• Src (pronounced "sarc" as it is short for sarcoma) is a proto-oncogene encoding a tyrosine kinase originally discovered by J. Michael Bishop and Harold E. Varmus, for which they were awarded the 1989 Nobel Prize in Physiology or Medicine. (wikipedia.org)
  • Eventually this normal gene mutated into an abnormally functioning oncogene within the Rous sarcoma virus. (wikipedia.org)
  • Similarly, c-Src should not be mistaken for v-Src , a viral (hence the prefix v- ) gene that shares similarity with c-Src and is also an oncogene, which can be found in Rous sarcoma virus . (wikidoc.org)
  • Sarcoma was in fact first discovered as an oncogene in a chicken retrovirus . (wikipedia.org)
  • Experiments performed by Dr. G. Steve Martin of the University of California, Berkeley demonstrated that the sarcoma was indeed the oncogene of the virus. (wikipedia.org)
  • PP2 is a ATP-competitive inhibitor of the Src family of protein tyrosine kinases. (csnpharm.com)
  • Phosphorylated ITAM motifs on CD3 recruit and activate SH2 domain-containing protein tyrosine kinases (PTK) such as Zap70 to further mediate downstream signalling through tyrosine phosphorylation, leading to transcription factor activation including NF-κB and consequent T cell activation. (wikipedia.org)
  • HIV-1 uses CD4 to gain entry into host T-cells and achieves this through its viral envelope protein known as gp120 . (wikipedia.org)
  • Following a structural change in another viral protein ( gp41 ), HIV inserts a fusion peptide into the host cell that allows the outer membrane of the virus to fuse with the cell membrane . (wikipedia.org)
  • This study investigates whether or not an interrelationship exists between the expression of resistance-related proteins (P-glycoprotein, glutathione S-transferase, topoisomerase II) and proto-oncogene products (c-fos, c-myc, c-K-ras, epidermal growth factor receptor [EGF-R], and c-neu proteins. (curehunter.com)
  • p>When browsing through different UniProt proteins, you can use the 'basket' to save them, so that you can back to find or analyse them later. (uniprot.org)
  • p>This section provides any useful information about the protein, mostly biological knowledge. (uniprot.org)
  • Each article introduces a different protein, exploring its biological function as it relates to other members of the protein family, examining common domain architectures and their biological distribution, and tying it in to a broader perspective on how the protein impacts today's medicine and the environment. (ebi.ac.uk)
  • The articles also serve as an introduction to the use of the InterPro database, exploring the relevant InterPro entries for each featured protein in detail, and relating them to the biological information discussed in the article. (ebi.ac.uk)
  • Thirty-eight human renal cell carcinomas of previously untreated patients were analyzed for expression of P-glycoprotein (P-170), glutathione S-transferase-pi (GST-pi), topoisomerase II (Topo II) and proto-oncogene proteins by means of immunohistochemistry. (curehunter.com)
  • Analysis of proto-oncogene and heat-shock protein gene expression in human derived cell-lines exposed in vitro to an intermittent 1.9 GHz pulse-modulated radiofrequency field. (emf-portal.org)
  • We have recently reported the identification of a new oncogene, named PTC, frequently activated in human thyroid papillary carcinomas. (nih.gov)
  • In an effort to further examine the role of this oncogene in human malignancies, we have investigated the expression of the ret oncogene in a number of human tumors. (nih.gov)
  • We consistently detected expression of normal-sized transcripts of the ret proto-oncogene in human pheochromocytomas and in human medullary thyroid carcinomas (MTC), both of familial and sporadic type. (nih.gov)
  • Nucleotide sequence analysis of cDNA clones showed that the c-syn gene could encode a protein-tyrosine kinase that is very similar in primary structure to the v-yes and human c-src proteins. (elsevier.com)
  • Recombinant Human NEDD8 E1 (APP-BP1/UBA3) is a member of the NEDD8-activating (E1) enzyme family that is required for the first step of the enzymatic cascade that subsequently utilizes a NEDD8-conjugating (E2) enzyme and a NEDD8 ligase (E3) to conjugate NEDD8 to substrate proteins. (rndsystems.com)
  • Human APP-BP1 is a 534 amino acid (aa) protein with a predicted molecular weight of 60 kDa that is expressed ubiquitously in fetal tissues and in the adult brain (1). (rndsystems.com)
  • Human UBA3 is a 463 aa protein with a predicted molecular weight of 52 kDa. (rndsystems.com)
  • Since the 1970s, dozens of oncogenes have been identified in human cancer. (wikipedia.org)
  • It has been shown that NCYM antisense RNA encodes for a protein that has originated de novo and is specific to human and chimpanzee. (wikipedia.org)
  • The human DEK gene encodes the DEK protein. (wikipedia.org)
  • The protein plays a role in cell cycle progression, apoptosis and cellular transformation. (bioportfolio.com)
  • RNA modifications impact numerous cellular processes such as pre-mRNA splicing and protein synthesis. (mendeley.com)
  • Since in recent years molecular and cellular en- docrinology has provided particularly important contributions to our knowledge, the European Workshops on Molecular and Celluar Endo- crinology of the Testis, held regularly during even years since 1980, have become a prominent forum for researchers in the field to discuss recent findings and exchange new ideas. (springer.com)
  • Another example of an oncogene is the Bcr-Abl gene found on the Philadelphia chromosome , a piece of genetic material seen in Chronic Myelogenous Leukemia caused by the translocation of pieces from chromosomes 9 and 22. (wikipedia.org)
  • Mechanistically, LMTK2 phosphorylated protein phosphatase 1A (PP1A) to prevent PP1A from dephosphorylating p-GSK3β(Ser9). (bioportfolio.com)
  • The protein product (PTEN) encodes a dual-specificity protein phosphatase and in addition can dephosphorylate certain lipid substrates. (pnas.org)
  • A PTEN mutant associated with Cowden's disease (PTEN;G129E) has protein phosphatase activity yet is defective in dephosphorylating inositol 1,3,4,5-tetrakisphosphate in vitro and fails to arrest cells in G 1 . (pnas.org)
  • Furthermore, a PTEN mutant, associated with CD, that retains protein phosphatase activity was defective in arresting cells in G 1 and was also defective in dephosphorylating inositol 1,3,4,5-tetrakisphosphate (IP 4 ). (pnas.org)