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  • adapter
  • Following MET activation, transphosphorylation occurs on Tyr 1234 and Tyr 1235 C-terminal region contains two crucial tyrosines (Tyr 1349 and Tyr 1356), which are inserted into the multisubstrate docking site, capable of recruiting downstream adapter proteins with Src homology-2 (SH2) domains. (wikipedia.org)
  • Subcellular
  • Src contains at least three flexible protein domains, which, in conjunction with myristoylation, can mediate attachment to membranes and determine subcellular localization. (wikipedia.org)
  • known
  • citation needed] Akt possesses a protein domain known as a PH domain, or Pleckstrin Homology domain, named after Pleckstrin, the protein in which it was first discovered. (wikipedia.org)
  • 2001
  • He was awarded the 2001 Nobel Prize in Physiology or Medicine with Paul Nurse and Leland H. Hartwell for their discoveries of protein molecules that control the division of cells. (wikipedia.org)
  • molecular
  • The fully glycosylated RET protein is reported to have a molecular weight of 170 kDa although it is not clear to which isoform this molecular weight relates. (wikipedia.org)
  • cell
  • In particular, Hunt discovered what he called cyclin: a protein in fertilised sea urchin eggs which cyclically aggregates and is depleted during cell division cycles. (wikipedia.org)
  • Cyclins are proteins that play a key role in regulating the cell-division cycle. (wikipedia.org)
  • He and others subsequently showed that cyclins bind and activate a family of protein kinases, now called the cyclin-dependent kinases, one of which had been identified as a crucial cell cycle regulator by Paul Nurse. (wikipedia.org)
  • This protein is located in the cell nucleus and must dimerize with another bHLH protein in order to bind DNA. (wikipedia.org)
  • defects
  • Mice deficient in GDNF, GFRα1 or the RET protein itself exhibit severe defects in kidney and enteric nervous system development. (wikipedia.org)
  • interaction
  • Region of homology to semaphorins (Sema domain), which includes the full α-chain and the N-terminal part of the β-chain Cysteine-rich MET-related sequence (MRS domain) Glycine-proline-rich repeats (G-P repeats) Four immunoglobulin-like structures (Ig domains), a typical protein-protein interaction region. (wikipedia.org)
  • synthesis
  • While there, they discovered that tiny amounts of glutathione inhibited protein synthesis in reticulocytes and that tiny amounts of RNA killed the synthesis altogether. (wikipedia.org)
  • The location provided a ready supply of surf clams and sea urchins amongst the reefs and fishing docks, and it was these invertebrates that were particularly useful for the study of the synthesis of proteins in embryogenesis, as the embryos were simply generated with the application of filtered sea water, and the transparency of the embryo cells was well suited to microscopic study. (wikipedia.org)
  • domain
  • MYB factors represent a family of proteins that include the conserved MYB DNA-binding domain. (wikipedia.org)
  • Plants contain a MYB-protein subfamily that is characterised by the R2R3-type MYB domain. (wikipedia.org)
  • The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. (wikipedia.org)
  • cells
  • N-Myc and MYCNOS are co-regulated both in normal development and in tumor cells, so it is possible that the two proteins are functionally related. (wikipedia.org)
  • mutations
  • These types of mutations are associated with papillary thyroid carcinoma (PTC), and the fusion oncoproteins generated are termed RET/PTC proteins. (wikipedia.org)
  • adaptor
  • Myocardial ischemia/reperfusion injury: the role of adaptor proteins Crk. (nih.gov)
  • TCR crosslinking promotes Crk adaptor protein binding to tyrosine-phosphorylated CD3ζ chain. (nih.gov)
  • phosphorylates
  • This protein phosphorylates specific tyrosine residues in other proteins. (wikipedia.org)
  • In addition to phosphorylating focal adhesion proteins, SRC is also active at the sites of cell-cell contact adherens junctions and phosphorylates substrates such as beta-catenin (CTNNB1), delta-catenin (CTNND1), and plakoglobin (JUP). (uniprot.org)
  • family
  • Myb proto-oncogene protein is a member of the MYB (myeloblastosis) family of transcription factors. (wikipedia.org)
  • MYB factors represent a family of proteins that include the conserved MYB DNA-binding domain. (wikipedia.org)
  • He and others subsequently showed that cyclins bind and activate a family of protein kinases, now called the cyclin-dependent kinases, one of which had been identified as a crucial cell cycle regulator by Paul Nurse. (wikipedia.org)
  • constitutive
  • Elevated and deregulated (constitutive) expression of c-myc proteins can cause tumorigenesis. (labome.org)
  • Chromosomal rearrangements that generate a fusion gene, resulting in the juxtaposition of the C-terminal region of the RET protein with an N-terminal portion of another protein, can also lead to constitutive activation of the RET kinase. (wikipedia.org)