Proto oncogene protein c ets 2. Medical search. Frequent questions

The mouse and human Fli1 genes are similarly regulated by Ets factors in T cells. (musc.edu)
Membrane proteins encoded by the BCL-2 GENES and serving as potent inhibitors of cell death by APOPTOSIS. (rush.edu)
Genes encoding proteins involved in processing of drugs and other xenobiotics. (gsea-msigdb.org)
We have learned that genes in mammalian cells are transcribed into messenger RNAs (mRNAs), which are to be translated into polypeptides (proteins). (intechopen.com)
Overexpression of ELF4 boosted CRC metastasis via transactivating its downstream target genes, fibroblast growth factor receptor 4 (FGFR4) and SRC proto-oncogene, non-receptor tyrosine kinase, SRC . (thno.org)
Proto-oncogenes are normal genes that help cells grow. (diaridelsestudiants.com)
Gene expression analysis identifies genes associated with SARS-COV-2 receptors, ACE2 and TMPRSS2, in normal human lung tissues. (diaridelsestudiants.com)
Of the 31 genes, the 21 upregulated genes were primarily associated with cell paracrine and intracellular signaling, transcription regulation and cell adhesion and migration, and their transcriptional products included transforming growth factor-β2 (TGF-β2), insulin-like growth factor-binding protein 2 and transcriptional factor AP-2α/γ ( 11 ). (spandidos-publications.com)
By contrast, the 10 downregulated genes were primarily associated with epithelial membrane proteins ( 11 ). (spandidos-publications.com)
Genes whose protein products stimulate or enhance the division and viability of cells. (cancerquest.org)
Genes whose protein products can directly or indirectly prevent cell division or lead to cell death. (cancerquest.org)
The normal versions of genes in the first group are called proto-oncogenes. (cancerquest.org)
The mutated or otherwise damaged versions of these genes are called oncogenes. (cancerquest.org)
Numerous genes have been identified as proto-oncogenes. (cancerquest.org)
As stated in the introduction to this section, the defective versions of these genes, known as oncogenes, can cause a cell to divide in an unregulated manner. (cancerquest.org)
Cellular DNA-binding proteins encoded by the rel gene (GENES, REL). (childrensmercy.org)
Human ELF-1, a transcription factor that appears to be required for the T- cell-receptor-mediated trans activation of HIV-2 genes. (expasy.org)

In a set of 15 potential biomarkers differentiating SLE patients and controls, two of the proteins were transcription factors, i.e. (nih.gov)
Using a combination of targeted mutagenesis of transcription factor-binding sites and gene silencing of transcription factors, we found that Gata and Ets factors are required for Flk1in10 enhancer activity in all endothelial cells. (ox.ac.uk)
ETS family of transcription factors including Elk1, ETS1 and ETS2 are some of the well-known targets for the EGFR-Ras-MEK1/2 signaling pathway [11]. (researchassistantresume.com)
ETS1 is usually Narlaprevir a founding family member of ETS-domain transcription factors. (researchassistantresume.com)
A member of the c-ets family of transcription factors that is preferentially expressed in cells of hematopoietic lineages and vascular endothelial cells. (childrensmercy.org)
TMPRSS2 is a prostate-specific and androgen-response gene that encodes a protein belonging to the serine protease family, which functions in prostate carcinogenesis and relies on gene fusion with ETS transcription factors, such as ERG and ETV1 (8). (diaridelsestudiants.com)
ERG is a member of the ETS (erythroblast transformation-specific) family of transcription factors. (diaridelsestudiants.com)
The Ets family of eukaryotic transcription factors is based around the conserved Ets DNA-binding domain. (hud.ac.uk)
This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. (nih.gov)
An exciting finding is that in approximately half of the cases, there are recurrent chromosomal rearrangements resulting in the fusion of transmembrane protease serine 2 (TMPRSS2 ) and a member of the ETS family transcription factors , most commonly ERG . (medscape.com)

Unique and selective effects of five Ets family members, Elf3, Ets1, Ets2, PEA3, and PU.1, on the promoter of the type II transforming growth factor-beta receptor gene. (musc.edu)
adiponectin receptor 2 [Source:HGNC Sy. (gsea-msigdb.org)
Epidermal growth factor receptor (EGFR)-mediated MEK1/2-ERK MAPK pathway activity has been shown to regulate virtually all aspects involved in tumourigenesis. (researchassistantresume.com)
Identification of ETS-like transcription factor 4 as a novel androgen receptor target in prostate cancer cells. (nih.gov)
HER2/neu (also called ERB B2 ) is the gene that encodes the human epidermal growth factor receptor type 2. (cancerquest.org)

The D domain plays the key role of binding to active Mitogen-activated protein kinases (MAPKs). (wikipedia.org)
As seen in Figure 2, Raf kinase acts upstream of MAPKs to activate them by phosphorylating and, thereby activating, MEKs, or MAPK or ERK kinases. (wikipedia.org)
Extracellular signal-regulated kinases 1 and 2 were activated and Elk-1 and AP-1 DNA binding activity was induced in Colo357L3.6pl cells. (duke.edu)
The protein encoded by this gene is phosphorylated by the kinases, MAPK1 and MAPK8. (nih.gov)

The reversed polarity of the posterior 2 ° precursor cell lineage requires WNT signaling mediated by both Frizzled class and Ryk class WNT-receptors LIN-17 and LIN-18 , respectively. (wormbook.org)

Protein kinase C, which is activated by phorbol esters, can fulfill the same function as Ras. (wikipedia.org)
CONCLUSION: These results suggest that overexpression of TrkB and activation of mitogen-activated protein kinase and AP-1, which may in turn induce the expression of vascular endothelial growth factor and interleukin 8, may mediate the cardinal clinical features of locally aggressive growth and metastasis of pancreatic cancer. (duke.edu)
death associated protein kinase 1 [Sou. (gsea-msigdb.org)
Canonical Notch signaling activates the transcription of BMI1 proto‑oncogene polycomb ring finger, cyclin D1, CD44, cyclin dependent kinase inhibitor 1A, hes family bHLH transcription factor 1, hes related family bHLH transcription factor with YRPW motif 1, MYC, NOTCH3, RE1 silencing transcription factor and transcription factor 7 in a cellular context‑dependent manner, while non‑canonical Notch signaling activates NF‑κB and Rac family small GTPase 1. (spandidos-publications.com)
Cyclin-dependent kinase 2 (CDK2) is a key mediator for EGF-induced cell transformation mediated through the ELK4/c-Fos signaling pathway. (nih.gov)
see RTKRas/MAP kinase signaling ), LIN-12 (see LIN-12/Notch signaling in C. elegans ), and WNT (see Wnt signaling ), as well as the functions of the SynMuv and mediator proteins (see Transcriptional regulation ). (wormbook.org)
Protein kinase Cd and c-Abl kinase are required for transforming growth factor ß induction of endothelial-mesenchymal transition in vitro. (jefferson.edu)

These genetic alterations often results in overexpression or activity of proto-oncogenes and inhibition of the function of tumor suppressor [1], [2].Therefore, understanding of the mechanisms by which the activity of both proto-oncogenes and tumor suppressors is usually altered in malignancy is usually crucially important both academically, and for development of new approaches to target malignancy cells for therapy. (researchassistantresume.com)
A useful analogy to consider when thinking about tumor suppressors and oncogenes is an automobile. (cancerquest.org)

Ets factors and a newly identified polymorphism regulate Fli1 promoter activity in lymphocytes. (musc.edu)
Friend leukemia virus integration 1 (FLI1), an ETS transcription factor family member, acts as an oncogenic driver in hematological malignancies and promotes tumor growth in solid tumors. (biomedcentral.com)
Using a CRISPR Cas9-guided immunoprecipitation assay, we identify a circular RNA in the FLI1 promoter chromatin complex, consisting of FLI1 exons 4-2-3, referred to as FECR1.Overexpression of FECR1 enhances invasiveness of MDA-MB231 breast cancer cells. (biomedcentral.com)
Among the ETS family members, Friend leukemia virus integration 1 ( FLI1 ) was first identified as a proto-oncogene activated by proviral integration in F-MuLV-induced erythroleukemias [ 4 ]. (biomedcentral.com)

C-X-C motif chemokine ligand 2 [Source. (gsea-msigdb.org)
The anchor cell also patterns nearby uterine cells, via the DSL ligand LAG-2 and LIN-12 , to generate the four uv1 cells that form the tight connection with the vulva. (wormbook.org)

GA binding protein (GAPB) α subunit. (expasy.org)

SCOS-mediated arteriogenesis requires a canonical Notch signaling pathway in Mφs via the glycosylation of protein O-glucosyltransferases 2, which results in promoting arterial differentiation and tissue repair in ischemia. (bvsalud.org)
Methods Pathways governing airway mucus cell differentiation include SRY (sex determining region Y)-box 2 (SOX2), Notch, forkhead box A3(FOXA3)/SAM pointed domain containing ETS transcription factor (SPDEF), epidermal growth factor (EGF) and the EGF-related neuregulins NRG1α and NRG1β. (bmj.com)

It is classified as a ternary complex factor (TCF), a subclass of the ETS family, which is characterized by a common protein domain that regulates DNA binding to target sequences. (wikipedia.org)

fibrillin 2 [Source:HGNC Symbol;Acc:HG. (gsea-msigdb.org)
acyl-CoA oxidase 2 [Source:HGNC Symbol. (gsea-msigdb.org)
arginase 2 [Source:HGNC Symbol;Acc:HGN. (gsea-msigdb.org)
C-reactive protein [Source:HGNC Symbol. (gsea-msigdb.org)

The ERG gene encodes for a protein, also called ERG, that functions as a transcriptional regulator. (diaridelsestudiants.com)
Establishing the transcriptional programme for blood: the SCL stem cell enhancer is regulated by a multiprotein complex containing Ets and GATA factors. (ox.ac.uk)
Human ERF, a potent transcriptional repressor that binds to the HI element of the Ets-2 promoter. (expasy.org)

The proprotein convertase furin is a type I transmembrane protein that is ubiquitously expressed in eukaryotic tissues and cells. (diaridelsestudiants.com)

These results also suggest that in addition to its established role in invasion and angiogenesis, ETS1 may support malignant cellular Narlaprevir growth via regulation of CIP2A expression and protein phosphatase 2A inhibition. (researchassistantresume.com)
Furthermore, we discuss recent advances in drug development for inhibition of Ets factors, and the roles structural biology can play in their future. (hud.ac.uk)

Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum reponse element in the promoter of the c-fos proto-oncogene. (nih.gov)
Mammalian ELK-1, ELK-3 (also known as Net or SAP-2) and ELK-4 (also known as SRF accessory protein 1 (SAP-1)), which all form a ternary complex with the serum response factor (SRF). (expasy.org)

The mutant proteins often retain some of their capabilities but are no longer sensitive to the controls that regulate the normal form of the protein. (cancerquest.org)

It has been linked to malignancy since its identification as an oncogenic fusion with the product of c-Myb proto-oncogene in the. (researchassistantresume.com)

It might have an important polymorphic association at the promoter regions of several MMPs such as MMP-1 (-1607 1G/2G), MMP-2 (-1306 C/T), MMP-3 (-1171 5A/6A), MMP-9 (-1562 C/T) and TIMP-2 (-418 G/C or C/C). Tissue inhibitors of metalloproteinases (TIMPs) are naturally occurring inhibitors of MMPs, which inhibit the activity of MMPs and control the breakdown of ECM. (biomedcentral.com)

Nuclear factors bound to SP1 and Ets sequences were detected, but were not altered upon OSM stimulation. (uea.ac.uk)

We have identified three critical motifs, which are essential for enhancer function and bind GATA-2, Fli-1 and Elf-1 in vivo. (ox.ac.uk)

Ultimately, phosphorylation of Elk1 can result in the production of many proteins, depending on the other factors involved and their specific interactions with each other. (wikipedia.org)
Drosophila protein pointed (pnt) which is required for glial-neuronal cell interactions. (expasy.org)

Overexpression of bcl-2 proteins, due to a translocation of the gene, is associated with follicular lymphoma. (rush.edu)

However, little is known about the mechanisms underlying the activation of this proto-oncogene in tumors. (biomedcentral.com)
In the present paper, we review the progress made over the last decade to elucidate the structural mechanisms involved in modulation of DNA binding and protein partner selection during dimerization. (hud.ac.uk)
We see that Ets domains, although conserved around a core architecture, have evolved to utilize a variety of interaction surfaces and binding mechanisms, reflecting Ets domains as dynamic interfaces for both DNA and protein interaction. (hud.ac.uk)

The EndoA enhancer contains multiple ETS binding site repeats and is regulated by ETS proteins. (musc.edu)

Fibroblast growth factor 19 (FGF19) upregulated ELF4 expression through the ERK1/2/SP1 axis. (thno.org)

The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA563995(MMP1 Antibody) at dilution 1/60, on the right is treated with fusion protein. (cusabio.com)

Narlaprevir Thus, ETS1 is probably mediating high CIP2A expression in human cancers with increased EGFR-MEK1/2-ERK pathway activity. (researchassistantresume.com)

It constitutes fibrous proteins such as collagen and elastin, elongated glycoproteins such as fibronectin and laminin, which provide cell matrix adhesion. (biomedcentral.com)

Adenovirus E1A enhancer-binding protein (E1A-F) (ETV4) (PEA3). (expasy.org)
PU.1 (also known as Spi-1), a protein that binds to a purine-rich sequence, the PU-box, that can act as a lymphoid-specific enhancer. (expasy.org)

Genetic mutation promotes biological evolution and results in biodiversity ( 2 , 3 ). (spandidos-publications.com)

Mdm2 Phosphorylation Regulates Its Stability and Has Contrasting Effects on Oncogene and Radiation-Induced Tumorigenesis. (umassmed.edu)

OSM stimulated a rapid and transient increase in c-Fos mRNA and nuclear protein that coincided with complex 2 formation. (uea.ac.uk)

Characterization of SAP-1, a protein recruited by serum response factor to the c-fos serum response element. (nih.gov)

Our objective was to obtain protein profiles to identify potential general biomarkers of SLE and to determine molecular subgroups within SLE for patient stratification. (nih.gov)
Unsupervised clustering of all investigated proteins identified three molecular subgroups among SLE patients, characterized by (1) high levels of rheumatoid factor-IgM, (2) low IRF5, and (3) high IRF5. (nih.gov)

Camostat mesilate is an inhibitor of TMPRSS2 and has been shown to be a potent antiviral agent against SARS-CoV-2 in vitro and against SARS-CoV-1 in vivo (mice). (diaridelsestudiants.com)

Evolution of the ets gene family. (expasy.org)

We identified Interferon regulating factor 5 (IRF5), solute carrier family 22 member 2 (SLC22A2) and S100 calcium binding protein A12 (S100A12) as the three proteins with the largest fold change between SLE patients and controls (SLE/Control = 1.4, 1.4, and 1.2 respectively). (nih.gov)
aldehyde dehydrogenase 2 family member. (gsea-msigdb.org)
Here, we investigated the function of E74-like factor 4 (ELF4), an ETS family member, in facilitating CRC progression. (thno.org)

cytochrome P450 family 2 subfamily C m. (gsea-msigdb.org)

Transmembrane serine protease 2 (TMPRSS2) is a cell surface protein primarily expressed by endothelial cells across the respiratory and digestive tracts. (diaridelsestudiants.com)
As a serine protease, it is involved in the cleaving peptide bonds of proteins that have serine as the nucleophilic amino acid within the active site. (diaridelsestudiants.com)
At cellular level, the trans-membrane protease serine 2 (TMPRSS2) primes the spike protein of human coronaviruses and facilitates cell entry and infection. (diaridelsestudiants.com)
Serine protease inhibitors, or serpins, comprise a family of proteins that antagonize the activity of serine proteases. (diaridelsestudiants.com)

cytoplasmic FMR1 interacting protein 2. (gsea-msigdb.org)

The proteins are found on mitochondrial, microsomal, and NUCLEAR MEMBRANE sites within many cell types. (rush.edu)

The others are the site-specific TFs or the DNA sequence-specific binding proteins. (intechopen.com)

Although previous studies have identified 2 Flk1 regulatory enhancers, these are dispensable for Flk1 expression, indicating that additional enhancers contribute to Flk1 regulation in endothelial cells. (ox.ac.uk)

these include the LIM domain protein LIN-11 , the Pax2/5/8 protein EGL-38 , the zinc finger protein LIN-29 , and the Nkx6.1/6.2 protein COG-1. (wormbook.org)

Mucus cells lining abnormal airways from patients with IPF expressed MUC5B and SOX2 but lacked SAM pointed domain containing ETS transcription factor (SPDEF) and forkhead box A3(FOXA3). (bmj.com)

In fact, proto-oncogenes are necessary for our survival. (diaridelsestudiants.com)

Below are the most recent publications written about "Proto-Oncogene Proteins c-bcl-2" by people in Profiles. (rush.edu)
Single-cell expression profiles of ACE2 and TMPRSS2 reveals potential vertical transmission and fetus infection of SARS-CoV-2. (diaridelsestudiants.com)

First, the general TFs (GTFs), including preinitiation complex components TFIIA, TFIIB, TFIID, TFIIE, TFIIF, and THIIH, are the primary protein factors that are required for the initiation of transcription from the TATA box (or TATA element), then elongation is executed by RNA polymerase II (RNA pol II) [ 1 ]. (intechopen.com)
Fos and Jun nuclear factors bound constitutively to this site as identified by supershift analysis in electrophoretic mobility shift assays, and oncostatin M (but not IL-6) induced an additional "complex 2" that contained c-Fos and JunD. (uea.ac.uk)
The incidence of head and neck squamous cell carcinoma (HNSCC) has increased probably because of the increased use of tobacco and alcohol, which are widely documented as risk factors for this malignancy [ 2 ]. (biomedcentral.com)

IRF5 and SAM pointed domain containing ETS transcription factor (SPDEF). (nih.gov)
The binding of Elk1 to SRF happens due to protein-protein interaction between the B domain of Elk1 and SRF and the protein-DNA interaction via the A domain. (wikipedia.org)
We have derived two signature patterns for the ETS-domain. (expasy.org)
The ETS-domain: a new DNA-binding motif that recognizes a purine-rich core DNA sequence. (expasy.org)

Cancerous inhibitor of protein phosphatase 2A (CIP2A) is usually a recently characterized human oncoprotein. (researchassistantresume.com)

DnaJ heat shock protein family (Hsp40). (gsea-msigdb.org)

Utilizing research on severe acute respiratory syndrome coronavirus (SARS-CoV) and the closely related SARS-CoV-2 cell entry mechanism, it has been demonstrated that SARS-CoV-2 cellular entry can be blocked by camostat mesilate. (diaridelsestudiants.com)
We have two copies of each gene and for oncogenes, a single defective copy is enough to cause a cell to divide. (cancerquest.org)
Some proto-oncogenes work to regulate cell death. (cancerquest.org)
The proto-oncogenes that have been identified so far have many different functions in the cell. (cancerquest.org)
[ 2 ] Another 25-40% of cases are initially diagnosed as prostatic adenocarcinoma and recur as small cell carcinoma after hormonal therapy. (medscape.com)

The prostaglandin-endoperoxide synthase 2 gene (PTGS2), which encodes cyclooxygenase-2, was found to upregulate the expression of TGF-β2 ( 14 ). (spandidos-publications.com)

Both ∆Elk1 and sElk1, truncated versions of full-length protein, are capable of binding to DNA and inducing various cellular signaling. (wikipedia.org)
V-ets and c-ets-1, its cellular progenitor, have been shown [ 1 ] to be nuclear DNA-binding proteins. (expasy.org)

This intermediate mesoderm then divides into the posterior nascent mesoderm (E8.5), arising from the posterior intermediate mesoderm, and the anterior intermediate mesoderm (E8.5), which gives rise to the ureteric bud generated from the Wolffian duct progenitor (E9.5) [ 2 , 3 ]. (j-organoid.org)

Clin Cancer Res , 11 (2 Pt 1), 440-449. (duke.edu)
Clin Cancer Res 11, no. 2 Pt 1 (January 15, 2005): 440-49. (duke.edu)

Anatomy8

Organisms2

Diseases18

Chemicals and Drugs81

Analytical, Diagnostic and Therapeutic Techniques and Equipment9

Phenomena and Processes37

Information Science3

Health Care1

Genes17

Transcription factors10

Receptor5

Kinases4

Receptors1

Kinase7

Tumor suppressors2

FLI14

Ligand2

Subunit1

Notch2

Ternary complex factor1

Source:HGNC Symbol4

Transcriptional3

Eukaryotic1

Inhibition2

Form a ternary complex2

Mutant proteins1

Oncogenic1

Promoter1

Sequences1

Gata1

Interactions2

Overexpression1

Mechanisms3

Repeats1

Fibroblast1

Fusion1

Ets11

Fibrous1

Enhancer2

Genetic1

Tumorigenesis1

MRNA1

Characterization1

Molecular2

Mice1

Gene family1

Member3

Subfamily1

Serine4

Cytoplasmic1

Mitochondrial1

Sequence-specific1

Endothelial cells1

Zinc finger1

Forkhead box1

Survival1

Profiles2

Factors3

Domain4

Phosphatase1

Heat shock protein1

Cell5

Encodes1

Cellular2

Progenitor1

Cancer Res2