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  • Embryo
  • 4. The process of any one of claims 1-3, wherein said packaging cell is chicken embryo fibroblast ("CEF") prepared by digestion of embryos tissue with trypsin and dispase. (patentsencyclopedia.com)
  • Humans
  • These results demonstrate that FLT3-ITD mutant proteins are sufficient to induce a myeloproliferative disorder, but are insufficient to recapitulate the AML phenotype observed in humans. (jove.com)
  • induce
  • B) Two representative clones of A673/TR/empty, A673/TR/preLOX, A673/TR/LOX-PP and A673/TR/LOXenz cells were incubated in the absence or in the presence of doxycycline (DOX, 1 µg/ml) during 48 hours to induce the expression of the corresponding proteins. (nih.gov)
  • Mitogenic
  • A genome-wide RNAi screen reveals a trio-regulated rho GTPase circuitry transducing Mitogenic signals initiated by G protein-coupled receptors. (thermofisher.com)
  • TEL‐induced oligomerization is shown to be essential for the constitutive activation of the protein kinase activity and mitogenic properties of TEL-platelet derived growth factor receptor β (PDGFRβ), a fusion oncoprotein characteristic of the leukemic cells of chronic myelomonocytic leukemia harboring a t(5;12) chromosomal translocation. (embopress.org)
  • antibody
  • If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production , custom recombinant protein production or custom antibody production . (mybiosource.com)
  • representative
  • Swapping experiments in which the TEL oligomerization domain was exchanged by the homologous domains of representative vertebrate ETS proteins including ETS‐1, ERG‐2 and GABPα show that oligomerization is a specific property of the TEL amino‐terminal conserved domain. (embopress.org)
  • We decided to investigate the proteic alterations of an ES cell line bearing a representative fusion protein. (omicsonline.org)
  • translocation
  • In particular, little effort has been devoted to characterization of the proteic component of the mechanisms and pathways deployed by the activation of the fusion protein resulting from chromosomal translocation. (omicsonline.org)
  • cancer
  • In this study, we report that Sam68, an RNA-binding protein frequently overexpressed in prostate cancer cells, enhances splicing of cyclin D1b and supports its expression in prostate cancer cells. (aacrjournals.org)
  • Activation
  • However, although antiandrogenic therapies are initially efficacious, PCa often evolves into a hormone therapy-resistant disease in which AR activation persists in spite of the treatments ( 1 ). (aacrjournals.org)
  • composition
  • 2. The process of claim 1, wherein said poxvirus composition comprises more than 5% EEV. (patentsencyclopedia.com)
  • 3. The process of claim 1 or claim 2, wherein said process for producing said poxvirus composition further comprises step g) of tangential filtration. (patentsencyclopedia.com)
  • syndrome
  • ERG also strongly cooperates with the GATA1s mutated protein, found in Down syndrome AMKL, to immortalize megakaryocyte progenitors, suggesting that the additional copy of ERG in trisomy 21 may have a role in Down syndrome AMKL. (aacrjournals.org)
  • results
  • These results indicate that the amino‐terminal domain conserved in a subset of the ETS proteins has evolved to generate a specialized protein-protein interaction interface which is likely to be an important determinant of their specificity as transcriptional regulators. (embopress.org)