec can selectively inhibit bcr/abl by inhibiting tyrosine kinases of abl. (justia.com)
Protein kinase affinity probe 1 is a novel protein kinase affinity probe for the functional identification of protein kinases (PKs) . (medchemexpress.com)
ROCK-IN-5 (compound I- B -37) is a potent inhibitor of ROCK , ERK , GSK , and AGC protein kinases . (medchemexpress.com)
using a yeast two-hybrid screen designed to characterize novel molecules that bind to homeoproteins, the homeodomain-interacting protein kinases (HIPKs), have been proven to be a tumor suppressor and one of the highly conserved factors regulating signaling and gene expressions. (oncotarget.com)

The ABL1 gene provides instructions for making a protein involved in many processes in cells throughout the body. (medlineplus.gov)
The ABL1 protein functions as a kinase, which is an enzyme that changes the activity of other proteins by adding a cluster of oxygen and phosphorus atoms (a phosphate group) at specific positions. (medlineplus.gov)
The ABL1 kinase can be turned on by a number of different triggers and can add a phosphate group to many different proteins (also called substrates). (medlineplus.gov)
The ABL1 kinase interacts with several proteins involved in the network of fibers called the actin cytoskeleton, which makes up the structural framework inside cells. (medlineplus.gov)
The ABL1 gene belongs to a class of genes known as oncogenes. (medlineplus.gov)
The protein produced from the abnormal fusion gene, called BCR-ABL1, functions as a kinase. (medlineplus.gov)
The constantly active BCR-ABL1 protein signals cells to continue dividing abnormally and prevents them from self-destructing, which leads to overproduction of the abnormal cells. (medlineplus.gov)
As in chronic myeloid leukemia, the BCR-ABL1 protein stimulates overproduction of abnormal white blood cells, leading to cancer. (medlineplus.gov)
Also, Abl1 knockdown partially phenocopies miR-4723 reexpression in prostate cancer cells suggesting that Abl is a functionally relevant target of miR-4723 in prostate cancer. (elsevierpure.com)

1. p210BCR/ABL, p190BCR/ABL, and TEL/ABL activate similar signal transduction pathways in hematopoietic cell lines. (nih.gov)
2. Interleukin-3 and p210 BCR/ABL activate both unique and overlapping pathways of signal transduction in a factor-dependent myeloid cell line. (nih.gov)
Subsequently, sequential phosphorylation of subfamily proteins proceeds as signal transduction progresses, leading to overexpression of transcription factors and eventually cancer. (justia.com)
For the last several years, our research has been focused toward (1) understanding the biologic activity of chaperone proteins, particularly HSP90, in mediating signal transduction in cancer cells, and (2) promoting the translational development of HSP90 inhibitors as novel anti-cancer agents. (nih.gov)
Our discovery in 1993 that the HSP90 family of chaperone proteins was the predominant intracellular target of benzoquinone ansamycins led to a series of ongoing, interrelated studies in which we are (1) delineating the drug-protein interaction, (2) characterizing the sequelae of this interaction, and (3) identifying the components of the signal transduction machinery that are the secondary targets of this interaction. (nih.gov)
We showed that this drug class disrupts HSP90/GRP94 interaction with several signal transduction proteins, resulting in destabilization and improper intracellular localization of the signal transducers. (nih.gov)

Loss of Abl and Arg expression or treatment with Abl inhibitors reduced Syk phosphorylation in response to FcγR ligation. (duke.edu)
5. Tyrosine phosphorylation and activation of focal adhesion kinase (p125FAK) by BCR-ABL oncoprotein. (nih.gov)
14. Selective inhibition of cell proliferation and BCR-ABL phosphorylation in acute lymphoblastic leukemia cells expressing Mr 190,000 BCR-ABL protein by a tyrosine kinase inhibitor (CGP-57148). (nih.gov)
Tyrosine phosphorylation is important for the regulation of c-Abl kinase activity. (ecmbio.com)
Phosphorylation of Tyr-245 is involved in activation of c-Abl kinase activity. (ecmbio.com)
Tyrosine 412 is located in the kinase activation loop of c-Abl, and phosphorylation of this residue is required for kinase activity. (ecmbio.com)
Thus, phosphorylation of Tyr-245 and Tyr-412 may be critical for activation of c-Abl in a variety of cell signaling pathways. (ecmbio.com)
Tyrosine phosphorylation of RNA polymerase II carboxyl-terminal domain by the Abl-related gene product. (nih.gov)
Inhibition of DNA binding by the phosphorylation of poly ADP-ribose polymerase protein catalysed by protein kinase C. Biochem Biophys Res Commun 187 , 730-736. (nih.gov)

the BCR-ABL junction peptides can elicit both CD4 and CD8 responses in patients with CML. (medscape.com)
Another approach uses peptide aptamers, short peptides held on the surface of a scaffold protein, which interact with sequences on the surface of intracellular proteins [ 11 ] . (medscape.com)

For example, the TP53 gene, located on chromosome 17, encodes a 53-kd nuclear protein that functions as a cell cycle checkpoint. (medscape.com)
This locus, however, also encodes a protein from an alternative reading frame, designated p19ARF. (medscape.com)
The c-Abl proto-oncogene encodes a nonreceptor type protein tyrosine kinase that is widely expressed and is distributed in both the nucleus and the cytoplasm of cells. (ecmbio.com)
RB1 encodes the protein pRB and was the first tumor suppressor gene to be molecularly defined. (medscape.com)
TP53 encodes the protein p53, which is known as the "guardian of the genome. (medscape.com)
PTEN encodes a protein kinase of the same name and functions as a tumor suppressor through regulation of cell proliferation. (medscape.com)
The Abelson (c-Abl) proto-oncogene encodes a highly conserved nonreceptor protein tyrosine kinase that plays a role in cell proliferation, differentiation, apoptosis and cell adhesion. (elsevierpure.com)

Inactivation of LZTR1 led to decreased ubiquitination and enhanced plasma membrane localization of endogenous KRAS (V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog). (nih.gov)

In addition, these alterations affect 3 principal categories of genes, as follows: proto-oncogenes, tumor suppressor genes, and DNA repair genes. (medscape.com)
This article briefly discusses tumor suppressor genes and then focuses on the role of proto-oncogenes in childhood cancer. (medscape.com)
Like Rb protein, many of the proteins encoded by tumor suppressor genes act at specific points in the cell cycle. (medscape.com)
The exact mechanisms by which these rare fusion genes lead to blood cancer are not completely understood, although it is likely that the proteins produced from them promote uncontrolled growth of cells. (medlineplus.gov)
Driver events in pediatric malignancies can occur through loss of function in tumor suppressor genes or gain of function in proto-oncogenes. (medscape.com)
Tumor suppressor genes encode proteins that normally provide negative control of cell proliferation. (medscape.com)
Proto-oncogenes are genes that function normally in healthy cells to promote growth and proliferation. (medscape.com)
While they are normally regulated by other genes, including tumor suppressor genes, proto-oncogenes can be activated to become oncogenes that are less sensitive to this regulation. (medscape.com)
Transcription factors, proteins that bind to the regulatory sequences of target genes, compose the largest class of oncogenes identified in pediatric tumors. (medscape.com)
78) The latest researcher will continue to investigation this new reactions of the embryo to help you these types of the brand new protein and you also hypothesize that he's most likely to see which of your own following the (if you find yourself embryonic genes are nevertheless not being shown)? (riki-tiki.pl)
Membrane proteins encoded by the BCL-2 GENES and serving as potent inhibitors of cell death by APOPTOSIS. (uchicago.edu)
Cellular proteins encoded by the c-mos genes (GENES, MOS). (uams.edu)

In genetic screens aimed at understanding drug resistance mechanisms in chronic myeloid leukemia cells, inactivation of the cullin 3 adapter protein-encoding leucine zipper-like transcription regulator 1 ( LZTR1 ) gene led to enhanced mitogen-activated protein kinase (MAPK) pathway activity and reduced sensitivity to tyrosine kinase inhibitors. (nih.gov)
C6-unsubstituted pyrazolo[3,4-d]pyrimidines are dual Src/Abl inhibitors effective against imatinib mesylate resistant chronic myeloid leukemia cell lines. (nih.gov)
Further, overexpression of membrane-targeted Syk in cells treated with Abl kinase inhibitors partially rescues the impairment in phagocytosis. (duke.edu)
Intrabodies have potential as molecular inhibitors because they can block protein or nucleic acid interaction sites, relocate proteins within the cell or cause proteolysis due to folding abnormalities. (medscape.com)
The ability of tyrphostins to discriminate between normal and transforming abl proteins suggests that it may be possible to design specific abl kinase inhibitors to combat abl- associated human leukemias. (huji.ac.il)
7. bcr/abl expression in 32D cl3(G) cells inhibits apoptosis induced by protein tyrosine kinase inhibitors. (nih.gov)

pronounced "sarc", as it is short for sarcoma), is a non-receptor tyrosine kinase protein that in humans is encoded by the SRC gene. (wikipedia.org)
Two transcript variants encoding the same protein have been found for this gene. (wikipedia.org)
Eventually this normal gene mutated into an abnormally functioning oncogene within the Rous sarcoma virus. (wikipedia.org)
[ 1 ] His prediction was subsequently supported by the cloning of the retinoblastoma tumor suppressor gene ( RB1 ) and by functional studies of the retinoblastoma protein, Rb. (medscape.com)
The BCR-ABL oncogene is a fusion gene resulting from a reciprocal translocation between chromosome 9 and chromosome 22 (Philadelphia chromosome) first described in 1960 [14, 15]. (ukaachen.de)
Overexpression of bcl-2 proteins, due to a translocation of the gene, is associated with follicular lymphoma. (uchicago.edu)
The bcr/abl fusion gene, formed by rearrangement of the breakpoint cluster region (bcr) on chromosome 22 with the c-abl proto-oncogene on chromosome 9, is present in CML (chronic myeloid leukemia) patients. (justia.com)
The chromosome containing bcr/abl gene is referred to as Philadelphia chromosome (Nowell, J. Natl. (justia.com)
In the bcr/abl fusion gene, the bcr gene part contains oligomerization domains, and the abl gene part contains tyrosine domains. (justia.com)
3 principle forms (p190, p210 and p230 kDa) of bcr/abl gene, determined by the breakpoints of the bcr gene, have been reported. (justia.com)
There are various mechanisms to cause the acquired Gleevec-resistance including amplification of bcr/abl gene, loss of bcr/abl gene, point mutations of bcr/abl gene. (justia.com)
The HIPK2 (serine/threonine homeodomain-interacting protein kinase 2) is a "caretaker" gene, its inactivation increases tumorigenicity while its activation inhibits tumor growth. (oncotarget.com)

Oncogenic transformation of c-abl arises when specific N-terminal amino acids are deleted, releasing the kinase from negative regulation. (bvsalud.org)
As the biochemical and structural details of oncogenic proteins become known, the possibility of creating custom therapeutic reagents can be investigated using molecular modeling to generate candidate small molecules that may interfere with the oncogenic proteins' intrinsic activity or interaction with other molecules. (medscape.com)
9. Intrinsic regulation of the interactions between the SH3 domain of p85 subunit of phosphatidylinositol-3 kinase and the protein network of BCR/ABL oncogenic tyrosine kinase. (nih.gov)
Oncogenic transformation can take place when c-mos proteins are expressed at the wrong time. (uams.edu)

3. Use of a temperature-sensitive mutant to define the biological effects of the p210BCR-ABL tyrosine kinase on proliferation of a factor-dependent murine myeloid cell line. (nih.gov)
16. Expression of the chronic myelogenous leukemia-associated p210bcr/abl oncoprotein in a murine IL-3 dependent myeloid cell line. (nih.gov)

They function in the cell cycle to maintain MATURATION PROMOTING FACTOR in the active state and have protein-serine/threonine kinase activity. (uams.edu)
A serine-threonine protein kinase family whose members are components in protein kinase cascades activated by diverse stimuli. (childrensmercy.org)
Serine/threonine-protein kinase that phosphorylates SFPQ/PSF, HNRNPA1 and EIF4E. (idrblab.net)
Cdc7-IN-5 (compound I- B ) is a potent Cdc7 kinase inhibitor extracted from patent WO2019165473A1, compound I- B . Cdc7 is a serine-threonine protein kinase enzyme which is essential for the initiation of DNA replication in the cell cycle. (medchemexpress.com)
HIPK2, a nuclear body localized 1189-amino-acid protein, belongs to the DYRK serine/threonine homeodomain-interacting kinase family [ 16 ]. (oncotarget.com)

Cell surface protein-tyrosine kinase receptors for HEPATOCYTE GROWTH FACTOR. (umassmed.edu)
This pathway is activated by the cell-surface death receptors CD95 (Apo-1 or Fas)/TRAIL/tumor necrosis factor (TNF) receptor 1 family proteins which are located on the plasma membrane, and directly activates the caspase cascade via the recruitment of the "initiator" caspase-8 within a death-inducing signaling complex (DISC) [ 8 ]. (hindawi.com)

Quantitative real-time PCR, western blot analysis and colony formation assay were used to evaluate changes induced by overexpression or inhibition of miR-23a or BCR/ABL. (nih.gov)
Description: Inhibition of native ABL kinase activity. (guidetoimmunopharmacology.org)
15. Inhibition of Abl tyrosine kinase enhances nerve growth factor-mediated signaling in Bcr-Abl transformed cells via the alteration of signaling complex and the receptor turnover. (nih.gov)

Western blot analysis of extracts from K562 cells, untreated or treated with an Abl inhibitor, using Phospho-c-Abl (Tyr245) Antibody. (cellsignal.com)
Phospho-c-Abl (Tyr-245) synthetic peptide (coupled to KLH) corresponding to amino acid residues around tyrosine 245 of human c-Abl. (ecmbio.com)
This antibody was cross-adsorbed to phospho-tyrosine coupled to agarose then affinity purified using phospho-c-Abl (Tyr-245) peptide (without carrier). (ecmbio.com)

However, therapeutic agents, such as Imatinib have now been approved for the treatment of advanced GISTs and others, such as everolimus, rapamycin, heat shock protein 90 and IGF are in trial stage demonstrate promising results for the management of GISTs. (biomedcentral.com)

BCL2 family of proteins is the hallmark of apoptosis regulation. (hindawi.com)
In the present paper, we describe current knowledge on the role of BCL2 apoptosis regulator proteins in acute and chronic leukemias. (hindawi.com)
The mechanism of apoptosis is evolutionarily conserved and is executed by a family of proteins, called caspases. (hindawi.com)

The CDK4-cyclinD complex normally phosphorylates the retinoblastoma protein (Rb protein), leading to release of the E2F transcription factor and cell cycle progression. (medscape.com)
the result of this translocation is the enhanced BCL2 protein transcription. (hindawi.com)
Retinoblastoma protein recruits histone deacetylase to repress transcription. (nih.gov)

This proto-oncogene may play a role in the regulation of embryonic development and cell growth. (wikipedia.org)
The aim of this study was to investigate the role and mechanism of miR-23a in the regulation of BCR/ABL and to provide a new prognostic biomarker for chronic myeloid leukemia (CML). (nih.gov)
BCL2 protein family, through its role in regulation of apoptotic pathways, is possibly related to cancer pathophysiology and resistance to conventional chemotherapy. (hindawi.com)
However, the mechanism of regulation of c-Abl is not known. (elsevierpure.com)

The proteins are found on mitochondrial, microsomal, and NUCLEAR MEMBRANE sites within many cell types. (uchicago.edu)

Characterization of compound 584, an Abl kinase inhibitor with lasting effects. (nih.gov)
The p16INK4A protein is a cell-cycle inhibitor that acts by inhibiting activated cyclin D:CDK4/6 complexes, which play a crucial role in the control of the cell cycle by phosphorylating Rb protein. (medscape.com)
PknB-IN-2 (Compound 10) is a Mycobacterium tuberculosis protein kinase B ( PknB ) inhibitor with an IC 50 of 12.1 μM. (medchemexpress.com)
B -Raf IN 5 (compound 3 b ) is a potent inhibitor of protein kinase B-Raf with an IC 50 of 2.0 nM. (medchemexpress.com)
OTS964 hydrochloride is an orally active, high affinity and selective TOPK (T-lymphokine-activated killer cell-originated protein kinase ) inhibitor with an IC 50 of 28 nM. (medchemexpress.com)

The first, which is called the intrinsic cell death pathway, is evoked by intracellular stresses like radiation, growth factor withdrawal, cytokine deprivation, cytotoxic drugs and is regulated by BCL2 family proteins [ 6 , 7 ]. (hindawi.com)
13. The proto-oncogene product p120CBL and the adaptor proteins CRKL and c-CRK link c-ABL, p190BCR/ABL and p210BCR/ABL to the phosphatidylinositol-3' kinase pathway. (nih.gov)

This peptide sequence has high homology to the conserved site in rat and mouse c-Abl, as well as in viral Abl and BCR-Abl fusion protein. (ecmbio.com)

The transforming abl proteins p160(gag-abl), p185(bcr-abl), and p210(bcr- abl) and the normal protein p140(c-abl) have identical catalytic sites, but differ in their N-terminal domains. (huji.ac.il)
In the present study, we demonstrate that two transforming abl proteins, p210(bcr-abl) and p160(gag-abl), exhibit a higher affinity toward ATP and synthetic tyrosine containing substrates than p140(c-abl). (huji.ac.il)

The fully differentiated cells of the rat mammary parenchyma, the ductal epithelial, alveolar, and myoepithelial cells, are distinguished by their ultrastructure and by their accumulation of immunocytochemically detectable marker proteins. (nih.gov)

Current research focuses on the prognostic impact and specific role of these proteins in the pathogenesis of leukemias. (hindawi.com)
Activation of proto-oncogenes is a common theme in childhood leukemias and solid tumors. (medscape.com)

The main mechanisms for activation of proto-oncogenes consist of point mutations, amplifications, and chromosomal translocations. (medscape.com)
The recently released drugs such as Nilotinib and Dasatinib effectively inhibit many point-mutations of abl kinase domains generated by the acquired Gleevec-resistance. (justia.com)

60% of patients with PMF harbor the JAK2V617F mutation, approximately 30% carry a calreticulin mutation (CALR), and 8% carry a myeloproliferative leukemia virus oncogene (MPL) mutation. (ukaachen.de)

Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. (idrblab.net)
Molecular remission (negative polymerase chain reaction [PCR] result for the mutational BCR/ABL mRNA), which represents an attempt for cure and prolongation of patient survival. (askhematologist.com)
Anemarsaponin B decreases the protein and mRNA levels of iNOS and COX-2 . (medchemexpress.com)

Description: Binding affinity for the unphosphorylated kinase domain of the human ABL protein. (guidetoimmunopharmacology.org)
Protein kinase affinity probe 1 is a modified Purvalanol B (HY-18299) probe with 50% beads loading (Compound S3). (medchemexpress.com)

These results suggest that the transforming potency of the abl proteins may result from their higher affinities toward intracellular signal transducers and demonstrate for the first time that oncogene products can differ from their homologous proto- oncogene product in substrate specificity. (huji.ac.il)
4. The leukaemic oncoproteins Bcr-Abl and Tel-Abl (ETV6/Abl) have altered substrate preferences and activate similar intracellular signalling pathways. (nih.gov)
Cdk5 and Abl enzyme substrate 1 [Source. (gsea-msigdb.org)

Chromosomal translocations create protein fusions that often exhibit unique properties. (medscape.com)
10. TLS/FUS, a pro-oncogene involved in multiple chromosomal translocations, is a novel regulator of BCR/ABL-mediated leukemogenesis. (nih.gov)

Interaction between replication protein A and p53 is disrupted after UV damage in a DNA repair-dependent manner. (nih.gov)
Single-stranded-DNA binding alters human replication protein A structure and facilitates interaction with DNA-dependent protein kinase. (nih.gov)
namely, that HSP90 function in vivo is highly specific and is regulated by interaction with unique accessory proteins. (nih.gov)
We have determined that, in addition to p185c-erbB2 and mutated p53, pp60v-src, c-raf-1, and HIF-1alpha proteins require HSP90 interaction for function. (nih.gov)

The fusion protein lacks an N-terminal myristoylated cap, undermining autoinhibitory SH2 and SH3 docking mechanisms and rendering BCR-ABL constitutively active [16, 17]. (ukaachen.de)
The bcr-abl fusion protein is the proto-oncogene from the Philadelphia chromosome found in CML. (abcmedicalnotes.com)

Among them, the most important factor inducing the acquired Gleevec-resistance is T315I-bcr/abl point mutation within the abl kinase domain. (justia.com)
Therefore, there are a number of attempts to develop a medicine inhibiting T315I-bcr/abl mutation. (justia.com)

Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Nitric Oxide Synthase Interacting Protein (NOSIP) in samples from Tissue homogenates and other biological fluids. (1elisakits.com)
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Mouse Fatty Acid Transport Protein 5 (FATP5) in samples from Tissue homogenates, cell lysates and other biological fluids. (lotusbiotechnologies.com)
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Fatty Acid Transport Protein 5 (FATP5) in Tissue homogenates and other biological fluids. (lotusbiotechnologies.com)

a protein that belongs to the PTP (protein tyrosine phosphatases) family. (nih.gov)
Furthermore, protein tyrosine kinase blockers from the tyrphostin family can discriminate between normal abl and transforming abl proteins of both human and mouse origin. (huji.ac.il)
their activation is mainly regulated by the BCL2 family proteins [ 2 - 4 ]. (hindawi.com)
A PROTEIN-TYROSINE KINASE family that was originally identified by homology to the Rous sarcoma virus ONCOGENE PROTEIN PP60(V-SRC ). (nih.gov)
Thus, cellular activity of multiple oncogene/proto-oncogene products depends on a common mechanism, making the HSP90 chaperone family an exciting new molecular target for anticancer drug development. (nih.gov)
A target that has fewer human similarity proteins outside its family is commonly regarded to possess a greater capacity to avoid undesired interactions and thus increase the possibility of finding successful drugs ( Brief Bioinform, 21: 649-662, 2020 ). (idrblab.net)

The best anticancer drugs are likely to be small entities with low toxicity and high specificity, such as the anti-kinase drug STI571 (Gleevec), which is effective against the kinase activity of the ABL portion of BCR-ABL even though it was not developed for this use [ 8 ] . (medscape.com)
Previous studies have indicated that the transforming abl proteins possess higher tyrosine kinase activity than the normal abl proto-oncogene product. (huji.ac.il)
c-Abl represents a specific anti-cancer target in prostate cancer as aberrant activity of this kinase has been implicated in the stimulation of prostate cancer growth and progression. (elsevierpure.com)
Role of protein-protein interactions in the function of replication protein A (RPA): RPA modulates the activity of DNA polymerase alpha by multiple mechanisms. (nih.gov)

Src contains at least three flexible protein domains, which, in conjunction with myristoylation, can mediate attachment to membranes and determine subcellular localization. (wikipedia.org)
18. Subcellular localization of Bcr, Abl, and Bcr-Abl proteins in normal and leukemic cells and correlation of expression with myeloid differentiation. (nih.gov)

Anatomy10

Organisms4

Diseases21

Chemicals and Drugs83

Analytical, Diagnostic and Therapeutic Techniques and Equipment8

Phenomena and Processes39

Information Science3

Kinases31

Abl19

Signal Transduction6

Phosphorylation9

Peptides2

Encodes7

Homolog1

Genes12

Inhibitors6

Gene12

Oncogenic4

Murine2

Serine5

Receptors2

Inhibition3

Phospho-c-Abl3

Imatinib1

Apoptosis3

Transcription3

Regulation4

Membrane1

Inhibitor5

Pathway2

Peptide1

P2102

Detectable1

Leukemias2

Point mutations2

Leukemia1

MRNA3

Affinity2

Substrate3

Chromosomal translocations2

Interaction4

Fusion protein2

Mutation2

Enzyme3

Family6

Activity4

Subcellular2